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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM205A Gene

protein-coding   GIFtS: 33
GCID: GC09M034723

Family With Sequence Similarity 205, Member A

  Search for FAM205A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 205, Member A1 2
C9orf144B2 3
Protein FAM205A2
Transmembrane Protein C9orf144B2

External Ids:    HGNC: 419111   Entrez Gene: 2593082   Ensembl: ENSG000002051087   UniProtKB: Q6ZU693   

Export aliases for FAM205A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM205A Gene: 
FAM205A (family with sequence similarity 205, member A) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM205A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM205A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM205A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

FAM205A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM205A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034723:  view genomic region     (about GC identifiers)

Start:
34,723,050 bp from pter      End:
34,729,535 bp from pter
Size:
6,486 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F205A_HUMAN, Q6ZU69 (See protein sequence)
Recommended Name: Protein FAM205A  
Size: 1335 amino acids; 148096 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAC86357.1; Type=Erroneous initiation;
Secondary accessions: A8MVW7

Explore the universe of human proteins at neXtProt for FAM205A: NX_Q6ZU69

Explore proteomics data for FAM205A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZU69

  • FAM205A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM205A Protein Expression
    REFSEQ proteins: NP_001135389.1  
    ENSEMBL proteins: 
     ENSP00000417711  

    Human Recombinant Protein Products for FAM205A: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    FAM205A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZU69

    UniProtKB/Swiss-Prot: F205A_HUMAN, Q6ZU69
    Similarity: Belongs to the FAM205 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM205A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM205A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM205A (F205A)

    Search CenterWatch for drugs/clinical trials and news about FAM205A / F205A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM205A gene: 
    NM_001141917.1  

    Unigene Cluster for FAM205A:

    Family with sequence similarity 205, member A
    Hs.522093  [show with all ESTs]
    Unigene Representative Sequence: NM_001141917
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378788(uc011lor.2)
    miRNA
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    Additional mRNA sequence: 

    AK125949.1 AK302320.1 

    3 DOTS entries:

    DT.302896  DT.100668430  DT.86858968 

    1 AceView cDNA sequence:

    CD300305 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM205A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAGAGTT
    FAM205A Expression
    About this image


    See FAM205A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM205A

    SOURCE GeneReport for Unigene cluster: Hs.522093
        SABiosciences Custom PCR Arrays for FAM205A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM205A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM205A gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm215985
    LOC1008623241
    protein FAM205A-like1 67.46(n)1
    47.69(a)1
      45
    1008623241  XM_003689246.11  XP_003689294.11 
     423183345 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    24(a)
    20(a)
    many → 1
    many → 1
    GL343650.1(134115-138616)
    GL343263.1(757476-761261)


    ENSEMBL Gene Tree for FAM205A (if available)
    TreeFam Gene Tree for FAM205A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM205A gene
    1 SIMAP similar gene for FAM205A using alignment to 1 protein entry:     F205A_HUMAN:
    FAM205B

    FAM205A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FAM205A
    PGOHUM00000250492


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 SNPs in FAM205A are shown (see all 181)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170445491,2
    F--34722594(+) GGCACG/ATAATA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1487006511,2
    --34722685(+) GCTTCC/TTCCTG 1 -- int10--------
    rs764657001,2
    F--34722784(+) GGTCTT/CACTAT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1172258691,2
    C,F--34723024(+) CAGCAG/AAGACA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs108141381,2
    C,F,A,H--34723035(+) AGGAGC/AAGACA 1 -- int115Minor allele frequency- A:0.13NS EA NA 1840
    rs1421572241,2
    --34723150(+) TGGGGA/TGCCTA 1 -- ut310--------
    rs22971321,2
    C,F,A,H--34723181(+) TGCATG/ATTCTC 1 -- ut3126Minor allele frequency- A:0.43EA MN NA NS CSA WA 4172
    rs70478391,2
    C,F--34723194(+) TGAGCG/AGACCA 1 -- ut312Minor allele frequency- A:0.03WA 120
    rs3742442211,2
    C--34723251(+) GTTTGG/TTGGCA 2 N T mis10--------
    rs1904005531,2
    C,F--34723278(+) AGTGAC/TGAGGG 2 H R mis11Minor allele frequency- T:0.01EU 367

    HapMap Linkage Disequilibrium report for FAM205A (34723050 - 34729535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FAM205A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738389CNV Deletion23290073
    dgv1337e199CNV Deletion23128226
    nsv509301CNV Insertion20534489
    nsv893040CNV Gain21882294
    nsv831544CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM205A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM205A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 259308 HGNC: 41911 AceView: LOC259308 Ensembl:ENSG00000205108 euGenes: HUgn259308
    ECgene: FAM205A H-InvDB: FAM205A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM205A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM205A gene:
    Search GeneIP for patents involving FAM205A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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