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Aliases for FAM20B Gene

Aliases for FAM20B Gene

  • Family With Sequence Similarity 20, Member B 2 3
  • Glycosaminoglycan Xylosylkinase 2 3
  • Xylose Kinase 3 4
  • Protein FAM20B 4
  • EC 2.7.1.- 4
  • KIAA0475 4
  • Gxk1 3

External Ids for FAM20B Gene

Previous GeneCards Identifiers for FAM20B Gene

  • GC01P175593
  • GC01P176234
  • GC01P175726
  • GC01P177261
  • GC01P178995
  • GC01P150222

Summaries for FAM20B Gene

GeneCards Summary for FAM20B Gene

FAM20B (Family With Sequence Similarity 20, Member B) is a Protein Coding gene. Diseases associated with FAM20B include exostosis. GO annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is FAM20A.

UniProtKB/Swiss-Prot for FAM20B Gene

  • Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.

Gene Wiki entry for FAM20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM20B Gene

Genomics for FAM20B Gene

Regulatory Elements for FAM20B Gene

Genomic Location for FAM20B Gene

Start:
179,025,804 bp from pter
End:
179,076,567 bp from pter
Size:
50,764 bases
Orientation:
Plus strand

Genomic View for FAM20B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM20B Gene

Proteins for FAM20B Gene

  • Protein details for FAM20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75063-XYLK_HUMAN
    Recommended name:
    Glycosaminoglycan xylosylkinase
    Protein Accession:
    O75063
    Secondary Accessions:
    • Q5W0C3
    • Q5W0C4

    Protein attributes for FAM20B Gene

    Size:
    409 amino acids
    Molecular mass:
    46432 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA32320.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM20B Gene

Proteomics data for FAM20B Gene at MOPED

Post-translational modifications for FAM20B Gene

  • Glycosylation at Asn193
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM20B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM20B Gene

Domains for FAM20B Gene

Protein Domains for FAM20B Gene

Suggested Antigen Peptide Sequences for FAM20B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75063

UniProtKB/Swiss-Prot:

XYLK_HUMAN :
  • O75063
Family:
  • Belongs to the FAM20 family.
genes like me logo Genes that share domains with FAM20B: view

No data available for Gene Families for FAM20B Gene

Function for FAM20B Gene

Molecular function for FAM20B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-xylose = ADP + D-xylose 2-phosphate.
UniProtKB/Swiss-Prot Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.

Enzyme Numbers (IUBMB) for FAM20B Gene

Gene Ontology (GO) - Molecular Function for FAM20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor IDA 19473117
genes like me logo Genes that share ontologies with FAM20B: view
genes like me logo Genes that share phenotypes with FAM20B: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM20B Gene

Localization for FAM20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM20B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM20B Gene COMPARTMENTS Subcellular localization image for FAM20B gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM20B: view

Pathways for FAM20B Gene

SuperPathways for FAM20B Gene

No Data Available

Interacting Proteins for FAM20B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263733%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000358674%0d%0a
Selected Interacting proteins: ENSP00000263733 for FAM20B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with FAM20B: view

No data available for Pathways by source for FAM20B Gene

Transcripts for FAM20B Gene

mRNA/cDNA for FAM20B Gene

Unigene Clusters for FAM20B Gene

Family with sequence similarity 20, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM20B Gene

No ASD Table

Relevant External Links for FAM20B Gene

GeneLoc Exon Structure for
FAM20B
ECgene alternative splicing isoforms for
FAM20B

Expression for FAM20B Gene

mRNA expression in normal human tissues for FAM20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM20B Gene

SOURCE GeneReport for Unigene cluster for FAM20B Gene Hs.5737

mRNA Expression by UniProt/SwissProt for FAM20B Gene

O75063-XYLK_HUMAN
Tissue specificity: Widely expressed. Strongly expressed in pancreas, spleen and fetal liver.
genes like me logo Genes that share expressions with FAM20B: view

No data available for mRNA differential expression in normal tissues for FAM20B Gene

Orthologs for FAM20B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM20B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM20B 35
  • 99.51 (n)
  • 99.02 (a)
FAM20B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM20B 35
  • 94.55 (n)
  • 97.44 (a)
FAM20B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM20B 35
  • 92.83 (n)
  • 97.8 (a)
FAM20B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam20b 35
  • 90.79 (n)
  • 97.31 (a)
Fam20b 16
Fam20b 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM20B 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM20B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam20b 35
  • 89.81 (n)
  • 96.82 (a)
chicken
(Gallus gallus)
Aves FAM20B 35
  • 83.78 (n)
  • 95.11 (a)
FAM20B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM20B 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam20b 35
  • 73.11 (n)
  • 81.17 (a)
MGC75786 35
zebrafish
(Danio rerio)
Actinopterygii fam20b 35
  • 70.1 (n)
  • 76.96 (a)
fam20b 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001051 35
  • 47.65 (n)
  • 43.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3631 35
  • 50.36 (n)
  • 43.61 (a)
CG3631 36
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6706 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9012 36
  • 47 (a)
OneToOne
Species with no ortholog for FAM20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM20B Gene

ENSEMBL:
Gene Tree for FAM20B (if available)
TreeFam:
Gene Tree for FAM20B (if available)

Paralogs for FAM20B Gene

Paralogs for FAM20B Gene

Selected SIMAP similar genes for FAM20B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM20B Gene

genes like me logo Genes that share paralogs with FAM20B: view

Variants for FAM20B Gene

Sequence variations from dbSNP and Humsavar for FAM20B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1220 -- 179,076,365(+) AAGCT(A/C)ATTTA utr-variant-3-prime
rs9249 -- 179,076,338(+) TGGGT(A/G)AAACT utr-variant-3-prime
rs15325 -- 179,076,417(+) TGATC(A/T)GCCAA utr-variant-3-prime
rs726401 -- 179,060,548(+) aggat(A/C)taggc intron-variant
rs1570808 -- 179,060,101(-) AAAAA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM20B Gene

Variant ID Type Subtype PubMed ID
nsv3721 CNV Insertion 18451855

Relevant External Links for FAM20B Gene

HapMap Linkage Disequilibrium report
FAM20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM20B Gene

Disorders for FAM20B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FAM20B Gene including...

Search for FAM20B Gene in MalaCards »

(1) University of Copenhagen DISEASES for FAM20B Gene

Relevant External Links for FAM20B

Genetic Association Database (GAD)
FAM20B
Human Genome Epidemiology (HuGE) Navigator
FAM20B
genes like me logo Genes that share disorders with FAM20B: view

No data available for UniProtKB/Swiss-Prot for FAM20B Gene

Publications for FAM20B Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. (PMID: 15676076) Nalbant D. … Williams S.C. (BMC Genomics 2005) 3 4 23
  3. FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region. (PMID: 19473117) Koike T. … Kitagawa H. (Biochem. J. 2009) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. (PMID: 16428749) Baxendale H.E. … Goldblatt D. (Infect. Immun. 2006) 3

Products for FAM20B Gene

Sources for FAM20B Gene

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