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Aliases for FAM19A1 Gene

Aliases for FAM19A1 Gene

  • Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A1 2 3
  • Chemokine-Like Protein TAFA-1 3 4
  • TAFA1 3 4
  • Protein FAM19A1 3
  • TAFA-1 3

External Ids for FAM19A1 Gene

Previous GeneCards Identifiers for FAM19A1 Gene

  • GC03P068139

Summaries for FAM19A1 Gene

Entrez Gene Summary for FAM19A1 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAM19A1 Gene

FAM19A1 (Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like) is a Protein Coding gene. Diseases associated with FAM19A1 include Retinitis Pigmentosa 11. An important paralog of this gene is FAM19A4.

Gene Wiki entry for FAM19A1 Gene

Additional gene information for FAM19A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A1 Gene

Genomics for FAM19A1 Gene

Regulatory Elements for FAM19A1 Gene

Enhancers for FAM19A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H068061 0.5 FANTOM5 17.8 +70.3 70330 0 ATF7 ATF2 FAM19A1 GC03P068140
GH03H067947 0.7 Ensembl ENCODE 4.9 -43.4 -43373 0 CTCF MNT FAM19A1 GC03M067897
GH03H068054 0.2 ENCODE 15.8 +63.8 63803 1 FAM19A1 GC03P068140
GH03H068275 0.3 FANTOM5 6.5 +283.9 283921 0 FAM19A1 GC03P068352 ENSG00000240568
GH03H068057 0.2 ENCODE 4.9 +66.3 66345 0 FAM19A1 GC03P068140
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM19A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A1 Gene

Chromosome:
3
Start:
67,991,592 bp from pter
End:
68,545,625 bp from pter
Size:
554,034 bases
Orientation:
Plus strand

Genomic View for FAM19A1 Gene

Genes around FAM19A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A1 Gene

Proteins for FAM19A1 Gene

  • Protein details for FAM19A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5A9-F19A1_HUMAN
    Recommended name:
    Protein FAM19A1
    Protein Accession:
    Q7Z5A9
    Secondary Accessions:
    • A8K0V3
    • Q8TCL8

    Protein attributes for FAM19A1 Gene

    Size:
    133 amino acids
    Molecular mass:
    14901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM19A1 Gene

Post-translational modifications for FAM19A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM19A1 Gene

Domains & Families for FAM19A1 Gene

Gene Families for FAM19A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM19A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM19A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5A9

UniProtKB/Swiss-Prot:

F19A1_HUMAN :
  • Belongs to the FAM19/TAFA family.
Family:
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A1: view

Function for FAM19A1 Gene

Phenotypes From GWAS Catalog for FAM19A1 Gene

Gene Ontology (GO) - Molecular Function for FAM19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM19A1: view
genes like me logo Genes that share phenotypes with FAM19A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM19A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A1 Gene

Localization for FAM19A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM19A1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with FAM19A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM19A1 Gene

Pathways & Interactions for FAM19A1 Gene

SuperPathways for FAM19A1 Gene

No Data Available

Interacting Proteins for FAM19A1 Gene

Gene Ontology (GO) - Biological Process for FAM19A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM19A1 Gene

Drugs & Compounds for FAM19A1 Gene

No Compound Related Data Available

Transcripts for FAM19A1 Gene

Unigene Clusters for FAM19A1 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM19A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A1 Gene

No ASD Table

Relevant External Links for FAM19A1 Gene

GeneLoc Exon Structure for
FAM19A1
ECgene alternative splicing isoforms for
FAM19A1

Expression for FAM19A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM19A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A1 Gene

This gene is overexpressed in Brain - Cortex (x10.5), Brain - Frontal Cortex (BA9) (x10.2), Brain - Anterior cingulate cortex (BA24) (x9.9), Brain - Hippocampus (x7.9), and Brain - Amygdala (x5.2).

