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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM210A Gene

protein-coding   GIFtS: 40
GCID: GC18M013663

Family With Sequence Similarity 210, Member A

(Previous name: chromosome 18 open reading frame 19)
(Previous symbol: C18orf19)
  Search for FAM210A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 210, Member A1 2
C18orf191 2 3
Chromosome 18 Open Reading Frame 191
HsT23292
Protein FAM210A2
Uncharacterized Protein C18orf192

External Ids:    HGNC: 283461   Entrez Gene: 1252282   Ensembl: ENSG000001771507   UniProtKB: Q96ND03   

Export aliases for FAM210A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM210A Gene: 
FAM210A (family with sequence similarity 210, member A) is a protein-coding gene. An important paralog of this gene is FAM210B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM210A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM210A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM210A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

FAM210A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM210A gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M013663:  view genomic region     (about GC identifiers)

Start:
13,663,346 bp from pter      End:
13,726,662 bp from pter
Size:
63,317 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F210A_HUMAN, Q96ND0 (See protein sequence)
Recommended Name: Protein FAM210A  
Size: 272 amino acids; 30777 Da
Subunit: Interacts with ATAD3A
Subcellular location: Membrane; Single-pass membrane protein (Potential). Mitochondrion (Probable)
Secondary accessions: D3DUJ4

Explore the universe of human proteins at neXtProt for FAM210A: NX_Q96ND0

Explore proteomics data for FAM210A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96ND0

  • FAM210A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM210A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001092271.1  NP_689565.2  

    ENSEMBL proteins: 
     ENSP00000323635   ENSP00000467381   ENSP00000465396   ENSP00000468361   ENSP00000386115  

    Human Recombinant Protein Products for FAM210A: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral to membrane IEA--

    FAM210A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009688 DUF1279

    Graphical View of Domain Structure for InterPro Entry Q96ND0

    ProtoNet protein and cluster: Q96ND0

    UniProtKB/Swiss-Prot: F210A_HUMAN, Q96ND0
    Similarity: Belongs to the FAM210 family
    Similarity: Contains 1 DUF1279 domain


    FAM210A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM210A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM210A 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM210A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FAM210A (Q96ND03 ENSP000003236354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    HDAC3ENSP000003029674STRING: ENSP00000302967
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM210A (F210A)

    Search CenterWatch for drugs/clinical trials and news about FAM210A / F210A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM210A gene (2 alternative transcripts): 
    NM_001098801.1  NM_152352.3  

    Unigene Cluster for FAM210A:

    Family with sequence similarity 210, member A
    Hs.13034  [show with all ESTs]
    Unigene Representative Sequence: NM_001098801
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322247(uc010dlg.3 uc002ksj.4) ENST00000585785 ENST00000588475
    ENST00000589346 ENST00000592976 ENST00000591269 ENST00000402563(uc010dlh.3 uc010dli.3 uc010dlj.3)

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM210A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM210A
    Clone
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    OriGene ORF clones in mouse, rat for FAM210A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for FAM210A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM210A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM210A
    Sirion Biotech Customized lentivirus for stable overexpression of FAM210A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM210A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM210A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM210A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM210A

    Additional mRNA sequence: 

    AK055618.1 AK309506.1 AK309819.1 U78519.1 

    8 DOTS entries:

    DT.91937524  DT.411573  DT.65286085  DT.92419177  DT.95372132  DT.95372133  DT.100775949  DT.86843028 

    24/97 AceView cDNA sequences (see all 97):

    AI188524 AA860551 BX409714 BI757783 CA396815 BM847696 AW665306 BM693219 
    BM850472 AA954800 BI753302 BM924294 AI969716 CB987819 AI192379 BX094210 
    BI764710 BE466763 BM821662 CB162255 CA489588 AA160871 BX331592 CB241986 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM210A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                          -                     
    SP3:              -     -     -                     


    ECgene alternative splicing isoforms for FAM210A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM210A expression in normal human tissues (normalized intensities)      FAM210A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCTAAA
    FAM210A Expression
    About this image


    FAM210A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose

    See FAM210A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM210A

    SOURCE GeneReport for Unigene cluster: Hs.13034
        SABiosciences Custom PCR Arrays for FAM210A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM210A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FAM210A gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam210a1 , 5 RIKEN cDNA 4933403F05 gene5
    family with sequence similarity 210, member A1
    80.51(n)1
    77.94(a)1
      18 (40.98 cM)5
    1086541  NM_153794.41  NP_722489.11 
     682601875 
    chicken
    (Gallus gallus)
    Aves FAM210A1 chromosome 2 open reading frame, human C18orf19 69.77(n)
    63.95(a)
      421045  NM_001031014.1  NP_001026185.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM210A6
    family with sequence similarity 210, member A
    51(a)
    1 ↔ 1
    4(43330569-43349000)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75642 Xenopus laevis transcribed sequence with weak similarity more 75.22(n)    AW159783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi06g082 Transcribed sequence with weak similarity to protein more 78.38(n)    57095302 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146136
    --
    27(a)
    1 ↔ 1
    X(21872095-21873849)
    worm
    (Caenorhabditis elegans)
    Secernentea Y56A3A.226
    Protein Y56A3A.22
    21(a)
    1 ↔ 1
    III(11921692-11923858)


    ENSEMBL Gene Tree for FAM210A (if available)
    TreeFam Gene Tree for FAM210A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM210A gene
    FAM210B2  
    18/59 SIMAP similar genes for FAM210A using alignment to 4 protein entries:     F210A_HUMAN (see all proteins) (see all similar genes):
    DYM    AURA2    ZNF20    DNMT1    ZNF461    C18orf8
    DCTN5    FAM3A    LINC00596    NF2    NSRP1    ZNF547
    TMEM44    LYRM4    SHANK2    ZNF564    ZNF737    UBIAD1

    FAM210A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1489 SNPs in FAM210A are shown (see all 1489)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356874
    A breast cancer sample4--see VAR_0356872 V E mis40--------
    VAR_0356864
    A breast cancer sample4--see VAR_0356862 R H mis40--------
    rs1892252771,2
    --13662875(+) TTCTGC/TGCATA 2 -- ds50010--------
    rs1491527181,2
    C--13662953(+) GCGGGC/TGGATC 2 -- ds50010--------
    rs1463820821,2
    C--13662974(+) GAGATC/TGAGAC 2 -- ds50010--------
    rs1807025561,2
    C--13663003(+) GAAACC/TGTCTC 2 -- ds50010--------
    rs577364761,2
    C--13663200(+) AAAAA-/AAAA  
      AA
    /ATA
    TATAT
    4 -- ds5001 cds12NA 4
    rs47969921,2
    C--13663204(+) AAAAAA/TATATA 2 -- ds50010--------
    rs3713795771,2
    C--13663206(+) AAAAA-/TATATATA 2 -- ds50010--------
    rs1389988701,2
    --13663319(+) AAGTGA/TAGATT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FAM210A (13663346 - 13726662 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM210A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM210A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM210A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM210A gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with FAM210A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. (PubMed id 22453275)2 He J....Holt I.J. (2012)
    3. Genome-wide meta-analysis identifies 56 bone mineral d ensity loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (2012)
    4. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    7. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 125228 HGNC: 28346 AceView: C18orf19 Ensembl:ENSG00000177150 euGenes: HUgn125228
    ECgene: FAM210A H-InvDB: FAM210A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM210A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM210A gene:
    Search GeneIP for patents involving FAM210A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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