Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM208A Gene

Aliases for FAM208A Gene

  • Family With Sequence Similarity 208 Member A 2 3 5
  • Retinoblastoma-Associated Protein RAP140 3 4
  • Transgene Activation Suppressor Protein 3 4
  • CTCL Tumor Antigen Se89-1 3 4
  • C3orf63 3 4
  • TASOR 3 4
  • Family With Sequence Similarity 208, Member A 2
  • Retinoblastoma-Associated Protein 140 3
  • Chromosome 3 Open Reading Frame 63 2
  • Transgene Activation Suppressor 2
  • Protein FAM208A 3
  • Protein TASOR 3
  • KIAA1105 4
  • RAP140 3
  • Se89-1 3

External Ids for FAM208A Gene

Previous HGNC Symbols for FAM208A Gene

  • C3orf63

Summaries for FAM208A Gene

GeneCards Summary for FAM208A Gene

FAM208A (Family With Sequence Similarity 208 Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM208B.

UniProtKB/Swiss-Prot for FAM208A Gene

  • Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM208A Gene

Genomics for FAM208A Gene

Regulatory Elements for FAM208A Gene

Enhancers for FAM208A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F056680 0.5 ENCODE 40.5 +0.9 877 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 KLF13 ZNF263 SP3 FAM208A CCDC66
GH03F057594 1.1 ENCODE 23.1 -914.3 -914330 6.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 DENND6A FAM208A ARF4 ACOX2 DENND6A-AS1 PDE12 FLNB-AS1 LOC101929159 APPL1 HESX1
GH03F056696 0.2 Ensembl 22.4 -13.6 -13559 0.4 ZNF585B FAM208A CCDC66 GC03M056697
GH03F056976 0.8 Ensembl ENCODE 19.5 -294.0 -293952 1.9 RFX1 ZNF140 ZBTB8A REST FEZF1 ZNF121 SCRT2 ZNF341 PRDM10 ZNF600 FAM208A DENND6A ARHGEF3-AS1 SPATA12
GH03F056692 1.2 Ensembl ENCODE 19.4 -11.1 -11117 3.5 PKNOX1 MTA2 CBFB BMI1 TBX21 RAD51 POLR2A IKZF1 MLLT1 SPI1 FAM208A CCDC66 GC03M056697
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM208A on UCSC Golden Path with GeneCards custom track

Promoters for FAM208A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001479487 1042 3201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 KLF13 ZNF263 SP3

Genomic Location for FAM208A Gene

Chromosome:
3
Start:
56,620,132 bp from pter
End:
56,683,242 bp from pter
Size:
63,111 bases
Orientation:
Minus strand

Genomic View for FAM208A Gene

Genes around FAM208A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM208A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM208A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM208A Gene

Proteins for FAM208A Gene

  • Protein details for FAM208A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK61-TASOR_HUMAN
    Recommended name:
    Protein TASOR
    Protein Accession:
    Q9UK61
    Secondary Accessions:
    • A1L3A4
    • B5ME28
    • Q9H2F7
    • Q9UPP7

    Protein attributes for FAM208A Gene

    Size:
    1670 amino acids
    Molecular mass:
    189032 Da
    Quaternary structure:
    • Component of the HUSH complex; at least composed of FAM208A/TASOR, PPHLN1 and MPHOSPH8.
    SequenceCaution:
    • Sequence=AAG34913.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM208A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM208A Gene

Post-translational modifications for FAM208A Gene

  • Asn-1105 may be N-glycosylated; however as this position is probably not extracellular, the in vivo relevance is not proven.
  • Ubiquitination at Lys 197, Lys 360, and Lys 563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM208A Gene

Domains & Families for FAM208A Gene

Protein Domains for FAM208A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM208A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK61

UniProtKB/Swiss-Prot:

TASOR_HUMAN :
  • Belongs to the FAM208 family.
Family:
  • Belongs to the FAM208 family.
genes like me logo Genes that share domains with FAM208A: view

