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Aliases for FAM19A1 Gene

Aliases for FAM19A1 Gene

  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A1 2 3 5
  • Chemokine-Like Protein TAFA-1 3 4
  • TAFA1 3 4
  • TAFA-1 3

External Ids for FAM19A1 Gene

Previous GeneCards Identifiers for FAM19A1 Gene

  • GC03P068139

Summaries for FAM19A1 Gene

Entrez Gene Summary for FAM19A1 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAM19A1 Gene

FAM19A1 (Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A1) is a Protein Coding gene. An important paralog of this gene is FAM19A3.

Gene Wiki entry for FAM19A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A1 Gene

Genomics for FAM19A1 Gene

Regulatory Elements for FAM19A1 Gene

Enhancers for FAM19A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM19A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM19A1 Gene

67,991,592 bp from pter
68,545,625 bp from pter
554,034 bases
Plus strand

Genomic View for FAM19A1 Gene

Genes around FAM19A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A1 Gene

Proteins for FAM19A1 Gene

  • Protein details for FAM19A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A1
    Protein Accession:
    Secondary Accessions:
    • A8K0V3
    • Q8TCL8

    Protein attributes for FAM19A1 Gene

    133 amino acids
    Molecular mass:
    14901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM19A1 Gene

Proteomics data for FAM19A1 Gene at MOPED

Post-translational modifications for FAM19A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM19A1 Gene

Antibody Products

  • R&D Systems Antibodies for FAM19A1 (TAFA1/FAM19A1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM19A1

No data available for DME Specific Peptides for FAM19A1 Gene

Domains & Families for FAM19A1 Gene

Protein Domains for FAM19A1 Gene


Suggested Antigen Peptide Sequences for FAM19A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A1: view

No data available for Gene Families for FAM19A1 Gene

Function for FAM19A1 Gene

genes like me logo Genes that share phenotypes with FAM19A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A1

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A1 Gene

Localization for FAM19A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A1 Gene


Subcellular locations from

Jensen Localization Image for FAM19A1 Gene COMPARTMENTS Subcellular localization image for FAM19A1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM19A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM19A1: view

Pathways & Interactions for FAM19A1 Gene

SuperPathways for FAM19A1 Gene

No Data Available

Interacting Proteins for FAM19A1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000417496 Q7Z5A9-F19A1_HUMAN for FAM19A1 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for FAM19A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM19A1 Gene

Drugs & Compounds for FAM19A1 Gene

No Compound Related Data Available

Transcripts for FAM19A1 Gene

Unigene Clusters for FAM19A1 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A1 Gene

No ASD Table

Relevant External Links for FAM19A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A1 Gene

mRNA expression in normal human tissues for FAM19A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A1 Gene

This gene is overexpressed in Brain - Cortex (x10.5), Brain - Frontal Cortex (BA9) (x10.2), Brain - Anterior cingulate cortex (BA24) (x9.9), Brain - Hippocampus (x7.9), and Brain - Amygdala (x5.2).

Protein differential expression in normal tissues from HIPED for FAM19A1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A1 Gene

SOURCE GeneReport for Unigene cluster for FAM19A1 Gene Hs.655061

mRNA Expression by UniProt/SwissProt for FAM19A1 Gene

Tissue specificity: Brain-specific.
genes like me logo Genes that share expression patterns with FAM19A1: view

Protein tissue co-expression partners for FAM19A1 Gene

- Elite partner

Primer Products

Orthologs for FAM19A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM19A1 35
  • 92.73 (n)
  • 98.5 (a)
FAM19A1 36
  • 97 (a)
(Canis familiaris)
Mammalia FAM19A1 35
  • 93.98 (n)
  • 99.25 (a)
FAM19A1 36
  • 89 (a)
(Mus musculus)
Mammalia Fam19a1 35
  • 90.98 (n)
  • 99.25 (a)
Fam19a1 16
Fam19a1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia FAM19A1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FAM19A1 36
  • 94 (a)
(Pan troglodytes)
Mammalia FAM19A1 36
  • 100 (a)
(Gallus gallus)
Aves FAM19A1 35
  • 88.72 (n)
  • 96.99 (a)
FAM19A1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia FAM19A1 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a1 35
  • 83.46 (n)
  • 92.48 (a)
(Danio rerio)
Actinopterygii LOC100329998 35
  • 76.9 (n)
  • 87.4 (a)
fam19a1 36
  • 73 (a)
Species with no ortholog for FAM19A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A1 Gene

Gene Tree for FAM19A1 (if available)
Gene Tree for FAM19A1 (if available)

Paralogs for FAM19A1 Gene

Paralogs for FAM19A1 Gene

(4) SIMAP similar genes for FAM19A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM19A1: view

Variants for FAM19A1 Gene

Sequence variations from dbSNP and Humsavar for FAM19A1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs63108 -- 68,358,730(+) AAACT(C/T)GTAGC intron-variant
rs724760 -- 68,013,951(+) CTCTG(A/G)GTCTG intron-variant
rs169023 -- 68,348,650(+) TGAAA(C/T)GCCAA intron-variant
rs171892 -- 68,381,470(+) ctcct(C/T)gaaga intron-variant
rs171893 -- 68,377,770(-) ccaaa(C/T)cacga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A1 Gene

Variant ID Type Subtype PubMed ID
nsv876924 CNV Loss 21882294
esv999186 CNV Insertion 20482838
esv2667612 CNV Deletion 23128226
nsv3861 CNV Insertion 18451855
nsv437864 CNV Loss 16468122
esv2752014 CNV Gain 17911159
esv2434953 CNV Insertion 19546169
nsv876925 CNV Loss 21882294
nsv876926 CNV Gain 21882294
nsv822119 CNV Loss 20364138
esv2670431 CNV Deletion 23128226
esv22648 CNV Loss 19812545
nsv834721 CNV Gain 17160897
esv1736654 CNV Deletion 17803354
nsv876927 CNV Loss 21882294
nsv876928 CNV Gain 21882294
nsv876929 CNV Loss 21882294

Variation tolerance for FAM19A1 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM19A1 Gene

Disorders for FAM19A1 Gene

Relevant External Links for FAM19A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM19A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A1 Gene

Publications for FAM19A1 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y. … Rupp F. (Genomics 2004) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract. (PMID: 20664687) Lin H.J. … Tsai F.J. (Mol. Vis. 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for FAM19A1 Gene

Sources for FAM19A1 Gene