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FAM20B Gene

protein-coding   GIFtS: 52
GCID: GC01P178995

Family With Sequence Similarity 20, Member B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 20, Member B1 2     EC 2.7.1.-3
Glycosaminoglycan Xylosylkinase1 2     KIAA04753
Xylose Kinase2 3     Protein FAM20B3
gxk12     

External Ids:    HGNC: 230171   Entrez Gene: 99172   Ensembl: ENSG000001161997   OMIM: 6110635   UniProtKB: O750633   

Export aliases for FAM20B gene to outside databases

Previous GC identifers: GC01P175593 GC01P176234 GC01P175726 GC01P177261 GC01P150222


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM20B Gene:
FAM20B (family with sequence similarity 20, member B) is a protein-coding gene. Diseases associated with FAM20B include exostosis, and amelogenesis imperfecta. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and kinase activity. An important paralog of this gene is FAM20A.

UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063
Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of
proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including
heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region
(GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of
monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence
the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage
regions on which the repeating disaccharide region is synthesized

Gene Wiki entry for FAM20B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM20B gene promoter:
         GATA-3   AML1a   GCNF   POU3F2 (N-Oct-5a)   Evi-1   GATA-2   GATA-1   c-Ets-1   GCNF-1   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM20B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM20B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

FAM20B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM20B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P178995:  view genomic region     (about GC identifiers)

Start:
178,994,939 bp from pter      End:
179,045,702 bp from pter
Size:
50,764 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063 (See protein sequence)
Recommended Name: Glycosaminoglycan xylosylkinase  
Size: 409 amino acids; 46432 Da
Sequence caution: Sequence=BAA32320.2; Type=Erroneous initiation;
Secondary accessions: Q5W0C3 Q5W0C4

Explore the universe of human proteins at neXtProt for FAM20B: NX_O75063

Explore proteomics data for FAM20B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn193
  • Modification sites at PhosphoSitePlus

  • See FAM20B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055679.1  
    ENSEMBL proteins: 
     ENSP00000404005   ENSP00000263733  

    FAM20B Human Recombinant Protein Products:

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    Novus Biologicals FAM20B Protein
    Sino Biological Recombinant Protein for FAM20B
    Sino Biological Cell Lysate for FAM20B
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM20B

    FAM20B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals FAM20B Antibody
    Abcam antibodies for FAM20B
    Cloud-Clone Corp. Antibodies for FAM20B
    Search ThermoFisher Antibodies for FAM20B
    Search LSBio for Antibodies for FAM20B

    FAM20B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FAM20B
    Cloud-Clone Corp. CLIAs for FAM20B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009581 DUF1193
     IPR024869 FAM20

    Graphical View of Domain Structure for InterPro Entry O75063

    ProtoNet protein and cluster: O75063

    1 Blocks protein domain: IPB009581 Protein of unknown function DUF1193

    UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063
    Similarity: Belongs to the FAM20 family


    FAM20B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: XYLK_HUMAN, O75063
    Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of
    proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including
    heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region
    (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of
    monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence
    the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage
    regions on which the repeating disaccharide region is synthesized
    Catalytic activity: ATP + D-xylose = ADP + D-xylose 2-phosphate

         Enzyme Number (IUBMB): EC 2.7.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity IEA--
    GO:0016773phosphotransferase activity, alcohol group as acceptor IDA19473117
         
    FAM20B for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fam20b):
     digestive/alimentary  embryogenesis  growth/size/body  liver/biliary system  mortality/aging 
     respiratory system  skeleton  vision/eye 

    FAM20B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM20B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM20B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM20B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM20B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM20B:
    hsa-mir-215-5p (MIRT024806), hsa-mir-26b-5p (MIRT029368), hsa-mir-21-5p (MIRT030835), hsa-mir-192-5p (MIRT026506), hsa-mir-26a-5p (MIRT050059), hsa-mir-193b-3p (MIRT016430)

    Block miRNA regulation of human, mouse, rat FAM20B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM20B (see all 46):
    hsa-miR-579 hsa-miR-2052 hsa-miR-4291 hsa-miR-19b-2* hsa-miR-301a hsa-miR-219-5p hsa-miR-500a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM20B

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM20B (NM_014864)
    Sino Biological Human cDNA Clone for FAM20B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM20B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM20B

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM20B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    XYLK_HUMAN, O75063: Golgi apparatus membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA19473117
    GO:0016021integral component of membrane IEA--

    FAM20B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM20B
    Interactions:

        Search GeneGlobe Interaction Network for FAM20B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FAM20B (ENSP000002637334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM20B (XYLK)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM20B gene: 
    NM_014864.3  

    Unigene Cluster for FAM20B:

