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Aliases for FAM209B Gene

Aliases for FAM209B Gene

  • Family With Sequence Similarity 209 Member B 2 3 5
  • C20orf107 3 4
  • Family With Sequence Similarity 209, Member B 2
  • Chromosome 20 Open Reading Frame 107 2
  • Uncharacterized Protein C20orf107 3
  • Protein FAM209B 3
  • DJ1153D9.4 3

External Ids for FAM209B Gene

Previous HGNC Symbols for FAM209B Gene

  • C20orf107

Previous GeneCards Identifiers for FAM209B Gene

  • GC20P055109

Summaries for FAM209B Gene

GeneCards Summary for FAM209B Gene

FAM209B (Family With Sequence Similarity 209 Member B) is a Protein Coding gene. An important paralog of this gene is FAM209A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM209B Gene

Genomics for FAM209B Gene

Regulatory Elements for FAM209B Gene

Enhancers for FAM209B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G056408 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -109.1 -109081 17.0 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 YBX1 YY1 ZNF766 CBX5 CASS4 RTFDC1 RPL39P FAM210B GCNT7 FAM209B
GH20G056554 1.2 Ensembl ENCODE 0.3 +29.0 28962 1.1 FOXA2 FEZF1 BRCA1 FOS ZNF263 JUNB TSHZ1 MEF2D MAFF SMARCA4 LINC01716 FAM209B
GH20G056550 0.8 ENCODE 0.3 +24.6 24605 0.2 ELF3 CTCF PKNOX1 INSM2 ARID4B YBX1 BRCA1 ZNF48 RAD21 RFX5 LINC01716 FAM209B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM209B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM209B Gene

56,526,195 bp from pter
56,536,521 bp from pter
10,327 bases
Plus strand

Genomic View for FAM209B Gene

Genes around FAM209B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM209B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM209B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM209B Gene

Proteins for FAM209B Gene

  • Protein details for FAM209B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM209B
    Protein Accession:
    Secondary Accessions:
    • Q3KRB5

    Protein attributes for FAM209B Gene

    171 amino acids
    Molecular mass:
    19499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM209B Gene

Post-translational modifications for FAM209B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM209B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM209B Gene

Domains & Families for FAM209B Gene

Protein Domains for FAM209B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM209 family.
  • Belongs to the FAM209 family.
genes like me logo Genes that share domains with FAM209B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM209B Gene

Function for FAM209B Gene

genes like me logo Genes that share phenotypes with FAM209B: view

Animal Models for FAM209B Gene

MGI Knock Outs for FAM209B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FAM209B Gene

Localization for FAM209B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM209B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM209B gene
Compartment Confidence
nucleus 5
extracellular 3

Gene Ontology (GO) - Cellular Components for FAM209B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM209B: view

Pathways & Interactions for FAM209B Gene

SuperPathways for FAM209B Gene

No Data Available

Interacting Proteins for FAM209B Gene

Gene Ontology (GO) - Biological Process for FAM209B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM209B Gene

Transcripts for FAM209B Gene

mRNA/cDNA for FAM209B Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM209B Gene

Family with sequence similarity 209, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM209B Gene

No ASD Table

Relevant External Links for FAM209B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM209B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM209B Gene

mRNA differential expression in normal tissues according to GTEx for FAM209B Gene

This gene is overexpressed in Testis (x36.7) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for FAM209B Gene

This gene is overexpressed in Testis (62.5) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM209B Gene

Protein tissue co-expression partners for FAM209B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM209B Gene:


SOURCE GeneReport for Unigene cluster for FAM209B Gene:

genes like me logo Genes that share expression patterns with FAM209B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM209B Gene

Orthologs for FAM209B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM209B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM209B 35
  • 97 (a)
(Canis familiaris)
Mammalia FAM209B 34
  • 78.97 (n)
C24H20ORF106 35
  • 67 (a)
(Bos Taurus)
Mammalia FAM209B 34 35
  • 75.35 (n)
-- 35
  • 43 (a)
-- 35
  • 41 (a)
-- 35
  • 34 (a)
-- 35
  • 33 (a)
(Rattus norvegicus)
Mammalia Fam209a 34
  • 72.62 (n)
(Mus musculus)
Mammalia Fam209 34 16 35
  • 72.56 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
Species where no ortholog for FAM209B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM209B Gene

Gene Tree for FAM209B (if available)
Gene Tree for FAM209B (if available)

Paralogs for FAM209B Gene

Paralogs for FAM209B Gene

(1) SIMAP similar genes for FAM209B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM209B: view

Variants for FAM209B Gene

Sequence variations from dbSNP and Humsavar for FAM209B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000002174 -- 56,527,567(+) GGGGC(C/T)GGTAC intron-variant, upstream-variant-2KB
rs1000155827 -- 56,533,760(+) ACAAT(A/T)GTCCC intron-variant, downstream-variant-500B
rs1000161665 -- 56,526,733(+) CTCCA(A/G)CCTGG intron-variant, upstream-variant-2KB
rs1000406086 -- 56,555,744(+) AAATA(C/G)AAAAA downstream-variant-500B
rs1000641649 -- 56,545,396(+) CCTGG(A/G)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM209B Gene

Variant ID Type Subtype PubMed ID
esv2722576 CNV deletion 23290073
nsv1056574 CNV gain 25217958
nsv525425 CNV gain 19592680
nsv834015 CNV loss 17160897
nsv962593 CNV duplication 23825009

Variation tolerance for FAM209B Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM209B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM209B Gene

Disorders for FAM209B Gene

Relevant External Links for FAM209B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM209B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM209B Gene

Publications for FAM209B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3 64
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64

Products for FAM209B Gene

Sources for FAM209B Gene

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