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Aliases for FAM19A5 Gene

Aliases for FAM19A5 Gene

  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A5 2 3 5
  • Chemokine-Like Protein TAFA-5 3 4
  • TAFA5 3 4
  • TAFA Protein 5 3
  • QLLK5208 3
  • UNQ5208 3
  • TAFA-5 3

External Ids for FAM19A5 Gene

Previous GeneCards Identifiers for FAM19A5 Gene

  • GC22P047206
  • GC22P047428
  • GC22P048885
  • GC22P031967

Summaries for FAM19A5 Gene

Entrez Gene Summary for FAM19A5 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]

GeneCards Summary for FAM19A5 Gene

FAM19A5 (Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A5) is a Protein Coding gene. An important paralog of this gene is FAM19A1.

Gene Wiki entry for FAM19A5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A5 Gene

Genomics for FAM19A5 Gene

Regulatory Elements for FAM19A5 Gene

Enhancers for FAM19A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM19A5 on UCSC Golden Path with GeneCards custom track

Promoters for FAM19A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM19A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A5 Gene

48,489,460 bp from pter
48,850,912 bp from pter
361,453 bases
Plus strand

Genomic View for FAM19A5 Gene

Genes around FAM19A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A5 Gene

Proteins for FAM19A5 Gene

  • Protein details for FAM19A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A5
    Protein Accession:
    Secondary Accessions:
    • A6NII9
    • B0QZ13
    • B0QZ14
    • B0QZ15
    • O95902
    • Q5H9C4
    • Q6UWC9
    • Q8IXR8

    Protein attributes for FAM19A5 Gene

    132 amino acids
    Molecular mass:
    14301 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD20061.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH39396.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM19A5 Gene


neXtProt entry for FAM19A5 Gene

Proteomics data for FAM19A5 Gene at MOPED

Post-translational modifications for FAM19A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM19A5 Gene

No data available for DME Specific Peptides for FAM19A5 Gene

Domains & Families for FAM19A5 Gene

Protein Domains for FAM19A5 Gene


Suggested Antigen Peptide Sequences for FAM19A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A5: view

No data available for Gene Families for FAM19A5 Gene

Function for FAM19A5 Gene

Phenotypes for FAM19A5 Gene

GenomeRNAi human phenotypes for FAM19A5:
genes like me logo Genes that share phenotypes with FAM19A5: view

Animal Model Products

CRISPR Products

miRNA for FAM19A5 Gene

miRTarBase miRNAs that target FAM19A5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A5 Gene

Localization for FAM19A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A5 Gene

Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for FAM19A5 Gene COMPARTMENTS Subcellular localization image for FAM19A5 gene
Compartment Confidence
extracellular 5
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM19A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM19A5: view

Pathways & Interactions for FAM19A5 Gene

SuperPathways for FAM19A5 Gene

No Data Available

Interacting Proteins for FAM19A5 Gene

Gene Ontology (GO) - Biological Process for FAM19A5 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM19A5 Gene

Drugs & Compounds for FAM19A5 Gene

No Compound Related Data Available

Transcripts for FAM19A5 Gene

Unigene Clusters for FAM19A5 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A5 Gene

No ASD Table

Relevant External Links for FAM19A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A5 Gene

mRNA expression in normal human tissues for FAM19A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM19A5 Gene

This gene is overexpressed in Bone (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A5 Gene

SOURCE GeneReport for Unigene cluster for FAM19A5 Gene Hs.436854

mRNA Expression by UniProt/SwissProt for FAM19A5 Gene

Tissue specificity: Isoform 2 is brain-specific.
genes like me logo Genes that share expression patterns with FAM19A5: view

Protein tissue co-expression partners for FAM19A5 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for FAM19A5 Gene

Orthologs for FAM19A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM19A5 35
  • 93.27 (n)
  • 99.12 (a)
FAM19A5 36
  • 99 (a)
(Canis familiaris)
Mammalia FAM19A5 35
  • 90.78 (n)
  • 100 (a)
FAM19A5 36
  • 69 (a)
(Mus musculus)
Mammalia Fam19a5 35
  • 92.68 (n)
  • 99.24 (a)
Fam19a5 16
Fam19a5 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Fam19a5 35
  • 92.68 (n)
  • 99.24 (a)
(Ornithorhynchus anatinus)
Mammalia FAM19A5 36
  • 59 (a)
(Pan troglodytes)
Mammalia FAM19A5 36
  • 100 (a)
(Gallus gallus)
Aves FAM19A5 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FAM19A5 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12555 35
(Danio rerio)
Actinopterygii fam19a5 36
  • 65 (a)
Species with no ortholog for FAM19A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A5 Gene

Gene Tree for FAM19A5 (if available)
Gene Tree for FAM19A5 (if available)

Paralogs for FAM19A5 Gene

Paralogs for FAM19A5 Gene

(4) SIMAP similar genes for FAM19A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM19A5: view

Variants for FAM19A5 Gene

Sequence variations from dbSNP and Humsavar for FAM19A5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs79797 -- 48,710,624(+) TCACC(A/G)TGTCA intron-variant
rs79798 -- 48,710,658(+) CACCA(C/T)GGGAG intron-variant
rs79799 -- 48,710,997(+) CCCCA(A/C)GTGGC intron-variant
rs79800 -- 48,711,012(+) AGCTC(A/G)GGAGA intron-variant
rs80517 -- 48,534,055(-) AGACC(A/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A5 Gene

