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Aliases for FAM19A2 Gene

Aliases for FAM19A2 Gene

  • Family With Sequence Similarity 19 Member A2, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A2 2 3
  • Chemokine-Like Protein TAFA-2 3 4
  • TAFA2 3 4
  • Protein FAM19A2 3
  • TAFA-2 3

External Ids for FAM19A2 Gene

Previous GeneCards Identifiers for FAM19A2 Gene

  • GC12M060389
  • GC12M062102
  • GC12M059153

Summaries for FAM19A2 Gene

Entrez Gene Summary for FAM19A2 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAM19A2 Gene

FAM19A2 (Family With Sequence Similarity 19 Member A2, C-C Motif Chemokine Like) is a Protein Coding gene. Diseases associated with FAM19A2 include Cornelia De Lange Syndrome 1. An important paralog of this gene is FAM19A4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A2 Gene

Genomics for FAM19A2 Gene

Regulatory Elements for FAM19A2 Gene

Enhancers for FAM19A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F062106 0.8 Ensembl ENCODE 9.9 +172.2 172234 1.0 FAM19A2 GC12P062100 GC12P062112
GH12F062128 0.2 ENCODE 9.4 +150.2 150222 0.7 CTCF ZNF654 SCRT2 FOS RAD21 FAM19A2 GC12M062122 GC12M062135
GH12F062271 0.6 Ensembl 8.1 +5.5 5450 4.6 HLF WRNIP1 BHLHE40 ZBTB40 OSR2 MEF2D ZNF121 ZNF580 HNF4G BCL6 USP15 FAM19A2 MIR6125
GH12F062263 1 FANTOM5 ENCODE 8.1 +14.5 14548 2.8 PKNOX1 ZNF362 STAT1 ZMYM3 CHD1 POLR2H HDAC2 CBX5 STAT2 NBN USP15 LINC01465 FAM19A2 MIR6125
GH12F062291 1.4 FANTOM5 Ensembl 8.1 -13.3 -13251 1.6 ZBTB33 FOS EBF1 NFE2 SPI1 TRIM28 EGR2 RNU6-595P FAM19A2 USP15 MON2 LINC01465 GC12M062335
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM19A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A2 Gene

Chromosome:
12
Start:
61,708,248 bp from pter
End:
62,279,150 bp from pter
Size:
570,903 bases
Orientation:
Minus strand

Genomic View for FAM19A2 Gene

Genes around FAM19A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A2 Gene

Proteins for FAM19A2 Gene

  • Protein details for FAM19A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3H0-F19A2_HUMAN
    Recommended name:
    Protein FAM19A2
    Protein Accession:
    Q8N3H0
    Secondary Accessions:
    • B3KVV4
    • Q4G0R9
    • Q68DK0
    • Q6GTX6

    Protein attributes for FAM19A2 Gene

    Size:
    131 amino acids
    Molecular mass:
    14620 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM19A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM19A2 Gene

Post-translational modifications for FAM19A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM19A2 Gene

Domains & Families for FAM19A2 Gene

Protein Domains for FAM19A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM19A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3H0

UniProtKB/Swiss-Prot:

F19A2_HUMAN :
  • Belongs to the FAM19/TAFA family.
Family:
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A2: view

No data available for Gene Families for FAM19A2 Gene

Function for FAM19A2 Gene

genes like me logo Genes that share phenotypes with FAM19A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A2

miRNA for FAM19A2 Gene

miRTarBase miRNAs that target FAM19A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A2 Gene

Localization for FAM19A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM19A2 Gene COMPARTMENTS Subcellular localization image for FAM19A2 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for FAM19A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FAM19A2: view

Pathways & Interactions for FAM19A2 Gene

SuperPathways for FAM19A2 Gene

No Data Available

Interacting Proteins for FAM19A2 Gene

Gene Ontology (GO) - Biological Process for FAM19A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM19A2 Gene

Transcripts for FAM19A2 Gene

Unigene Clusters for FAM19A2 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A2 Gene

No ASD Table

Relevant External Links for FAM19A2 Gene

GeneLoc Exon Structure for
FAM19A2
ECgene alternative splicing isoforms for
FAM19A2

Expression for FAM19A2 Gene

mRNA expression in normal human tissues for FAM19A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.4), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Cortex (x6.4), Brain - Amygdala (x6.0), and Brain - Hippocampus (x4.5).

