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Aliases for FAM213A Gene

Aliases for FAM213A Gene

  • Family With Sequence Similarity 213 Member A 2 3 5
  • Peroxiredoxin-Like 2 Activated In M-CSF Stimulated Monocytes 2 3 4
  • C10orf58 3 4
  • PAMM 3 4
  • Peroxiredoxin (PRX)-Like 2 Activated In M-CSF Stimulated Monocytes 3
  • Family With Sequence Similarity 213, Member A 2
  • Chromosome 10 Open Reading Frame 58 2
  • Redox-Regulatory Protein FAM213A 3
  • Redox-Regulatory Protein PAMM 3
  • UPF0765 Protein C10orf58 3
  • Protein PAMM 4

External Ids for FAM213A Gene

Previous HGNC Symbols for FAM213A Gene

  • C10orf58

Previous GeneCards Identifiers for FAM213A Gene

  • GC10P082167

Summaries for FAM213A Gene

GeneCards Summary for FAM213A Gene

FAM213A (Family With Sequence Similarity 213 Member A) is a Protein Coding gene. Diseases associated with FAM213A include Common Bile Duct Disease. GO annotations related to this gene include antioxidant activity. An important paralog of this gene is FAM213B.

UniProtKB/Swiss-Prot for FAM213A Gene

  • Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).

Gene Wiki entry for FAM213A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM213A Gene

Genomics for FAM213A Gene

Regulatory Elements for FAM213A Gene

Enhancers for FAM213A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F080453 1.2 FANTOM5 Ensembl ENCODE 27.1 +56.5 56539 22.7 HDGF PKNOX1 SIN3A DMAP1 ZNF143 FOS KLF13 ZNF263 SP5 JUNB FAM213A TSPAN14 LOC101929574 DYDC1 DYDC2 ANXA11 PLAC9 MBL1P SH2D4B PIR41876
GH10F080435 0.2 ENCODE 24.9 +29.0 29024 2.4 GATA3 CTBP1 DPF2 TCF7L2 FAM213A DYDC1 DYDC2 ANXA11 PIR57963 TSPAN14
GH10F080406 1.1 FANTOM5 Ensembl ENCODE 19.7 +3.8 3828 10.9 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 SP3 SP5 FAM213A DYDC2 DYDC1 MBL1P PLAC9 ANXA11 PIR57963
GH10F080357 1.1 ENCODE 19.5 -50.3 -50329 0.9 POLR2A MAX FAM213A DYDC1
GH10F080356 0.2 ENCODE 19.4 -51.1 -51050 0.2 RFX1 RNF2 NRF1 BMI1 FAM213A DYDC2 DYDC1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM213A on UCSC Golden Path with GeneCards custom track

Promoters for FAM213A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000358111 771 2001 ARID4B SIN3A ZNF48 YY1 SLC30A9 GLIS2 SP3 SP5 MXD4 REST

Genomic Location for FAM213A Gene

Chromosome:
10
Start:
80,407,829 bp from pter
End:
80,437,115 bp from pter
Size:
29,287 bases
Orientation:
Plus strand

Genomic View for FAM213A Gene

Genes around FAM213A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM213A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM213A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM213A Gene

Proteins for FAM213A Gene

  • Protein details for FAM213A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX8-F213A_HUMAN
    Recommended name:
    Redox-regulatory protein FAM213A
    Protein Accession:
    Q9BRX8
    Secondary Accessions:
    • B2RD81
    • Q6UW08
    • Q8N2K3
    • Q8NBK9
    • Q96JR0

    Protein attributes for FAM213A Gene

    Size:
    229 amino acids
    Molecular mass:
    25764 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.
    SequenceCaution:
    • Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM213A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM213A Gene

Post-translational modifications for FAM213A Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM213A Gene

Domains & Families for FAM213A Gene

Protein Domains for FAM213A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM213A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX8

UniProtKB/Swiss-Prot:

F213A_HUMAN :
  • Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily.
Family:
  • Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily.
genes like me logo Genes that share domains with FAM213A: view

No data available for Gene Families for FAM213A Gene

Function for FAM213A Gene

Molecular function for FAM213A Gene

UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).
UniProtKB/Swiss-Prot Induction:
By CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11.

