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Aliases for FAM205A Gene

Aliases for FAM205A Gene

  • Family With Sequence Similarity 205 Member A 2 3 5
  • C9orf144B 3 4
  • Family With Sequence Similarity 205, Member A 2
  • Transmembrane Protein C9orf144B 3
  • Protein FAM205A 3

External Ids for FAM205A Gene

Summaries for FAM205A Gene

GeneCards Summary for FAM205A Gene

FAM205A (Family With Sequence Similarity 205 Member A) is a Protein Coding gene. An important paralog of this gene is FAM205C.

Additional gene information for FAM205A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM205A Gene

Genomics for FAM205A Gene

Regulatory Elements for FAM205A Gene

Enhancers for FAM205A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H034987 1.6 FANTOM5 ENCODE dbSUPER 12 -263.7 -263742 10 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS DEK SP3 VCP UBAP2 ARHGEF39 TPM2 FANCG CCDC107 TLN1 YBX1P10 PIGO FAM205A
GH09H035069 1.3 ENCODE dbSUPER 11.9 -342.4 -342357 4 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS SP3 CEBPZ VCP FANCG TMEM8B FAM205A C9orf131 ENSG00000228352 ATP8B5P PIGO NPR2 RN7SL338P
GH09H033867 1.3 Ensembl ENCODE dbSUPER 10.9 +861.0 861038 1 ZFP64 ZNF354C ZNF202 ZNF654 ZNF680 ZC3H11A CEBPB REST ZNF518A ZNF781 NOL6 ASS1P12 NFX1 ENSG00000228352 SMU1 TCEA1P4 UBAP2 ENSG00000230074 FAM205A APTX
GH09H034327 1.1 ENCODE 11.9 +400.5 400547 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 NUDT2 UBAP2 NOL6 FAM205A ENSG00000228352 C9orf131 UNC13B VCP PIGO KIF24
GH09H034619 0.9 ENCODE 12 +109.2 109152 1 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ELK1 FOS UBAP2 FAM205A RPP25L C9orf131 ATP8B5P VCP SIGMAR1 DCTN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM205A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM205A Gene

Chromosome:
9
Start:
34,723,053 bp from pter
End:
34,729,538 bp from pter
Size:
6,486 bases
Orientation:
Minus strand

Genomic View for FAM205A Gene

Genes around FAM205A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM205A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM205A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM205A Gene

Proteins for FAM205A Gene

  • Protein details for FAM205A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU69-F205A_HUMAN
    Recommended name:
    Protein FAM205A
    Protein Accession:
    Q6ZU69
    Secondary Accessions:
    • A8MVW7

    Protein attributes for FAM205A Gene

    Size:
    1335 amino acids
    Molecular mass:
    148096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86357.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM205A Gene

Post-translational modifications for FAM205A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM205A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM205A Gene

Domains & Families for FAM205A Gene

Gene Families for FAM205A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM205A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM205A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZU69

UniProtKB/Swiss-Prot:

F205A_HUMAN :
  • Belongs to the FAM205 family.
Family:
  • Belongs to the FAM205 family.
genes like me logo Genes that share domains with FAM205A: view

Function for FAM205A Gene

Phenotypes From GWAS Catalog for FAM205A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM205A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM205A Gene

Localization for FAM205A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM205A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM205A gene
Compartment Confidence
nucleus 5
plasma membrane 3
golgi apparatus 3
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FAM205A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM205A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM205A Gene

Pathways & Interactions for FAM205A Gene

SuperPathways for FAM205A Gene

No Data Available

Interacting Proteins for FAM205A Gene

Gene Ontology (GO) - Biological Process for FAM205A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM205A Gene

Drugs & Compounds for FAM205A Gene

No Compound Related Data Available

Transcripts for FAM205A Gene

mRNA/cDNA for FAM205A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM205A Gene

Family with sequence similarity 205, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM205A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM205A Gene

No ASD Table

Relevant External Links for FAM205A Gene

GeneLoc Exon Structure for
FAM205A
ECgene alternative splicing isoforms for
FAM205A

Expression for FAM205A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM205A Gene

mRNA differential expression in normal tissues according to GTEx for FAM205A Gene

This gene is overexpressed in Testis (x48.5).

