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FAM210B Gene

protein-coding   GIFtS: 38
GCID: GC20P054934

Family With Sequence Similarity 210, Member B

(Previous name: chromosome 20 open reading frame 108)
(Previous symbol: C20orf108)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 210, Member B1 2     5A32
C20orf1081 2 3     dJ1167H4.12
Chromosome 20 Open Reading Frame 1081     Protein FAM210B2
Hypothetical Protein LOC1161511     Transmembrane Protein C20orf1082

External Ids:    HGNC: 161021   Entrez Gene: 1161512   Ensembl: ENSG000001240987   UniProtKB: Q96KR63   

Export aliases for FAM210B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM210B Gene:
FAM210B (family with sequence similarity 210, member B) is a protein-coding gene. An important paralog of this gene is FAM210A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM210B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM210B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM210B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

FAM210B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM210B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P054934:  view genomic region     (about GC identifiers)

Start:
54,933,971 bp from pter      End:
54,943,719 bp from pter
Size:
9,749 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F210B_HUMAN, Q96KR6 (See protein sequence)
Recommended Name: Protein FAM210B  
Size: 192 amino acids; 20424 Da
Secondary accessions: B2RBQ9 E1P5Y7 Q8WVN2 Q9BYL6 Q9H418

Explore the universe of human proteins at neXtProt for FAM210B: NX_Q96KR6

Explore proteomics data for FAM210B at MOPED


See FAM210B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_543011.2  
ENSEMBL proteins: 
 ENSP00000360437   ENSP00000389768  

FAM210B Human Recombinant Protein Products:

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Search eBioscience for Proteins for FAM210B 

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Search eBioscience for ELISAs for FAM210B 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009688 DUF1279

Graphical View of Domain Structure for InterPro Entry Q96KR6

ProtoNet protein and cluster: Q96KR6

UniProtKB/Swiss-Prot: F210B_HUMAN, Q96KR6
Similarity: Belongs to the FAM210 family
Similarity: Contains 1 DUF1279 domain


Find genes that share domains with FAM210B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 MGI phenotypic allele for Fam210b (no phenotypes)

Find genes that share phenotypes with FAM210B           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM210B
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM210B

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Predesigned siRNA for gene silencing in human, mouse, rat FAM210B

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM210B

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
F210B_HUMAN, Q96KR6: Membrane; Multi-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with FAM210B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM210B
Interactions:

    Search GeneGlobe Interaction Network for FAM210B

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for FAM210B (ENSP000003604374) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IMMTENSP000003872624STRING: ENSP00000387262
ZC3H14ENSP000002510384STRING: ENSP00000251038
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FAM210B (F210B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FAM210B gene: 
NM_080821.2  

Unigene Cluster for FAM210B:

Family with sequence similarity 210, member B
Hs.143736  [show with all ESTs]
Unigene Representative Sequence: NM_080821
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371384(uc002xxc.3) ENST00000437418
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFAM210B 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat FAM210B
Clone
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OriGene ORF clones in mouse, rat for FAM210B
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM210B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM210B
Primer
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OriGene qPCR primer pairs and template standards for FAM210B
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  QuantiFast Probe-based Assays in human, mouse, rat FAM210B

Additional mRNA sequence: 

AJ311123.1 AK075565.1 AK314768.1 AL133555.1 BC017725.1 L17329.1 

8 DOTS entries:

DT.91927494  DT.100727398  DT.102830257  DT.99977637  DT.101975029  DT.120806896  DT.120806898  DT.92431794 

Selected AceView cDNA sequences (see all 312):

BM697537 BE904060 AI204204 BM797036 AA156430 AA662475 BM971945 AW009428 
CB163203 BM675243 AI818756 AW160993 BM726467 BE549622 AL133555 AI185932 
BQ431501 BQ675129 BU740658 CB157165 BM714058 BQ679538 CB045070 CB178738 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FAM210B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGTTTACAC
FAM210B Expression
About this image


FAM210B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Epiblast (Early Embryonic Tissues)
         Epiblast Stem Cell line 5
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
 
