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Aliases for FAM212B Gene

Aliases for FAM212B Gene

  • Family With Sequence Similarity 212 Member B 2 3 5
  • C1orf183 3 4
  • Family With Sequence Similarity 212, Member B 2
  • Chromosome 1 Open Reading Frame 183 2
  • Protein FAM212B 3

External Ids for FAM212B Gene

Previous HGNC Symbols for FAM212B Gene

  • C1orf183

Previous GeneCards Identifiers for FAM212B Gene

  • GC01M112223

Summaries for FAM212B Gene

GeneCards Summary for FAM212B Gene

FAM212B (Family With Sequence Similarity 212 Member B) is a Protein Coding gene. An important paralog of this gene is FAM212A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM212B Gene

Genomics for FAM212B Gene

Regulatory Elements for FAM212B Gene

Enhancers for FAM212B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F111601 1 Ensembl ENCODE 15.9 +151.7 151715 5.4 HDGF TBP PKNOX1 WRNIP1 DDX20 FEZF1 YY1 RELA POLR2A EED FAM212B RAP1A KRT18P57 RNU6-151P DDX20 C1orf162 LINC01160 PIFO TMIGD3
GH01F111664 0.9 Ensembl ENCODE 15.8 +91.1 91124 2.6 HLF CEBPB CEBPG ZBTB40 ZNF664 IRF9 CEBPA TRIM24 FAM212B DDX20 RAP1A RNU6-151P GC01P111714
GH01F111724 0.2 ENCODE 12.7 +29.9 29945 2.5 ESRRA ZNF76 KLF17 BACH1 RAD21 ZIC2 ZNF316 ZFHX2 GLIS2 PATZ1 DDX20 FAM212B RAP1A GC01M111722 FAM212B-AS1
GH01F111723 0.8 Ensembl ENCODE 12.7 +32.2 32224 1.2 BCOR ZNF263 SMARCA5 PKNOX1 MTA2 ZMYM3 POLR2A HDAC2 ADNP PRDM10 DDX20 FAM212B GC01M111722 GC01P111714
GH01F111714 0.4 ENCODE 12.6 +40.8 40771 0.2 HDGF BCOR CTCF ZNF384 ZBTB40 ZNF2 RAD21 SMC3 FOS SMARCA5 DDX20 FAM212B GC01P111714 GC01M111722
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM212B on UCSC Golden Path with GeneCards custom track

Promoters for FAM212B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542714 -76 2201 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for FAM212B Gene

Chromosome:
1
Start:
111,680,630 bp from pter
End:
111,755,824 bp from pter
Size:
75,195 bases
Orientation:
Minus strand

Genomic View for FAM212B Gene

Genes around FAM212B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM212B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM212B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM212B Gene

Proteins for FAM212B Gene

  • Protein details for FAM212B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTI7-F212B_HUMAN
    Recommended name:
    Protein FAM212B
    Protein Accession:
    Q9NTI7
    Secondary Accessions:
    • B3KP38
    • B4DF94
    • Q9NTI6

    Protein attributes for FAM212B Gene

    Size:
    297 amino acids
    Molecular mass:
    32759 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM212B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM212B Gene

Post-translational modifications for FAM212B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM212B Gene

No data available for DME Specific Peptides for FAM212B Gene

Domains & Families for FAM212B Gene

Protein Domains for FAM212B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NTI7

UniProtKB/Swiss-Prot:

F212B_HUMAN :
  • Belongs to the FAM212 family.
Family:
  • Belongs to the FAM212 family.
genes like me logo Genes that share domains with FAM212B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM212B Gene

Function for FAM212B Gene

genes like me logo Genes that share phenotypes with FAM212B: view

Animal Models for FAM212B Gene

MGI Knock Outs for FAM212B:

Animal Model Products

miRNA for FAM212B Gene

miRTarBase miRNAs that target FAM212B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM212B Gene

Localization for FAM212B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM212B Gene COMPARTMENTS Subcellular localization image for FAM212B gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM212B Gene

Pathways & Interactions for FAM212B Gene

SuperPathways for FAM212B Gene

No Data Available

Interacting Proteins for FAM212B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349805%0d%0a9606.ENSP00000263925%0d%0a
Selected Interacting proteins: Q9NTI7-F212B_HUMAN ENSP00000349805 for FAM212B Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM212B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM212B Gene

Transcripts for FAM212B Gene

Unigene Clusters for FAM212B Gene

Family with sequence similarity 212, member B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM212B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for FAM212B Gene

GeneLoc Exon Structure for
FAM212B
ECgene alternative splicing isoforms for
FAM212B

Expression for FAM212B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM212B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM212B Gene

This gene is overexpressed in Whole Blood (x12.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM212B Gene:

FAM212B

SOURCE GeneReport for Unigene cluster for FAM212B Gene:

Hs.193406
genes like me logo Genes that share expression patterns with FAM212B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM212B Gene

Orthologs for FAM212B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM212B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM212B 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia FAM212B 34 35
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Fam212b 34
  • 80.36 (n)
mouse
(Mus musculus)
Mammalia Fam212b 34 16 35
  • 80.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM212B 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM212B 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1ORF183 34
  • 62.85 (n)
FAM212B 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM212B 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam212b 34
  • 54.41 (n)
Str.19495 34
zebrafish
(Danio rerio)
Actinopterygii LOC101886856 34
  • 48.65 (n)
Species where no ortholog for FAM212B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM212B Gene

ENSEMBL:
Gene Tree for FAM212B (if available)
TreeFam:
Gene Tree for FAM212B (if available)

Paralogs for FAM212B Gene

Paralogs for FAM212B Gene

genes like me logo Genes that share paralogs with FAM212B: view

Variants for FAM212B Gene

Sequence variations from dbSNP and Humsavar for FAM212B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000947 -- 111,734,975(+) AATCC(C/T)GGCTC intron-variant
rs10489472 -- 111,735,295(+) TCTTA(C/T)GCAAA intron-variant
rs10571384 -- 111,745,293(+) tatat(A/T)ttttt intron-variant, downstream-variant-500B
rs10610613 -- 111,725,730(+) AACTG(-/TTTTT)TTTTA utr-variant-3-prime
rs1076742 -- 111,732,875(+) GGCCC(C/T)ACACT intron-variant

Variation tolerance for FAM212B Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM212B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM212B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM212B Gene

Disorders for FAM212B Gene

Relevant External Links for FAM212B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM212B

No disorders were found for FAM212B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM212B Gene

Publications for FAM212B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Biochemical and computational analysis of LNX1 interacting proteins. (PMID: 22087225) Wolting C.D. … McGlade C.J. (PLoS ONE 2011) 3 64

Products for FAM212B Gene

Sources for FAM212B Gene

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