FAM19A5 Gene
protein-coding GIFtS : 45
GCID: GC22 P048885
family with sequence similarity 19 (chemokine (C-C motif)-like),...
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Aliasesfor FAM19A5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), MemberA5 1 2 QLLK52082 TAFA-51 2 UNQ52082 Chemokine-Like Protein TAFA-52 3 Protein FAM19A52 TAFA52 3 TAFA Protein 52
Export aliases for FAM19A5 gene to outside databases Previous GC identifers: GC22P047206 GC22P047428 GC22P031967
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Summariesfor FAM19A5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FAM19A5 : This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. (provided by RefSeq, Jul 2008) Gene Wiki entry for FAM19A5
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Genomic Viewsfor FAM19A5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FAM19A5 gene promoter: AML1a GATA-6 Pax-5 FOXO4 Egr-1 c-Myb STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for FAM19A5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM19A5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q13.32 Ensembl cytogenetic band: 22q13.32 HGNC cytogenetic band: 22q13.32 FAM19A5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P048885: view genomic region
(about GC identifiers )
Start:
48,885,272 bp from pter
End:
49,246,724 bp from pter
Size:
361,453 bases
Orientation:
plus strand
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Proteinsfor FAM19A5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7 (See
protein sequence )Recommended Name: Protein FAM19A5 Size : 132 amino acids; 14301 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Subcellular location : Isoform 2: Secreted
Sequence caution : Sequence=AAD20061.1; Type=Erroneous initiation; Sequence=AAH39396.2; Type=Erroneous initiation;
Secondary accessions : A6NII9 B0QZ13 B0QZ14 B0QZ15 O95902 Q5H9C4 Q6UWC9 Q8IXR8Alternative splicing : 3 isoforms : Q7Z5A7-1 Q7Z5A7-2 Q7Z5A7-3 (No experimental confirmation available. Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for FAM19A5: NX_Q7Z5A7 FAM19A5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001076436.1 NP_056196.2 ENSEMBL proteins: ENSP00000383933 ENSP00000336812 ENSP00000351043 ENSP00000385603 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0016021 integral to membrane
IEA --
FAM19A5 for ontologies About GeneDecksing FAM19A5 Antibody Products: Assay Products for FAM19A5:
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Protein
Domains / Familiesfor FAM19A5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FAM19A5 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7Z5A7 ProtoNet protein and cluster: Q7Z5A7
UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7 Similarity : Belongs to the FAM19/TAFA family
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Functionfor FAM19A5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM19A5 (NM_001082967 ) Sino Biological Human cDNA Clone for FAM19A5 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM19A5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM19A5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM19A5
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Pathways & Interactionsfor FAM19A5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM19A5
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Drugs & Compoundsfor FAM19A5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM19A5 Search CenterWatch for drugs/clinical trials and news about FAM19A5 / F19A5
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Transcriptsfor FAM19A5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM19A5 gene (2 alternative transcripts): NM_001082967.1 NM_015381.5 Unigene Cluster for FAM19A5:
Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 Hs.436854 [show with all ESTs ] Unigene Representative Sequence: NM_015381 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000402357 ENST00000336769 ENST00000358295 (uc003bim.4 uc003bio.4 )ENST00000473898 ENST00000406880 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FAM19A5 (NM_001082967 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM19A5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM19A5
Additional cDNA sequence: AF131851.1 AK123443.1 AK125256.1 AY358847.1 BC039396.1
9 DOTS entries : DT.445780 DT.209304
DT.75102199 DT.101982189 DT.101982190 DT.100019770 DT.100833968 DT.75156550 DT.99965644 24/78 AceView cDNA sequences (see all 78 ):
AW015133 AI362754 BF115495 BM704238 AW006084 H55332 AI863408 BX430931 BM714846 BI915401 BU731010 BE047699 AI933317 AA629251 AW592960 AI743767 H28702 AI740873 AI565754 AI199671 R42607 BX096219 AI084095 BX119733 GeneLoc Exon Structure
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Expression for FAM19A5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM19A5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGGGTCTCC
About this image FAM19A5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FAM19A5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM19A5 SOURCE GeneReport for Unigene cluster: Hs.436854 UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7 Tissue specificity : Isoform 2 is brain-specific SABiosciences Custom PCR Arrays for FAM19A5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM19A5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM19A5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM19A5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM19A5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM19A5
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Orthologsfor FAM19A5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM19A5 gene from 4/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FAM19A51
family with sequence similarity 19 (chemokine (C-C more
77.87(n) 94.4(a)
 
768638 XM_001231693.2 XP_001231694.2
lizard (Anolis carolinensis)
Reptilia
FAM19A56
--
93(a)
1 ↔ 1
5(70771601-70891390)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.125552
Transcribed sequences
76.7(n)
 
BX715376.1
zebrafish (Danio rerio)
Actinopterygii
fam19a51
family with sequence similarity 19 (chemokine (C-C more
71.84(n) 81.55(a)
 
100002919 NM_001122744.1 NP_001116216.1
ENSEMBL Gene Tree for FAM19A5 (if available)TreeFam Gene Tree for FAM19A5 (if available)
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Paralogsfor FAM19A5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM19A5 gene FAM19A4 2 FAM19A1 2 FAM19A3 2 FAM19A2 2 4 SIMAP similar genes for FAM19A5 using alignment to 2 protein entries: F19A5_HUMAN (see all proteins ):FAM19A4 FAM19A1 FAM19A3 FAM19A2
FAM19A5 for paralogs About GeneDecksing
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Genomic Variantsfor FAM19A5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FAM19A5 (48885272 - 49135272 bp, first 250kb of FAM19A5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 23 variations for FAM19A5 9 CNVs : 62017 103207 43263 73858 73853 10630 103204 4137 73857 14 Indels : 12276 27091 46248 73856 46251 73854 46249 73859 46250 103206 73852 46247 27090 40510
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM19A5
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Disorders
/ Diseasesfor FAM19A5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FAM19A5 for disorders About GeneDecksing 1 disease for FAM19A5 : About MalaCards glioblastoma Human Genome Epidemiology (HuGE) Navigator: FAM19A5 (2 documents) Export disorders for FAM19A5 gene to outside databases
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Publicationsfor FAM19A5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM19A5 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with FAM19A5) Utopia : connect your pdf to the dynamic world of online information
TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PubMed id 15028294) 1 , 2 , 3 Tom Tang Y....Rupp F. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) Genome-wide association study identifies five loci ass ociated with susceptibility to pancreatic cancer in Chinese populations. (PubMed id 22158540) 1 Wu C....Lin D. (2012) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 1 Yu W.... Gibbs R.A. (1997) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for FAM19A5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM19A5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM19A5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FAM19A5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM19A5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM19A5 gene: Search GeneIP for patents involving FAM19A5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM19A5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM19A5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM19A5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM19A5 OriGene Protein Over-expression Lysate for FAM19A5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM19A5 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM19A5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM19A5 OriGene Custom Protein Services for FAM19A5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM19A5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM19A5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FAM19A5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM19A5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM19A5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM19A5
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FAM19A5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM19A5
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM19A5
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Aliases for FAM19A5
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Disorders / Diseases for FAM19A5
Domains / Families for FAM19A5
Drugs / Compounds for FAM19A5
Expression for FAM19A5
Function for FAM19A5
Genomic Views for FAM19A5
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Pathways / Interactions for FAM19A5
Products for FAM19A5
Proteins for FAM19A5
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Transcripts for FAM19A5
Variants for FAM19A5
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