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Aliases for FAM208A Gene

Aliases for FAM208A Gene

  • Family With Sequence Similarity 208, Member A 2 3
  • Retinoblastoma-Associated Protein RAP140 3 4
  • Transgene Activation Suppressor Protein 3 4
  • CTCL Tumor Antigen Se89-1 3 4
  • C3orf63 3 4
  • Retinoblastoma-Associated Protein 140 3
  • Chromosome 3 Open Reading Frame 63 2
  • Protein FAM208A 3
  • KIAA1105 4
  • RAP140 3
  • Se89-1 3
  • TASOR 4

External Ids for FAM208A Gene

Previous HGNC Symbols for FAM208A Gene

  • C3orf63

Summaries for FAM208A Gene

GeneCards Summary for FAM208A Gene

FAM208A (Family With Sequence Similarity 208, Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM208B.

UniProtKB/Swiss-Prot for FAM208A Gene

  • Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM208A Gene

Genomics for FAM208A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM208A Gene

Chromosome:
3
Start:
56,620,132 bp from pter
End:
56,683,242 bp from pter
Size:
63,111 bases
Orientation:
Minus strand

Genomic View for FAM208A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM208A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM208A Gene

No data available for Regulatory Elements for FAM208A Gene

Proteins for FAM208A Gene

  • Protein details for FAM208A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK61-TASOR_HUMAN
    Recommended name:
    Protein TASOR
    Protein Accession:
    Q9UK61
    Secondary Accessions:
    • A1L3A4
    • B5ME28
    • Q9H2F7
    • Q9UPP7

    Protein attributes for FAM208A Gene

    Size:
    1670 amino acids
    Molecular mass:
    189032 Da
    Quaternary structure:
    • Component of the HUSH complex; at least composed of FAM208A/TASOR, PPHLN1 and MPHOSPH8.
    SequenceCaution:
    • Sequence=AAG34913.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM208A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM208A Gene

Proteomics data for FAM208A Gene at MOPED

Post-translational modifications for FAM208A Gene

  • Asn-1105 may be N-glycosylated; however as this position is probably not extracellular, the in vivo relevance is not proven.
  • Ubiquitination at Lys 197, Lys 360, and Lys 563
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM208A Gene

No data available for DME Specific Peptides for FAM208A Gene

Domains & Families for FAM208A Gene

Protein Domains for FAM208A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM208A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK61

UniProtKB/Swiss-Prot:

TASOR_HUMAN :
  • Belongs to the FAM208 family.
Family:
  • Belongs to the FAM208 family.
genes like me logo Genes that share domains with FAM208A: view

No data available for Gene Families for FAM208A Gene

Function for FAM208A Gene

Molecular function for FAM208A Gene

UniProtKB/Swiss-Prot Function:
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

Gene Ontology (GO) - Molecular Function for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM208A: view

Phenotypes for FAM208A Gene

GenomeRNAi human phenotypes for FAM208A:
genes like me logo Genes that share phenotypes with FAM208A: view

Animal Model Products

CRISPR Products

miRNA for FAM208A Gene

miRTarBase miRNAs that target FAM208A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM208A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM208A Gene

Localization for FAM208A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM208A Gene

Nucleus. Chromosome. Note=Localizes to chromatin. {ECO:0000269 PubMed:26022416}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM208A Gene COMPARTMENTS Subcellular localization image for FAM208A gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with FAM208A: view

Pathways & Interactions for FAM208A Gene

SuperPathways for FAM208A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FAM208A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM208A Gene

Drugs & Compounds for FAM208A Gene

No Compound Related Data Available

Transcripts for FAM208A Gene

Unigene Clusters for FAM208A Gene

Family with sequence similarity 208, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM208A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM208A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ·
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6: - -
SP7:

ExUns: 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:

Relevant External Links for FAM208A Gene

GeneLoc Exon Structure for
FAM208A
ECgene alternative splicing isoforms for
FAM208A

Expression for FAM208A Gene

mRNA expression in normal human tissues for FAM208A Gene

Protein differential expression in normal tissues from HIPED for FAM208A Gene

This gene is overexpressed in Testis (22.7) and Peripheral blood mononuclear cells (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM208A Gene



SOURCE GeneReport for Unigene cluster for FAM208A Gene Hs.116877

genes like me logo Genes that share expression patterns with FAM208A: view

Protein tissue co-expression partners for FAM208A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM208A Gene

Orthologs for FAM208A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM208A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM208A 35
  • 92.51 (n)
  • 90.03 (a)
FAM208A 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM208A 35
  • 93.86 (n)
  • 92.62 (a)
FAM208A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D14Abb1e 35
  • 86.87 (n)
  • 82.86 (a)
D14Abb1e 16
D14Abb1e 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM208A 35
  • 98.88 (n)
  • 98.53 (a)
FAM208A 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam208a 35
  • 86.42 (n)
  • 82.78 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM208A 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM208A 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM208A 35
  • 70.24 (n)
  • 64.15 (a)
FAM208A 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM208A 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam208a 35
  • 56.27 (n)
  • 48.65 (a)
zebrafish
(Danio rerio)
Actinopterygii fam208ab 35
  • 53.41 (n)
  • 43.89 (a)
CABZ01044611.1 36
  • 26 (a)
OneToMany
fam208ab 36
  • 26 (a)
OneToMany
Species with no ortholog for FAM208A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM208A Gene

ENSEMBL:
Gene Tree for FAM208A (if available)
TreeFam:
Gene Tree for FAM208A (if available)

Paralogs for FAM208A Gene

Paralogs for FAM208A Gene

Pseudogenes.org Pseudogenes for FAM208A Gene

genes like me logo Genes that share paralogs with FAM208A: view

Variants for FAM208A Gene

Sequence variations from dbSNP and Humsavar for FAM208A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs873840 -- 56,684,776(+) TCGAA(A/T)CAATT upstream-variant-2KB
rs953539 -- 56,657,936(-) AGCCA(C/G)TTGTC intron-variant
rs953540 -- 56,657,760(-) cattt(A/G)tttag intron-variant
rs958755 - 56,682,894(+) TTTGT(G/T)GGGAG reference, missense, upstream-variant-2KB
rs1054092 -- 56,675,785(-) TTTAG(A/G)AGTAT intron-variant

Variation tolerance for FAM208A Gene

Residual Variation Intolerance Score: 18.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.96; 89.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM208A Gene

HapMap Linkage Disequilibrium report
FAM208A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM208A Gene

Disorders for FAM208A Gene

Relevant External Links for FAM208A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM208A
genes like me logo Genes that share disorders with FAM208A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM208A Gene

Publications for FAM208A Gene

  1. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 67
  3. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. (PMID: 26022416) Tchasovnikarova I.A. … Lehner P.J. (Science 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67

Products for FAM208A Gene

Sources for FAM208A Gene

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