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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM211B Gene

protein-coding   GIFtS: 35
GCID: GC22M024983

Family With Sequence Similarity 211, Member B

(Previous name: chromosome 22 open reading frame 36)
(Previous symbol: C22orf36)
  Search for FAM211B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 211, Member B1 2
C22orf361 2 3
Chromosome 22 Open Reading Frame 361
Leucine-Rich Repeat-Containing Protein C22orf362
Leucine-Rich Repeat-Containing Protein FAM211B2

External Ids:    HGNC: 331551   Entrez Gene: 3888862   Ensembl: ENSG000001780267   UniProtKB: Q2VPJ93   

Export aliases for FAM211B gene to outside databases

Previous GC identifer: GC22M024982


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM211B Gene: 
FAM211B (family with sequence similarity 211, member B) is a protein-coding gene. An important paralog of this gene is FAM211A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM211B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM211B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM211B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

FAM211B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM211B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024983:  view genomic region     (about GC identifiers)

Start:
24,981,588 bp from pter      End:
24,989,175 bp from pter
Size:
7,588 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F211B_HUMAN, Q2VPJ9 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein FAM211B  
Size: 315 amino acids; 34740 Da
Secondary accessions: Q8N0S9 Q8N8B1
Alternative splicing: 2 isoforms:  Q2VPJ9-1   Q2VPJ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM211B: NX_Q2VPJ9

Explore proteomics data for FAM211B at MOPED 

FAM211B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM211B Protein Expression

REFSEQ proteins: NP_997527.2  
ENSEMBL proteins: 
 ENSP00000320520   ENSP00000400102   ENSP00000384130  

Human Recombinant Protein Products for FAM211B: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q2VPJ9

1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: F211B_HUMAN, Q2VPJ9
Similarity: Belongs to the FAM211 family
Similarity: Contains 2 LRR (leucine-rich) repeats


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for FAM211B:
 Decreased viability of wild-ty 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM211B 
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM211B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM211B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM211B (F211B)

Search CenterWatch for drugs/clinical trials and news about FAM211B / F211B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM211B gene: 
NM_207644.2  

Unigene Cluster for FAM211B:

Family with sequence similarity 211, member B
Hs.113314  [show with all ESTs]
Unigene Representative Sequence: AK097054
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000318753 ENST00000446942(uc003aao.2 uc003aaq.2) ENST00000491910
ENST00000404045 ENST00000460524 ENST00000495297 ENST00000465334 ENST00000464490

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFAM211B 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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                     Customized lentivirus expression plasmids for stable overexpression of FAM211B 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM211B

Additional mRNA sequence: 

AK097054.1 BC017595.1 BC032388.1 BC108684.1 

16 DOTS entries:

DT.95228550  DT.120642611  DT.100776090  DT.100776089  DT.100768826  DT.120642778  DT.100670087  DT.100771068 
DT.120642531  DT.91800185  DT.100712026  DT.100732909  DT.100759339  DT.120642897  DT.100863856  DT.70102112 

24/85 AceView cDNA sequences (see all 85):

BM727589 BM725261 AI669102 BX368809 BE255471 BM971987 AI810832 CR614356 
CR613314 NM_207644 BC017595 BM674209 BU728854 AK097054 BC032388 AI201981 
BQ932323 BM715883 BU616633 CA432513 CA414009 BM974005 BX338904 BU681641 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM211B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGCTGTGCT
FAM211B Expression
About this image


See FAM211B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM211B

SOURCE GeneReport for Unigene cluster: Hs.113314
    SABiosciences Custom PCR Arrays for FAM211B
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM211B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM211B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM211B gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam211b1 , 5 expressed sequence AI6460235
family with sequence similarity 211, member B1
83.88(n)1
83.01(a)1
  10 (38.55 cM)5
1927341  NM_198860.21  NP_942560.11 
 755501255 
chicken
(Gallus gallus)
Aves C15H22orf361 chromosome 15 open reading frame, human C22orf36 70.8(n)
65.04(a)
  769750  XM_001233040.1  XP_001233041.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1001488881 leucine-rich repeat-containing protein C22orf36-like 62.03(n)
59.85(a)
  100148888  XM_001923224.2  XP_001923259.1 


ENSEMBL Gene Tree for FAM211B (if available)
TreeFam Gene Tree for FAM211B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM211B gene
FAM211A2  
1 SIMAP similar gene for FAM211B using alignment to 3 protein entries:     F211B_HUMAN (see all proteins):
FAM211A

FAM211B for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for FAM211B
PGOHUM00000235040


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in FAM211B are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0511254
----see VAR_0511252 S R mis40--------

HapMap Linkage Disequilibrium report for FAM211B (24981588 - 24989175 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM211B: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FAM211B
DNA2.0 Custom Variant and Variant Library Synthesis for FAM211B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM211B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM211B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Large-scale genome-wide association studies in East As ians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1 Kim Y.J....Cho Y.S. (2011)
  4. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1 Yuan X....Mooser V. (2008)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388886 HGNC: 33155 AceView: LOC388886 Ensembl:ENSG00000178026 euGenes: HUgn388886
ECgene: FAM211B H-InvDB: FAM211B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM211B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM211B gene:
Search GeneIP for patents involving FAM211B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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