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FAM208B Gene

protein-coding   GIFtS: 40
GCID: GC10P005727

Family With Sequence Similarity 208, Member B

(Previous name: chromosome 10 open reading frame 18)
(Previous symbol: C10orf18)
  Search for FAM208B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 208, Member B1 2     Protein FAM208B2
C10orf181 2 3     Uncharacterized Protein C10orf182
Chromosome 10 Open Reading Frame 181     KIAA20063
bA318E3.22     

External Ids:    HGNC: 234841   Entrez Gene: 549062   Ensembl: ENSG000001080217   UniProtKB: Q5VWN63   

Export aliases for FAM208B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM208B Gene:
FAM208B (family with sequence similarity 208, member B) is a protein-coding gene. An important paralog of this gene is FAM208A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM208B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM208B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM208B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

FAM208B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM208B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005727:  view genomic region     (about GC identifiers)

Start:
5,726,801 bp from pter      End:
5,805,703 bp from pter
Size:
78,903 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F208B_HUMAN, Q5VWN6 (See protein sequence)
Recommended Name: Protein FAM208B  
Size: 2430 amino acids; 268843 Da
Sequence caution: Sequence=BAA91115.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14336.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14993.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC87251.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q2YD91 Q5VWN5 Q6ZRQ8 Q8IVG4 Q9BUZ7 Q9H5J9 Q9H7A4 Q9H996 Q9NXA1
Alternative splicing: 2 isoforms:  Q5VWN6-1   Q5VWN6-2   

Explore the universe of human proteins at neXtProt for FAM208B: NX_Q5VWN6

Explore proteomics data for FAM208B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys694, Lys768
  • Modification sites at PhosphoSitePlus

  • See FAM208B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060252.4  
    ENSEMBL proteins: 
     ENSP00000328426   ENSP00000434941   ENSP00000369623  

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    Cloud-Clone Corp. CLIAs for FAM208B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022188 DUF3715
     IPR022168 DUF3699

    Graphical View of Domain Structure for InterPro Entry Q5VWN6

    ProtoNet protein and cluster: Q5VWN6

    UniProtKB/Swiss-Prot: F208B_HUMAN, Q5VWN6
    Similarity: Belongs to the FAM208 family


    FAM208B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM208B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM208B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM208B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM208B

    miRNA
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    miRTarBase miRNAs that target FAM208B:
    hsa-mir-504-5p (MIRT041082), hsa-mir-26b-5p (MIRT029480), hsa-mir-149-5p (MIRT045445)

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    Predesigned siRNA for gene silencing in human, mouse, rat FAM208B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM208B
    Interactions:

        Search GeneGlobe Interaction Network for FAM208B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for FAM208B (Q5VWN62, 3 ENSP000003284264) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=3 STRING: ENSP00000311695
    LDOC1O957513, ENSP000003595574I2D: score=3 STRING: ENSP00000359557
    COX5BP106063I2D: score=1 
    ERHP840903I2D: score=1 
    YWHAZP631043I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM208B (F208B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM208B gene: 
    NM_017782.4  

    Unigene Cluster for FAM208B:

    Family with sequence similarity 208, member B
    Hs.610717  [show with all ESTs]
    Unigene Representative Sequence: NM_017782
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328090(uc001iij.3 uc001iik.3) ENST00000477043 ENST00000473789
    ENST00000496681 ENST00000480839 ENST00000532424(uc021pmm.1) ENST00000482419
    ENST00000463468 ENST00000527124 ENST00000532080 ENST00000380270 ENST00000487196
    ENST00000459693
    miRNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM208B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM208B
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM208B
      QuantiFast Probe-based Assays in human, mouse, rat FAM208B

    Additional mRNA sequence: 

    AB095927.1 AK000367.1 AK022966.1 AK024762.1 AK027014.1 AK091392.1 AK126513.1 AK128051.1 
    AK128055.1 AK128151.1 AK225352.1 AK309877.1 AL832762.1 BC001759.1 BC016688.1 BC071976.1 
    BC110339.1 BX649177.1 CR936780.1 

    12 DOTS entries:

    DT.213838  DT.100794669  DT.100794665  DT.92070658  DT.101984231  DT.75171366  DT.100794663  DT.40214500 
    DT.70103688  DT.75157942  DT.95364199  DT.101960764 

    Selected AceView cDNA sequences (see all 217):

    AK128151 BC016688 BF514936 BU683214 BF448595 BX112201 AI807640 AA482383 
    AI332872 BQ186407 AI925713 BX480880 CB158706 AI640690 BF512655 BU189725 
    AB095927 AW006863 AW440981 BM720849 BQ009358 AA314386 AI351702 AA832003 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM208B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATGTCAG
    FAM208B Expression
    About this image

    FAM208B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM208B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.610717
        Custom PCR Arrays for FAM208B
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FAM208B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM208B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM208B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0164231 , 5 cDNA sequence BC0164231, 5 73.92(n)1
    59.04(a)1
      13 (1.99 cM)5
    1052031  NM_134063.31  NP_598824.31 
     35660365 
    chicken
    (Gallus gallus)
    Aves FAM208B6
    family with sequence similarity 208, member B
    28(a)
    1 ↔ 1
    1(1016281-1061797)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    42(a)
    23(a)
    many → 1
    many → 1
    5(3946892-3953744)
    5(3958383-3976778)
    zebrafish
    (Danio rerio)
    Actinopterygii fam208b6
    family with sequence similarity 208, member B
    13(a)
    1 ↔ 1
    8(11504699-11532799) ENSDARG00000074168


    ENSEMBL Gene Tree for FAM208B (if available)
    TreeFam Gene Tree for FAM208B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM208B gene
    FAM208A2  
    1 SIMAP similar gene for FAM208B using alignment to 2 protein entries:     F208B_HUMAN (see all proteins):
    C10orf18

    FAM208B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM208B (see all 1940)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94241981,2
    C,F--5642345(+) CTCCAC/TGTATT 1 -- us2k17Minor allele frequency- T:0.28NA CSA WA EA 365
    rs1808505011,2
    --5642439(+) TTCTGC/TCCTTG 1 -- us2k10--------
    rs94242011,2
    C,F--5642505(+) ATTGTT/CATCTG 1 -- us2k16Minor allele frequency- C:0.23NA WA EA 364
    rs1499075381,2
    --5642519(+) TTCTAC/TTTTCT 1 -- us2k10--------
    rs94239151,2
    C--5642630(+) TATTAC/TACATG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs785243161,2
    C,F--5642630(+) TATTAC/TAGCAC 1 -- us2k16Minor allele frequency- T:0.25NA CSA WA EA 363
    rs1859014291,2
    C--5642696(+) GTGCTC/TGACTC 1 -- us2k10--------
    rs1173506641,2
    F--5642706(+) CATGAT/AACATG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1448755121,2
    C--5642722(+) TAGCAA/CTTAAT 1 -- us2k10--------
    rs1902841471,2
    --5642726(+) ACTTAA/GTCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM208B (5726801 - 5805703 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM208B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM208B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM208B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM208B gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with FAM208B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Genome-wide association study identifies two susceptibility loci for osteosarcoma. (PubMed id 23727862)1 Savage S.A....Chanock S.J. (Nat. Genet. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54906 HGNC: 23484 AceView: C10orf18 Ensembl:ENSG00000108021 euGenes: HUgn54906
    ECgene: FAM208B H-InvDB: FAM208B

    (According to HUGE)
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    HUGE: KIAA2006

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM208B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM208B gene:
    Search GeneIP for patents involving FAM208B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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