Protein differential expression in normal tissues from HIPED for FAM19A1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A1 Gene



Protein tissue co-expression partners for FAM19A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM19A1 Gene:

FAM19A1

SOURCE GeneReport for Unigene cluster for FAM19A1 Gene:

Hs.655061

mRNA Expression by UniProt/SwissProt for FAM19A1 Gene:

Q7Z5A9-F19A1_HUMAN
Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for FAM19A1 Gene

  • Nervous system(4.3)
  • Kidney(4)
genes like me logo Genes that share expression patterns with FAM19A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM19A1 Gene

Orthologs for FAM19A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM19A1 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM19A1 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM19A1 33 34
  • 93.98 (n)
cow
(Bos Taurus)
Mammalia FAM19A1 33 34
  • 92.73 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM19A1 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam19a1 33 16 34
  • 90.98 (n)
chicken
(Gallus gallus)
Aves FAM19A1 33 34
  • 88.72 (n)
lizard
(Anolis carolinensis)
Reptilia FAM19A1 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a1 33
  • 83.46 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329998 33
  • 76.9 (n)
fam19a1 34
  • 73 (a)
OneToOne
Species where no ortholog for FAM19A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A1 Gene

ENSEMBL:
Gene Tree for FAM19A1 (if available)
TreeFam:
Gene Tree for FAM19A1 (if available)

Paralogs for FAM19A1 Gene

Paralogs for FAM19A1 Gene

(4) SIMAP similar genes for FAM19A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM19A1: view

Variants for FAM19A1 Gene

Sequence variations from dbSNP and Humsavar for FAM19A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000000515 -- 68,211,475(+) TCTGC(A/T)AGTCA intron-variant
rs1000003330 -- 68,008,663(+) GACCA(G/T)GCCAA intron-variant
rs1000005102 -- 68,512,161(+) CACGT(A/G)ATGCA intron-variant
rs1000023083 -- 68,518,709(+) TAGGG(A/G)GAATG intron-variant
rs1000023653 -- 68,068,370(+) ATAAG(A/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A1 Gene

Variant ID Type Subtype PubMed ID
dgv4770n100 CNV gain 25217958
esv1736654 CNV deletion 17803354
esv22648 CNV loss 19812545
esv2434953 CNV insertion 19546169
esv2667612 CNV deletion 23128226
esv2670431 CNV deletion 23128226
esv2752014 CNV gain 17911159
esv3399066 CNV insertion 20981092
esv3429381 CNV duplication 20981092
esv3568835 CNV loss 25503493
esv3596475 CNV loss 21293372
esv3596476 CNV loss 21293372
esv3596478 CNV loss 21293372
esv3596479 CNV loss 21293372
esv3596480 CNV gain 21293372
esv3596481 CNV loss 21293372
esv999186 CNV insertion 20482838
nsv1003158 CNV loss 25217958
nsv1003779 CNV loss 25217958
nsv1010992 CNV gain 25217958
nsv1013531 CNV gain 25217958
nsv1109520 CNV deletion 24896259
nsv1127965 CNV deletion 24896259
nsv1139122 CNV deletion 24896259
nsv1160944 CNV duplication 26073780
nsv3861 CNV insertion 18451855
nsv437864 CNV loss 16468122
nsv473043 CNV novel sequence insertion 20440878
nsv476547 CNV novel sequence insertion 20440878
nsv478283 CNV novel sequence insertion 20440878
nsv590562 CNV gain 21841781
nsv590563 CNV gain 21841781
nsv822119 CNV loss 20364138
nsv834721 CNV gain 17160897
nsv998582 CNV gain 25217958

Variation tolerance for FAM19A1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM19A1 Gene

Human Gene Mutation Database (HGMD)
FAM19A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM19A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A1 Gene

Disorders for FAM19A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM19A1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM19A1

Genetic Association Database (GAD)
FAM19A1
Human Genome Epidemiology (HuGE) Navigator
FAM19A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM19A1
genes like me logo Genes that share disorders with FAM19A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM19A1 Gene

Publications for FAM19A1 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4 60
  2. Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract. (PMID: 20664687) Lin HJ … Tsai FJ (Molecular vision 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for FAM19A1 Gene

Sources for FAM19A1 Gene

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