FAM20B Gene
protein-coding GIFtS: 48
GCID: GC01P178995
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|
family with sequence similarity 20, member B
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Aliases
for FAM20B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 20, Member B1 2 | | Gxk11 | | KIAA04751 3 | | EC 2.7.1.-3 | | Xylose Kinase2 3 | | Protein FAM20B3 | | Glycosaminoglycan Xylosylkinase2 | | |
Export aliases for FAM20B gene to outside databasesPrevious GC identifers: GC01P175593 GC01P176234 GC01P175726 GC01P177261 GC01P150222 |
Summaries
for FAM20B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region ofproteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), includingheparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region(GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition ofmonosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence thecatalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions onwhich the repeating disaccharide region is synthesized
Gene Wiki entry for FAM20B
|
Genomic Views
for FAM20B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM20B gene promoter:
GATA-3 AML1a GCNF POU3F2 (N-Oct-5a) Evi-1 GATA-2 GATA-1 c-Ets-1 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM20B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM20B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q25.2FAM20B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P178995: view genomic region
(about GC identifiers)
Start:
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178,994,939 bp from pter |
End:
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179,045,702 bp from pter |
Size:
|
50,764 bases |
Orientation:
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plus strand |
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Proteins
for FAM20B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063 (See
protein sequence)Recommended Name: Glycosaminoglycan xylosylkinase Size: 409 amino acids; 46432 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAA32320.2; Type=Erroneous initiation;
Secondary accessions: Q5W0C3 Q5W0C4Explore the universe of human proteins at neXtProt for FAM20B: NX_O75063
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75063
FAM20B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055679.1
ENSEMBL proteins: ENSP00000404005 ENSP00000263733
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FAM20B for ontologies About GeneDecksing
FAM20B Antibody Products:
Assay Products for FAM20B: |
Protein
Domains /
Families
for FAM20B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM20B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75063ProtoNet protein and cluster: O75063 1 Blocks protein family: IPB009581 Protein of unknown function DUF1193
UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063Similarity: Belongs to the FAM20 family |
Function
for FAM20B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region ofproteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), includingheparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region(GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition ofmonosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence thecatalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions onwhich the repeating disaccharide region is synthesizedCatalytic activity: ATP + D-xylose = ADP + D-xylose 2-phosphateEnzyme Number (IUBMB): EC 2.7.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM20B (NM_014864) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM20B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM20B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM20B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FAM20B for ontologies About GeneDecksing
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fam20b):
FAM20B for phenotypes About GeneDecksing
|
Pathways & Interactions
for FAM20B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM20B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FAM20B (ENSP000002637334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FAM20B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM20B
Search CenterWatch for drugs/clinical trials and news about FAM20B / XYLK
|
Transcripts
for FAM20B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM20B gene: NM_014864.3 Unigene Cluster for FAM20B: Family with sequence similarity 20, member B Hs.711441 [show with all ESTs]Unigene Representative Sequence: AB0079442 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000440702 ENST00000263733(uc001gmc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM20B (NM_014864) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM20B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM20B |
Additional cDNA sequence: AB007944.1 AB480690.1 AK289989.1 AY044151.1 BC046441.1 BC051794.1 6 DOTS entries: DT.218333 DT.95118261 DT.121446600 DT.121446482 DT.121446487 DT.121446627 24/232 AceView cDNA sequences (see all 232): AI160448 AA811322 AA488841 BM725025 BI870023 BE465226 AA737186 F11385 BC046441 BM708405 BI754845 AA662169 BM988852 AA769502 BE669640 AA488911 BG832389 AA827072 CB127352 R93677 AL713357 BU730730 AI700940 AI668946
GeneLoc Exon Structure
|
Expression
for FAM20B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM20B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAAAAGTA
About this image
See FAM20B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM20B
SOURCE GeneReport for Unigene cluster: Hs.711441
UniProtKB/Swiss-Prot: XYLK_HUMAN, O75063Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for FAM20B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM20B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM20B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM20B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM20B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM20B |
Orthologs
for FAM20B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FAM20B gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for FAM20B (if available)
TreeFam Gene Tree for FAM20B (if available) |
Paralogs
for FAM20B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM20B gene
- FAM20A2 FAM20C2
2 SIMAP similar genes for FAM20B using alignment to 1 protein entry: XYLK_HUMAN:FAM20C FAM20A
FAM20B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FAM20B
PGOHUM00000238266
|
Genomic Variants
for FAM20B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM20B (178994939 - 179045702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM20B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM20B |
|
Disorders
/ Diseases
for FAM20B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FAM20B for disorders About GeneDecksing
OMIM gene information: 611063
OMIM disorders: --
4  diseases for FAM20B: About MalaCardstonsillitis hepatitis b hepatitis alcoholism
1 disease from the University of Copenhagen DISEASES database for FAM20B:Amelogenesis imperfecta Human Genome Epidemiology (HuGE) Navigator: FAM20B (1 document)
Export disorders for FAM20B gene to outside databases
|
Publications
for FAM20B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM20B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FAM20B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region. (PubMed id 19473117)1, 2, 3 Koike T.... Kitagawa H. (2009)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
- FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. (PubMed id 15676076)1, 2, 9 Nalbant D.... Williams S.C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- 2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. (PubMed id 18400750)2 Tone Y....Sugahara K. (2008)
- Correlation of molecular characteristics, isotype, and in vitro functional activity of human antipneumococcal monoclonal antibodies. (PubMed id 16428749)1 Baxendale H.E. and Goldblatt D. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for FAM20B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM20B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM20B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM20B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM20B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM20B gene:
Search GeneIP for patents involving FAM20B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM20B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM20B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM20B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM20B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM20B | | OriGene 3'-UTR Clone for FAM20B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM20B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM20B | | OriGene Custom Protein Services for FAM20B | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM20B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM20B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM20B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM20B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM20B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM20B |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM20B |
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 | | | FAM20B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM20B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM20B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM20B |
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