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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM200A Gene

protein-coding   GIFtS: 40
GCID: GC07M099143

Family With Sequence Similarity 200, Member A

(Previous name: chromosome 7 open reading frame 38)
(Previous symbol: C7orf38)
  Search for FAM200A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 200, Member A1 2
C7orf381 2 3
Chromosome 7 Open Reading Frame 381
Protein FAM200A2

External Ids:    HGNC: 254011   Entrez Gene: 2217862   Ensembl: ENSG000002219097   UniProtKB: Q8TCP93   

Export aliases for FAM200A gene to outside databases

Previous GC identifer: GC07M093780


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAM200A Gene:
This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in
human and mouse. (provided by RefSeq, Jul 2008)

GeneCards Summary for FAM200A Gene: 
FAM200A (family with sequence similarity 200, member A) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED5.

Gene Wiki entry for FAM200A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM200A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FAM200A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM200A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM200A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

FAM200A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM200A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099143:  view genomic region     (about GC identifiers)

Start:
99,143,923 bp from pter      End:
99,156,159 bp from pter
Size:
12,237 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,503,715-98,509,550     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F200A_HUMAN, Q8TCP9 (See protein sequence)
Recommended Name: Protein FAM200A  
Size: 573 amino acids; 66276 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A4D293 A8K3V9 B2RD92 C9J6A8 D6W5T2 Q8N9P3

Explore the universe of human proteins at neXtProt for FAM200A: NX_Q8TCP9

Explore proteomics data for FAM200A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TCP9

  • FAM200A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM200A Protein Expression
    REFSEQ proteins: NP_659802.1  
    ENSEMBL proteins: 
     ENSP00000411372   ENSP00000386191  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    FAM200A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR025398 DUF4371
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TCP9

    ProtoNet protein and cluster: Q8TCP9

    UniProtKB/Swiss-Prot: F200A_HUMAN, Q8TCP9
    Similarity: Belongs to the FAM200 family


    FAM200A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
         
    FAM200A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM200A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM200A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM200A (F200A)

    Search CenterWatch for drugs/clinical trials and news about FAM200A / F200A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM200A gene: 
    NM_145111.3  

    Unigene Cluster for FAM200A:

    Family with sequence similarity 200, member A
    Hs.596587  [show with all ESTs]
    Unigene Representative Sequence: AK315452
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449309(uc003ura.3 uc003urb.3) ENST00000408938
    miRNA
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    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of FAM200A 
                         Customized lentivirus expression plasmids for stable overexpression of FAM200A 
    Primer
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    OriGene qPCR primer pairs and template standards for FAM200A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM200A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM200A

    Additional mRNA sequence: 

    AK315452.1 BC009536.1 

    5 DOTS entries:

    DT.40231783  DT.95189157  DT.207349  DT.100709472  DT.121051551 

    24/32 AceView cDNA sequences (see all 32):

    NM_145111 AI500145 AA452899 AL713672 BE856146 BC009536 AK094113 AI610989 
    BC040214 CF130313 BX490533 BG105726 AI921395 AI669858 AK024526 BG165969 
    BX100666 AA830263 W15300 BX490532 AA862413 T53175 AA360717 BG106637 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM200A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACGGACAA
    FAM200A Expression
    About this image


    See FAM200A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM200A

    SOURCE GeneReport for Unigene cluster: Hs.596587
        SABiosciences Custom PCR Arrays for FAM200A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM200A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM200A gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FAM200A1 family with sequence similarity 200, member A 90.01(n)
    90.43(a)
      100687167  XM_003434768.1  XP_003434816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 1005357306
    Uncharacterized protein
    34(a)
    1 → many
    6(17293919-17295680)


    ENSEMBL Gene Tree for FAM200A (if available)
    TreeFam Gene Tree for FAM200A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM200A gene
    ZBED52  KRBA22  C5orf542  SCAND32  GTF2IRD22  FAM200B2  EPM2AIP12  GTF2IRD2B2  
    4 SIMAP similar genes for FAM200A using alignment to 2 protein entries:     F200A_HUMAN (see all proteins):
    FAM200B    ZMYM6    SCAND3    ZBED5

    FAM200A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/159 SNPs in FAM200A are shown (see all 159)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563133581,2
    F--99143503(+) AAAAAA/TTTTTT 1 -- int11Minor allele frequency- T:0.07NA 120
    rs1930777641,2
    --99143576(+) CTGTAA/GCCTCG 1 -- int10--------
    rs1835547551,2
    --99143676(+) ATTTTC/TTGTAG 1 -- int10--------
    rs1887440721,2
    --99143793(+) GTGCTA/GGCCTC 1 -- int10--------
    rs1930344201,2
    --99143909(+) ACTATA/GTAGAA 1 -- int10--------
    rs1424042441,2
    C--99144391(+) CTGGTG/ACACTA 2 /A /V mis11Minor allele frequency- A:0.00NA 2590
    rs1455046271,2
    C,F--99144416(+) CTTCTT/GTGTTT 2 /K /Q mis11Minor allele frequency- G:0.00NA 2590
    rs1879694641,2
    --99144427(+) TTAACA/CGTGTC 2 R L mis10--------
    rs1914701811,2
    --99144711(+) TTCTCC/TTCCGG 2 E syn10--------
    rs615807921,2
    C,F--99144717(+) TCCGGA/TAAGTA 2 L F mis10--------

    HapMap Linkage Disequilibrium report for FAM200A (99143923 - 99156159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM200A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2507396CNV Insertion19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM200A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM200A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PubMed id 10607616)1, 3 Smit A.F.A. (1999)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Sequence diversity and haplotype structure at the human CYP3A cluster. (PubMed id 16314882)1 Thompson E.E....Di Rienzo A. (2006)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221786 HGNC: 25401 AceView: DKFZp727G131 Ensembl:ENSG00000221909 euGenes: HUgn221786
    ECgene: FAM200A H-InvDB: FAM200A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM200A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM200A gene:
    Search GeneIP for patents involving FAM200A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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