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FAM210A Gene

protein-coding   GIFtS: 41
GCID: GC18M013663

Family With Sequence Similarity 210, Member A

(Previous name: chromosome 18 open reading frame 19)
(Previous symbol: C18orf19)
  Search for FAM210A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 210, Member A1 2
C18orf191 2 3
Chromosome 18 Open Reading Frame 191
HsT23292
Protein FAM210A2
Uncharacterized Protein C18orf192

External Ids:    HGNC: 283461   Entrez Gene: 1252282   Ensembl: ENSG000001771507   UniProtKB: Q96ND03   

Export aliases for FAM210A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM210A Gene:
FAM210A (family with sequence similarity 210, member A) is a protein-coding gene. An important paralog of this gene is FAM210B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010859.15  NC_018929.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM210A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM210A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM210A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

FAM210A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM210A gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M013663:  view genomic region     (about GC identifiers)

Start:
13,663,346 bp from pter      End:
13,726,662 bp from pter
Size:
63,317 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F210A_HUMAN, Q96ND0 (See protein sequence)
Recommended Name: Protein FAM210A  
Size: 272 amino acids; 30777 Da
Subunit: Interacts with ATAD3A
Secondary accessions: D3DUJ4

Explore the universe of human proteins at neXtProt for FAM210A: NX_Q96ND0

Explore proteomics data for FAM210A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM210A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092271.1  NP_689565.2  

    ENSEMBL proteins: 
     ENSP00000323635   ENSP00000467381   ENSP00000465396   ENSP00000468361   ENSP00000386115  

    FAM210A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FAM210A
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    Novus Biologicals FAM210A Protein
    Novus Biologicals FAM210A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FAM210A 

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    FAM210A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FAM210A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009688 DUF1279

    Graphical View of Domain Structure for InterPro Entry Q96ND0

    ProtoNet protein and cluster: Q96ND0

    UniProtKB/Swiss-Prot: F210A_HUMAN, Q96ND0
    Similarity: Belongs to the FAM210 family
    Similarity: Contains 1 DUF1279 domain


    Find genes that share domains with FAM210A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM210A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM210A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM210A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM210A

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM210A:
    hsa-mir-93-5p (MIRT028072), hsa-mir-130b-3p (MIRT020172), hsa-mir-590-3p (MIRT016174)

    Block miRNA regulation of human, mouse, rat FAM210A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAM210A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM210A

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for FAM210A
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM210A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM210A

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F210A_HUMAN, Q96ND0: Membrane; Single-pass membrane protein (Potential). Mitochondrion (Probable)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM210A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM210A
    Interactions:

        Search GeneGlobe Interaction Network for FAM210A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for FAM210A (Q96ND03 ENSP000003236354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    HDAC3ENSP000003029674STRING: ENSP00000302967
    HSPB1ENSP000002485534STRING: ENSP00000248553
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM210A (F210A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM210A gene (2 alternative transcripts): 
    NM_001098801.1  NM_152352.3  

    Unigene Cluster for FAM210A:

    Family with sequence similarity 210, member A
    Hs.13034  [show with all ESTs]
    Unigene Representative Sequence: NM_001098801
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322247(uc010dlg.3 uc002ksj.4) ENST00000585785 ENST00000588475
    ENST00000589346 ENST00000592976 ENST00000591269 ENST00000402563(uc010dlh.3 uc010dli.3 uc010dlj.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM210A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FAM210A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM210A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM210A
    Clone
    Products:
         
    OriGene clones in human, mouse for FAM210A (see all 11)
    OriGene ORF clones in mouse, rat for FAM210A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for FAM210A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM210A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM210A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM210A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM210A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FAM210A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM210A
      QuantiFast Probe-based Assays in human, mouse, rat FAM210A

    Additional mRNA sequence: 

    AK055618.1 AK309506.1 AK309819.1 U78519.1 

    8 DOTS entries:

    DT.91937524  DT.411573  DT.65286085  DT.92419177  DT.95372132  DT.95372133  DT.100775949  DT.86843028 

    Selected AceView cDNA sequences (see all 97):

