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Aliases for FAM207A Gene

Aliases for FAM207A Gene

  • Family With Sequence Similarity 207 Member A 2 3 5
  • Family With Sequence Similarity 207, Member A 2 3
  • C21orf70 3 4
  • Chromosome 21 Open Reading Frame 70 2
  • PRED56 3

External Ids for FAM207A Gene

Previous HGNC Symbols for FAM207A Gene

  • C21orf70

Previous GeneCards Identifiers for FAM207A Gene

  • GC21P046360

Summaries for FAM207A Gene

GeneCards Summary for FAM207A Gene

FAM207A (Family With Sequence Similarity 207 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM207A Gene

Genomics for FAM207A Gene

Regulatory Elements for FAM207A Gene

Promoters for FAM207A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM207A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM207A Gene

Chromosome:
21
Start:
44,939,998 bp from pter
End:
44,976,989 bp from pter
Size:
36,992 bases
Orientation:
Plus strand

Genomic View for FAM207A Gene

Genes around FAM207A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM207A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM207A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM207A Gene

Proteins for FAM207A Gene

  • Protein details for FAM207A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSI2-F207A_HUMAN
    Recommended name:
    Protein FAM207A
    Protein Accession:
    Q9NSI2

    Protein attributes for FAM207A Gene

    Size:
    230 amino acids
    Molecular mass:
    25456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM207A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM207A Gene

Proteomics data for FAM207A Gene at MOPED

Post-translational modifications for FAM207A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM207A Gene

Domains & Families for FAM207A Gene

Protein Domains for FAM207A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NSI2

UniProtKB/Swiss-Prot:

F207A_HUMAN :
  • Belongs to the FAM207 family.
Family:
  • Belongs to the FAM207 family.
genes like me logo Genes that share domains with FAM207A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FAM207A Gene

Function for FAM207A Gene

genes like me logo Genes that share phenotypes with FAM207A: view

Animal Model Products

CRISPR Products

miRNA for FAM207A Gene

miRTarBase miRNAs that target FAM207A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM207A Gene

Localization for FAM207A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM207A Gene COMPARTMENTS Subcellular localization image for FAM207A gene
Compartment Confidence
golgi apparatus 3
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM207A Gene

Pathways & Interactions for FAM207A Gene

SuperPathways for FAM207A Gene

No Data Available

Interacting Proteins for FAM207A Gene

Gene Ontology (GO) - Biological Process for FAM207A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM207A Gene

Drugs & Compounds for FAM207A Gene

No Compound Related Data Available

Transcripts for FAM207A Gene

Unigene Clusters for FAM207A Gene

Family with sequence similarity 207, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM207A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7:

Relevant External Links for FAM207A Gene

GeneLoc Exon Structure for
FAM207A
ECgene alternative splicing isoforms for
FAM207A

Expression for FAM207A Gene

mRNA expression in normal human tissues for FAM207A Gene

Protein differential expression in normal tissues from HIPED for FAM207A Gene

This gene is overexpressed in Bone (23.6), Platelet (16.3), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM207A Gene



SOURCE GeneReport for Unigene cluster for FAM207A Gene Hs.410830

mRNA Expression by UniProt/SwissProt for FAM207A Gene

Q9NSI2-F207A_HUMAN
Tissue specificity: Not detected in any tested tissue.
genes like me logo Genes that share expression patterns with FAM207A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM207A Gene

Orthologs for FAM207A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM207A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM207A 35
  • 81.93 (n)
  • 77.1 (a)
C1H21ORF70 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM207A 35
  • 82.48 (n)
  • 75.35 (a)
FAM207A 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam207a 35
  • 79.69 (n)
  • 74.88 (a)
Fam207a 16
Fam207a 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM207A 35
  • 97.39 (n)
  • 97.83 (a)
FAM207A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam207a 35
  • 80.31 (n)
  • 75.81 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM207A 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM207A 35
  • 58.97 (n)
  • 49.04 (a)
FAM207A 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam207a 35
  • 53.53 (n)
  • 46.63 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-84a8.8 35
  • 50.16 (n)
  • 40.65 (a)
fam207a 36
  • 32 (a)
OneToOne
Species with no ortholog for FAM207A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM207A Gene

ENSEMBL:
Gene Tree for FAM207A (if available)
TreeFam:
Gene Tree for FAM207A (if available)

Paralogs for FAM207A Gene

Pseudogenes.org Pseudogenes for FAM207A Gene

genes like me logo Genes that share paralogs with FAM207A: view

No data available for Paralogs for FAM207A Gene

Variants for FAM207A Gene

Sequence variations from dbSNP and Humsavar for FAM207A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs3737075 - 44,976,744(+) CCCTG(C/G)TGGCC reference, missense
rs394531 -- 44,968,750(+) TCTCT(A/G)TGCTT intron-variant
rs1883072 -- 44,942,777(-) CCCCA(A/C/T)GTGGT intron-variant
rs881317 -- 44,958,579(-) CCAGT(C/T)GGTGC intron-variant
rs881318 -- 44,958,532(-) ATTCC(C/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM207A Gene

Variant ID Type Subtype PubMed ID
dgv4778n71 CNV Loss 21882294
nsv913974 CNV Loss 21882294
nsv834110 CNV Loss 17160897
dgv4780n71 CNV Loss 21882294
nsv913981 CNV Loss 21882294
dgv4781n71 CNV Loss 21882294
dgv4782n71 CNV Loss 21882294
esv2670703 CNV Deletion 23128226
esv2218502 CNV Deletion 18987734
esv2658603 CNV Deletion 23128226
dgv4783n71 CNV Loss 21882294
nsv913997 CNV Gain 21882294
esv1168895 CNV Insertion 17803354
nsv187379 CNV Insertion 16902084
nsv913998 CNV Loss 21882294
esv2723698 CNV Deletion 23290073

Variation tolerance for FAM207A Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM207A Gene

HapMap Linkage Disequilibrium report
FAM207A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM207A Gene

Disorders for FAM207A Gene

Relevant External Links for FAM207A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM207A

No disorders were found for FAM207A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM207A Gene

Publications for FAM207A Gene

  1. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for FAM207A Gene

Sources for FAM207A Gene

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