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FAM206A Gene

protein-coding   GIFtS: 40
GCID: GC09P111697

Family With Sequence Similarity 206, Member A

(Previous name: chromosome 9 open reading frame 6)
(Previous symbol: C9orf6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 206, Member A1 2
C9orf61 2 3
Chromosome 9 Open Reading Frame 61
CG-82
Protein FAM206A2

External Ids:    HGNC: 13641   Entrez Gene: 549422   Ensembl: ENSG000001193287   UniProtKB: Q9NX383   

Export aliases for FAM206A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM206A Gene:
FAM206A (family with sequence similarity 206, member A) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM206A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM206A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM206A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31

FAM206A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM206A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P111697:  view genomic region     (about GC identifiers)

Start:
111,696,461 bp from pter      End:
111,713,024 bp from pter
Size:
16,564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F206A_HUMAN, Q9NX38 (See protein sequence)
Recommended Name: Protein FAM206A  
Size: 181 amino acids; 20378 Da
Sequence caution: Sequence=CAI39468.1; Type=Erroneous gene model prediction; Sequence=CAI39469.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q5JTR0 Q5JTR1

Explore the universe of human proteins at neXtProt for FAM206A: NX_Q9NX38

Explore proteomics data for FAM206A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM206A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060302.1  
    ENSEMBL proteins: 
     ENSP00000363753   ENSP00000363754   ENSP00000398018  

    FAM206A Human Recombinant Protein Products:

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    antibodies-online proteins for FAM206A (4 products) 

     
    Search antibodies-online for peptides for FAM206A

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    antibodies-online antibodies for FAM206A (15 products) 

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    antibodies-online kits for FAM206A (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011053 Single_hybrid_motif
     IPR002930 GCV_H

    Graphical View of Domain Structure for InterPro Entry Q9NX38

    ProtoNet protein and cluster: Q9NX38

    UniProtKB/Swiss-Prot: F206A_HUMAN, Q9NX38
    Similarity: Belongs to the FAM206 family


    Find genes that share domains with FAM206A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM206A

    miRNA
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    miRTarBase miRNAs that target FAM206A:
    hsa-mir-124-3p (MIRT022663)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM206A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005960glycine cleavage complex IEA--

    Find genes that share ontologies with FAM206A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM206A
    Interactions:

        Search GeneGlobe Interaction Network for FAM206A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for FAM206A (Q9NX383 ENSP000003637534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681043I2D: score=4 
    PUS10ENSP000003260034STRING: ENSP00000326003
    GCSHENSP000003195314STRING: ENSP00000319531
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006546glycine catabolic process IEA--

    Find genes that share ontologies with FAM206A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM206A (F206A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM206A gene: 
    NM_017832.3  

    Unigene Cluster for FAM206A:

    Family with sequence similarity 206, member A
    Hs.29276  [show with all ESTs]
    Unigene Representative Sequence: BC051827
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322940(uc004bdn.3 uc010mtr.3) ENST00000466200 ENST00000374624
    ENST00000445175
    miRNA
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM206A
    Primer
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    OriGene qPCR primer pairs and template standards for FAM206A
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM206A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat FAM206A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM206A
      QuantiFast Probe-based Assays in human, mouse, rat FAM206A

    Additional mRNA sequence: 

    AF153417.1 AK000464.1 AK310297.1 BC015795.1 BC051827.1 

    9 DOTS entries:

    DT.455449  DT.448141  DT.92003217  DT.121189478  DT.75123070  DT.208637  DT.40114272  DT.97801139 
    DT.100833869 

    Selected AceView cDNA sequences (see all 115):

    AK000464 CD251887 AA505864 AA829516 AA548370 BC051827 BM931151 AA905233 
    CR609752 AA505845 AI242697 AA758524 BQ574464 CB140062 AI339940 AI863836 
    CR601308 AA952945 N23764 BU850224 AI086660 AA427780 BM684603 AI363483 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FAM206A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -                                                   
    SP2:                                                                        
    SP3:                    -           -                                       
    SP4:                    -     -     -                                       


    ECgene alternative splicing isoforms for FAM206A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM206A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATATCAC
    FAM206A Expression
    About this image

    FAM206A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM206A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29276
        Custom PCR Arrays for FAM206A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM206A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAM206A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0265901 , 5 cDNA sequence BC0265901, 5 86.59(n)1
    87.93(a)1
      4 (31.66 cM)5
    2302341  NM_001081420.11  NP_001074889.11 
     568023455 
    chicken
    (Gallus gallus)
    Aves FAM206A1 family with sequence similarity 206, member A 74.85(n)
    76.69(a)
      420983  NM_001006383.1  NP_001006383.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM206A6
    family with sequence similarity 206, member A
    73(a)
    1 ↔ 1
    4(67570011-67575697)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.36302 Xenopus laevis transcribed sequence with moderate similarity more 77.18(n)    48055119 
    zebrafish
    (Danio rerio)
    Actinopterygii fam206a1 family with sequence similarity 206, member A 68.65(n)
    72.02(a)
      560419  NM_001044929.3  NP_001038394.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92881 CG9288 48.53(n)
    48.3(a)
      41689  NM_142059.3  NP_650316.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F54F2.76
    Protein F54F2.7 (F54F2.7) mRNA, complete cds
    27(a)
    1 ↔ 1
    III(8806231-8807346) WBGene00018835
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G759801 AT1G75980 46.84(n)
    33.33(a)
      843930  NM_106247.3  NP_177725.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01204001 Os02g0120400 47.26(n)
    32.84(a)
      4328112  NM_001052244.1  NP_001045709.1 


    ENSEMBL Gene Tree for FAM206A (if available)
    TreeFam Gene Tree for FAM206A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM206A (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172394731,2
    C,F--111698617(+) ATCTCA/GTCCAG 2 H R mis13Minor allele frequency- G:0.00NA EU 5987
    rs2011367081,2
    --111698621(+) CATCCA/GGTTCT 2 P syn10--------
    rs2002580291,2
    --111698666(+) CAGATC/GAGTAC 2 I M mis10--------
    rs1507257601,2
    C,F--111698715(+) TTAAGC/TGGGTA 2 R W mis12Minor allele frequency- T:0.00NA EU 5789
    rs109796151,2
    C,F,H--111698789(+) TGAACC/TTTAGA 1 -- int126Minor allele frequency- T:0.08NS EA NA CSA 2794
    rs1849186181,2
    --111698938(+) CTACTA/CTCCCT 1 -- int10--------
    rs1898022791,2
    --111699004(+) AGCAAC/TATAAC 1 -- int10--------
    rs1152782081,2
    F--111699007(+) AATATA/GACAAG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1931762431,2
    C--111699092(+) CCATAC/TATTTC 1 -- int10--------
    rs109796161,2
    C,F,H--111699156(+) GAAAAA/CCATGG 1 -- int1 trp37Minor allele frequency- C:0.09NS EA NA 662

    HapMap Linkage Disequilibrium report for FAM206A (111696461 - 111713024 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM206A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM206A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM206A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM206A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM206A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. (PubMed id 15607035)1 Ahn J.... Hoe K.-L. (J. Biochem. Mol. Biol. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54942 HGNC: 1364 AceView: FLJ20457 Ensembl:ENSG00000119328 euGenes: HUgn54942
    ECgene: FAM206A H-InvDB: FAM206A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM206A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM206A gene:
    Search GeneIP for patents involving FAM206A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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