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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM19A5 Gene

protein-coding   GIFtS: 45
GCID: GC22P048885

family with sequence similarity 19 (chemokine (C-C motif)-like),...

 Explore 1 disease affiliated with
FAM19A5 via our new
 Human Malady Compendium 
Biological research products
for FAM19A5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member
A51 2
     QLLK52082
TAFA-51 2     UNQ52082
Chemokine-Like Protein TAFA-52 3     Protein FAM19A52
TAFA52 3     TAFA Protein 52

External Ids:    HGNC: 215921   Entrez Gene: 258172   Ensembl: ENSG000002194387   UniProtKB: Q7Z5A73   

Export aliases for FAM19A5 gene to outside databases

Previous GC identifers: GC22P047206 GC22P047428 GC22P031967


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FAM19A5:
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted
proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to
MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of
the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune
and nervous cells. (provided by RefSeq, Jul 2008)

Gene Wiki entry for FAM19A5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM19A5 gene promoter:
         AML1a   GATA-6   Pax-5   FOXO4   Egr-1   c-Myb   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM19A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM19A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM19A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.32   Ensembl cytogenetic band:  22q13.32   HGNC cytogenetic band: 22q13.32

FAM19A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM19A5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P048885:  view genomic region     (about GC identifiers)

Start:
48,885,272 bp from pter      End:
49,246,724 bp from pter
Size:
361,453 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7 (See protein sequence)
Recommended Name: Protein FAM19A5  
Size: 132 amino acids; 14301 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Subcellular location: Isoform 2: Secreted
Sequence caution: Sequence=AAD20061.1; Type=Erroneous initiation; Sequence=AAH39396.2; Type=Erroneous initiation;
Secondary accessions: A6NII9 B0QZ13 B0QZ14 B0QZ15 O95902 Q5H9C4 Q6UWC9 Q8IXR8
Alternative splicing: 3 isoforms:  Q7Z5A7-1   Q7Z5A7-2   Q7Z5A7-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FAM19A5: NX_Q7Z5A7

FAM19A5 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_001076436.1  NP_056196.2  

ENSEMBL proteins: 
 ENSP00000383933   ENSP00000336812   ENSP00000351043   ENSP00000385603  

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Uscn Proteins for FAM19A5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0016021integral to membrane IEA--


FAM19A5 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FAM19A5 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR020350 Chemokine-like_FAM19A2

Graphical View of Domain Structure for InterPro Entry Q7Z5A7

ProtoNet protein and cluster: Q7Z5A7

UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7
Similarity: Belongs to the FAM19/TAFA family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM19A5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM19A5
Search CenterWatch for drugs/clinical trials and news about FAM19A5 / F19A5 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM19A5 gene (2 alternative transcripts): 
NM_001082967.1  NM_015381.5  

Unigene Cluster for FAM19A5:

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
Hs.436854  [show with all ESTs]
Unigene Representative Sequence: NM_015381
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000402357 ENST00000336769 ENST00000358295(uc003bim.4 uc003bio.4)
ENST00000473898 ENST00000406880

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Additional cDNA sequence: 

AF131851.1 AK123443.1 AK125256.1 AY358847.1 BC039396.1 

9 DOTS entries:

DT.445780  DT.209304  DT.75102199  DT.101982189  DT.101982190  DT.100019770  DT.100833968  DT.75156550 
DT.99965644 

24/78 AceView cDNA sequences (see all 78):

AW015133 AI362754 BF115495 BM704238 AW006084 H55332 AI863408 BX430931 
BM714846 BI915401 BU731010 BE047699 AI933317 AA629251 AW592960 AI743767 
H28702 AI740873 AI565754 AI199671 R42607 BX096219 AI084095 BX119733 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM19A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGTCTCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

FAM19A5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
3 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
Neural TubeMetencephalonNeural Tube
Spinal CordPresumptive Spinal CordSpinal Cord
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Definitive endoderm-like cells (A scalable, suspensi...)

