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Aliases for FAM208B Gene

Aliases for FAM208B Gene

  • Family With Sequence Similarity 208 Member B 2 3 5
  • C10orf18 3 4
  • Family With Sequence Similarity 208, Member B 2
  • Chromosome 10 Open Reading Frame 18 2
  • Protein FAM208B 3
  • BA318E3.2 3
  • KIAA2006 4

External Ids for FAM208B Gene

Previous HGNC Symbols for FAM208B Gene

  • C10orf18

Summaries for FAM208B Gene

GeneCards Summary for FAM208B Gene

FAM208B (Family With Sequence Similarity 208 Member B) is a Protein Coding gene. An important paralog of this gene is FAM208A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM208B Gene

Genomics for FAM208B Gene

Regulatory Elements for FAM208B Gene

Enhancers for FAM208B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G005843 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9 +160.5 160479 4.2 HDGF PKNOX1 ARNT ZFP64 YY1 GLIS2 ZNF766 CBX5 FOS JUNB ANKRD16 LOC105376384 FBXO18 NRBF2P5 FAM208B ASB13 GDI2 PFKFB3 IL15RA TRV-TAC3-1
GH10G005631 1.4 Ensembl ENCODE dbSUPER 11.1 -52.2 -52180 2.6 ELF3 PKNOX1 ARID4B SIN3A RAD21 RARA YY1 FOS MIXL1 EGR2 ASB13 FAM208B GDI2 LOC102723629
GH10G005808 1.4 ENCODE dbSUPER 10.4 +127.5 127537 6.9 MLX CREB3L1 AGO1 YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC GDI2 LOC105376384 FBXO18 ANKRD16 FAM208B ENSG00000226647 ASB13 ENSG00000272764 GC10P005778
GH10G005628 1.3 Ensembl ENCODE dbSUPER 10.6 -55.4 -55389 2.4 FOXA2 RB1 ARID4B ZNF2 THRB ZNF48 ZBTB40 RAD21 YY1 ZNF143 ASB13 FAM208B NET1 RN7SL445P ENSG00000228685
GH10G005873 1.3 Ensembl ENCODE dbSUPER 10.2 +188.9 188938 1.3 HDGF CTCF ARID4B RAD21 POLR2A ZNF143 SMC3 RELB ZNF263 GATAD2A LOC105376384 GDI2 ENSG00000226647 ASB13 FAM208B FBXO18 GC10M005869 GC10P005874
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM208B on UCSC Golden Path with GeneCards custom track

Promoters for FAM208B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023882 628 2001 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 NFYC MEF2D ZNF610 GLIS1

Genomic Location for FAM208B Gene

Chromosome:
10
Start:
5,684,772 bp from pter
End:
5,765,779 bp from pter
Size:
81,008 bases
Orientation:
Plus strand

Genomic View for FAM208B Gene

Genes around FAM208B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM208B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM208B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM208B Gene

Proteins for FAM208B Gene

  • Protein details for FAM208B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWN6-F208B_HUMAN
    Recommended name:
    Protein FAM208B
    Protein Accession:
    Q5VWN6
    Secondary Accessions:
    • Q2YD91
    • Q5VWN5
    • Q6ZRQ8
    • Q8IVG4
    • Q9BUZ7
    • Q9H5J9
    • Q9H7A4
    • Q9H996
    • Q9NXA1

    Protein attributes for FAM208B Gene

    Size:
    2430 amino acids
    Molecular mass:
    268843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91115.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14336.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14993.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM208B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM208B Gene

Post-translational modifications for FAM208B Gene

  • Ubiquitination at Lys694 and Lys768
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM208B Gene

Domains & Families for FAM208B Gene

Protein Domains for FAM208B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM208B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VWN6

UniProtKB/Swiss-Prot:

F208B_HUMAN :
  • Belongs to the FAM208 family.
Family:
  • Belongs to the FAM208 family.
genes like me logo Genes that share domains with FAM208B: view

No data available for Gene Families for FAM208B Gene

Function for FAM208B Gene

Gene Ontology (GO) - Molecular Function for FAM208B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM208B: view

Phenotypes for FAM208B Gene

GenomeRNAi human phenotypes for FAM208B:
genes like me logo Genes that share phenotypes with FAM208B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM208B Gene

Localization for FAM208B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM208B gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM208B Gene

Pathways & Interactions for FAM208B Gene

SuperPathways for FAM208B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM208B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM208B Gene

Drugs & Compounds for FAM208B Gene

No Compound Related Data Available

Transcripts for FAM208B Gene

Unigene Clusters for FAM208B Gene

Family with sequence similarity 208, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM208B Gene

No ASD Table

Relevant External Links for FAM208B Gene

GeneLoc Exon Structure for
FAM208B
ECgene alternative splicing isoforms for
FAM208B

Expression for FAM208B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM208B Gene

Protein differential expression in normal tissues from HIPED for FAM208B Gene

This gene is overexpressed in Liver (48.5) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM208B Gene



Protein tissue co-expression partners for FAM208B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM208B Gene:

FAM208B

SOURCE GeneReport for Unigene cluster for FAM208B Gene:

Hs.610717
genes like me logo Genes that share expression patterns with FAM208B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM208B Gene

Orthologs for FAM208B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM208B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM208B 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia FAM208B 34 35
  • 77.34 (n)
mouse
(Mus musculus)
Mammalia BC016423 34 35
  • 73.92 (n)
Fam208b 16
rat
(Rattus norvegicus)
Mammalia Fam208b 34
  • 73.92 (n)
cow
(Bos Taurus)
Mammalia FAM208B 34 35
  • 73.01 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM208B 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM208B 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM208B 35
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam208b 35
  • 13 (a)
OneToOne
Species where no ortholog for FAM208B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM208B Gene

ENSEMBL:
Gene Tree for FAM208B (if available)
TreeFam:
Gene Tree for FAM208B (if available)

Paralogs for FAM208B Gene

Paralogs for FAM208B Gene

(1) SIMAP similar genes for FAM208B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM208B: view

Variants for FAM208B Gene

Sequence variations from dbSNP and Humsavar for FAM208B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000025150 -- 5,722,639(+) TGAAG(A/G)GTATT intron-variant
rs1000057828 -- 5,764,170(+) GAAAA(A/G)GAAAG downstream-variant-500B
rs1000076581 -- 5,692,744(+) CGCGG(A/G)GCCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000120070 -- 5,706,406(+) TTAAC(A/G)TCCCC intron-variant
rs1000236510 -- 5,716,336(+) ATACA(A/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM208B Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
dgv36n21 CNV loss 19592680
esv1004136 CNV insertion 20482838
esv2759729 CNV gain 17122850
nsv1050663 CNV loss 25217958
nsv522415 CNV gain 19592680
nsv528504 CNV gain 19592680
nsv549895 CNV loss 21841781
nsv831775 CNV loss 17160897
nsv8600 CNV gain 18304495

Variation tolerance for FAM208B Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM208B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM208B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM208B Gene

Disorders for FAM208B Gene

Relevant External Links for FAM208B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM208B

No disorders were found for FAM208B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM208B Gene

Publications for FAM208B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FAM208B Gene

Sources for FAM208B Gene

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