 Ovary (Reproductive System)
 
 Adrenal Gland (Endocrine System)
FAM210B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FAM210B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.143736
    Custom PCR Arrays for FAM210B
Primer
Products:
OriGene qPCR primer pairs and template standards for FAM210B
OriGene qSTAR qPCR primer pairs in human, mouse for FAM210B
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QuantiFast Probe-based Assays in human, mouse, rat FAM210B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FAM210B gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam210b1 , 5 RIKEN cDNA 2010011I20 gene5
family with sequence similarity 210, member B1
77.54(n)1
77.37(a)1
  2 (94.83 cM)5
670171  NM_025912.41  NP_080188.31 
 1723455655 
chicken
(Gallus gallus)
Aves C20H20ORF1081 chromosome 20 open reading frame, human C20orf108 67.15(n)
68.84(a)
  428168  NM_001031493.1  NP_001026664.1 
lizard
(Anolis carolinensis)
Reptilia FAM210B6
family with sequence similarity 210, member B
70(a)
1 ↔ 1
GL343217.1(2084683-2089494)
African clawed frog
(Xenopus laevis)
Amphibia Xl.186652 Xenopus laevis transcribed sequence with moderate similarity more 71.93(n)    BX847553.1 
zebrafish
(Danio rerio)
Actinopterygii fam210b6
family with sequence similarity 210, member B
38(a)
1 ↔ 1
6(59354086-59360885) ENSDARG00000052638
fruit fly
(Drosophila melanogaster)
Insecta CG154036
CG175086
--
33(a)
21(a)
many → 1
many → 1
2L(3128720-3129489)
2R(1496129-1499091)


ENSEMBL Gene Tree for FAM210B (if available)
TreeFam Gene Tree for FAM210B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FAM210B gene
FAM210A2  

Find genes that share paralogs with FAM210B           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for FAM210B
PGOHUM00000238380 PGOHUM00000260621


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FAM210B (see all 283)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs20123971,2
C,F,A--54932006(+) GAGGCT/GGAGGT 1 -- us2k14Minor allele frequency- G:0.25NA WA 8
rs1113250051,2
C,F--54932028(+) GAGACC/TGCGCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
rs566725661,2
C--54932075(+) TCTCC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00CSA 2
rs1866450091,2
--54932257(+) AAGAAC/GTGTGT 1 -- us2k10--------
rs24266141,2
C,F,A,H--54932426(+) TCCCCA/GGCTTC 1 -- us2k117Minor allele frequency- G:0.07NS EA NA 2034
rs1477021211,2
--54932499(+) CCCTGC/TTACTT 1 -- us2k10--------
rs60248211,2
C,F,A,H--54932502(+) TGTTAT/CTTTCA 1 -- us2k132Minor allele frequency- C:0.44NS EA NA WA CSA 3141
rs114760141,2
C--54932538(+) AAATAT/-TTTTT 1 -- us2k1 tfbs31Minor allele frequency- -:0.00NA 2
rs1177488491,2
F--54932632(+) TCTTTT/CGTAAA 1 -- us2k11Minor allele frequency- C:0.02NA 120
rs1491687141,2
C--54932756(+) TCTGCA/GTCAGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FAM210B (54933971 - 54943719 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM210B: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FAM210B
DNA2.0 Custom Variant and Variant Library Synthesis for FAM210B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FAM210B gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with FAM210B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2, 3 Deloukas P....Rogers J. (Nature 2001)
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  7. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1 Palmieri R.T.... . (amp 2008)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Identification of human pre-T/NK cell-associated genes. (PubMed id 8228263)1 Ranes-Goldberg M.G.... Spits H. (J. Immunol. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116151 HGNC: 16102 AceView: C20orf108 Ensembl:ENSG00000124098 euGenes: HUgn116151
ECgene: FAM210B H-InvDB: FAM210B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FAM210B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FAM210B gene:
Search GeneIP for patents involving FAM210B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat FAM210B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAM210B
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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