Aliases for FAM20B Gene
External Ids for FAM20B Gene
Previous GeneCards Identifiers for FAM20B Gene
GeneCards Summary for FAM20B Gene
FAM20B (FAM20B, Glycosaminoglycan Xylosylkinase) is a Protein Coding gene. GO annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is FAM20C.
UniProtKB/Swiss-Prot for FAM20B Gene
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.