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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM212B Gene

protein-coding   GIFtS: 38
GCID: GC01M112223

Family With Sequence Similarity 212, Member B

(Previous name: chromosome 1 open reading frame 183)
(Previous symbol: C1orf183)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 212, Member B1 2
C1orf1831 2 3
Chromosome 1 Open Reading Frame 1831
Protein FAM212B2
Uncharacterized Protein C1orf1832

External Ids:    HGNC: 280451   Entrez Gene: 559242   Ensembl: ENSG000001978527   UniProtKB: Q9NTI73   

Export aliases for FAM212B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM212B Gene: 
FAM212B (family with sequence similarity 212, member B) is a protein-coding gene. Diseases associated with FAM212B include renal cell carcinoma. An important paralog of this gene is FAM212A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM212B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM212B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM212B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

FAM212B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM212B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M112223:  view genomic region     (about GC identifiers)

Start:
112,223,252 bp from pter      End:
112,298,446 bp from pter
Size:
75,195 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F212B_HUMAN, Q9NTI7 (See protein sequence)
Recommended Name: Protein FAM212B  
Size: 297 amino acids; 32759 Da
Secondary accessions: B3KP38 B4DF94 Q9NTI6
Alternative splicing: 2 isoforms:  Q9NTI7-1   Q9NTI7-2   

Explore the universe of human proteins at neXtProt for FAM212B: NX_Q9NTI7

Explore proteomics data for FAM212B at MOPED 

FAM212B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM212B Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_061972.1  NP_945120.1  

ENSEMBL proteins: 
 ENSP00000349805   ENSP00000436075   ENSP00000408238   ENSP00000437205  

Human Recombinant Protein Products for FAM212B: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026761 Fam212b

Graphical View of Domain Structure for InterPro Entry Q9NTI7

ProtoNet protein and cluster: Q9NTI7

UniProtKB/Swiss-Prot: F212B_HUMAN, Q9NTI7
Similarity: Belongs to the FAM212 family


FAM212B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     2 GenomeRNAi human phenotypes for FAM212B:
 Decreased viability with pacli  Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM212B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM212B

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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM212B 

miRNA
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Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM212B

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of FAM212B

Clone
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM212B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM212B

1 Interacting protein for FAM212B (Q9NTI73) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TM2D1Q9BX743I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM212B (F212B)

Search CenterWatch for drugs/clinical trials and news about FAM212B / F212B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM212B gene (2 alternative transcripts): 
NM_019099.4  NM_198926.2  

Unigene Cluster for FAM212B:

Family with sequence similarity 212, member B
Hs.193406  [show with all ESTs]
Unigene Representative Sequence: NM_019099
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000527570 ENST00000357260(uc001ebo.2 uc001ebp.2) ENST00000534365
ENST00000444059 ENST00000527621 ENST00000412270(uc001ebr.3) ENST00000527660

miRNA
Products:
     
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FAM212B
SwitchGear 3'UTR luciferase reporter plasmidFAM212B 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FAM212B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM212B
Clone
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OriGene ORF clones in mouse, rat for FAM212B
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM212B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM212B
Sirion Biotech Customized lentivirus for stable overexpression of FAM212B 
                     Customized lentivirus expression plasmids for stable overexpression of FAM212B 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FAM212B
OriGene qSTAR qPCR primer pairs in human, mouse for FAM212B
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat FAM212B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM212B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM212B

Additional mRNA sequence: 

AK055667.1 AK092074.1 AK094997.1 AK293989.1 AL137198.1 AL137199.1 BC031558.1 

6 DOTS entries:

DT.438072  DT.91755599  DT.40212498  DT.121440569  DT.121440577  DT.95263414 

24/31 AceView cDNA sequences (see all 31):

AL137198 AL137199 BC031558 BF308793 BX341652 BG394636 BX327535 CB117550 
NM_198926 BP372771 BF305812 BI115206 BP374879 BE297160 NM_019099 AA595469 
BX506153 AK055667 CA449552 BE296090 D20490 BX498523 BP373359 BX117330 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for FAM212B    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1:              -               
SP2:                              


