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Aliases for FAM213A Gene

Aliases for FAM213A Gene

  • Family With Sequence Similarity 213, Member A 2 3
  • Peroxiredoxin-Like 2 Activated In M-CSF Stimulated Monocytes 2 3 4
  • C10orf58 3 4
  • PAMM 3 4
  • Peroxiredoxin (PRX)-Like 2 Activated In M-CSF Stimulated Monocytes 3
  • Chromosome 10 Open Reading Frame 58 2
  • Redox-Regulatory Protein FAM213A 3
  • Redox-Regulatory Protein PAMM 3
  • UPF0765 Protein C10orf58 3
  • Protein PAMM 4

External Ids for FAM213A Gene

Previous Symbols for FAM213A Gene

  • C10orf58

Summaries for FAM213A Gene

GeneCards Summary for FAM213A Gene

FAM213A (Family With Sequence Similarity 213, Member A) is a Protein Coding gene. GO annotations related to this gene include antioxidant activity. An important paralog of this gene is FAM213B.

UniProtKB/Swiss-Prot for FAM213A Gene

  • Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass.

Gene Wiki entry for FAM213A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM213A Gene

Genomics for FAM213A Gene

Genomic Location for FAM213A Gene

Start:
80,407,829 bp from pter
End:
80,437,115 bp from pter
Size:
29,287 bases
Orientation:
Plus strand

Genomic View for FAM213A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM213A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM213A Gene

No data available for Regulatory Elements for FAM213A Gene

Proteins for FAM213A Gene

  • Protein details for FAM213A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX8-F213A_HUMAN
    Recommended name:
    Redox-regulatory protein FAM213A
    Protein Accession:
    Q9BRX8
    Secondary Accessions:
    • B2RD81
    • Q6UW08
    • Q8N2K3
    • Q8NBK9
    • Q96JR0

    Protein attributes for FAM213A Gene

    Size:
    229 amino acids
    Molecular mass:
    25764 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The active site cysteines correspond to the redox-active cysteines of peroxiredoxins
    SequenceCaution:
    • Sequence=AAK55527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37828.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM213A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM213A Gene

Proteomics data for FAM213A Gene at MOPED

Post-translational modifications for FAM213A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys122

No data available for DME Specific Peptides for FAM213A Gene

Domains for FAM213A Gene

Protein Domains for FAM213A Gene

ProtoNet:

UniProtKB/Swiss-Prot:

F213A_HUMAN
Family:
  • Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily.:
    • Q9BRX8
genes like me logo Genes that share domains with FAM213A: view

No data available for Gene Families for FAM213A Gene

Function for FAM213A Gene

Molecular function for FAM213A Gene

UniProtKB/Swiss-Prot Function: Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass.
UniProtKB/Swiss-Prot Induction: By CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11

Gene Ontology (GO) - Molecular Function for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IDA 19951071
genes like me logo Genes that share ontologies with FAM213A: view

miRNA for FAM213A Gene

miRTarBase miRNAs that target FAM213A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM213A Gene

Localization for FAM213A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM213A Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19951071
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FAM213A: view

Pathways for FAM213A Gene

SuperPathways for FAM213A Gene

No Data Available

Interacting Proteins for FAM213A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361254%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361254 for FAM213A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FAM213A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045670 regulation of osteoclast differentiation IDA 19951071
GO:0055114 oxidation-reduction process IDA 19951071
genes like me logo Genes that share ontologies with FAM213A: view

No data available for Pathways by source for FAM213A Gene

Transcripts for FAM213A Gene

Unigene Clusters for FAM213A Gene

Family with sequence similarity 213, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM213A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for FAM213A Gene

GeneLoc Exon Structure for
FAM213A
ECgene alternative splicing isoforms for
FAM213A

Expression for FAM213A Gene

mRNA expression in normal human tissues for FAM213A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM213A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM213A Gene

SOURCE GeneReport for Unigene cluster for FAM213A Gene Hs.500333

mRNA Expression by UniProt/SwissProt for FAM213A Gene

Q9BRX8-F213A_HUMAN
Tissue specificity: Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).
genes like me logo Genes that share expressions with FAM213A: view

Orthologs for FAM213A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM213A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM213A 36
  • 99.27 (n)
  • 99.56 (a)
FAM213A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM213A 36
  • 88.23 (n)
  • 87.61 (a)
FAM213A 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM213A 36
  • 88.21 (n)
  • 90.83 (a)
FAM213A 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam213a 36
  • 83.88 (n)
  • 88.37 (a)
Fam213a 16
Fam213a 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM213A 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM213A 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309676 36
  • 84.5 (n)
  • 86.84 (a)
chicken
(Gallus gallus)
Aves C10ORF58 36
  • 72.8 (n)
  • 74.44 (a)
C10ORF58 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM213A 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6886 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf58 36
  • 70.09 (n)
  • 72.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1007 36
zebrafish
(Danio rerio)
Actinopterygii fam213aa 36
  • 66.51 (n)
  • 69.71 (a)
fam213aa 37
  • 63 (a)
OneToMany
fam213ab 37
  • 55 (a)
OneToMany
wufb06a02 36
worm
(Caenorhabditis elegans)
Secernentea R53.5 36
  • 50.9 (n)
  • 42.57 (a)
R53.5 37
  • 35 (a)
OneToMany
Species with no ortholog for FAM213A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM213A Gene

ENSEMBL:
Gene Tree for FAM213A (if available)
TreeFam:
Gene Tree for FAM213A (if available)

Paralogs for FAM213A Gene

Paralogs for FAM213A Gene

Selected SIMAP similar genes for FAM213A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM213A Gene

genes like me logo Genes that share paralogs with FAM213A: view

Variants for FAM213A Gene

Sequence variations from dbSNP and Humsavar for FAM213A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8735 -- 80,432,957(+) AAAAA(A/T)GTCCA utr-variant-3-prime
rs946889 -- 80,409,041(-) GCCCC(C/T)GGGCC intron-variant, synonymous-codon, reference
rs1063161 -- 80,432,369(+) ggtgc(A/G)gtggc utr-variant-3-prime
rs1140130 -- 80,432,562(+) cttga(A/G)cctgg utr-variant-3-prime
rs1417220 -- 80,408,398(-) TCGGG(C/T)GTGTG intron-variant, upstream-variant-2KB

Relevant External Links for FAM213A Gene

HapMap Linkage Disequilibrium report
FAM213A

No data available for Structural Variations from Database of Genomic Variants (DGV) for FAM213A Gene

Disorders for FAM213A Gene

No disorders were found for FAM213A Gene.

No data available for UniProtKB/Swiss-Prot for FAM213A Gene

Publications for FAM213A Gene

  1. PAMM: a redox regulatory protein that modulates osteoclast differentiation. (PMID: 19951071) Xu Y. … Battaglino R.A. (Antioxid. Redox Signal. 2010) 2 3 4
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FAM213A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FAM213A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FAM213A
    • Block miRNA regulation of FAM213A using miScript Target Protectors

    Sources for FAM213A Gene

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