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Aliases for FAM19A4 Gene

Aliases for FAM19A4 Gene

  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A4 2 3 5
  • Chemokine-Like Protein TAFA-4 3 4
  • TAFA4 3 4
  • TAFA-4 3

External Ids for FAM19A4 Gene

Previous GeneCards Identifiers for FAM19A4 Gene

  • GC03M068864

Summaries for FAM19A4 Gene

Entrez Gene Summary for FAM19A4 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM19A4 Gene

FAM19A4 (Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A4) is a Protein Coding gene. An important paralog of this gene is FAM19A1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A4 Gene

Genomics for FAM19A4 Gene

Regulatory Elements for FAM19A4 Gene

Genomic Location for FAM19A4 Gene

Chromosome:
3
Start:
68,731,764 bp from pter
End:
68,953,297 bp from pter
Size:
221,534 bases
Orientation:
Minus strand

Genomic View for FAM19A4 Gene

Genes around FAM19A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A4 Gene

Proteins for FAM19A4 Gene

  • Protein details for FAM19A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR4-F19A4_HUMAN
    Recommended name:
    Protein FAM19A4
    Protein Accession:
    Q96LR4
    Secondary Accessions:
    • A8MVT2

    Protein attributes for FAM19A4 Gene

    Size:
    140 amino acids
    Molecular mass:
    15682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM19A4 Gene

Proteomics data for FAM19A4 Gene at MOPED

Post-translational modifications for FAM19A4 Gene

No Post-translational modifications

Other Protein References for FAM19A4 Gene

Antibody Products

  • R&D Systems Antibodies for FAM19A4 (TAFA4/FAM19A4)
  • Cloud-Clone Corp. Antibodies for FAM19A4

No data available for DME Specific Peptides for FAM19A4 Gene

Domains & Families for FAM19A4 Gene

Protein Domains for FAM19A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM19A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LR4

UniProtKB/Swiss-Prot:

F19A4_HUMAN :
  • Belongs to the FAM19/TAFA family.
Family:
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A4: view

No data available for Gene Families for FAM19A4 Gene

Function for FAM19A4 Gene

Phenotypes for FAM19A4 Gene

GenomeRNAi human phenotypes for FAM19A4:
genes like me logo Genes that share phenotypes with FAM19A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A4

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM19A4 Gene

Localization for FAM19A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM19A4 Gene COMPARTMENTS Subcellular localization image for FAM19A4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for FAM19A4 Gene

Pathways & Interactions for FAM19A4 Gene

SuperPathways for FAM19A4 Gene

No Data Available

Interacting Proteins for FAM19A4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295569%0d%0a9606.ENSP00000083182%0d%0a
Selected Interacting proteins: Q96LR4-F19A4_HUMAN ENSP00000295569 for FAM19A4 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for FAM19A4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM19A4 Gene

Drugs & Compounds for FAM19A4 Gene

No Compound Related Data Available

Transcripts for FAM19A4 Gene

mRNA/cDNA for FAM19A4 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM19A4 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for FAM19A4 Gene

GeneLoc Exon Structure for
FAM19A4
ECgene alternative splicing isoforms for
FAM19A4

Expression for FAM19A4 Gene

mRNA expression in normal human tissues for FAM19A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.4), Adrenal Gland (x6.7), Brain - Substantia nigra (x5.5), and Stomach (x5.3).

SOURCE GeneReport for Unigene cluster for FAM19A4 Gene Hs.187873

mRNA Expression by UniProt/SwissProt for FAM19A4 Gene

Q96LR4-F19A4_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with FAM19A4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FAM19A4 Gene

Orthologs for FAM19A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM19A4 35
  • 92.38 (n)
  • 97.14 (a)
FAM19A4 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam19a4 35
  • 88.4 (n)
  • 93.33 (a)
Fam19a4 16
Fam19a4 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM19A4 35
  • 100 (n)
  • 100 (a)
FAM19A4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam19a4 35
  • 88.15 (n)
  • 94.07 (a)
cow
(Bos Taurus)
Mammalia FAM19A4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM19A4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM19A4 35
  • 82.97 (n)
  • 90.65 (a)
FAM19A4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM19A4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a4 35
  • 76.81 (n)
  • 85.51 (a)
zebrafish
(Danio rerio)
Actinopterygii fam19a4b 35
  • 71.31 (n)
  • 76.23 (a)
fam19a4b 36
  • 70 (a)
OneToOne
Species with no ortholog for FAM19A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A4 Gene

ENSEMBL:
Gene Tree for FAM19A4 (if available)
TreeFam:
Gene Tree for FAM19A4 (if available)

Paralogs for FAM19A4 Gene

Paralogs for FAM19A4 Gene

(4) SIMAP similar genes for FAM19A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM19A4: view

Variants for FAM19A4 Gene

Sequence variations from dbSNP and Humsavar for FAM19A4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17319 -- 68,930,441(-) AAGTC(A/C)CAATT intron-variant
rs17320 -- 68,930,363(-) TTTCT(C/G)TRTCT intron-variant
rs17321 -- 68,930,361(-) TCTCT(A/G)TCTTT intron-variant
rs17322 -- 68,930,295(-) TATCT(C/T)TGCTT intron-variant
rs902245 -- 68,808,018(-) atata(C/T)atatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A4 Gene

Variant ID Type Subtype PubMed ID
nsv834722 CNV Gain 17160897
esv270165 CNV Insertion 20981092
dgv5160n71 CNV Loss 21882294
esv2504953 CNV Deletion 19546169
esv2141895 CNV Deletion 18987734
esv3358 CNV Deletion 18987735
esv989471 CNV Deletion 20482838
esv1734354 CNV Deletion 17803354
esv8699 CNV Loss 19470904
esv2725381 CNV Deletion 23290073
dgv1467e1 CNV Complex 17122850
esv2725382 CNV Deletion 23290073
esv2658323 CNV Deletion 23128226
nsv236602 CNV Loss 16902084
esv2678597 CNV Deletion 23128226
nsv525701 CNV Gain 19592680
esv1011141 CNV Insertion 20482838

Variation tolerance for FAM19A4 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM19A4 Gene

HapMap Linkage Disequilibrium report
FAM19A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A4 Gene

Disorders for FAM19A4 Gene

Relevant External Links for FAM19A4

Genetic Association Database (GAD)
FAM19A4
Human Genome Epidemiology (HuGE) Navigator
FAM19A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM19A4

No disorders were found for FAM19A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A4 Gene

Publications for FAM19A4 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 67
  2. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. (PMID: 25109685) Wang W. … Han W. (Cell. Mol. Immunol. 2014) 2 3
  3. Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions. (PMID: 25281488) De Strooper L.M. … Heideman D.A. (Cancer Prev Res (Phila) 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for FAM19A4 Gene

Sources for FAM19A4 Gene

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