ECgene alternative splicing isoforms for FAM212B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM212B expression in normal human tissues (normalized intensities)      FAM212B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM212B Expression
About this image


FAM212B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
         brain/midbrain/lateral wall   
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Medulla Oblongata
         brain/midbrain/lateral wall   
 
 Blood (Hematopoietic System)
         neutrophils   

See FAM212B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM212B

SOURCE GeneReport for Unigene cluster: Hs.193406
    SABiosciences Custom PCR Arrays for FAM212B
Primer
Products:
OriGene qPCR primer pairs and template standards for FAM212B
OriGene qSTAR qPCR primer pairs in human, mouse for FAM212B
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat FAM212B
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM212B
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM212B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM212B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM212B gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam212b1 , 5 RIKEN cDNA 6530418L21 gene5
family with sequence similarity 212, member B1
80.13(n)1
79.8(a)1
  3 (46.44 cM)5
1090501  NM_175398.41  NP_780607.21 
 1057045995 
chicken
(Gallus gallus)
Aves C26H1orf1831 chromosome 26 open reading frame, human C1orf183 62.14(n)
59.64(a)
  419868  XM_417995.3  XP_417995.3 
lizard
(Anolis carolinensis)
Reptilia FAM212B6
family with sequence similarity 212, member B
38(a)
1 ↔ 1
4(126669992-126711680)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.194952 Transcribed sequence with weak similarity to protein more 77.47(n)    BX779803.1 


ENSEMBL Gene Tree for FAM212B (if available)
TreeFam Gene Tree for FAM212B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM212B gene
FAM212A2  

FAM212B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/511 SNPs in FAM212B are shown (see all 511)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1850130151,2
--112264189(+) GAAGCC/TGGGGA 2 -- ds50010--------
rs783816161,2
C,F--112264190(+) AAGCCG/AGGGAC 2 -- ds50012Minor allele frequency- A:0.10CSA WA 120
rs20765911,2
C,F,H--112264274(+) GCATAT/CGGTGA 2 -- ds500135Minor allele frequency- C:0.25EA NA NS WA CSA 4888
rs775811001,2
F--112264295(+) CCCCTT/GGTCAA 2 -- ds50011Minor allele frequency- G:0.04WA 118
rs794952271,2
C,F--112264379(+) ATTTTC/GAGGGG 2 -- ds50012Minor allele frequency- G:0.06NA 122
rs1906590661,2
--112264432(+) TGTGTC/GTGTGT 2 -- ds50010--------
rs1433514351,2
C--112264450(+) GTGGCA/GGGGAC 2 -- ds50010--------
rs20765921,2
C,F,O,H--112264540(+) GGGGCG/ACCCGT 2 -- ds500127Minor allele frequency- A:0.15EA NA NS WA 4376
rs762407111,2
C,F--112264553(+) ATGTGC/TATGTG 2 -- ds50011Minor allele frequency- T:0.14WA 118
rs1483699621,2
--112264637(+) GGGTAA/GAGAGC 2 -- ds50010--------

HapMap Linkage Disequilibrium report for FAM212B (112223252 - 112298446 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM212B: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FAM212B
DNA2.0 Custom Variant and Variant Library Synthesis for FAM212B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for FAM212B:    About MalaCards
renal cell carcinoma    


FAM212B for disorders           About GeneDecksing


Export disorders for FAM212B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM212B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FAM212B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
  3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  4. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)1 Clague J....Wu X. (2010)
  5. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1 Horikawa Y....Wu X. (2008)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 55924 HGNC: 28045 AceView: LOC55924 Ensembl:ENSG00000197852 euGenes: HUgn55924
ECgene: FAM212B H-InvDB: FAM212B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM212B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM212B gene:
Search GeneIP for patents involving FAM212B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM212B
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM212B
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM212B
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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