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FAM203B Gene

protein-coding   GIFtS: 27
GCID: GC08P145437          (predicted)

Family With Sequence Similarity 203, Member B

(Previous name: chromosome 8 open reading frame 30B)
(Previous symbol: C8orf30B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 203, Member B1 2
C8orf30B1 2 3
BRP16L2 3
Chromosome 8 Open Reading Frame 30B1
Protein FAM203B2
Brain Protein 16-Like3

External Ids:    HGNC: 323231   Entrez Gene: 7280712   Ensembl: ENSG000002305677   UniProtKB: P0CB433   

Export aliases for FAM203B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM203B Gene:
FAM203B (family with sequence similarity 203, member B) is a protein-coding gene. Diseases associated with FAM203B include malaria. An important paralog of this gene is FAM203A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM203B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM203B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM203B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

FAM203B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM203B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145437:  view genomic region     (about GC identifiers)

Start:
145,437,880 bp from pter      End:
145,440,835 bp from pter
Size:
2,956 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F203B_HUMAN, P0CB43 (See protein sequence)
Recommended Name: Protein FAM203B  
Size: 390 amino acids; 42128 Da

Explore the universe of human proteins at neXtProt for FAM203B: NX_P0CB43

Explore proteomics data for FAM203B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM203B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000366623   ENSP00000433997   ENSP00000436978  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR007205 FAM203_N
     IPR011989 ARM-like
     IPR007206 FAM203_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry P0CB43

    ProtoNet protein and cluster: P0CB43

    UniProtKB/Swiss-Prot: F203B_HUMAN, P0CB43
    Similarity: Belongs to the FAM203 family


    FAM203B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    FAM203B for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM203B
    Interactions:

        Search GeneGlobe Interaction Network for FAM203B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FAM203B (P0CB433 ENSP000003666234) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2P136393, ENSP000003079404I2D: score=8 STRING: ENSP00000307940
    CCT7Q998323, ENSP000002580914I2D: score=1 STRING: ENSP00000258091
    ENSG00000258947Q135093I2D: score=1 
    NSFP464593, ENSP000003812934I2D: score=1 STRING: ENSP00000381293
    TUBB3Q135093I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM203B (F203B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377406(uc010mfu.3 uc003zbo.3) ENST00000527236 ENST00000528360
    ENST00000524697 ENST00000527694 ENST00000532046 ENST00000527666 ENST00000527928
    ENST00000527931
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM203B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM203B Expression
    About this image

    FAM203B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM203B Protein Expression
        Custom PCR Arrays for FAM203B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM203B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FAM203B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    GL343744.1(153709-156820)
    zebrafish
    (Danio rerio)
    Actinopterygii fam203a6
    CABZ01049059.16
    Uncharacterized protein
    63(a)
    41(a)
    many ↔ many
    many ↔ many
    19(3351694-3358869) ENSDARG00000035696
    19(3370387-3370932) ENSDARG00000091075
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60736
    --
    34(a)
    1 → many
    3R(22012740-22014526)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54H5A.26
    Protein Y54H5A.2 (Y54H5A.2) mRNA, complete cds
    22(a)
    1 → many
    III(5137322-5149578) WBGene00021900
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HGH1(YGR187C)4 Nonessential protein of unknown function; predicted more   --   7(871416-870232) 853099  NP_011703.1 
            Species with no ortholog for FAM203B

    ENSEMBL Gene Tree for FAM203B (if available)
    TreeFam Gene Tree for FAM203B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM203B gene
    FAM203A2  
    2 SIMAP similar genes for FAM203B using alignment to 2 protein entries:     F203B_HUMAN (see all proteins):
    FAM203A    C8orf30A

    FAM203B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM203B (see all 18)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760422311,2
    C--145467288(+) TCCCCA/GCCCTC 1 -- int10--------
    rs1464504111,2
    C,F--145467331(+) GGACCT/AGAGGT 2 /P syn12Minor allele frequency- A:0.00NA EU 5749
    rs558877551,2
    C--145468377(+) GCTACA/GCTTAG 1 -- ut310--------
    rs78391481,2
    C--145468565(+) TGGGGA/CCTGGA 1 -- ut310--------
    rs78214411,2
    C--145468618(+) CAATCA/CCCAGG 1 -- ut310--------
    rs78432021,2
    C,F,A--145469028(+) GTGGTA/CGAGCC 1 -- ut311Minor allele frequency- C:0.26NA 90
    rs78436061,2
    A--145469242(+) CCGTCA/GAGCCC 1 -- ut310--------
    rs2016041271,2
    ----145467409(+) CGTGAG/CTGGCT 1 -- int11Minor allele frequency- C:0.00EU 1301
    rs3709650601,2
    ----145467335(+) CTGAGA/GTGGAC 2 M V mis10--------
    rs3680469281,2
    ----145467418(+) CTAGTA/GTGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM203B (145437880 - 145440835 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FAM203B: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FAM203B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM203B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for FAM203B:    
    About MalaCards
    malaria


    FAM203B for disorders           About GeneDecksing


    Export disorders for FAM203B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM203B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM203B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
    2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728071 HGNC: 32323 Ensembl:ENSG00000230567 euGenes: HUgn728071 ECgene: FAM203B
    H-InvDB: FAM203B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM203B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM203B gene:
    Search GeneIP for patents involving FAM203B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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