Aliases for FAM20C Gene
Aliases for FAM20C Gene
External Ids for FAM20C Gene
- HGNC: 22140
- Entrez Gene: 56975
- Ensembl: ENSG00000177706
- OMIM: 611061
- UniProtKB: Q8IXL6
Previous GeneCards Identifiers for FAM20C Gene
- GC07U900326
- GC07P000276
- GC07P000289
- GC07P000290
Summaries for FAM20C Gene
-
This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]
GeneCards Summary for FAM20C Gene
FAM20C (FAM20C, Golgi Associated Secretory Pathway Kinase) is a Protein Coding gene. Diseases associated with FAM20C include Raine Syndrome and Caffey Disease. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein serine/threonine kinase activity. An important paralog of this gene is FAM20A.
UniProtKB/Swiss-Prot for FAM20C Gene
-
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).
Additional gene information for FAM20C Gene
- Monarch Initiative
- Search for FAM20C at DataMed
- Search for FAM20C at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM20C Gene
Genomics for FAM20C Gene
GeneHancer (GH) Regulatory Elements for FAM20C Gene
Regulatory Element Products
Genomic Locations for FAM20C Gene
- chr7:192,777-260,774
- (GRCh38/hg38)
- Size:
- 67,998 bases
- Orientation:
- Plus strand
- chr7:192,969-300,711
- (GRCh37/hg19)
Genomic View for FAM20C Gene
- Cytogenetic band:
-
- 7p22.3 by Ensembl
- 7p22.3 by Entrez Gene
- 7p22.3 by HGNC


RefSeq DNA sequence for FAM20C Gene
Proteins for FAM20C Gene
-
Protein details for FAM20C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IXL6-FA20C_HUMAN
- Recommended name:
- Extracellular serine/threonine protein kinase FAM20C
- Protein Accession:
- Q8IXL6
- A4D2Q5
- L8B5W8
- Q5I0W9
- Q7Z4I0
- Q9NPT2
Protein attributes for FAM20C Gene
- Size:
- 584 amino acids
- Molecular mass:
- 66234 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with FAM20A; probably forming a heterotetramer of 2 subunits of FAM20A and 2 subunits of FAM20C.
- SequenceCaution:
-
- Sequence=AAH40074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for FAM20C Gene
Post-translational modifications for FAM20C Gene
- Autophosphorylated.
- N-glycosylation is required for folding.
- Glycosylation at Ser41, Ser47, posLast=7474, posLast=7575, posLast=101101, Ser148, Asn335, and Asn470
Other Protein References for FAM20C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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- antibodies-online: Search results for 3 available FAM20C Proteins ranked by validation data
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-
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Assay Products
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-
Quality Products:
No data available for DME Specific Peptides for FAM20C Gene
Domains & Families for FAM20C Gene
Gene Families for FAM20C Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for FAM20C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FAM20C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IXL6- Family:
-
- Belongs to the FAM20 family.
Function for FAM20C Gene
Molecular function for FAM20C Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.8 uM for manganese/ATP {ECO:0000269 PubMed:23754375};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Serine/threonine protein kinase activity is increased upon interaction with FAM20A.
- UniProtKB/Swiss-Prot Function:
- Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039).
Enzyme Numbers (IUBMB) for FAM20C Gene
Phenotypes From GWAS Catalog for FAM20C Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 22582013 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
Phenotypes for FAM20C Gene
- MGI mutant phenotypes for FAM20C:
-
inferred from 2 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for FAM20C:
Animal Models for FAM20C Gene
- MGI Knock Outs for FAM20C:
-
- Fam20c tm1Lex
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-
-
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-
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-
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miRNA for FAM20C Gene
- miRTarBase miRNAs that target FAM20C
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Cell Line Products
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-
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-
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-
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No data available for Transcription Factor Targets and HOMER Transcription for FAM20C Gene
Localization for FAM20C Gene
Subcellular locations from UniProtKB/Swiss-Prot for FAM20C Gene
- Secreted. Golgi apparatus.
