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Aliases for FAM19A2 Gene

Aliases for FAM19A2 Gene

  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A2 2 3 5
  • Chemokine-Like Protein TAFA-2 3 4
  • TAFA2 3 4
  • TAFA-2 3

External Ids for FAM19A2 Gene

Previous GeneCards Identifiers for FAM19A2 Gene

  • GC12M060389
  • GC12M062102
  • GC12M059153

Summaries for FAM19A2 Gene

Entrez Gene Summary for FAM19A2 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAM19A2 Gene

FAM19A2 (Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A2) is a Protein Coding gene. An important paralog of this gene is FAM19A1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A2 Gene

Genomics for FAM19A2 Gene

Regulatory Elements for FAM19A2 Gene

Enhancers for FAM19A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM19A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A2 Gene

Chromosome:
12
Start:
61,708,248 bp from pter
End:
62,279,150 bp from pter
Size:
570,903 bases
Orientation:
Minus strand

Genomic View for FAM19A2 Gene

Genes around FAM19A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A2 Gene

Proteins for FAM19A2 Gene

  • Protein details for FAM19A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3H0-F19A2_HUMAN
    Recommended name:
    Protein FAM19A2
    Protein Accession:
    Q8N3H0
    Secondary Accessions:
    • B3KVV4
    • Q4G0R9
    • Q68DK0
    • Q6GTX6

    Protein attributes for FAM19A2 Gene

    Size:
    131 amino acids
    Molecular mass:
    14620 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM19A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM19A2 Gene

Proteomics data for FAM19A2 Gene at MOPED

Post-translational modifications for FAM19A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM19A2 Gene

Domains & Families for FAM19A2 Gene

Protein Domains for FAM19A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM19A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3H0

UniProtKB/Swiss-Prot:

F19A2_HUMAN :
  • Belongs to the FAM19/TAFA family.
Family:
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A2: view

No data available for Gene Families for FAM19A2 Gene

Function for FAM19A2 Gene

Phenotypes for FAM19A2 Gene

genes like me logo Genes that share phenotypes with FAM19A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A2

miRNA for FAM19A2 Gene

miRTarBase miRNAs that target FAM19A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A2 Gene

Localization for FAM19A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM19A2 Gene COMPARTMENTS Subcellular localization image for FAM19A2 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for FAM19A2 Gene

Pathways & Interactions for FAM19A2 Gene

SuperPathways for FAM19A2 Gene

No Data Available

Interacting Proteins for FAM19A2 Gene

Gene Ontology (GO) - Biological Process for FAM19A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM19A2 Gene

Drugs & Compounds for FAM19A2 Gene

No Compound Related Data Available

Transcripts for FAM19A2 Gene

Unigene Clusters for FAM19A2 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A2 Gene

No ASD Table

Relevant External Links for FAM19A2 Gene

GeneLoc Exon Structure for
FAM19A2
ECgene alternative splicing isoforms for
FAM19A2

Expression for FAM19A2 Gene

mRNA expression in normal human tissues for FAM19A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.4), Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Cortex (x6.4), Brain - Amygdala (x6.0), and Brain - Hippocampus (x4.5).

Protein differential expression in normal tissues from HIPED for FAM19A2 Gene

This gene is overexpressed in Oral epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A2 Gene



SOURCE GeneReport for Unigene cluster for FAM19A2 Gene Hs.269745

mRNA Expression by UniProt/SwissProt for FAM19A2 Gene

Q8N3H0-F19A2_HUMAN
Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with FAM19A2: view

Protein tissue co-expression partners for FAM19A2 Gene

Primer Products

In Situ Assay Products

Orthologs for FAM19A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM19A2 35
  • 96.95 (n)
  • 100 (a)
FAM19A2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM19A2 35
  • 94.66 (n)
  • 100 (a)
FAM19A2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam19a2 35
  • 89.06 (n)
  • 96.95 (a)
Fam19a2 16
Fam19a2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100610890 35
  • 99.75 (n)
  • 100 (a)
FAM19A2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam19a2 35
  • 89.57 (n)
  • 96.95 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM19A2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM19A2 35
  • 88.46 (n)
  • 96.15 (a)
FAM19A2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM19A2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a2 35
  • 81.28 (n)
  • 87.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882435 35
  • 65.59 (n)
  • 71.77 (a)
FAM19A2 36
  • 83 (a)
OneToOne
Species with no ortholog for FAM19A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A2 Gene

ENSEMBL:
Gene Tree for FAM19A2 (if available)
TreeFam:
Gene Tree for FAM19A2 (if available)

Paralogs for FAM19A2 Gene

Paralogs for FAM19A2 Gene

(4) SIMAP similar genes for FAM19A2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM19A2: view

Variants for FAM19A2 Gene

Sequence variations from dbSNP and Humsavar for FAM19A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1920704 -- 62,003,279(+) AGCAA(C/T)GCCTT intron-variant
rs1920705 -- 61,977,062(-) ATAAC(A/T)TTTGA intron-variant
rs1920706 -- 61,960,588(-) AAATT(G/T)TAGTT intron-variant
rs1975494 -- 62,114,416(-) CCTAT(C/T)TGCAG intron-variant
rs1985820 -- 62,116,700(-) GGTCC(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A2 Gene

Variant ID Type Subtype PubMed ID
nsv520898 CNV Gain 19592680
nsv899151 CNV Loss 21882294
dgv291n67 CNV Loss 20364138
esv2673200 CNV Deletion 23128226
esv27603 CNV Loss 19812545
esv2673654 CNV Deletion 23128226
esv2421373 CNV Deletion 20811451
nsv442272 CNV CNV 18776908
nsv514672 CNV Complex 21397061
esv2745960 CNV Deletion 23290073
nsv516147 CNV Loss 19592680
esv2572564 CNV Deletion 19546169
esv2745961 CNV Deletion 23290073
dgv10e194 CNV Deletion 18987734
esv3192 CNV Deletion 18987735
esv2745962 CNV Deletion 23290073
esv1006216 CNV Deletion 20482838
esv1703729 CNV Deletion 17803354
nsv53083 CNV Loss 16902084
nsv737 CNV Insertion 18451855
nsv899152 CNV Gain 21882294
esv2633161 CNV Deletion 19546169
esv2028037 CNV Deletion 18987734
esv5428 CNV Deletion 18987735
esv2745964 CNV Deletion 23290073
esv23013 CNV Loss 19812545
esv6636 CNV Loss 19470904
esv2745965 CNV Deletion 23290073
nsv832435 CNV Gain 17160897
esv274206 CNV Insertion 20981092
esv268674 CNV Insertion 20981092

Variation tolerance for FAM19A2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM19A2 Gene

HapMap Linkage Disequilibrium report
FAM19A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A2 Gene

Disorders for FAM19A2 Gene

Relevant External Links for FAM19A2

Genetic Association Database (GAD)
FAM19A2
Human Genome Epidemiology (HuGE) Navigator
FAM19A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM19A2

No disorders were found for FAM19A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A2 Gene

Publications for FAM19A2 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 67
  2. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3
  3. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. (PMID: 24621683) Cho M.H. … Beaty T.H. (Lancet Respir Med 2014) 3
  4. Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. (PMID: 25112515) Parker M.M. … Beaty T.H. (Genet. Epidemiol. 2014) 3
  5. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. (PMID: 24388013) Ferreira M.A. … Hopper J.L. (J. Allergy Clin. Immunol. 2013) 3

Products for FAM19A2 Gene

Sources for FAM19A2 Gene

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