Gene Ontology (GO) - Molecular Function for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IEA,IDA 19951071
genes like me logo Genes that share ontologies with FAM213A: view
genes like me logo Genes that share phenotypes with FAM213A: view

Animal Models for FAM213A Gene

MGI Knock Outs for FAM213A:

Animal Model Products

miRNA for FAM213A Gene

miRTarBase miRNAs that target FAM213A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM213A Gene

Localization for FAM213A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM213A Gene

Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000269 PubMed:26438880}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM213A Gene COMPARTMENTS Subcellular localization image for FAM213A gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19951071
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM213A: view

Pathways & Interactions for FAM213A Gene

SuperPathways for FAM213A Gene

No Data Available

Interacting Proteins for FAM213A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361254%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361254 Q9BRX8-F213A_HUMAN for FAM213A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045670 regulation of osteoclast differentiation IDA 19951071
GO:0055114 oxidation-reduction process IDA 19951071
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with FAM213A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM213A Gene

Transcripts for FAM213A Gene

Unigene Clusters for FAM213A Gene

Family with sequence similarity 213, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM213A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for FAM213A Gene

GeneLoc Exon Structure for
FAM213A
ECgene alternative splicing isoforms for
FAM213A

Expression for FAM213A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM213A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM213A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for FAM213A Gene

This gene is overexpressed in Nasal epithelium (20.5), Adipocyte (8.8), and Nasopharynx (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM213A Gene



Protein tissue co-expression partners for FAM213A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM213A Gene:

FAM213A

SOURCE GeneReport for Unigene cluster for FAM213A Gene:

Hs.500333

mRNA Expression by UniProt/SwissProt for FAM213A Gene:

Q9BRX8-F213A_HUMAN
Tissue specificity: Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
genes like me logo Genes that share expression patterns with FAM213A: view

Primer Products

Orthologs for FAM213A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM213A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM213A 34 35
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia FAM213A 34 35
  • 88.23 (n)
dog
(Canis familiaris)
Mammalia FAM213A 34 35
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309676 34
  • 84.5 (n)
mouse
(Mus musculus)
Mammalia Fam213a 34 16 35
  • 83.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM213A 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM213A 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF58 34 35
  • 72.8 (n)
lizard
(Anolis carolinensis)
Reptilia FAM213A 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf58 34
  • 70.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6886 34
zebrafish
(Danio rerio)
Actinopterygii fam213aa 34 35
  • 66.51 (n)
fam213ab 35
  • 55 (a)
OneToMany
wufb06a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1007 34
worm
(Caenorhabditis elegans)
Secernentea R53.5 34 35
  • 50.9 (n)
Species where no ortholog for FAM213A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM213A Gene

ENSEMBL:
Gene Tree for FAM213A (if available)
TreeFam:
Gene Tree for FAM213A (if available)

Paralogs for FAM213A Gene

Paralogs for FAM213A Gene

(1) SIMAP similar genes for FAM213A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM213A Gene

genes like me logo Genes that share paralogs with FAM213A: view

Variants for FAM213A Gene

Sequence variations from dbSNP and Humsavar for FAM213A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1063161 -- 80,432,369(+) ggtgc(A/G)gtggc utr-variant-3-prime
rs10712446 -- 80,432,656(+) AAAAA(-/A)TTGAT utr-variant-3-prime
rs10736364 -- 80,430,768(+) GCTGA(A/G)TGGCC intron-variant
rs10736365 -- 80,437,154(+) TGCAG(A/C)GGGTG downstream-variant-500B
rs10749595 -- 80,413,219(+) CAAGA(C/T)ACCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM213A Gene

Variant ID Type Subtype PubMed ID
nsv1051052 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv469837 CNV loss 16826518
nsv524518 CNV loss 19592680
nsv831923 CNV loss 17160897
nsv831924 CNV loss 17160897

Variation tolerance for FAM213A Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM213A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM213A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM213A Gene

Disorders for FAM213A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM213A Gene - From: DISEASES

Disorder Aliases PubMed IDs
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM213A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM213A
genes like me logo Genes that share disorders with FAM213A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM213A Gene

Publications for FAM213A Gene

  1. PAMM: a redox regulatory protein that modulates osteoclast differentiation. (PMID: 19951071) Xu Y. … Battaglino R.A. (Antioxid. Redox Signal. 2010) 2 3 4 64
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3 4 64
  3. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. (PMID: 26438880) Guo F. … Fu M. (Biochem. J. 2015) 3 4 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for FAM213A Gene

Sources for FAM213A Gene

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