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FAM203A Gene

protein-coding   GIFtS: 44
GCID: GC08P145194

Family With Sequence Similarity 203, Member A

(Previous name: chromosome 8 open reading frame 30A)
(Previous symbol: C8orf30A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 203, Member A1 2
C8orf30A1 2 3
Brain Protein 161 2 3
BRP162 3
Chromosome 8 Open Reading Frame 30A1
Protein FAM203A2

External Ids:    HGNC: 241611   Entrez Gene: 512362   Ensembl: ENSG000002351737   UniProtKB: Q9BTY73   

Export aliases for FAM203A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM203A Gene:
FAM203A (family with sequence similarity 203, member A) is a protein-coding gene. An important paralog of this gene is FAM203B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM203A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM203A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM203A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

FAM203A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM203A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145194:  view genomic region     (about GC identifiers)

Start:
145,192,672 bp from pter      End:
145,195,746 bp from pter
Size:
3,075 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F203A_HUMAN, Q9BTY7 (See protein sequence)
Recommended Name: Protein FAM203A  
Size: 390 amino acids; 42129 Da

Explore the universe of human proteins at neXtProt for FAM203A: NX_Q9BTY7

Explore proteomics data for FAM203A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM203A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057542.2  
    ENSEMBL proteins: 
     ENSP00000321320   ENSP00000431970  

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    antibodies-online proteins for FAM203A (3 products) 

     
    antibodies-online peptides for FAM203A

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    antibodies-online antibodies for FAM203A (22 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR007205 FAM203_N
     IPR011989 ARM-like
     IPR007206 FAM203_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BTY7

    ProtoNet protein and cluster: Q9BTY7

    UniProtKB/Swiss-Prot: F203A_HUMAN, Q9BTY7
    Similarity: Belongs to the FAM203 family


    Find genes that share domains with FAM203A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005488binding ----
         
    Find genes that share ontologies with FAM203A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FAM203A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM203A

    miRNA
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    miRTarBase miRNAs that target FAM203A:
    hsa-mir-92a-3p (MIRT049804), hsa-let-7b-5p (MIRT005436)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with FAM203A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM203A
    Interactions:

        Search GeneGlobe Interaction Network for FAM203A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FAM203A (Q9BTY72, 3 ENSP000003213204) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOMO954452, 3MINT-65339 I2D: score=4 
    ENSG00000206409O954452, 3MINT-65339 I2D: score=4 
    ENSG00000224290O954452, 3MINT-65339 I2D: score=4 
    ENSG00000226215O954452, 3MINT-65339 I2D: score=4 
    ENSG00000227567O954452, 3MINT-65339 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with FAM203A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM203A (F203A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM203A gene: 
    NM_016458.2  

    Unigene Cluster for FAM203A:

    Family with sequence similarity 203, member A
    Hs.300224  [show with all ESTs]
    Unigene Representative Sequence: NM_016458
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347708(uc010mfs.3) ENST00000533266(uc003zbf.3) ENST00000530074
    ENST00000530409 ENST00000525101 ENST00000534255
    miRNA
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for FAM203A
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      QuantiTect SYBR Green Assays in human, mouse, rat FAM203A
      QuantiFast Probe-based Assays in human, mouse, rat FAM203A

    Additional mRNA sequence: 

    AF151022.1 AK098226.1 BC003035.1 BC009915.2 BC015471.1 

    15 DOTS entries:

    DT.95311583  DT.91856187  DT.111209  DT.99935555  DT.216491  DT.121473002  DT.121492282  DT.121473006 
    DT.95167991  DT.121492099  DT.121492190  DT.121492216  DT.121492281  DT.40132482  DT.91992380 

    Selected AceView cDNA sequences (see all 122):

    BM767308 BE675360 BQ438887 AW188332 NM_016458 BQ060913 BM770543 BQ059867 
    BM742540 BM757041 BM741389 BQ053012 BP346676 BM767244 BC009915 BQ026895 
    AI591122 BM848508 BM756948 AW452994 BM770758 BQ233213 BM748032 AI937362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM203A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM203A Expression
    About this image

    FAM203A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM203A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300224
        Custom PCR Arrays for FAM203A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM203A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FAM203A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam203a1 , 5 family with sequence similarity 203, member A1, 5 80.83(n)1
    82.5(a)1
      15 (35.78 cM)5
    590531  NM_021555.21  NP_067530.21 
     763688985 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    GL343744.1(153709-156820)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.227402 Xenopus laevis transcribed sequence with weak similarity more 71.75(n)    BJ045495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167932 Transcribed sequence with weak similarity to protein more 73.03(n)    BI983142.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60731 CG6073 48.27(n)
    37.69(a)
      43180  NM_143211.3  NP_651468.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54H5A.26
    Protein Y54H5A.2 (Y54H5A.2) mRNA, complete cds
    22(a)
    1 → many
    III(5137322-5149578) WBGene00021900
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HGH11 HGH1 40.71(n)
    34.73(a)
      853099   NP_011703.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G143001 AT1G14300 45.86(n)
    32.28(a)
      837991  NM_101296.4  NP_172882.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04068001 Os10g0406800 41.89(n)
    30.6(a)
      4348588  NM_001071101.1  NP_001064566.1 


    ENSEMBL Gene Tree for FAM203A (if available)
    TreeFam Gene Tree for FAM203A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM203A gene
    FAM203B2  
    2 SIMAP similar genes for FAM203A using alignment to 2 protein entries:     F203A_HUMAN (see all proteins):
    FAM203B    C8orf30A

    Find genes that share paralogs with FAM203A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for FAM203A    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995103231,2
    ----145190855(+) CCAGGA/CTGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM203A (145192672 - 145195746 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM203A (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989584CNV Deletion20482838
    dgv7949n71CNV Loss21882294
    dgv7950n71CNV Loss21882294
    dgv906n27CNV Loss19166990
    nsv891827CNV Loss21882294
    nsv891815CNV Loss21882294
    dgv7957n71CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7955n71CNV Loss21882294
    nsv891807CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM203A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM203A gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FAM203A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    3. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    4. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51236 HGNC: 24161 AceView: LOC51236 Ensembl:ENSG00000235173 euGenes: HUgn51236
    ECgene: FAM203A H-InvDB: FAM203A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM203A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM203A gene:
    Search GeneIP for patents involving FAM203A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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