See FAM19A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM19A5

SOURCE GeneReport for Unigene cluster: Hs.436854

UniProtKB/Swiss-Prot: F19A5_HUMAN, Q7Z5A7
Tissue specificity: Isoform 2 is brain-specific

    SABiosciences Custom PCR Arrays for FAM19A5
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM19A5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A5 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FAM19A51 family with sequence similarity 19 (chemokine (C-C more 77.87(n)
94.4(a)
  768638  XM_001231693.2  XP_001231694.2 
lizard
(Anolis carolinensis)
Reptilia FAM19A56
--
93(a)
1 ↔ 1
5(70771601-70891390)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.125552 Transcribed sequences 76.7(n)    BX715376.1 
zebrafish
(Danio rerio)
Actinopterygii fam19a51 family with sequence similarity 19 (chemokine (C-C more 71.84(n)
81.55(a)
  100002919  NM_001122744.1  NP_001116216.1 


ENSEMBL Gene Tree for FAM19A5 (if available)
TreeFam Gene Tree for FAM19A5 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM19A5 gene
FAM19A42  FAM19A12  FAM19A32  FAM19A22  
4 SIMAP similar genes for FAM19A5 using alignment to 2 protein entries:     F19A5_HUMAN (see all proteins):
FAM19A4    FAM19A1    FAM19A3    FAM19A2

FAM19A5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/6675 NCBI SNPs in FAM19A5 are shown (see all 6675    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs590966531,2
F,--48883304(+) GAGTTC/TGGGAT 1 -- us2k11Minor allele frequency- T:0.05EA 120
rs731714671,2
C,--48883313(+) ATGGAC/TAGGAT 1 -- us2k14Minor allele frequency- T:0.06NA WA EA 360
rs1497917591,2
--48883450(+) AGGGAG/TCCCCT 1 -- us2k10--------
rs20010911,2
C,F,A,H,--48883472(-) TGGGCA/CTGGGA 1 -- us2k110Minor allele frequency- C:0.15MN WA NA CSA EA 554
rs60078651,2
C,F,A,H,--48883476(+) AGGCCC/TACCCT 1 -- us2k16Minor allele frequency- T:0.43WA NA EA 364
rs558324231,2
C,--48883578(+) GAGAGC/TGGGGA 1 -- us2k10--------
rs1466195821,2
C,--48883607(+) ATACT-/AAACAG 1 -- us2k10--------
rs117054311,2
C,H,--48883621(+) AGTCAA/GCGTTT 1 -- us2k10--------
rs731714691,2
C,--48883633(+) AATTAA/CACAGG 1 -- us2k14Minor allele frequency- C:0.06NA WA EA 360
rs1909530851,2
--48883722(+) AGCTTC/TAGTGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FAM19A5 (48885272 - 49135272 bp, first 250kb of FAM19A5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 23 variations for FAM19A5
     9 CNVs: 62017 103207 43263 73858 73853 10630 103204 4137 73857
     14 Indels: 12276 27091 46248 73856 46251 73854 46249 73859 46250 103206 73852 46247 27090 40510

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM19A5 for disorders           About GeneDecksing

1 disease for FAM19A5:    About MalaCards
glioblastoma

Human Genome Epidemiology (HuGE) Navigator: FAM19A5 (2 documents)

Export disorders for FAM19A5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM19A5 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FAM19A5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PubMed id 15028294)1, 2, 3 Tom Tang Y....Rupp F. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
  5. Genome-wide association study identifies five loci ass ociated with susceptibility to pancreatic cancer in Chinese populations. (PubMed id 22158540)1 Wu C....Lin D. (2012)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 25817 HGNC: 21592 AceView: TAFA5 Ensembl:ENSG00000219438 euGenes: HUgn25817
ECgene: FAM19A5 H-InvDB: FAM19A5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM19A5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM19A5 gene:
Search GeneIP for patents involving FAM19A5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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