Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM210B Gene

Aliases for FAM210B Gene

  • Family With Sequence Similarity 210 Member B 2 3 5
  • C20orf108 3 4
  • Family With Sequence Similarity 210, Member B 2
  • Chromosome 20 Open Reading Frame 108 2
  • Transmembrane Protein C20orf108 3
  • Hypothetical Protein LOC116151 2
  • Protein FAM210B, Mitochondrial 3
  • Protein FAM210B 3
  • DJ1167H4.1 3
  • 5A3 3

External Ids for FAM210B Gene

Previous HGNC Symbols for FAM210B Gene

  • C20orf108

Previous GeneCards Identifiers for FAM210B Gene

  • GC20P054934

Summaries for FAM210B Gene

GeneCards Summary for FAM210B Gene

FAM210B (Family With Sequence Similarity 210 Member B) is a Protein Coding gene. An important paralog of this gene is FAM210A.

UniProtKB/Swiss-Prot for FAM210B Gene

  • Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).

Additional gene information for FAM210B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM210B Gene

Genomics for FAM210B Gene

GeneHancer (GH) Regulatory Elements for FAM210B Gene

Promoters and enhancers for FAM210B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I056358 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 567.1 +2.5 2457 6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 SP3 FAM210B AURKA CSTF1 GC20P056367
GH20I056408 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +58.2 58199 17 HNRNPUL1 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 YBX1 YY1 POLR2B ZNF766 CASS4 RTF2 RPL39P CSTF1 ENSG00000280387 FAM210B GCNT7 FAM209B
GH20I056426 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 +70.0 70011 5.8 HDAC1 NCOA2 TCF12 EGR1 FOS ETV6 CREM EGR2 SMARCA5 ZBTB2 CASS4 RTF2 RPL39P FAM209A FAM210B
GH20I056368 Enhancer 0.5 dbSUPER 16.5 +10.1 10096 0.6 MITF POLR2A USF2 SUPT5H FAM210B CSTF1 AURKA GC20P056367
GH20I056483 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.3 +125.0 125018 1.3 MITF CTCF GABPA FAM209A RPL39P AURKA CSTF1 FAM210B LOC105372681 RTF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM210B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM210B Gene

Genomic Locations for FAM210B Gene
9,749 bases
Plus strand

Genomic View for FAM210B Gene

Genes around FAM210B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM210B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM210B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM210B Gene

Proteins for FAM210B Gene

  • Protein details for FAM210B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM210B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RBQ9
    • E1P5Y7
    • Q8WVN2
    • Q9BYL6
    • Q9H418

    Protein attributes for FAM210B Gene

    192 amino acids
    Molecular mass:
    20424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM210B Gene

Post-translational modifications for FAM210B Gene

No Post-translational modifications

Other Protein References for FAM210B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM210B Gene

Domains & Families for FAM210B Gene

Gene Families for FAM210B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM210B Gene


Suggested Antigen Peptide Sequences for FAM210B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM210 family.
  • Belongs to the FAM210 family.
genes like me logo Genes that share domains with FAM210B: view

Function for FAM210B Gene

Molecular function for FAM210B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the erythroid transcription factor GATA1 (PubMed:26968549).

Phenotypes From GWAS Catalog for FAM210B Gene

genes like me logo Genes that share phenotypes with FAM210B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM210B Gene

Localization for FAM210B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM210B Gene

Mitochondrion. Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM210B gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM210B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IDA,IEA 26968549
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane IDA 26968549
genes like me logo Genes that share ontologies with FAM210B: view

Pathways & Interactions for FAM210B Gene

SuperPathways for FAM210B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM210B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0043249 erythrocyte maturation IEA --
GO:0045648 positive regulation of erythrocyte differentiation IMP 26968549
GO:0071392 cellular response to estradiol stimulus IDA 26968549
genes like me logo Genes that share ontologies with FAM210B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM210B Gene

Drugs & Compounds for FAM210B Gene

No Compound Related Data Available

Transcripts for FAM210B Gene

mRNA/cDNA for FAM210B Gene

Unigene Clusters for FAM210B Gene

Family with sequence similarity 210, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM210B Gene

No ASD Table

Relevant External Links for FAM210B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM210B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM210B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM210B Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for FAM210B Gene

This gene is overexpressed in Hair follicle (12.4) and Adrenal (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM210B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM210B Gene:


SOURCE GeneReport for Unigene cluster for FAM210B Gene:


mRNA Expression by UniProt/SwissProt for FAM210B Gene:

Tissue specificity: Expressed in late erythroblast differentiation stages (PubMed:26968549). Underexpressed in ovarian cancer epithelia cells compared with normal human ovarian surface epithelia (PubMed:28594398).

Evidence on tissue expression from TISSUES for FAM210B Gene

  • Liver(4.4)
  • Lung(4.3)
  • Nervous system(2.3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with FAM210B: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM210B Gene

Orthologs for FAM210B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM210B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM210B 33 34
  • 98.96 (n)
(Canis familiaris)
Mammalia FAM210B 33 34
  • 85.24 (n)
(Bos Taurus)
Mammalia FAM210B 33
  • 83.85 (n)
C13H20ORF108 34
  • 83 (a)
(Mus musculus)
Mammalia Fam210b 33 16 34
  • 77.54 (n)
(Rattus norvegicus)
Mammalia Fam210b 33
  • 76.49 (n)
(Ornithorhynchus anatinus)
Mammalia FAM210B 34
  • 73 (a)
(Monodelphis domestica)
Mammalia FAM210B 34
  • 58 (a)
(Gallus gallus)
Aves C20H20ORF108 33 34
  • 67.15 (n)
(Anolis carolinensis)
Reptilia FAM210B 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam210b 33
  • 60.31 (n)
Str.15729 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18665 33
(Danio rerio)
Actinopterygii fam210b 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15403 34
  • 33 (a)
CG17508 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6707 34
  • 25 (a)
Species where no ortholog for FAM210B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM210B Gene

Gene Tree for FAM210B (if available)
Gene Tree for FAM210B (if available)

Paralogs for FAM210B Gene

Paralogs for FAM210B Gene Pseudogenes for FAM210B Gene

genes like me logo Genes that share paralogs with FAM210B: view

Variants for FAM210B Gene

Sequence variations from dbSNP and Humsavar for FAM210B Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000105592 -- 56,367,441(+) C/T 3_prime_UTR_variant
rs1000338162 -- 56,362,507(+) C/G intron_variant
rs1000520773 -- 56,357,771(+) G/C upstream_transcript_variant
rs1000796424 -- 56,357,522(+) T/C upstream_transcript_variant
rs1001518486 -- 56,363,391(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM210B Gene

Variant ID Type Subtype PubMed ID
dgv2269n106 CNV deletion 24896259
nsv522197 CNV loss 19592680
nsv526373 CNV loss 19592680
nsv828755 CNV gain 20364138
nsv828756 CNV gain 20364138
nsv834013 CNV gain 17160897
nsv964411 CNV duplication 23825009

Variation tolerance for FAM210B Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 83.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM210B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM210B Gene

Disorders for FAM210B Gene

Additional Disease Information for FAM210B

No disorders were found for FAM210B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM210B Gene

Publications for FAM210B Gene

  1. Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. (PMID: 26968549) Kondo A … Harigae H (International journal of hematology 2016) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 58
  3. Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. (PMID: 28594398) Sun S … Wu P (Cell death & disease 2017) 3 4 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FAM210B Gene

Sources for FAM210B Gene

Loading form....