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Aliases for FAM213A Gene

Aliases for FAM213A Gene

  • Family With Sequence Similarity 213, Member A 2 3
  • Peroxiredoxin-Like 2 Activated In M-CSF Stimulated Monocytes 2 3 4
  • C10orf58 3 4
  • PAMM 3 4
  • Peroxiredoxin (PRX)-Like 2 Activated In M-CSF Stimulated Monocytes 3
  • Chromosome 10 Open Reading Frame 58 2
  • Redox-Regulatory Protein PAMM 3
  • UPF0765 Protein C10orf58 3
  • Protein PAMM 4

External Ids for FAM213A Gene

Previous HGNC Symbols for FAM213A Gene

  • C10orf58

Previous GeneCards Identifiers for FAM213A Gene

  • GC10P082167

Summaries for FAM213A Gene

GeneCards Summary for FAM213A Gene

FAM213A (Family With Sequence Similarity 213, Member A) is a Protein Coding gene. GO annotations related to this gene include antioxidant activity. An important paralog of this gene is FAM213B.

UniProtKB/Swiss-Prot for FAM213A Gene

  • Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass.

Gene Wiki entry for FAM213A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM213A Gene

Genomics for FAM213A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM213A Gene

Chromosome:
10
Start:
80,407,829 bp from pter
End:
80,437,115 bp from pter
Size:
29,287 bases
Orientation:
Plus strand

Genomic View for FAM213A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM213A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM213A Gene

No data available for Regulatory Elements for FAM213A Gene

Proteins for FAM213A Gene

  • Protein details for FAM213A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX8-F213A_HUMAN
    Recommended name:
    Redox-regulatory protein FAM213A
    Protein Accession:
    Q9BRX8
    Secondary Accessions:
    • B2RD81
    • Q6UW08
    • Q8N2K3
    • Q8NBK9
    • Q96JR0

    Protein attributes for FAM213A Gene

    Size:
    229 amino acids
    Molecular mass:
    25764 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The active site cysteines correspond to the redox-active cysteines of peroxiredoxins
    SequenceCaution:
    • Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM213A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM213A Gene

Proteomics data for FAM213A Gene at MOPED

Post-translational modifications for FAM213A Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM213A Gene

Domains & Families for FAM213A Gene

Protein Domains for FAM213A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM213A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX8

UniProtKB/Swiss-Prot:

F213A_HUMAN :
  • Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily.
Family:
  • Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily.
genes like me logo Genes that share domains with FAM213A: view

No data available for Gene Families for FAM213A Gene

Function for FAM213A Gene

Molecular function for FAM213A Gene

UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass.
UniProtKB/Swiss-Prot Induction:
By CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11

Gene Ontology (GO) - Molecular Function for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IDA 19951071
genes like me logo Genes that share ontologies with FAM213A: view

Phenotypes for FAM213A Gene

GenomeRNAi human phenotypes for FAM213A:
genes like me logo Genes that share phenotypes with FAM213A: view

Animal Model Products

CRISPR Products

miRNA for FAM213A Gene

miRTarBase miRNAs that target FAM213A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM213A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM213A Gene

Localization for FAM213A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM213A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM213A Gene COMPARTMENTS Subcellular localization image for FAM213A gene
Compartment Confidence
extracellular 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19951071
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM213A: view

Pathways & Interactions for FAM213A Gene

SuperPathways for FAM213A Gene

No Data Available

Interacting Proteins for FAM213A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361254%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361254 for FAM213A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045670 regulation of osteoclast differentiation IDA 19951071
GO:0055114 oxidation-reduction process IDA 19951071
genes like me logo Genes that share ontologies with FAM213A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM213A Gene

Drugs & Compounds for FAM213A Gene

No Compound Related Data Available

Transcripts for FAM213A Gene

Unigene Clusters for FAM213A Gene

Family with sequence similarity 213, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM213A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM213A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for FAM213A Gene

GeneLoc Exon Structure for
FAM213A
ECgene alternative splicing isoforms for
FAM213A

Expression for FAM213A Gene

mRNA expression in normal human tissues for FAM213A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM213A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for FAM213A Gene

This gene is overexpressed in Nasal epithelium (20.5), Adipocyte (8.8), and Nasopharynx (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM213A Gene



SOURCE GeneReport for Unigene cluster for FAM213A Gene Hs.500333

mRNA Expression by UniProt/SwissProt for FAM213A Gene

Q9BRX8-F213A_HUMAN
Tissue specificity: Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
genes like me logo Genes that share expression patterns with FAM213A: view

Protein tissue co-expression partners for FAM213A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for FAM213A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM213A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM213A 35
  • 88.23 (n)
  • 87.61 (a)
FAM213A 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM213A 35
  • 88.21 (n)
  • 90.83 (a)
FAM213A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam213a 35
  • 83.88 (n)
  • 88.37 (a)
Fam213a 16
Fam213a 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM213A 35
  • 99.27 (n)
  • 99.56 (a)
FAM213A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309676 35
  • 84.5 (n)
  • 86.84 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM213A 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM213A 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF58 35
  • 72.8 (n)
  • 74.44 (a)
C10ORF58 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM213A 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf58 35
  • 70.09 (n)
  • 72.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6886 35
zebrafish
(Danio rerio)
Actinopterygii fam213aa 35
  • 66.51 (n)
  • 69.71 (a)
wufb06a02 35
fam213aa 36
  • 63 (a)
OneToMany
fam213ab 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1007 35
worm
(Caenorhabditis elegans)
Secernentea R53.5 35
  • 50.9 (n)
  • 42.57 (a)
R53.5 36
  • 35 (a)
OneToMany
Species with no ortholog for FAM213A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM213A Gene

ENSEMBL:
Gene Tree for FAM213A (if available)
TreeFam:
Gene Tree for FAM213A (if available)

Paralogs for FAM213A Gene

Paralogs for FAM213A Gene

(1) SIMAP similar genes for FAM213A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM213A Gene

genes like me logo Genes that share paralogs with FAM213A: view

Variants for FAM213A Gene

Sequence variations from dbSNP and Humsavar for FAM213A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8735 -- 80,432,957(+) AAAAA(A/T)GTCCA utr-variant-3-prime
rs946889 -- 80,409,041(-) GCCCC(C/T)GGGCC intron-variant, upstream-variant-2KB
rs1063161 -- 80,432,369(+) ggtgc(A/G)gtggc utr-variant-3-prime
rs1140130 -- 80,432,562(+) cttga(A/G)cctgg utr-variant-3-prime
rs1417220 -- 80,408,398(-) TCGGG(C/T)GTGTG intron-variant, upstream-variant-2KB

Variation tolerance for FAM213A Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM213A Gene

HapMap Linkage Disequilibrium report
FAM213A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM213A Gene

Disorders for FAM213A Gene

Relevant External Links for FAM213A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM213A
genes like me logo Genes that share disorders with FAM213A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM213A Gene

Publications for FAM213A Gene

  1. PAMM: a redox regulatory protein that modulates osteoclast differentiation. (PMID: 19951071) Xu Y. … Battaglino R.A. (Antioxid. Redox Signal. 2010) 2 67
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67

Products for FAM213A Gene

Sources for FAM213A Gene

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