Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM199X Gene

Aliases for FAM199X Gene

  • Family With Sequence Similarity 199, X-Linked 2 3 5
  • CXorf39 3 4
  • Chromosome X Open Reading Frame 39 2
  • Protein FAM199X 3

External Ids for FAM199X Gene

Previous HGNC Symbols for FAM199X Gene

  • CXorf39

Previous GeneCards Identifiers for FAM199X Gene

  • GC0XP103411
  • GC0XP093038

Summaries for FAM199X Gene

GeneCards Summary for FAM199X Gene

FAM199X (Family With Sequence Similarity 199, X-Linked) is a Protein Coding gene.

Additional gene information for FAM199X Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM199X Gene

Genomics for FAM199X Gene

Regulatory Elements for FAM199X Gene

Enhancers for FAM199X Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH104108 1.1 Ensembl ENCODE 11.7 -55.4 -55426 5.5 CTCF PKNOX1 MXI1 KLF1 ZIC2 RAD21 ZFHX2 GLIS2 ZBTB48 ZNF366 H2BFM FAM199X SLC25A53 ZCCHC18 LOC101060236
GH0XH104135 0.9 Ensembl ENCODE 9 -30.1 -30099 1.6 SCRT1 CTCF ZNF654 TRIM22 CEBPG REST RAD21 YY1 SCRT2 ZNF143 FAM199X LOC286437 SLC25A53
GH0XH103917 0.8 ENCODE 8.3 -247.4 -247382 2.8 CTCF PKNOX1 MXI1 SIN3A MAX E2F1 ZFHX2 GLIS2 POLR2A SCRT2 H2BFM ENSG00000235946 SLC25A53 FAM199X RAB9B TMSB15B LOC100128594
GH0XH103962 0.7 ENCODE 8.8 -203.6 -203631 1.7 GTF2F1 MAZ ESRRA NFIB L3MBTL2 SP2 ELF1 ZBTB8A RFX5 ZNF217 FAM199X SLC25A53 DPPA3P1 H2BFXP
GH0XH104165 1 ENCODE 0.7 +0.2 174 2.8 ATF1 ARNT ZFP64 SIN3A ZNF2 ZNF121 GLIS2 ELK1 ZNF143 ZNF207 SLC25A53 FAM199X GC0XM104199
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM199X on UCSC Golden Path with GeneCards custom track

Promoters for FAM199X Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247756 725 2801 ATF1 ARNT ZFP64 SIN3A ZNF2 ZNF121 GLIS2 ELK1 ZNF143 ZNF207

Genomic Locations for FAM199X Gene

Genomic Locations for FAM199X Gene
chrX:104,166,475-104,195,902
(GRCh38/hg38)
Size:
29,428 bases
Orientation:
Plus strand
chrX:103,411,156-103,440,583
(GRCh37/hg19)

Genomic View for FAM199X Gene

Genes around FAM199X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM199X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM199X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM199X Gene

Proteins for FAM199X Gene

  • Protein details for FAM199X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEV8-F199X_HUMAN
    Recommended name:
    Protein FAM199X
    Protein Accession:
    Q6PEV8
    Secondary Accessions:
    • Q8WVP6
    • Q96AV3

    Protein attributes for FAM199X Gene

    Size:
    388 amino acids
    Molecular mass:
    42801 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM199X Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM199X Gene

Post-translational modifications for FAM199X Gene

  • Ubiquitination at isoforms=2199
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM199X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM199X Gene

Domains & Families for FAM199X Gene

Gene Families for FAM199X Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM199X Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM199X Gene

Graphical View of Domain Structure for InterPro Entry

Q6PEV8

UniProtKB/Swiss-Prot:

F199X_HUMAN :
  • Belongs to the FAM199 family.
Family:
  • Belongs to the FAM199 family.
genes like me logo Genes that share domains with FAM199X: view

Function for FAM199X Gene

Gene Ontology (GO) - Molecular Function for FAM199X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27705803
genes like me logo Genes that share ontologies with FAM199X: view
genes like me logo Genes that share phenotypes with FAM199X: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM199X Gene

Localization for FAM199X Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM199X gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM199X Gene

Pathways & Interactions for FAM199X Gene

SuperPathways for FAM199X Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM199X Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM199X Gene

Drugs & Compounds for FAM199X Gene

No Compound Related Data Available

Transcripts for FAM199X Gene

mRNA/cDNA for FAM199X Gene

Unigene Clusters for FAM199X Gene

Family with sequence similarity 199, X-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM199X Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for FAM199X Gene

GeneLoc Exon Structure for
FAM199X
ECgene alternative splicing isoforms for
FAM199X

Expression for FAM199X Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM199X Gene

Protein differential expression in normal tissues from HIPED for FAM199X Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM199X Gene



Protein tissue co-expression partners for FAM199X Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM199X Gene:

FAM199X

SOURCE GeneReport for Unigene cluster for FAM199X Gene:

Hs.496535

Evidence on tissue expression from TISSUES for FAM199X Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM199X: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM199X Gene

Orthologs for FAM199X Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM199X Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM199X 33 34
  • 99.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM199X 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM199X 33 34
  • 95.88 (n)
cow
(Bos Taurus)
Mammalia FAM199X 33 34
  • 95.45 (n)
mouse
(Mus musculus)
Mammalia Fam199x 33 16 34
  • 92.87 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM199X 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679168 33
  • 91.71 (n)
chicken
(Gallus gallus)
Aves FAM199X 33 34
  • 82.48 (n)
lizard
(Anolis carolinensis)
Reptilia FAM199X 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam199x 33
  • 79.42 (n)
Str.13994 33
zebrafish
(Danio rerio)
Actinopterygii fam199x 33 34
  • 73.79 (n)
Species where no ortholog for FAM199X was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM199X Gene

ENSEMBL:
Gene Tree for FAM199X (if available)
TreeFam:
Gene Tree for FAM199X (if available)

Paralogs for FAM199X Gene

(1) SIMAP similar genes for FAM199X Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM199X: view

No data available for Paralogs for FAM199X Gene

Variants for FAM199X Gene

Sequence variations from dbSNP and Humsavar for FAM199X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000174740 -- 104,164,540(+) CTCCG(C/G)TTTAA intron-variant, upstream-variant-2KB
rs1000358771 -- 104,190,497(+) TTTAA(A/G)TGATG utr-variant-3-prime
rs1000476025 -- 104,161,609(+) AGGCC(A/G)AGGTG intron-variant
rs1000536481 -- 104,162,691(+) TTTCA(A/T)TAAGT intron-variant
rs1000708333 -- 104,188,744(+) AAAAA(G/T)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM199X Gene

Variant ID Type Subtype PubMed ID
esv2758880 CNV gain 17122850

Variation tolerance for FAM199X Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM199X Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM199X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM199X Gene

Disorders for FAM199X Gene

Relevant External Links for FAM199X

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM199X

No disorders were found for FAM199X Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM199X Gene

Publications for FAM199X Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FAM199X Gene

Sources for FAM199X Gene

Content
Loading form....