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Aliases for FAM19A2 Gene

Aliases for FAM19A2 Gene

  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A2 2 3
  • Chemokine-Like Protein TAFA-2 3 4
  • TAFA2 3 4
  • Protein FAM19A2 3
  • TAFA-2 3

External Ids for FAM19A2 Gene

Previous GeneCards Identifiers for FAM19A2 Gene

  • GC12M060389
  • GC12M062102
  • GC12M059153

Summaries for FAM19A2 Gene

Entrez Gene Summary for FAM19A2 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAM19A2 Gene

FAM19A2 (Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A2) is a Protein Coding gene. An important paralog of this gene is FAM19A1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A2 Gene

Genomics for FAM19A2 Gene

Regulatory Elements for FAM19A2 Gene

Genomic Location for FAM19A2 Gene

61,708,248 bp from pter
62,279,150 bp from pter
570,903 bases
Minus strand

Genomic View for FAM19A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM19A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A2 Gene

Proteins for FAM19A2 Gene

  • Protein details for FAM19A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A2
    Protein Accession:
    Secondary Accessions:
    • B3KVV4
    • Q4G0R9
    • Q68DK0
    • Q6GTX6

    Protein attributes for FAM19A2 Gene

    131 amino acids
    Molecular mass:
    14620 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM19A2 Gene


neXtProt entry for FAM19A2 Gene

Proteomics data for FAM19A2 Gene at MOPED

Post-translational modifications for FAM19A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for FAM19A2 (TAFA2/FAM19A2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM19A2

No data available for DME Specific Peptides for FAM19A2 Gene

Domains for FAM19A2 Gene

Protein Domains for FAM19A2 Gene


Suggested Antigen Peptide Sequences for FAM19A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A2: view

No data available for Gene Families for FAM19A2 Gene

Function for FAM19A2 Gene

Animal Model Products

miRNA for FAM19A2 Gene

miRTarBase miRNAs that target FAM19A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A2 Gene

Localization for FAM19A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A2 Gene


Subcellular locations from

Jensen Localization Image for FAM19A2 Gene COMPARTMENTS Subcellular localization image for FAM19A2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for FAM19A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAM19A2: view

Pathways for FAM19A2 Gene

SuperPathways for FAM19A2 Gene

No Data Available

Interacting Proteins for FAM19A2 Gene

Gene Ontology (GO) - Biological Process for FAM19A2 Gene


No data available for Pathways by source for FAM19A2 Gene

Transcripts for FAM19A2 Gene

Unigene Clusters for FAM19A2 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A2 Gene

No ASD Table

Relevant External Links for FAM19A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A2 Gene

mRNA expression in normal human tissues for FAM19A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (9.4), Brain - Anterior cingulate cortex (BA24) (8.3), Brain - Cortex (6.4), Brain - Amygdala (6.0), and Brain - Hippocampus (4.5).

Protein differential expression in normal tissues for FAM19A2 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM19A2 Gene

SOURCE GeneReport for Unigene cluster for FAM19A2 Gene Hs.269745

mRNA Expression by UniProt/SwissProt for FAM19A2 Gene

Tissue specificity: Brain-specific.
genes like me logo Genes that share expressions with FAM19A2: view

Expression partners for FAM19A2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for FAM19A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM19A2 35
  • 96.95 (n)
  • 100 (a)
FAM19A2 36
  • 99 (a)
(Canis familiaris)
Mammalia FAM19A2 35
  • 94.66 (n)
  • 100 (a)
FAM19A2 36
  • 99 (a)
(Mus musculus)
Mammalia Fam19a2 35
  • 89.06 (n)
  • 96.95 (a)
Fam19a2 16
Fam19a2 36
  • 93 (a)
(Pan troglodytes)
Mammalia LOC100610890 35
  • 99.75 (n)
  • 100 (a)
FAM19A2 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Fam19a2 35
  • 89.57 (n)
  • 96.95 (a)
(Monodelphis domestica)
Mammalia FAM19A2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia FAM19A2 36
  • 96 (a)
(Gallus gallus)
Aves FAM19A2 35
  • 88.46 (n)
  • 96.15 (a)
FAM19A2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia FAM19A2 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a2 35
  • 81.28 (n)
  • 87.69 (a)
(Danio rerio)
Actinopterygii LOC101882435 35
  • 65.59 (n)
  • 71.77 (a)
FAM19A2 36
  • 83 (a)
Species with no ortholog for FAM19A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A2 Gene

Gene Tree for FAM19A2 (if available)
Gene Tree for FAM19A2 (if available)

Paralogs for FAM19A2 Gene

Paralogs for FAM19A2 Gene

(4) SIMAP similar genes for FAM19A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM19A2: view

Variants for FAM19A2 Gene

Sequence variations from dbSNP and Humsavar for FAM19A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs191551 -- 62,057,814(+) CTAAT(C/T)AGACA intron-variant
rs348631 -- 62,053,751(+) TTCTA(C/T)TGCTT intron-variant
rs348632 -- 62,053,881(+) CACTA(C/T)AAACA intron-variant
rs348633 -- 62,054,143(+) GATAC(C/T)AAAGC intron-variant
rs348634 -- 62,054,592(-) TTCTA(A/G)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A2 Gene

Variant ID Type Subtype PubMed ID
nsv520898 CNV Gain 19592680
nsv899151 CNV Loss 21882294
dgv291n67 CNV Loss 20364138
esv2673200 CNV Deletion 23128226
esv27603 CNV Loss 19812545
esv2673654 CNV Deletion 23128226
esv2421373 CNV Deletion 20811451
nsv442272 CNV CNV 18776908
nsv514672 CNV Complex 21397061
esv2745960 CNV Deletion 23290073
nsv516147 CNV Loss 19592680
esv2572564 CNV Deletion 19546169
esv2745961 CNV Deletion 23290073
dgv10e194 CNV Deletion 18987734
esv3192 CNV Deletion 18987735
esv2745962 CNV Deletion 23290073
esv1006216 CNV Deletion 20482838
esv1703729 CNV Deletion 17803354
nsv53083 CNV Loss 16902084
nsv737 CNV Insertion 18451855
nsv899152 CNV Gain 21882294
esv2633161 CNV Deletion 19546169
esv2028037 CNV Deletion 18987734
esv5428 CNV Deletion 18987735
esv2745964 CNV Deletion 23290073
esv23013 CNV Loss 19812545
esv6636 CNV Loss 19470904
esv2745965 CNV Deletion 23290073
nsv832435 CNV Gain 17160897
esv274206 CNV Insertion 20981092
esv268674 CNV Insertion 20981092

Relevant External Links for FAM19A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A2 Gene

Disorders for FAM19A2 Gene

(1) University of Copenhagen DISEASES for FAM19A2 Gene

Relevant External Links for FAM19A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FAM19A2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FAM19A2 Gene

Publications for FAM19A2 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. (PMID: 21348951) Parsa A. … Liggett S.B. (Clin Transl Sci 2011) 3

Products for FAM19A2 Gene

Sources for FAM19A2 Gene

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