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Aliases for FAM213B Gene

Aliases for FAM213B Gene

  • Family With Sequence Similarity 213, Member B 2 3
  • Prostamide/Prostaglandin F Synthase 2 3
  • Prostamide/PG F Synthase 3 4
  • Prostamide/PGF Synthase 3 4
  • C1orf93 3 4
  • Chromosome 1 Open Reading Frame 93 2
  • Protein FAM213B 4
  • EC 1.11.1.20 4

External Ids for FAM213B Gene

Previous HGNC Symbols for FAM213B Gene

  • C1orf93

Previous GeneCards Identifiers for FAM213B Gene

  • GC01P002517

Summaries for FAM213B Gene

GeneCards Summary for FAM213B Gene

FAM213B (Family With Sequence Similarity 213, Member B) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. An important paralog of this gene is FAM213A.

UniProtKB/Swiss-Prot for FAM213B Gene

  • Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM213B Gene

Genomics for FAM213B Gene

Genomic Location for FAM213B Gene

Start:
2,586,460 bp from pter
End:
2,591,469 bp from pter
Size:
5,010 bases
Orientation:
Plus strand

Genomic View for FAM213B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM213B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM213B Gene

No data available for Regulatory Elements for FAM213B Gene

Proteins for FAM213B Gene

  • Protein details for FAM213B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF2-PGFS_HUMAN
    Recommended name:
    Prostamide/prostaglandin F synthase
    Protein Accession:
    Q8TBF2
    Secondary Accessions:
    • A8K793
    • B3KPY3
    • B4DQR9
    • B4E0S5
    • B7ZAC8
    • B9DI90
    • B9DI92
    • J3KQD0
    • Q8N2H0

    Protein attributes for FAM213B Gene

    Size:
    198 amino acids
    Molecular mass:
    21223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM213B Gene

neXtProt entry for FAM213B Gene

Proteomics data for FAM213B Gene at MOPED

Post-translational modifications for FAM213B Gene

  • Ubiquitination at Lys101 and Lys120
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM213B Gene

Domains for FAM213B Gene

Protein Domains for FAM213B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TBF2

UniProtKB/Swiss-Prot:

PGFS_HUMAN :
  • Q8TBF2
Family:
  • Belongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily.
genes like me logo Genes that share domains with FAM213B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM213B Gene

Function for FAM213B Gene

Molecular function for FAM213B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thioredoxin + prostaglandin H(2) = thioredoxin disulfide + prostaglandin F(2-alpha)
UniProtKB/Swiss-Prot Function: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).

Enzyme Numbers (IUBMB) for FAM213B Gene

Gene Ontology (GO) - Molecular Function for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS --
GO:0047017 prostaglandin-F synthase activity ISS 18006499
genes like me logo Genes that share ontologies with FAM213B: view

Phenotypes for FAM213B Gene

genes like me logo Genes that share phenotypes with FAM213B: view

miRNA for FAM213B Gene

miRTarBase miRNAs that target FAM213B

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM213B Gene

Localization for FAM213B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM213B Gene

Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS 18006499
GO:0005783 endoplasmic reticulum ISS 18006499
GO:0005829 cytosol IEA --
GO:0043209 myelin sheath ISS 18006499
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FAM213B: view

No data available for Subcellular locations from COMPARTMENTS for FAM213B Gene

Pathways for FAM213B Gene

genes like me logo Genes that share pathways with FAM213B: view

Gene Ontology (GO) - Biological Process for FAM213B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019371 cyclooxygenase pathway TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FAM213B: view

Transcripts for FAM213B Gene

Unigene Clusters for FAM213B Gene

Family with sequence similarity 213, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM213B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10: - -
SP11: - - -
SP12: - -
SP13: - - - - - -
SP14: - - - - -
SP15: - -

ExUns: 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FAM213B Gene

GeneLoc Exon Structure for
FAM213B
ECgene alternative splicing isoforms for
FAM213B

Expression for FAM213B Gene

mRNA expression in normal human tissues for FAM213B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM213B Gene

SOURCE GeneReport for Unigene cluster for FAM213B Gene Hs.462033

genes like me logo Genes that share expressions with FAM213B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM213B Gene

Orthologs for FAM213B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM213B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM213B 35
  • 98.1 (n)
  • 98.25 (a)
FAM213B 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM213B 35
  • 87.14 (n)
  • 89.34 (a)
FAM213B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM213B 35
  • 85.86 (n)
  • 87.88 (a)
FAM213B 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam213b 35
  • 83.16 (n)
  • 88.38 (a)
Fam213b 16
Fam213b 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM213B 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam213b 35
  • 83.33 (n)
  • 87.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9472 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fam213b 35
  • 61.11 (n)
  • 63.13 (a)
zebrafish
(Danio rerio)
Actinopterygii fam213b 35
  • 62.12 (n)
  • 59.6 (a)
fam213b 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R53.5 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
CSA.10285 36
  • 43 (a)
OneToMany
Species with no ortholog for FAM213B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM213B Gene

ENSEMBL:
Gene Tree for FAM213B (if available)
TreeFam:
Gene Tree for FAM213B (if available)

Paralogs for FAM213B Gene

Paralogs for FAM213B Gene

Selected SIMAP similar genes for FAM213B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM213B: view

Variants for FAM213B Gene

Sequence variations from dbSNP and Humsavar for FAM213B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6667564 -- 2,588,863(+) TGGTA(C/T)GTGGC intron-variant
rs6670198 -- 2,589,088(+) GCCCC(C/T)AGGTC intron-variant
rs6701238 -- 2,589,061(+) GGGGC(A/G)CTGCC intron-variant
rs7547725 -- 2,587,523(+) GCCCC(G/T)CCGGC intron-variant
rs7553267 -- 2,586,412(+) CAGCT(C/T)CGCCT upstream-variant-2KB

Relevant External Links for FAM213B Gene

HapMap Linkage Disequilibrium report
FAM213B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM213B Gene

Disorders for FAM213B Gene

No disorders were found for FAM213B Gene.

No data available for UniProtKB/Swiss-Prot for FAM213B Gene

Publications for FAM213B Gene

  1. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. (PMID: 18006499) Moriuchi H. … Watanabe K. (J. Biol. Chem. 2008) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. (PMID: 14710190) Castellano S. … GuigA^ R. (EMBO Rep. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for FAM213B Gene

Sources for FAM213B Gene

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