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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM212B Gene

protein-coding GIFtS: 39
GCID: GC01M112223

family with sequence similarity 212, member B

(Previous name: chromosome 1 open reading frame 183 )
(Previous symbol: C1orf183)

Explore 2 diseases affiliated with
FAM212B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 212, Member B¹ ²
C1orf183¹ ² ³
FLJ31105¹
Chromosome 1 Open Reading Frame 183¹
Protein FAM212B²
Uncharacterized Protein C1orf183²

External Ids:	HGNC: 28045¹	Entrez Gene: 55924²	Ensembl: ENSG00000197852⁷	UniProtKB: Q9NTI7³

Export aliases for FAM212B gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for FAM212B
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM212B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM212B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

FAM212B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM212B gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M112223: view genomic region (about GC identifiers)

Start:	112,223,252 bp from pter	End:	112,298,446 bp from pter
Size:	75,195 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F212B_HUMAN, Q9NTI7 (See protein sequence)

Recommended Name: Protein FAM212B

Size: 297 amino acids; 32759 Da

Secondary accessions: B3KP38 B4DF94 Q9NTI6

Alternative splicing: 2 isoforms: Q9NTI7-1 Q9NTI7-2

Explore the universe of human proteins at neXtProt for FAM212B: NX_Q9NTI7

FAM212B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_061972.1 NP_945120.1

ENSEMBL proteins:

ENSP00000349805 ENSP00000436075 ENSP00000408238 ENSP00000437205

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM212B for domains About GeneDecksing

1 InterPro domain/family:

IPR026761 Fam212b

Graphical View of Domain Structure for InterPro Entry Q9NTI7

ProtoNet protein and cluster: Q9NTI7

UniProtKB/Swiss-Prot: F212B_HUMAN, Q9NTI7

Similarity: Belongs to the FAM212 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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2 GenomeRNAi human phenotypes for FAM212B:

Decreased viability with pacli

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM212B

1 Interacting protein for FAM212B (Q9NTI7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TM2D1	Q9BX74³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM212B
Search CenterWatch for drugs/clinical trials and news about FAM212B / F212B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM212B gene (2 alternative transcripts):

NM_019099.4 NM_198926.2

Unigene Cluster for FAM212B:

Family with sequence similarity 212, member B

Hs.193406 [show with all ESTs]

Unigene Representative Sequence: NM_019099

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527570 ENST00000357260(uc001ebo.2 uc001ebp.2) ENST00000534365

ENST00000444059 ENST00000527621 ENST00000412270(uc001ebr.3) ENST00000527660

ENST00000530619

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Additional cDNA sequence:

AK055667.1 AK092074.1 AK094997.1 AK293989.1 AL137198.1 AL137199.1 BC031558.1

6 DOTS entries:

DT.438072 DT.91755599 DT.40212498 DT.121440569 DT.121440577 DT.95263414

24/31 AceView cDNA sequences (see all 31):

AL137198 AL137199 BC031558 BF308793 BF305812 BX341652 AK055667 BX506153

CB117550 BP374879 BE296090 D20490 BE297160 BX327535 BG394636 BI115206

NM_198926 AA595469 NM_019099 CA449552 BP372771 BX498523 BP373359 BI824357

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM212B About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c
SP1:					-
SP2:

ECgene alternative splicing isoforms for FAM212B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM212B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

FAM212B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM212B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM212B

SOURCE GeneReport for Unigene cluster: Hs.193406

SABiosciences Custom PCR Arrays for FAM212B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM212B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM212B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	C26H1orf183¹	chromosome 26 open reading frame, human C1orf183	62.14(n) 59.64(a)		419868 XM_417995.3 XP_417995.3
lizard (Anolis carolinensis)	Reptilia	C1orf183⁶	--	48(a)	1 ↔ 1	4(126671432-126672737)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19495²	Transcribed sequence with weak similarity to protein more	77.47(n)		BX779803.1

ENSEMBL Gene Tree for FAM212B (if available)
TreeFam Gene Tree for FAM212B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM212B gene