Protein differential expression in normal tissues from HIPED for FAM205A Gene

This gene is overexpressed in Testis (57.3) and Ovary (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM205A Gene



Protein tissue co-expression partners for FAM205A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM205A Gene:

FAM205A

SOURCE GeneReport for Unigene cluster for FAM205A Gene:

Hs.522093
genes like me logo Genes that share expression patterns with FAM205A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM205A Gene

Orthologs for FAM205A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM205A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746223 33
  • 98.75 (n)
FAM205A 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM205A 33 34
  • 78.21 (n)
rat
(Rattus norvegicus)
Mammalia Fam205a 33
  • 67.2 (n)
mouse
(Mus musculus)
Mammalia Gm20938 33 34
  • 67.13 (n)
Gm21093 34
  • 47 (a)
OneToMany
Gm3883 34
  • 47 (a)
OneToMany
CT868723.2 34
  • 47 (a)
OneToMany
OTTMUSG00000011338 34
  • 47 (a)
OneToMany
Gm12394 34
  • 46 (a)
OneToMany
FAM205A 34
  • 45 (a)
OneToMany
Gm12429 34
  • 45 (a)
OneToMany
Gm13298 34
  • 45 (a)
OneToMany
Gm21598 34
  • 45 (a)
OneToMany
CR974586.7 34
  • 45 (a)
OneToMany
Gm2163 34
  • 44 (a)
OneToMany
GM7819 34
  • 44 (a)
OneToMany
CR974586.1 34
  • 43 (a)
OneToMany
Gm10600 34
  • 36 (a)
OneToMany
BC049635 34
  • 31 (a)
OneToMany
Fam205a4 16
cow
(Bos Taurus)
Mammalia -- 34
  • 62 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FAM205A 34
  • 35 (a)
OneToOne
Species where no ortholog for FAM205A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM205A Gene

ENSEMBL:
Gene Tree for FAM205A (if available)
TreeFam:
Gene Tree for FAM205A (if available)

Paralogs for FAM205A Gene

Paralogs for FAM205A Gene

(1) SIMAP similar genes for FAM205A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAM205A Gene

genes like me logo Genes that share paralogs with FAM205A: view

Variants for FAM205A Gene

Sequence variations from dbSNP and Humsavar for FAM205A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs373701758 Benign 34,723,621(+) CTCTG(G/T)AAGGC reference, missense
rs374244221 Benign 34,723,254(+) GTTTG(G/T)TGGCA reference, missense
rs527869852 Benign 34,724,686(+) TGCAA(C/T)GTCTG reference, missense
rs548036648 Benign 34,724,788(+) TTCCA(A/C/T)GGGAC reference, missense
rs571906331 Benign 34,724,301(+) TGGAA(A/C/G/T)TGGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM205A Gene

Variant ID Type Subtype PubMed ID
dgv1337e199 CNV deletion 23128226
esv2738389 CNV deletion 23290073
esv3576650 CNV gain 25503493
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv509301 CNV insertion 20534489
nsv614157 CNV loss 21841781
nsv831544 CNV gain 17160897
nsv972309 CNV duplication 23825009

Variation tolerance for FAM205A Gene

Gene Damage Index Score: 22.70; 99.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM205A Gene

Human Gene Mutation Database (HGMD)
FAM205A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM205A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM205A Gene

Disorders for FAM205A Gene

Relevant External Links for FAM205A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM205A

No disorders were found for FAM205A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM205A Gene

Publications for FAM205A Gene

  1. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 60

Products for FAM205A Gene

Sources for FAM205A Gene

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