Protein differential expression in normal tissues from HIPED for FAM19A2 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A2 Gene



Protein tissue co-expression partners for FAM19A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM19A2 Gene:

FAM19A2

SOURCE GeneReport for Unigene cluster for FAM19A2 Gene:

Hs.269745

mRNA Expression by UniProt/SwissProt for FAM19A2 Gene:

Q8N3H0-F19A2_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with FAM19A2: view

Primer Products

Orthologs for FAM19A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610890 34
  • 99.75 (n)
FAM19A2 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM19A2 34 35
  • 96.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM19A2 34 35
  • 94.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM19A2 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam19a2 34
  • 89.57 (n)
mouse
(Mus musculus)
Mammalia Fam19a2 34 16 35
  • 89.06 (n)
chicken
(Gallus gallus)
Aves FAM19A2 34 35
  • 88.46 (n)
lizard
(Anolis carolinensis)
Reptilia FAM19A2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a2 34
  • 81.28 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM19A2 35
  • 83 (a)
OneToOne
LOC101882435 34
  • 65.59 (n)
Species where no ortholog for FAM19A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A2 Gene

ENSEMBL:
Gene Tree for FAM19A2 (if available)
TreeFam:
Gene Tree for FAM19A2 (if available)

Paralogs for FAM19A2 Gene

Paralogs for FAM19A2 Gene

(4) SIMAP similar genes for FAM19A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM19A2: view

Variants for FAM19A2 Gene

Sequence variations from dbSNP and Humsavar for FAM19A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10083102 -- 61,887,269(+) TACTA(C/T)GTCTA intron-variant
rs1009168 -- 62,116,714(-) TCTGC(C/T)GTTTT intron-variant
rs1012225 -- 62,013,672(+) AACTG(A/C)AATAA intron-variant
rs10160858 -- 62,170,883(+) TGGCC(A/G)TTGGC intron-variant
rs10161280 -- 61,938,963(+) tacaa(C/T)gtaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A2 Gene

Variant ID Type Subtype PubMed ID
dgv10e194 CNV deletion 18987734
dgv291n67 CNV loss 20364138
dgv821n106 CNV deletion 24896259
esv1006216 CNV deletion 20482838
esv1703729 CNV deletion 17803354
esv2028037 CNV deletion 18987734
esv23013 CNV loss 19812545
esv2421373 CNV deletion 20811451
esv2572564 CNV deletion 19546169
esv2633161 CNV deletion 19546169
esv2673200 CNV deletion 23128226
esv2673654 CNV deletion 23128226
esv2745960 CNV deletion 23290073
esv2745961 CNV deletion 23290073
esv2745962 CNV deletion 23290073
esv2745964 CNV deletion 23290073
esv2745965 CNV deletion 23290073
esv27603 CNV loss 19812545
esv3192 CNV loss 18987735
esv3372293 CNV insertion 20981092
esv3380421 CNV insertion 20981092
esv3549295 CNV deletion 23714750
esv3549296 CNV deletion 23714750
esv3549297 CNV deletion 23714750
esv3580290 CNV loss 25503493
esv3581660 CNV gain 25503493
esv3629724 CNV loss 21293372
esv3629725 CNV loss 21293372
esv3629726 CNV loss 21293372
esv3629727 CNV loss 21293372
esv3629729 CNV loss 21293372
esv5428 CNV loss 18987735
esv6636 CNV loss 19470904
nsv1039741 CNV loss 25217958
nsv1040154 CNV loss 25217958
nsv1042044 CNV gain 25217958
nsv1071039 CNV deletion 25765185
nsv1139570 CNV duplication 24896259
nsv442272 CNV loss 18776908
nsv514672 CNV gain+loss 21397061
nsv516147 CNV loss 19592680
nsv520898 CNV gain 19592680
nsv53083 CNV deletion 16902084
nsv559151 CNV loss 21841781
nsv559152 CNV loss 21841781
nsv559153 CNV loss 21841781
nsv559154 CNV loss 21841781
nsv737 CNV insertion 18451855
nsv832435 CNV gain 17160897
nsv958662 CNV deletion 24416366
nsv975502 CNV duplication 23825009
nsv976633 CNV duplication 23825009
nsv976634 CNV duplication 23825009
nsv977138 CNV deletion 23825009

Variation tolerance for FAM19A2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM19A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM19A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A2 Gene

Disorders for FAM19A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM19A2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cornelia de lange syndrome 1
  • cornelia de lange syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM19A2

Genetic Association Database (GAD)
FAM19A2
Human Genome Epidemiology (HuGE) Navigator
FAM19A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM19A2
genes like me logo Genes that share disorders with FAM19A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM19A2 Gene

Publications for FAM19A2 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FAM19A2 Gene

Sources for FAM19A2 Gene

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