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Aliases for FAM213B Gene

Aliases for FAM213B Gene

  • Family With Sequence Similarity 213 Member B 2 3 5
  • Prostamide/Prostaglandin F Synthase 2 3
  • Thioredoxin-Type PGF Synthase 2 3
  • Prostamide/PG F Synthase 3 4
  • Prostamide/PGF Synthase 3 4
  • C1orf93 3 4
  • Family With Sequence Similarity 213, Member B 2
  • Chromosome 1 Open Reading Frame 93 2
  • Protein FAM213B 4
  • EC 1.11.1.20 4

External Ids for FAM213B Gene

Previous HGNC Symbols for FAM213B Gene

  • C1orf93

Previous GeneCards Identifiers for FAM213B Gene

  • GC01P002517

Summaries for FAM213B Gene

GeneCards Summary for FAM213B Gene

FAM213B (Family With Sequence Similarity 213 Member B) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and prostaglandin-F synthase activity. An important paralog of this gene is FAM213A.

UniProtKB/Swiss-Prot for FAM213B Gene

  • Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM213B Gene

Genomics for FAM213B Gene

Regulatory Elements for FAM213B Gene

Enhancers for FAM213B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G002574 2 FANTOM5 Ensembl ENCODE dbSUPER 9.5 -9.5 -9479 5.2 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B DMAP1 YY1 ZNF143 ZNF207 MMEL1 TNFRSF14 FAM213B SKI GC01M002574
GH01G002580 1.4 ENCODE dbSUPER 9.7 -2.0 -2047 7.2 HDGF ARNT ZFP64 WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 MMEL1 FAM213B GC01M002574
GH01G002640 1.7 FANTOM5 Ensembl ENCODE 7.9 +56.1 56075 3.2 FOXA2 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF207 MMEL1 ACTRT2 FAM213B MORN1 PANK4 GC01M002636 GC01P002648
GH01G002543 1.8 FANTOM5 ENCODE dbSUPER 6.7 -39.4 -39374 7.5 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MORN1 MMEL1 LOC100129381 LOC100288379 TNFRSF14 LOC100129534 SLC35E2 MIB2 SLC35E2B FAM213B
GH01G002559 1.2 ENCODE dbSUPER 9.3 -23.8 -23770 6.2 HDGF DMAP1 TCF12 GLIS2 FOS SP5 TSHZ1 TBX21 ZNF592 NFIL3 MMEL1 MORN1 LOC100129534 SLC35E2 MIB2 SLC35E2B LOC100129381 FAM213B TNFRSF14-AS1 ENSG00000225931
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM213B on UCSC Golden Path with GeneCards custom track

Promoters for FAM213B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000372 40 2201 HDGF ARNT ZFP64 WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207

Genomic Location for FAM213B Gene

Chromosome:
1
Start:
2,586,460 bp from pter
End:
2,591,469 bp from pter
Size:
5,010 bases
Orientation:
Plus strand

Genomic View for FAM213B Gene

Genes around FAM213B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM213B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM213B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM213B Gene

Proteins for FAM213B Gene

  • Protein details for FAM213B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF2-PGFS_HUMAN
    Recommended name:
    Prostamide/prostaglandin F synthase
    Protein Accession:
    Q8TBF2
    Secondary Accessions:
    • A8K793
    • B3KPY3
    • B4DQR9
    • B4E0S5
    • B7ZAC8
    • B9DI90
    • B9DI92
    • J3KQD0
    • Q8N2H0

    Protein attributes for FAM213B Gene

    Size:
    198 amino acids
    Molecular mass:
    21223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM213B Gene

neXtProt entry for FAM213B Gene

Post-translational modifications for FAM213B Gene

  • Ubiquitination at Lys101 and Lys120
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM213B Gene

Domains & Families for FAM213B Gene

Protein Domains for FAM213B Gene

Suggested Antigen Peptide Sequences for FAM213B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBF2

UniProtKB/Swiss-Prot:

PGFS_HUMAN :
  • Belongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily.
Family:
  • Belongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily.
genes like me logo Genes that share domains with FAM213B: view

No data available for Gene Families for FAM213B Gene

Function for FAM213B Gene

Molecular function for FAM213B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thioredoxin + prostaglandin H(2) = thioredoxin disulfide + prostaglandin F(2-alpha).
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

