FAM208B Gene
protein-coding GIFtS: 38
GCID: GC10P005727
|
|
family with sequence similarity 208, member B(Previous name: chromosome 10 open reading frame 18 )
(Previous symbol: C10orf18)
| |
Aliases
for FAM208B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Family With Sequence Similarity 208, Member B1 2 | | FLJ203601 | | C10orf181 2 3 | | Chromosome 10 Open Reading Frame 181 | | BA318E3.21 | | Protein FAM208B2 | | KIAA20061 3 | | Uncharacterized Protein C10orf182 |
Export aliases for FAM208B gene to outside databases |
Summaries
for FAM208B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FAM208B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FAM208B
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM208B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM208B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1FAM208B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P005727: view genomic region
(about GC identifiers)
Start:
|
5,726,801 bp from pter |
End:
|
5,805,703 bp from pter |
Size:
|
78,903 bases |
Orientation:
|
plus strand |
|
Proteins
for FAM208B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F208B_HUMAN, Q5VWN6 (See
protein sequence)Recommended Name: Protein FAM208B Size: 2430 amino acids; 268843 Da
Sequence caution: Sequence=BAA91115.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB14336.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14993.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC87251.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
Secondary accessions: Q2YD91 Q5VWN5 Q6ZRQ8 Q8IVG4 Q9BUZ7 Q9H5J9 Q9H7A4 Q9H996 Q9NXA1Alternative splicing: 2 isoforms: Q5VWN6-1 Q5VWN6-2 Explore the universe of human proteins at neXtProt for FAM208B: NX_Q5VWN6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VWN6
FAM208B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060252.4
ENSEMBL proteins: ENSP00000328426 ENSP00000434941 ENSP00000369623
Human Recombinant Protein Products:
FAM208B Antibody Products:
Assay Products for FAM208B: |
Protein
Domains /
Families
for FAM208B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FAM208B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VWN6ProtoNet protein and cluster: Q5VWN6 UniProtKB/Swiss-Prot: F208B_HUMAN, Q5VWN6Similarity: Belongs to the FAM208 family |
Function
for FAM208B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FAM208B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM208B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM208B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM208B |
|
Pathways & Interactions
for FAM208B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM208B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for FAM208B (Q5VWN62, 3 ENSP000003284264) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for FAM208B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM208B
Search CenterWatch for drugs/clinical trials and news about FAM208B / F208B
|
Transcripts
for FAM208B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM208B gene: NM_017782.4 Unigene Cluster for FAM208B: Family with sequence similarity 208, member B Hs.610717 [show with all ESTs]Unigene Representative Sequence: NM_01778213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328090(uc001iij.3 uc001iik.3) ENST00000480839 ENST00000477043
ENST00000473789 ENST00000496681 ENST00000532424(uc021pmm.1) ENST00000482419
ENST00000463468 ENST00000527124 ENST00000532080 ENST00000380270 ENST00000487196
ENST00000459693
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FAM208B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM208B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM208B |
Additional cDNA sequence: AB095927.1 AK000367.1 AK022966.1 AK024762.1 AK027014.1 AK091392.1 AK126513.1 AK128051.1 AK128055.1 AK128151.1 AK225352.1 AK309877.1 AL832762.1 BC001759.1 BC016688.1 BC071976.1 BC110339.1 BX649177.1 CR936780.1 12 DOTS entries: DT.213838 DT.100794665 DT.100794669 DT.92070658 DT.101984231 DT.75171366 DT.40214500 DT.100794663 DT.70103688 DT.75157942 DT.95364199 DT.101960764 24/217 AceView cDNA sequences (see all 217): AK128051 AI807640 BX112201 BQ186407 AI332872 AA482383 AI925713 BX480880 AI640690 CB158706 BF514936 BU683214 BF448595 BF512655 BC016688 AL832762 AA832003 AI701314 CD652894 BQ009358 AW440981 AW006863 BU189725 AB095927
GeneLoc Exon Structure
|
Expression
for FAM208B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM208B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAATGTCAG
About this image
See FAM208B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM208B
SOURCE GeneReport for Unigene cluster: Hs.610717
SABiosciences Custom PCR Arrays for FAM208B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM208B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM208B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM208B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM208B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM208B |
Orthologs
for FAM208B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM208B gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for FAM208B (if available)
TreeFam Gene Tree for FAM208B (if available) |
Paralogs
for FAM208B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM208B gene
- FAM208A2
1 SIMAP similar gene for FAM208B using alignment to 2 protein entries: F208B_HUMAN (see all proteins):C10orf18
FAM208B for paralogs About GeneDecksing
|
Genomic Variants
for FAM208B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM208B (5726801 - 5805703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM208B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM208B |
|
Disorders
/ Diseases
for FAM208B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM208B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM208B gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FAM208B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for FAM208B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FAM208B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM208B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FAM208B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM208B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM208B gene:
Search GeneIP for patents involving FAM208B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM208B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM208B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM208B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM208B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM208B | | OriGene 3'-UTR Clone for FAM208B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM208B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM208B | | OriGene Custom Protein Services for FAM208B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM208B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM208B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM208B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM208B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM208B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM208B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FAM208B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FAM208B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM208B |
|  |  |  | | | | Search ThermoFisher Antibodies for FAM208B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM208B |
|
|
|
|
