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Aliases for FAM19A3 Gene

Aliases for FAM19A3 Gene

  • Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A3 2 3
  • Chemokine-Like Protein TAFA-3 3 4
  • TAFA3 3 4
  • Protein FAM19A3 3
  • TAFA-3 3

External Ids for FAM19A3 Gene

Previous GeneCards Identifiers for FAM19A3 Gene

  • GC01P112976
  • GC01P113064
  • GC01P113263
  • GC01P111122

Summaries for FAM19A3 Gene

Entrez Gene Summary for FAM19A3 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM19A3 Gene

FAM19A3 (Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like) is a Protein Coding gene. An important paralog of this gene is FAM19A4.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A3 Gene

Genomics for FAM19A3 Gene

Regulatory Elements for FAM19A3 Gene

Enhancers for FAM19A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G112794 0.8 ENCODE 12.2 +76.0 76008 2.0 HDAC1 LEF1 IRF2 ATF1 ZNF316 GATA2 NR2F6 CREM SMARCE1 RNF2 FAM19A3 PPM1J RHOC LRIG2 GC01P112820 GC01M112752
GH01G112722 1 Ensembl ENCODE 0.7 +3.9 3937 1.9 CTCF KLF1 FOSL1 ZFHX2 POLR2A SCRT2 ZNF600 NR2F6 EGR2 NFIA PPM1J FAM19A3 NUTF2P4
GH01G112718 0.9 Ensembl 0.7 0.0 -18 0.8 RB1 ARID4B SIN3A ZNF2 ZNF48 RAD21 GLIS2 EGR1 ZNF143 RCOR1 ENSG00000225075 MOV10 ENSG00000238761 FAM19A3 GC01P112725
GH01G112735 0.6 ENCODE 0.4 +16.9 16890 1.5 FOSL1 NFIC JUND JUN FOS MAFK SLC16A1 NUTF2P4 FAM19A3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM19A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A3 Gene

112,718,994 bp from pter
112,727,235 bp from pter
8,242 bases
Plus strand

Genomic View for FAM19A3 Gene

Genes around FAM19A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A3 Gene

Proteins for FAM19A3 Gene

  • Protein details for FAM19A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A3
    Protein Accession:
    Secondary Accessions:
    • B7ZLU0
    • Q2M1P9
    • Q7Z5A6

    Protein attributes for FAM19A3 Gene

    133 amino acids
    Molecular mass:
    14776 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM19A3 Gene


neXtProt entry for FAM19A3 Gene

Post-translational modifications for FAM19A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM19A3 Gene

No data available for DME Specific Peptides for FAM19A3 Gene

Domains & Families for FAM19A3 Gene

Protein Domains for FAM19A3 Gene


Suggested Antigen Peptide Sequences for FAM19A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A3: view

No data available for Gene Families for FAM19A3 Gene

Function for FAM19A3 Gene

Phenotypes for FAM19A3 Gene

GenomeRNAi human phenotypes for FAM19A3:
genes like me logo Genes that share phenotypes with FAM19A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A3 Gene

Localization for FAM19A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM19A3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM19A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25595455
genes like me logo Genes that share ontologies with FAM19A3: view

Pathways & Interactions for FAM19A3 Gene

SuperPathways for FAM19A3 Gene

No Data Available

Interacting Proteins for FAM19A3 Gene

Gene Ontology (GO) - Biological Process for FAM19A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903979 negative regulation of microglial cell activation IEA,ISS --
GO:1903980 positive regulation of microglial cell activation IEA,ISS --
genes like me logo Genes that share ontologies with FAM19A3: view

No data available for Pathways by source and SIGNOR curated interactions for FAM19A3 Gene

Drugs & Compounds for FAM19A3 Gene

No Compound Related Data Available

Transcripts for FAM19A3 Gene

mRNA/cDNA for FAM19A3 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM19A3 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for FAM19A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM19A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A3 Gene

This gene is overexpressed in Testis (x15.7), Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x6.2), and Adrenal Gland (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM19A3 Gene:


SOURCE GeneReport for Unigene cluster for FAM19A3 Gene:


mRNA Expression by UniProt/SwissProt for FAM19A3 Gene:

Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for FAM19A3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM19A3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM19A3 Gene

Orthologs for FAM19A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM19A3 34 35
  • 99.75 (n)
(Bos Taurus)
Mammalia FAM19A3 34
  • 87.97 (n)
(Mus musculus)
Mammalia Fam19a3 34 16 35
  • 87.28 (n)
(Rattus norvegicus)
Mammalia Fam19a3 34
  • 85.96 (n)
(Ornithorhynchus anatinus)
Mammalia FAM19A3 35
  • 51 (a)
(Canis familiaris)
Mammalia FAM19A3 35
  • 50 (a)
(Monodelphis domestica)
Mammalia FAM19A3 35
  • 24 (a)
(Gallus gallus)
Aves FAM19A3 34 35
  • 76.95 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a3 34
  • 66.98 (n)
(Danio rerio)
Actinopterygii si:ch211-254n4.3 34
  • 72.98 (n)
si:dkey-238f9.1 35
  • 44 (a)
Species where no ortholog for FAM19A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A3 Gene

Gene Tree for FAM19A3 (if available)
Gene Tree for FAM19A3 (if available)

Paralogs for FAM19A3 Gene

Paralogs for FAM19A3 Gene

(4) SIMAP similar genes for FAM19A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM19A3: view

Variants for FAM19A3 Gene

Sequence variations from dbSNP and Humsavar for FAM19A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000495836 -- 112,727,205(+) AAGGA(A/G)AGTAA utr-variant-3-prime
rs1000807781 -- 112,717,122(+) ATATA(A/C)CTCCT nc-transcript-variant, upstream-variant-2KB
rs1001014954 -- 112,721,569(+) TTGGC(C/G)TCCCA intron-variant
rs1001155217 -- 112,717,298(+) AGGGA(C/G)AATAA nc-transcript-variant, upstream-variant-2KB
rs1001804335 -- 112,717,782(+) ACATT(C/T)GCATC nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM19A3 Gene

Variant ID Type Subtype PubMed ID
esv27598 CNV loss 19812545
nsv547566 CNV gain 21841781
nsv818378 CNV gain 17921354
nsv998794 CNV gain 25217958

Variation tolerance for FAM19A3 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM19A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A3 Gene

Disorders for FAM19A3 Gene

Relevant External Links for FAM19A3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM19A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A3 Gene

Publications for FAM19A3 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 64
  2. FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. (PMID: 25595455) Shao Y. … Wang Y. (FEBS Lett. 2015) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J. … Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for FAM19A3 Gene

Sources for FAM19A3 Gene

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