FAM212A²

FAM212B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185013015^1,2		--	112264189(+)	`GAAGCC/TGGGGA`	2	--	ds500¹		0	--	--	--	--
rs78381616^1,2		--	112264190(+)	`AAGCCG/AGGGAC`	2	--	ds500¹		2		CSA WA	120
rs2076591^1,2	C,F,H,	--	112264274(+)	`GCATAT/CGGTGA`	2	--	ds500¹		35		EA NA NS WA CSA	4888
rs77581100^1,2	F,	--	112264295(+)	`CCCCTT/GGTCAA`	2	--	ds500¹		1		WA	118
rs79495227^1,2		--	112264379(+)	`ATTTTC/GAGGGG`	2	--	ds500¹		2		NA	122
rs190659066^1,2		--	112264432(+)	`TGTGTC/GTGTGT`	2	--	ds500¹		0	--	--	--	--
rs143351435^1,2		--	112264450(+)	`GTGGCA/GGGGAC`	2	--	ds500¹		0	--	--	--	--
rs2076592^1,2	C,F,O,H,	--	112264540(+)	`GGGGCG/ACCCGT`	2	--	ds500¹		27		EA NA NS WA	4376
rs76240711^1,2	F,	--	112264553(+)	`ATGTGC/TATGTG`	2	--	ds500¹		1		WA	118
rs148369962^1,2		--	112264637(+)	`GGGTAA/GAGAGC`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM212B (112223252 - 112298446 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM212B: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM212B for disorders About GeneDecksing

2 diseases for FAM212B: About MalaCards

renal cell carcinoma carcinoma

Export disorders for FAM212B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM212B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM212B)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)¹ Wolting C.D....McGlade C.J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)¹ Clague J....Wu X. (2010)
Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)¹ Horikawa Y....Wu X. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55924	HGNC: 28045	AceView: LOC55924	Ensembl:ENSG00000197852	euGenes: HUgn55924
ECgene: FAM212B	H-InvDB: FAM212B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM212B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM212B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM212B gene:
Search GeneIP for patents involving FAM212B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM212B

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ThermoFisher Antibodies for FAM212B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM212B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM212B gene at Home site.

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FAM212B Gene

family with sequence similarity 212, member B

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for FAM212B gene

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for FAM212B gene

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for FAM212B gene

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for FAM212B gene

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Export list of displayed genes

FAM212B Gene

family with sequence similarity 212, member B

Aliasesfor FAM212B gene

Summariesfor FAM212B gene

Genomic Viewsfor FAM212B gene

Proteinsfor FAM212B gene

Protein Domains /Familiesfor FAM212B gene

Functionfor FAM212B gene

Pathways & Interactionsfor FAM212B gene

Drugs & Compoundsfor FAM212B gene

Transcriptsfor FAM212B gene

Expression for FAM212B gene

Orthologsfor FAM212B gene

Paralogsfor FAM212B gene

Genomic Variantsfor FAM212B gene

Disorders / Diseasesfor FAM212B gene

Publicationsfor FAM212B gene

External Searches for FAM212B gene

Genome Databases showing FAM212B gene

Other Databases showing FAM212B gene

Specialized Databases showing FAM212B gene

Intellectual Propertyfor FAM212B gene

Productsfor FAM212B gene

View Random Gene

Aliases
for FAM212B gene

Summaries
for FAM212B gene

Genomic Views
for FAM212B gene

Proteins
for FAM212B gene

Protein Domains /
Families
for FAM212B gene

Function
for FAM212B gene

Pathways & Interactions
for FAM212B gene

Drugs & Compounds
for FAM212B gene

Transcripts
for FAM212B gene

Expression
for FAM212B gene

Orthologs
for FAM212B gene

Paralogs
for FAM212B gene

Genomic Variants
for FAM212B gene

Disorders / Diseases
for FAM212B gene

Publications
for FAM212B gene

Intellectual Property
for FAM212B gene

Products
for FAM212B gene