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Aliases for FAM209A Gene

Aliases for FAM209A Gene

  • Family With Sequence Similarity 209 Member A 2 3 5
  • C20orf106 3 4
  • Family With Sequence Similarity 209, Member A 2
  • Chromosome 20 Open Reading Frame 106 2
  • Uncharacterized Protein C20orf106 3
  • Protein FAM209A 3
  • DJ1153D9.3 3

External Ids for FAM209A Gene

Previous HGNC Symbols for FAM209A Gene

  • C20orf106

Previous GeneCards Identifiers for FAM209A Gene

  • GC20P055093

Summaries for FAM209A Gene

GeneCards Summary for FAM209A Gene

FAM209A (Family With Sequence Similarity 209 Member A) is a Protein Coding gene. An important paralog of this gene is FAM209B.

Additional gene information for FAM209A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM209A Gene

Genomics for FAM209A Gene

GeneHancer (GH) Regulatory Elements for FAM209A Gene

Promoters and enhancers for FAM209A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I056515 Enhancer 0.6 ENCODE 550.8 -1.0 -975 2 SMARCA5 SIX4 CTCF ZSCAN4 PAX8 YBX1 RAD21 SMC3 FAM209A GCNT7 LOC105372681 RTF2
GH20I056524 Promoter 0.6 EPDnew 550.4 +7.5 7538 0.1 CREB1 FAM209B GCNT7 FAM209A RTF2 FAM210B GC20P056523
GH20I057439 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.4 +924.2 924232 5.6 PKNOX1 NFIB NFXL1 BMI1 ZBTB7B RAD21 RFX5 YY1 ELK1 HSF1 RBM38 FAM209A GCNT7 LOC100291105 ENSG00000280387 PIR61563
GH20I056629 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +116.1 116095 9.4 HDGF PKNOX1 CLOCK NEUROD1 SIN3A ZBTB7B BRCA1 ELK1 ZNF207 ZNF143 TFAP2C CSTF1 ENSG00000280387 RNU6-1146P RAE1 FAM209A PTMAP6
GH20I057409 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 15.4 +892.6 892611 2.4 HDGF PKNOX1 SMAD1 ARNT NEUROD1 ZBTB7B POLR2B ZNF766 E2F8 ZNF207 ENSG00000280387 FAM209A GCNT7 PPP4R1L RBM38 CTCFL ZBP1 LOC100291105 PIR61563
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM209A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM209A Gene

Genomic Locations for FAM209A Gene
chr20:56,517,187-56,526,152
(GRCh38/hg38)
Size:
8,966 bases
Orientation:
Plus strand
chr20:55,092,243-55,101,208
(GRCh37/hg19)

Genomic View for FAM209A Gene

Genes around FAM209A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM209A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM209A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM209A Gene

Proteins for FAM209A Gene

  • Protein details for FAM209A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JX71-F209A_HUMAN
    Recommended name:
    Protein FAM209A
    Protein Accession:
    Q5JX71
    Secondary Accessions:
    • Q05C43

    Protein attributes for FAM209A Gene

    Size:
    171 amino acids
    Molecular mass:
    19603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29411.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for FAM209A Gene

Post-translational modifications for FAM209A Gene

No Post-translational modifications

Other Protein References for FAM209A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM209A Gene

Domains & Families for FAM209A Gene

Gene Families for FAM209A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM209A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JX71

UniProtKB/Swiss-Prot:

F209A_HUMAN :
  • Belongs to the FAM209 family.
Family:
  • Belongs to the FAM209 family.
genes like me logo Genes that share domains with FAM209A: view

No data available for Suggested Antigen Peptide Sequences for FAM209A Gene

Function for FAM209A Gene

Phenotypes From GWAS Catalog for FAM209A Gene

Gene Ontology (GO) - Molecular Function for FAM209A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM209A: view

Phenotypes for FAM209A Gene

genes like me logo Genes that share phenotypes with FAM209A: view

Animal Model Products

miRNA for FAM209A Gene

miRTarBase miRNAs that target FAM209A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM209A Gene

Localization for FAM209A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM209A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM209A gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM209A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with FAM209A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM209A Gene

Pathways & Interactions for FAM209A Gene

SuperPathways for FAM209A Gene

No Data Available

Interacting Proteins for FAM209A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360379%0d%0a9606.ENSP00000284273%0d%0a
Selected Interacting proteins: ENSP00000360379 Q5JX71-F209A_HUMAN for FAM209A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM209A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM209A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM209A Gene

Drugs & Compounds for FAM209A Gene

No Compound Related Data Available

Transcripts for FAM209A Gene

mRNA/cDNA for FAM209A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(781) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM209A Gene

Family with sequence similarity 209, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM209A Gene

No ASD Table

Relevant External Links for FAM209A Gene

GeneLoc Exon Structure for
FAM209A
ECgene alternative splicing isoforms for
FAM209A

Expression for FAM209A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM209A Gene

mRNA differential expression in normal tissues according to GTEx for FAM209A Gene

This gene is overexpressed in Testis (x32.0) and Whole Blood (x7.8).

Protein differential expression in normal tissues from HIPED for FAM209A Gene

This gene is overexpressed in Testis (47.6) and Ovary (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM209A Gene



Protein tissue co-expression partners for FAM209A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM209A Gene:

FAM209A

SOURCE GeneReport for Unigene cluster for FAM209A Gene:

Hs.504907
genes like me logo Genes that share expression patterns with FAM209A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM209A Gene

Orthologs for FAM209A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM209A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM209A 33 34
  • 97.86 (n)
dog
(Canis familiaris)
Mammalia C24H20ORF106 34
  • 67 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM209B 34
  • 61 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Fam209 34
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
OneToMany
Species where no ortholog for FAM209A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM209A Gene

ENSEMBL:
Gene Tree for FAM209A (if available)
TreeFam:
Gene Tree for FAM209A (if available)

Paralogs for FAM209A Gene

Paralogs for FAM209A Gene

(1) SIMAP similar genes for FAM209A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM209A: view

Variants for FAM209A Gene

Sequence variations from dbSNP and Humsavar for FAM209A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000002174 -- 56,527,567(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000155827 -- 56,533,760(+) A/T downstream_transcript_variant
rs1000161665 -- 56,526,733(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000562973 -- 56,524,050(+) C/T upstream_transcript_variant
rs1000892213 -- 56,527,619(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM209A Gene

Variant ID Type Subtype PubMed ID
nsv1056574 CNV gain 25217958
nsv525425 CNV gain 19592680
nsv834015 CNV loss 17160897

Variation tolerance for FAM209A Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM209A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM209A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM209A Gene

Disorders for FAM209A Gene

Additional Disease Information for FAM209A

No disorders were found for FAM209A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM209A Gene

Publications for FAM209A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3 58

Products for FAM209A Gene

Sources for FAM209A Gene

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