- Cytosol (2)
- Golgi apparatus (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA,IEA | 22582013 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005794 | Golgi apparatus | IEA,IDA | 22582013 |
Pathways & Interactions for FAM20C Gene
Interacting Proteins for FAM20C Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IEA | -- |
GO:0006468 | protein phosphorylation | IDA,IEA | 23754375 |
GO:0016310 | phosphorylation | IEA | -- |
GO:0030501 | positive regulation of bone mineralization | IEA | -- |
GO:0031214 | biomineral tissue development | IMP | 22582013 |
No data available for Pathways by source and SIGNOR curated interactions for FAM20C Gene
Drugs & Compounds for FAM20C Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 |
Transcripts for FAM20C Gene
mRNA/cDNA for FAM20C Gene
- (7) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (60) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM20C Gene
CRISPR Products
-
OriGene CRISPR knockouts for FAM20C
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM20C
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for FAM20C
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-
ViGene Biosciences ready-to-package AAV shRNAs for FAM20C gene
Clone Products
- Sino Biological Human cDNA Clone for FAM20C
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FAM20C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | ||||||||||||
SP3: | - | - | - | - | |||||||||
SP4: |
Expression for FAM20C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM20C Gene
NURSA nuclear receptor signaling pathways regulating expression of FAM20C Gene:
FAM20CSOURCE GeneReport for Unigene cluster for FAM20C Gene:
Hs.134742mRNA Expression by UniProt/SwissProt for FAM20C Gene:
Q8IXL6-FA20C_HUMANEvidence on tissue expression from TISSUES for FAM20C Gene
- Nervous system(4.6)
- Liver(4.2)
- Kidney(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM20C Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- skull
- tongue
- chest wall
- clavicle
- diaphragm
- heart
- lung
- rib
- rib cage
- scapula
- sternum
- biliary tract
- liver
- pelvis
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
- blood
- red blood cell
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for FAM20C
-
OriGene qPCR primer pairs and template standards for FAM20C
- genomics-online: primer clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
No data available for mRNA differential expression in normal tissues for FAM20C Gene
Orthologs for FAM20C Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LOC740357 33 |
|
||
FAM20C 34 |
|
OneToOne | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | FAM20C 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | FAM20C 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Fam20c 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Fam20c 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FAM20C 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FAM20C 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | FAM20C 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100498448 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | FAM20C (1 of 2) 34 |
|
OneToMany | |
fam20cb 33 34 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG31145 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | H03A11.1 34 |
|
OneToMany |
- Species where no ortholog for FAM20C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FAM20C Gene
Variants for FAM20C Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs145750007 | benign, likely-benign, not specified, not provided | 259,906(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
rs148276213 | benign, likely-pathogenic, not specified, Raine syndrome | 256,004(+) | T/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
rs150401144 | benign, not specified, not provided | 193,245(+) | G/T | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
rs267606795 | pathogenic, Raine syndrome | 255,869(+) | G/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
rs371584776 | uncertain-significance, Raine syndrome | 259,905(+) | C/A/T | coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, stop_gained, synonymous_variant |
Additional Variant Information for FAM20C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM20C Gene
Disorders for FAM20C Gene

(7) MalaCards diseases for FAM20C Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
raine syndrome |
|
|
caffey disease |
|
|
hypophosphatemia |
|
|
amelogenesis imperfecta, type ig |
|
|
choanal atresia, posterior |
|
|
UniProtKB/Swiss-Prot
FA20C_HUMAN- Raine syndrome (RNS) [MIM:259775]: Autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. {ECO:0000269 PubMed:17924334, ECO:0000269 PubMed:22582013, ECO:0000269 PubMed:25789606}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FAM20C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FAM20C Gene
Publications for FAM20C Gene
- Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. (PMID: 17924334) Simpson MA … Crosby AH (American journal of human genetics 2007) 2 3 4 58
- FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. (PMID: 15676076) Nalbant D … Williams SC (BMC genomics 2005) 3 4 22 58
- Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone. (PMID: 26324849) Yang X … Wang X (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 2 3 58
- A secretory kinase complex regulates extracellular protein phosphorylation. (PMID: 25789606) Cui J … Dixon JE (eLife 2015) 3 4 58
- A Single Kinase Generates the Majority of the Secreted Phosphoproteome. (PMID: 26091039) Tagliabracci VS … Dixon JE (Cell 2015) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 30 available FAM20C Antibodies ranked by validation data
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- Quality Products:
- GeneTex FAM20C antibody for FAM20C
- Search GeneTex for Proteins for FAM20C
- ViGene Biosciences adenoviral particle packaged cDNA for FAM20C gene
- ViGene Biosciences lentiviral particle packaged cDNA for FAM20C gene
- ViGene Biosciences ready-to-package AAV shRNAs for FAM20C gene
- Search ViGene Biosciences for FAM20C
- Horizon Cell Lines for FAM20C
- genomics-online: cdna clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
- orf clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
- genomics-online: gRNA clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
- genomics-online: primer clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
- genomics-online: shRNA clones - Search results for 86 available FAM20C gene related products
- Overview of 86 available FAM20C gene related products
Sources for FAM20C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew