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Aliases for FAM20B Gene

Aliases for FAM20B Gene

  • Family With Sequence Similarity 20 Member B 2 3 5
  • Family With Sequence Similarity 20, Member B 2 3
  • Xylose Kinase 3 4
  • Glycosaminoglycan Xylosylkinase 2
  • EC 2.7.1.- 4
  • KIAA0475 4
  • Gxk1 3

External Ids for FAM20B Gene

Previous GeneCards Identifiers for FAM20B Gene

  • GC01P175593
  • GC01P176234
  • GC01P175726
  • GC01P177261
  • GC01P178995
  • GC01P150222

Summaries for FAM20B Gene

GeneCards Summary for FAM20B Gene

FAM20B (Family With Sequence Similarity 20 Member B) is a Protein Coding gene. GO annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is FAM20A.

UniProtKB/Swiss-Prot for FAM20B Gene

  • Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.

Gene Wiki entry for FAM20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM20B Gene

Genomics for FAM20B Gene

Regulatory Elements for FAM20B Gene

Promoters for FAM20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM20B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM20B Gene

Chromosome:
1
Start:
179,025,804 bp from pter
End:
179,076,567 bp from pter
Size:
50,764 bases
Orientation:
Plus strand

Genomic View for FAM20B Gene

Genes around FAM20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM20B Gene

Proteins for FAM20B Gene

  • Protein details for FAM20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75063-XYLK_HUMAN
    Recommended name:
    Glycosaminoglycan xylosylkinase
    Protein Accession:
    O75063
    Secondary Accessions:
    • Q5W0C3
    • Q5W0C4

    Protein attributes for FAM20B Gene

    Size:
    409 amino acids
    Molecular mass:
    46432 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32320.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM20B Gene

Proteomics data for FAM20B Gene at MOPED

Post-translational modifications for FAM20B Gene

  • Glycosylation at Asn 193
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM20B Gene

No data available for DME Specific Peptides for FAM20B Gene

Domains & Families for FAM20B Gene

Protein Domains for FAM20B Gene

Suggested Antigen Peptide Sequences for FAM20B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75063

UniProtKB/Swiss-Prot:

XYLK_HUMAN :
  • Belongs to the FAM20 family.
Family:
  • Belongs to the FAM20 family.
genes like me logo Genes that share domains with FAM20B: view

No data available for Gene Families for FAM20B Gene

Function for FAM20B Gene

Molecular function for FAM20B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-xylose = ADP + D-xylose 2-phosphate.
UniProtKB/Swiss-Prot Function:
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.

Enzyme Numbers (IUBMB) for FAM20B Gene

genes like me logo Genes that share phenotypes with FAM20B: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM20B Gene

Localization for FAM20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM20B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM20B Gene COMPARTMENTS Subcellular localization image for FAM20B gene
Compartment Confidence
golgi apparatus 5
nucleus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM20B: view

Pathways & Interactions for FAM20B Gene

SuperPathways for FAM20B Gene

No Data Available

Interacting Proteins for FAM20B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263733%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000358674%0d%0a
Selected Interacting proteins: ENSP00000263733 for FAM20B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM20B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM20B Gene

Drugs & Compounds for FAM20B Gene

(1) Drugs for FAM20B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for FAM20B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
D-Xylose
  • D-(+)-Xylose
  • D-Xylo-pentose
  • D-Xylose
  • Wood sugar
  • Xylo-pfan
58-86-6
genes like me logo Genes that share compounds with FAM20B: view

Transcripts for FAM20B Gene

Unigene Clusters for FAM20B Gene

Family with sequence similarity 20, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM20B Gene

No ASD Table

Relevant External Links for FAM20B Gene

GeneLoc Exon Structure for
FAM20B
ECgene alternative splicing isoforms for
FAM20B

Expression for FAM20B Gene

mRNA expression in normal human tissues for FAM20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM20B Gene

This gene is overexpressed in Breast (22.8), Peripheral blood mononuclear cells (15.3), Testis (7.7), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM20B Gene



SOURCE GeneReport for Unigene cluster for FAM20B Gene Hs.5737

mRNA Expression by UniProt/SwissProt for FAM20B Gene

O75063-XYLK_HUMAN
Tissue specificity: Widely expressed. Strongly expressed in pancreas, spleen and fetal liver.
genes like me logo Genes that share expression patterns with FAM20B: view

Protein tissue co-expression partners for FAM20B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM20B Gene

Orthologs for FAM20B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM20B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM20B 35
  • 94.55 (n)
  • 97.44 (a)
FAM20B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM20B 35
  • 92.83 (n)
  • 97.8 (a)
FAM20B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam20b 35
  • 90.79 (n)
  • 97.31 (a)
Fam20b 16
Fam20b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM20B 35
  • 99.51 (n)
  • 99.02 (a)
FAM20B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam20b 35
  • 89.81 (n)
  • 96.82 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM20B 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM20B 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM20B 35
  • 83.78 (n)
  • 95.11 (a)
FAM20B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM20B 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam20b 35
  • 73.11 (n)
  • 81.17 (a)
MGC75786 35
zebrafish
(Danio rerio)
Actinopterygii fam20b 35
  • 70.1 (n)
  • 76.96 (a)
fam20b 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001051 35
  • 47.65 (n)
  • 43.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3631 35
  • 50.36 (n)
  • 43.61 (a)
CG3631 36
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6706 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9012 36
  • 47 (a)
OneToOne
Species with no ortholog for FAM20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM20B Gene

ENSEMBL:
Gene Tree for FAM20B (if available)
TreeFam:
Gene Tree for FAM20B (if available)

Paralogs for FAM20B Gene

Paralogs for FAM20B Gene

(3) SIMAP similar genes for FAM20B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM20B Gene

genes like me logo Genes that share paralogs with FAM20B: view

Variants for FAM20B Gene

Sequence variations from dbSNP and Humsavar for FAM20B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1220 -- 179,076,365(+) AAGCT(A/C)ATTTA utr-variant-3-prime
rs9249 -- 179,076,338(+) TGGGT(A/G)AAACT utr-variant-3-prime
rs15325 -- 179,076,417(+) TGATC(A/T)GCCAA utr-variant-3-prime
rs726401 -- 179,060,548(+) aggat(A/C)taggc intron-variant
rs1570808 -- 179,060,101(-) AAAAA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM20B Gene

Variant ID Type Subtype PubMed ID
nsv3721 CNV Insertion 18451855

Variation tolerance for FAM20B Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM20B Gene

HapMap Linkage Disequilibrium report
FAM20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM20B Gene

Disorders for FAM20B Gene

Relevant External Links for FAM20B

Genetic Association Database (GAD)
FAM20B
Human Genome Epidemiology (HuGE) Navigator
FAM20B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM20B

No disorders were found for FAM20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM20B Gene

Publications for FAM20B Gene

  1. FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region. (PMID: 19473117) Koike T. … Kitagawa H. (Biochem. J. 2009) 2 3 4 67
  2. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. (PMID: 15676076) Nalbant D. … Williams S.C. (BMC Genomics 2005) 3 23
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for FAM20B Gene

Sources for FAM20B Gene

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