Enzyme Numbers (IUBMB) for FAM213B Gene

Gene Ontology (GO) - Molecular Function for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA,ISS 18006499
GO:0047017 prostaglandin-F synthase activity ISS,IEA 18006499
genes like me logo Genes that share ontologies with FAM213B: view
genes like me logo Genes that share phenotypes with FAM213B: view

Animal Model Products

CRISPR Products

miRNA for FAM213B Gene

miRTarBase miRNAs that target FAM213B

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM213B Gene

Localization for FAM213B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM213B Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM213B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IEA 18006499
GO:0005783 endoplasmic reticulum IEA,ISS 18006499
GO:0005829 cytosol IEA --
GO:0043209 myelin sheath ISS,IEA 18006499
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FAM213B: view

Pathways & Interactions for FAM213B Gene

genes like me logo Genes that share pathways with FAM213B: view

Gene Ontology (GO) - Biological Process for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS 18006499
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA --
genes like me logo Genes that share ontologies with FAM213B: view

No data available for SIGNOR curated interactions for FAM213B Gene

Transcripts for FAM213B Gene

Unigene Clusters for FAM213B Gene

Family with sequence similarity 213, member B:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM213B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: - - -
SP12: - -
SP13: - - - - - -
SP14: - - - - -
SP15: - -

ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FAM213B Gene

GeneLoc Exon Structure for
FAM213B
ECgene alternative splicing isoforms for
FAM213B

Expression for FAM213B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM213B Gene

Protein differential expression in normal tissues from HIPED for FAM213B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.7) and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM213B Gene



Protein tissue co-expression partners for FAM213B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM213B Gene:

FAM213B

SOURCE GeneReport for Unigene cluster for FAM213B Gene:

Hs.462033

Evidence on tissue expression from TISSUES for FAM213B Gene

  • Nervous system(4.8)
  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with FAM213B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM213B Gene

Orthologs for FAM213B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM213B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM213B 34 35
  • 98.1 (n)
cow
(Bos Taurus)
Mammalia FAM213B 34 35
  • 87.14 (n)
dog
(Canis familiaris)
Mammalia FAM213B 34 35
  • 85.86 (n)
rat
(Rattus norvegicus)
Mammalia Fam213b 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Fam213b 34 16 35
  • 83.16 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM213B 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam213b 34
  • 61.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9472 34
zebrafish
(Danio rerio)
Actinopterygii fam213b 34 35
  • 62.12 (n)
worm
(Caenorhabditis elegans)
Secernentea R53.5 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10285 35
  • 43 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
Species where no ortholog for FAM213B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM213B Gene

ENSEMBL:
Gene Tree for FAM213B (if available)
TreeFam:
Gene Tree for FAM213B (if available)

Paralogs for FAM213B Gene

Paralogs for FAM213B Gene

(1) SIMAP similar genes for FAM213B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM213B: view

Variants for FAM213B Gene

Sequence variations from dbSNP and Humsavar for FAM213B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000675166 -- 2,587,319(+) CGCGG(C/T)GGCGC intron-variant
rs1001255069 -- 2,588,461(+) TGTGC(-/GGGTCA)GGGTC intron-variant
rs1001658938 -- 2,586,250(+) GTCTC(A/G)CGCGA upstream-variant-2KB
rs1001817311 -- 2,590,762(+) AGCCC(C/T)GCGGG nc-transcript-variant, utr-variant-3-prime
rs1001866344 -- 2,587,513(+) GACGA(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM213B Gene

Variant ID Type Subtype PubMed ID
esv3582248 CNV gain 25503493
nsv470684 CNV loss 18288195
nsv545077 CNV gain 21841781
nsv545082 CNV loss 21841781
nsv545083 CNV gain 21841781
nsv7171 OTHER inversion 18451855
nsv829648 CNV loss 17160897
nsv951592 CNV deletion 24416366

Variation tolerance for FAM213B Gene

Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM213B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM213B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM213B Gene

Disorders for FAM213B Gene

Relevant External Links for FAM213B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM213B

No disorders were found for FAM213B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM213B Gene

Publications for FAM213B Gene

  1. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. (PMID: 20950588) Yoshikawa K. … Shimada A. (Brain Res. 2011) 2 3 64
  2. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. (PMID: 18006499) Moriuchi H. … Watanabe K. (J. Biol. Chem. 2008) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for FAM213B Gene

Sources for FAM213B Gene

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