Variant ID Type Subtype PubMed ID
nsv834232 CNV Loss 17160897
dgv778n67 CNV Gain 20364138
nsv915409 CNV Loss 21882294
nsv915410 CNV Loss 21882294
nsv829304 CNV Gain 20364138
dgv5029n71 CNV Loss 21882294
nsv829305 CNV Gain 20364138
dgv779n67 CNV Gain 20364138
nsv829310 CNV Gain 20364138
nsv829311 CNV Gain 20364138
nsv829312 CNV Gain 20364138
esv2724546 CNV Deletion 23290073
esv2358153 CNV Deletion 18987734
esv2538802 CNV Deletion 19546169
esv28019 CNV Loss 19812545
esv2724547 CNV Deletion 23290073
nsv818005 CNV Loss 17921354
esv2724548 CNV Deletion 23290073
esv2724549 CNV Deletion 23290073
nsv915414 CNV Loss 21882294
dgv5030n71 CNV Loss 21882294
nsv915416 CNV Gain 21882294
dgv5031n71 CNV Loss 21882294
esv2675054 CNV Deletion 23128226
nsv915419 CNV Loss 21882294
nsv915420 CNV Loss 21882294
nsv829313 CNV Gain 20364138
nsv829315 CNV Gain 20364138
dgv5032n71 CNV Loss 21882294
esv2619129 CNV Insertion 19546169
nsv513596 CNV Insertion 21212237
esv2250197 CNV Deletion 18987734
esv2724551 CNV Deletion 23290073
esv998435 CNV Deletion 20482838
esv2666627 CNV Deletion 23128226
esv2724552 CNV Deletion 23290073
esv24783 CNV Gain 19812545
nsv915425 CNV Loss 21882294
nsv915426 CNV Loss 21882294
nsv915427 CNV Loss 21882294
dgv5033n71 CNV Loss 21882294
dgv5034n71 CNV Loss 21882294
esv2724553 CNV Deletion 23290073
esv2724554 CNV Deletion 23290073
esv2724555 CNV Deletion 23290073
esv29647 CNV Loss 19812545
esv997814 CNV Insertion 20482838
nsv915433 CNV Loss 21882294
esv29827 CNV Loss 19812545
esv28096 CNV Loss 19812545
nsv512662 CNV Loss 21212237
esv2462207 CNV Deletion 19546169
esv996738 CNV Deletion 20482838
esv1984946 CNV Deletion 18987734
esv3974 CNV Deletion 18987735
esv1005087 CNV Loss 20482838
nsv820625 CNV Deletion 20802225
esv1337416 CNV Deletion 17803354
esv6768 CNV Loss 19470904
esv2724556 CNV Deletion 23290073
esv1705117 CNV Deletion 17803354
nsv915434 CNV Loss 21882294
nsv915435 CNV Loss 21882294
nsv524377 CNV Loss 19592680
nsv191479 CNV Loss 16902084
esv2724557 CNV Deletion 23290073
esv2300898 CNV Deletion 18987734
esv993242 CNV Deletion 20482838
esv2663229 CNV Deletion 23128226
esv2724558 CNV Deletion 23290073
nsv3660 CNV Insertion 18451855
esv2661095 CNV Deletion 23128226
dgv5035n71 CNV Loss 21882294
nsv915438 CNV Loss 21882294
esv275178 CNV Loss 21479260
nsv459914 CNV Loss 19166990
nsv915439 CNV Loss 21882294
dgv5036n71 CNV Loss 21882294
esv2673355 CNV Deletion 23128226
esv2724559 CNV Deletion 23290073
dgv5037n71 CNV Loss 21882294
nsv915443 CNV Loss 21882294
nsv829316 CNV Gain 20364138
esv2724560 CNV Deletion 23290073
esv1166452 CNV Insertion 17803354
nsv829317 CNV Gain 20364138
nsv459915 CNV Loss 19166990
esv22451 CNV Gain 19812545
esv1138502 CNV Insertion 17803354
esv2724562 CNV Deletion 23290073
esv1418211 CNV Insertion 17803354
esv2149667 CNV Deletion 18987734
dgv794e201 CNV Deletion 23290073
dgv5038n71 CNV Loss 21882294
nsv915446 CNV Loss 21882294
nsv915447 CNV Loss 21882294
nsv829318 CNV Gain 20364138
esv2724564 CNV Deletion 23290073
nsv521221 CNV Loss 19592680
dgv1419e1 CNV Complex 17122850
nsv829320 CNV Gain 20364138

Variation tolerance for FAM19A5 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM19A5 Gene

Disorders for FAM19A5 Gene

Relevant External Links for FAM19A5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM19A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A5 Gene

Publications for FAM19A5 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 67
  2. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham S.J. … Biernacka J.M. (Mol. Psychiatry 2013) 3
  3. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. (PMID: 22158540) Wu C. … Lin D. (Nat. Genet. 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Chromosome 22 tiling-path array-CGH analysis identifies germ-line- and tumor-specific aberrations in patients with glioblastoma multiforme. (PMID: 15945096) DA-az de StAYhl T. … Dumanski J.P. (Genes Chromosomes Cancer 2005) 23

Products for FAM19A5 Gene

Sources for FAM19A5 Gene