    Family with sequence similarity 20, member B
    Hs.5737  [show with all ESTs]
    Unigene Representative Sequence: AB007944
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440702 ENST00000263733(uc001gmc.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM20B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM20B (see all 46):
    hsa-miR-579 hsa-miR-2052 hsa-miR-4291 hsa-miR-19b-2* hsa-miR-301a hsa-miR-219-5p hsa-miR-500a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FAM20B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM20B
    Clone
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    OriGene clones in human, mouse for FAM20B (see all 5)
    OriGene ORF clones in mouse, rat for FAM20B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM20B (NM_014864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM20B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM20B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FAM20B
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM20B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM20B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM20B
      QuantiFast Probe-based Assays in human, mouse, rat FAM20B

    Additional mRNA sequence: 

    AB007944.1 AB480690.1 AK289989.1 AY044151.1 BC046441.1 BC051794.1 

    7 DOTS entries:

    DT.218333  DT.95118261  DT.121446600  DT.121446482  DT.121446487  DT.121446627  DT.95118260 

    Selected AceView cDNA sequences (see all 232):

    CB127352 AI700940 AA064792 AA662169 AA488911 AA827072 AA488841 BM725025 
    BQ006075 CB139549 AA769502 BM989361 CB242172 BM450573 BP364169 BE669640 
    AI668946 AA732981 AW614718 BE465226 BE467281 AA737186 BU730730 BM704159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM20B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAAAAGTA
    FAM20B Expression
    About this image


    FAM20B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    FAM20B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM20B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5737

    UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063
    Tissue specificity: Widely expressed

        Custom PCR Arrays for FAM20B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM20B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM20B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam20b1 , 5 family with sequence similarity 20, member B1, 5 90.79(n)1
    97.31(a)1
      1 (67.71 cM)5
    2150151  NM_145413.41  NP_663388.11 
     1566785455 
    chicken
    (Gallus gallus)
    Aves FAM20B1 family with sequence similarity 20, member B 83.78(n)
    95.11(a)
      424427  NM_001031268.1  NP_001026439.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM20B6
    family with sequence similarity 20, member B
    94(a)
    1 ↔ 1
    GL343300.1(765562-790672)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757862 hypothetical protein MGC75786 75.18(n)    BC063339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam20b1 family with sequence similarity 20, member B (H. sapiens) 70.1(n)
    76.96(a)
      557060  NM_001044818.1  NP_001038283.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36311 CG3631 50.36(n)
    43.61(a)
      41797  NM_206490.2  NP_996212.1 


    ENSEMBL Gene Tree for FAM20B (if available)
    TreeFam Gene Tree for FAM20B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM20B gene
    FAM20A2  FAM20C2  
    3 SIMAP similar genes for FAM20B using alignment to 1 protein entry:     XYLK_HUMAN:
    FAM20C    FAM20A    Fam20A

    FAM20B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM20B
    PGOHUM00000238266


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM20B (see all 1019)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406492111,2
    --178993131(+) GGTGCA/TGGTGC 1 -- us2k10--------
    rs756286471,2
    F--178993171(+) ATGCAA/GCATGG 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1504799211,2
    --178993189(+) AAAACC/TGGGGG 1 -- us2k10--------
    rs1384080471,2
    --178993195(+) GGGGGA/GCAGAA 1 -- us2k10--------
    rs1488177851,2
    --178993242(+) CTGAAC/TCCATA 1 -- us2k10--------
    rs1813258401,2
    C--178993315(+) TAGATA/GGATGC 1 -- us2k10--------
    rs757132581,2
    C,F--178993456(+) GAACAG/TTGACA 1 -- us2k12Minor allele frequency- T:0.07WA EA 238
    rs1452110671,2
    --178993760(+) TAATAC/TAATGC 1 -- us2k10--------
    rs359173151,2
    C,F--178993856(+) TTTCTC/ATAGGA 1 -- us2k13Minor allele frequency- A:0.25NA 8
    rs1859258201,2
    --178994019(+) ATGCTC/TAGCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM20B (178994939 - 179045702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM20B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3721CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM20B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM20B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611063    OMIM disorders: --

    6 diseases for FAM20B:    
    About MalaCards
    exostosis    amelogenesis imperfecta    tonsillitis    hepatitis b
    hepatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for FAM20B:
    Exostosis

    FAM20B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM20B
    Human Genome Epidemiology (HuGE) Navigator: FAM20B (1 document)

    Export disorders for FAM20B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM20B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FAM20B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region. (PubMed id 19473117)1, 2, 3 Koike T.... Kitagawa H. (Biochem. J. 2009)
    2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (DNA Res. 1997)
    3. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. (PubMed id 15676076)1, 2, 9 Nalbant D.... Williams S.C. (BMC Genomics 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    6. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. (PubMed id 18400750)2 Tone Y.... Sugahara K. (J. Biol. Chem. 2008)
    9. Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. (PubMed id 16428749)1 Baxendale H.E. and Goldblatt D. (Infect. Immun. 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9917 HGNC: 23017 AceView: FAM20B Ensembl:ENSG00000116199 euGenes: HUgn9917
    ECgene: FAM20B H-InvDB: FAM20B

    (According to HUGE)
    About This Section

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    HUGE: KIAA0475

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM20B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM20B gene:
    Search GeneIP for patents involving FAM20B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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