No data available for Gene Families for FAM208A Gene

Function for FAM208A Gene

Molecular function for FAM208A Gene

UniProtKB/Swiss-Prot Function:
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

Gene Ontology (GO) - Molecular Function for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FAM208A: view
genes like me logo Genes that share phenotypes with FAM208A: view

Animal Model Products

miRNA for FAM208A Gene

miRTarBase miRNAs that target FAM208A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM208A Gene

Localization for FAM208A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM208A Gene

Nucleus. Chromosome. Note=Localizes to chromatin. {ECO:0000269 PubMed:26022416}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM208A Gene COMPARTMENTS Subcellular localization image for FAM208A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with FAM208A: view

Pathways & Interactions for FAM208A Gene

SuperPathways for FAM208A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FAM208A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM208A Gene

Transcripts for FAM208A Gene

Unigene Clusters for FAM208A Gene

Family with sequence similarity 208, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM208A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ·
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:
SP6: - -
SP7:

ExUns: 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:

Relevant External Links for FAM208A Gene

GeneLoc Exon Structure for
FAM208A
ECgene alternative splicing isoforms for
FAM208A

Expression for FAM208A Gene

mRNA expression in normal human tissues for FAM208A Gene

Protein differential expression in normal tissues from HIPED for FAM208A Gene

This gene is overexpressed in Testis (22.7) and Peripheral blood mononuclear cells (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM208A Gene



Protein tissue co-expression partners for FAM208A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM208A Gene:

FAM208A

SOURCE GeneReport for Unigene cluster for FAM208A Gene:

Hs.116877
genes like me logo Genes that share expression patterns with FAM208A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM208A Gene

Orthologs for FAM208A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM208A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM208A 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia FAM208A 34 35
  • 93.86 (n)
cow
(Bos Taurus)
Mammalia FAM208A 34 35
  • 92.51 (n)
mouse
(Mus musculus)
Mammalia D14Abb1e 34 35
  • 86.87 (n)
Fam208a 16
rat
(Rattus norvegicus)
Mammalia Fam208a 34
  • 86.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM208A 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM208A 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM208A 34 35
  • 70.24 (n)
lizard
(Anolis carolinensis)
Reptilia FAM208A 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam208a 34
  • 56.27 (n)
zebrafish
(Danio rerio)
Actinopterygii fam208ab 34 35
  • 53.41 (n)
CABZ01044611.1 35
  • 26 (a)
OneToMany
Species where no ortholog for FAM208A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM208A Gene

ENSEMBL:
Gene Tree for FAM208A (if available)
TreeFam:
Gene Tree for FAM208A (if available)

Paralogs for FAM208A Gene

Paralogs for FAM208A Gene

genes like me logo Genes that share paralogs with FAM208A: view

Variants for FAM208A Gene

Sequence variations from dbSNP and Humsavar for FAM208A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049468 -- 56,654,403(+) GGGGT(G/T)GGGGG intron-variant
rs1015329 -- 56,619,853(+) AAAAA(C/T)AGGGA nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs10212341 -- 56,635,120(+) CATCA(C/T)ACTTT intron-variant
rs10222629 -- 56,628,699(+) CTGAT(A/T)AGCTT intron-variant
rs1045926 -- 56,620,572(-) ATTTT(C/G)AAATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FAM208A Gene

Variant ID Type Subtype PubMed ID
nsv460557 CNV loss 19166990
nsv590362 CNV loss 21841781

Variation tolerance for FAM208A Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.96; 89.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM208A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM208A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM208A Gene

Disorders for FAM208A Gene

Relevant External Links for FAM208A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM208A

No disorders were found for FAM208A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM208A Gene

Publications for FAM208A Gene

  1. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. (PMID: 26022416) Tchasovnikarova I.A. … Lehner P.J. (Science 2015) 2 3 4 64
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Identification and cloning of the cDNA of a Rb-associated protein RAP140a. (PMID: 18726359) Li Q. … Ao S. (Sci. China, Ser. C, Life Sci. 2000) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4 64

Products for FAM208A Gene

Sources for FAM208A Gene

Content
Loading form....