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Aliases for FAM208B Gene

Aliases for FAM208B Gene

  • Family With Sequence Similarity 208 Member B 2 3 5
  • C10orf18 3 4
  • Family With Sequence Similarity 208, Member B 2
  • Chromosome 10 Open Reading Frame 18 2
  • Protein FAM208B 3
  • BA318E3.2 3
  • KIAA2006 4

External Ids for FAM208B Gene

Previous HGNC Symbols for FAM208B Gene

  • C10orf18

Summaries for FAM208B Gene

GeneCards Summary for FAM208B Gene

FAM208B (Family With Sequence Similarity 208 Member B) is a Protein Coding gene. An important paralog of this gene is FAM208A.

Additional gene information for FAM208B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM208B Gene

Genomics for FAM208B Gene

Regulatory Elements for FAM208B Gene

Enhancers for FAM208B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H005852 1.9 FANTOM5 Ensembl ENCODE dbSUPER 55.8 +168.3 168260 1.9 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF121 GTF3C2 ZNF143 ATF7 RUNX3 FAM208B FBXO18 LOC105376384 ENSG00000226647 ANKRD16 GDI2 RBM17 NRBF2P5 PFKFB3 IL15RA
GH10H005543 2 FANTOM5 Ensembl ENCODE dbSUPER 48.3 -135.0 -135043 11.7 FEZF1 DMAP1 ZNF143 SP3 MCM3 MEF2D SSRP1 ZNF610 GLIS1 RCOR2 FAM208B FBXO18 LOC105376384 CALML3-AS1 ENSG00000226647 CALML3 NRBF2P5 ENSG00000256462 GDI2 CALML5
GH10H006088 1.4 ENCODE dbSUPER 42.6 +404.7 404747 2.5 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF143 MXD4 FAM208B FBXO18 ENSG00000226647 LOC105376384 NRBF2P5 GDI2 CALML3-AS1 RBM17 GC10P006113
GH10H005887 1.1 ENCODE 48 +205.6 205586 5.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF766 FAM208B FBXO18 LOC105376384 IL15RA RBM17 ANKRD16 ENSG00000226647 GDI2 NRBF2P5 ASB13
GH10H004780 1.4 Ensembl ENCODE dbSUPER 34.6 -904.0 -904024 1.3 INSM2 ZNF76 ZEB1 ZNF366 FOS ZNF391 SP3 ZNF362 YY2 CEBPB FAM208B AKR1E2 LOC105376375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM208B on UCSC Golden Path with GeneCards custom track

Promoters for FAM208B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for FAM208B Gene

Genomic Locations for FAM208B Gene
81,008 bases
Plus strand

Genomic View for FAM208B Gene

Genes around FAM208B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM208B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM208B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM208B Gene

Proteins for FAM208B Gene

  • Protein details for FAM208B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM208B
    Protein Accession:
    Secondary Accessions:
    • Q2YD91
    • Q5VWN5
    • Q6ZRQ8
    • Q8IVG4
    • Q9BUZ7
    • Q9H5J9
    • Q9H7A4
    • Q9H996
    • Q9NXA1

    Protein attributes for FAM208B Gene

    2430 amino acids
    Molecular mass:
    268843 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91115.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14336.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14993.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM208B Gene


neXtProt entry for FAM208B Gene

Post-translational modifications for FAM208B Gene

  • Ubiquitination at isoforms=694 and posLast=768768
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM208B Gene

Domains & Families for FAM208B Gene

Gene Families for FAM208B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM208B Gene


Suggested Antigen Peptide Sequences for FAM208B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM208 family.
  • Belongs to the FAM208 family.
genes like me logo Genes that share domains with FAM208B: view

Function for FAM208B Gene

Phenotypes From GWAS Catalog for FAM208B Gene

Gene Ontology (GO) - Molecular Function for FAM208B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM208B: view

Phenotypes for FAM208B Gene

GenomeRNAi human phenotypes for FAM208B:
genes like me logo Genes that share phenotypes with FAM208B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM208B Gene

Localization for FAM208B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM208B gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM208B Gene

Pathways & Interactions for FAM208B Gene

SuperPathways for FAM208B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM208B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM208B Gene

Drugs & Compounds for FAM208B Gene

No Compound Related Data Available

Transcripts for FAM208B Gene

Unigene Clusters for FAM208B Gene

Family with sequence similarity 208, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM208B Gene

No ASD Table

Relevant External Links for FAM208B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM208B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM208B Gene

Protein differential expression in normal tissues from HIPED for FAM208B Gene

This gene is overexpressed in Liver (48.5) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM208B Gene

Protein tissue co-expression partners for FAM208B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM208B Gene:


SOURCE GeneReport for Unigene cluster for FAM208B Gene:

genes like me logo Genes that share expression patterns with FAM208B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM208B Gene

Orthologs for FAM208B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM208B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM208B 33 34
  • 98.88 (n)
(Canis familiaris)
Mammalia FAM208B 33 34
  • 77.34 (n)
(Mus musculus)
Mammalia BC016423 33 34
  • 73.92 (n)
Fam208b 16
(Rattus norvegicus)
Mammalia Fam208b 33
  • 73.92 (n)
(Bos Taurus)
Mammalia FAM208B 33 34
  • 73.01 (n)
(Monodelphis domestica)
Mammalia FAM208B 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia FAM208B 34
  • 33 (a)
(Gallus gallus)
Aves FAM208B 34
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
-- 34
  • 23 (a)
(Danio rerio)
Actinopterygii fam208b 34
  • 13 (a)
Species where no ortholog for FAM208B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM208B Gene

Gene Tree for FAM208B (if available)
Gene Tree for FAM208B (if available)

Paralogs for FAM208B Gene

Paralogs for FAM208B Gene

(1) SIMAP similar genes for FAM208B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM208B: view

Variants for FAM208B Gene

Sequence variations from dbSNP and Humsavar for FAM208B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000025150 -- 5,722,639(+) TGAAG(A/G)GTATT intron-variant
rs1000057828 -- 5,764,170(+) GAAAA(A/G)GAAAG downstream-variant-500B
rs1000076581 -- 5,692,744(+) CGCGG(A/G)GCCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000120070 -- 5,706,406(+) TTAAC(A/G)TCCCC intron-variant
rs1000236510 -- 5,716,336(+) ATACA(A/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM208B Gene

Variant ID Type Subtype PubMed ID
nsv8600 CNV gain 18304495
nsv831775 CNV loss 17160897
nsv549895 CNV loss 21841781
nsv528504 CNV gain 19592680
nsv522415 CNV gain 19592680
nsv1050663 CNV loss 25217958
esv2759729 CNV gain 17122850
esv1004136 CNV insertion 20482838
dgv36n21 CNV loss 19592680
dgv1e49 CNV loss 18971310

Variation tolerance for FAM208B Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM208B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM208B Gene

Disorders for FAM208B Gene

Relevant External Links for FAM208B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM208B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM208B Gene

Publications for FAM208B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60

Products for FAM208B Gene

Sources for FAM208B Gene

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