    BI753302 CA396815 BI757783 BM847696 AA954800 BM850472 BM693219 AI188524 
    AW665306 BX409714 AA860551 BI760571 BQ441232 BX331592 BI764710 BE466763 
    CA489588 BE326738 AI288894 AA776462 CB241986 BF979092 BX119277 BM821662 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM210A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                          -                     
    SP3:              -     -     -                     


    ECgene alternative splicing isoforms for FAM210A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM210A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCTAAA
    FAM210A Expression
    About this image


    FAM210A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
    FAM210A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM210A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13034
        Custom PCR Arrays for FAM210A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAM210A
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    QuantiFast Probe-based Assays in human, mouse, rat FAM210A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM210A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM210A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam210a1 , 5 RIKEN cDNA 4933403F05 gene5
    family with sequence similarity 210, member A1
    80.51(n)1
    77.94(a)1
      18 (40.98 cM)5
    1086541  NM_153794.41  NP_722489.11 
     682601875 
    chicken
    (Gallus gallus)
    Aves C2H18ORF191 chromosome 2 open reading frame, human C18orf19 69.77(n)
    63.95(a)
      421045  NM_001031014.1  NP_001026185.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM210A6
    family with sequence similarity 210, member A
    53(a)
    1 ↔ 1
    4(43330569-43349000)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75642 Xenopus laevis transcribed sequence with weak similarity more 75.22(n)    AW159783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi06g082 Transcribed sequence with weak similarity to protein more 78.38(n)    57095302 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146136
    --
    28(a)
    1 ↔ 1
    X(21872095-21873849)
    worm
    (Caenorhabditis elegans)
    Secernentea Y56A3A.226
    Protein Y56A3A.22 (Y56A3A.22) mRNA, complete cds
    20(a)
    1 ↔ 1
    III(11921692-11923858) WBGene00013239


    ENSEMBL Gene Tree for FAM210A (if available)
    TreeFam Gene Tree for FAM210A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM210A gene
    FAM210B2  
    Selected SIMAP similar genes for FAM210A using alignment to 4 protein entries:     F210A_HUMAN (see all proteins) (see all similar genes):
    DYM    AURA2    CTSS    ZNF20    DNMT1    ZNF461
    C18orf8    DCTN5    FAM3A    LINC00596    NF2    NSRP1
    ZNF547    TMEM44    LYRM4    SHANK2    ZNF564    ZNF737

    Find genes that share paralogs with FAM210A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM210A (see all 1489)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356874
    A breast cancer sample4--see VAR_0356872 V E mis40--------
    VAR_0356864
    A breast cancer sample4--see VAR_0356862 R H mis40--------
    rs1892252771,2
    --13662875(+) TTCTGC/TGCATA 2 -- ds50010--------
    rs1491527181,2
    C--13662953(+) GCGGGC/TGGATC 2 -- ds50010--------
    rs1463820821,2
    C--13662974(+) GAGATC/TGAGAC 2 -- ds50010--------
    rs1807025561,2
    C--13663003(+) GAAACC/TGTCTC 2 -- ds50010--------
    rs577364761,2
    C--13663200(+) AAAAA-/AAAA  
      AA
    /ATA
    TATAT
    4 -- ds5001 cds12NA 4
    rs47969921,2
    C--13663204(+) AAAAAA/TATATA 2 -- ds50010--------
    rs3713795771,2
    C--13663206(+) AAAAA-/TATATATA 2 -- ds50010--------
    rs1389988701,2
    --13663319(+) AAGTGA/TAGATT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for FAM210A (13663346 - 13726662 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM210A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM210A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM210A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM210A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM210A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. (PubMed id 22453275)2 He J....Holt I.J. (Nucleic Acids Res. 2012)
    3. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125228 HGNC: 28346 AceView: C18orf19 Ensembl:ENSG00000177150 euGenes: HUgn125228
    ECgene: FAM210A H-InvDB: FAM210A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM210A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM210A gene:
    Search GeneIP for patents involving FAM210A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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