Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM198B Gene

Aliases for FAM198B Gene

  • Family With Sequence Similarity 198 Member B 2 3 5
  • Expressed In Nerve And Epithelium During Development 3 4
  • Family With Sequence Similarity 198, Member B 2 3
  • C4orf18 3 4
  • Chromosome 4 Open Reading Frame 18 2
  • AD021 3
  • AD036 3
  • ENED 4

External Ids for FAM198B Gene

Previous HGNC Symbols for FAM198B Gene

  • C4orf18

Previous GeneCards Identifiers for FAM198B Gene

  • GC04M159266
  • GC04M159048
  • GC04M154797

Summaries for FAM198B Gene

GeneCards Summary for FAM198B Gene

FAM198B (Family With Sequence Similarity 198 Member B) is a Protein Coding gene. An important paralog of this gene is FAM198A.

Gene Wiki entry for FAM198B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198B Gene

Genomics for FAM198B Gene

Genomic Location for FAM198B Gene

Chromosome:
4
Start:
158,124,474 bp from pter
End:
158,173,318 bp from pter
Size:
48,845 bases
Orientation:
Minus strand

Genomic View for FAM198B Gene

Genes around FAM198B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM198B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM198B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198B Gene

No data available for Regulatory Elements for FAM198B Gene

Proteins for FAM198B Gene

  • Protein details for FAM198B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWH4-F198B_HUMAN
    Recommended name:
    Protein FAM198B
    Protein Accession:
    Q6UWH4
    Secondary Accessions:
    • Q498Z3
    • Q6IAF9
    • Q6ZMF2
    • Q86XL0

    Protein attributes for FAM198B Gene

    Size:
    519 amino acids
    Molecular mass:
    57552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM198B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM198B Gene

Proteomics data for FAM198B Gene at MOPED

Post-translational modifications for FAM198B Gene

  • Glycosylation at Ser 137 and Asn 289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM198B Gene

Domains & Families for FAM198B Gene

Protein Domains for FAM198B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM198B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWH4

UniProtKB/Swiss-Prot:

F198B_HUMAN :
  • Belongs to the FAM198 family.
Family:
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198B: view

No data available for Gene Families for FAM198B Gene

Function for FAM198B Gene

Phenotypes for FAM198B Gene

genes like me logo Genes that share phenotypes with FAM198B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM198B

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM198B Gene

Localization for FAM198B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM198B Gene COMPARTMENTS Subcellular localization image for FAM198B gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM198B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM198B: view

Pathways & Interactions for FAM198B Gene

SuperPathways for FAM198B Gene

No Data Available

Interacting Proteins for FAM198B Gene

Gene Ontology (GO) - Biological Process for FAM198B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM198B Gene

Drugs & Compounds for FAM198B Gene

No Compound Related Data Available

Transcripts for FAM198B Gene

Unigene Clusters for FAM198B Gene

Family with sequence similarity 198, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for FAM198B Gene

GeneLoc Exon Structure for
FAM198B
ECgene alternative splicing isoforms for
FAM198B

Expression for FAM198B Gene

mRNA expression in normal human tissues for FAM198B Gene

mRNA differential expression in normal tissues according to GTEx for FAM198B Gene

This gene is overexpressed in Adrenal Gland (x7.9).

Protein differential expression in normal tissues from HIPED for FAM198B Gene

This gene is overexpressed in Fetal testis (41.9), Liver (10.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM198B Gene



SOURCE GeneReport for Unigene cluster for FAM198B Gene Hs.567498

genes like me logo Genes that share expression patterns with FAM198B: view

Protein tissue co-expression partners for FAM198B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM198B Gene

Orthologs for FAM198B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Fam198b 35
  • 81.23 (n)
  • 80.39 (a)
Fam198b 16
Fam198b 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM198B 35
  • 99.81 (n)
  • 99.62 (a)
FAM198B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam198b 35
  • 80.74 (n)
  • 79.57 (a)
cow
(Bos Taurus)
Mammalia FAM198B 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM198B 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM198B 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM198B 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM198B 35
  • 65.68 (n)
  • 63.04 (a)
FAM198B 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM198B 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam198b 35
  • 58.93 (n)
  • 55.85 (a)
zebrafish
(Danio rerio)
Actinopterygii fam198b 35
  • 55.51 (n)
  • 52.49 (a)
fam198b 36
  • 48 (a)
OneToOne
Species with no ortholog for FAM198B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198B Gene

ENSEMBL:
Gene Tree for FAM198B (if available)
TreeFam:
Gene Tree for FAM198B (if available)

Paralogs for FAM198B Gene

Paralogs for FAM198B Gene

(2) SIMAP similar genes for FAM198B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM198B: view

Variants for FAM198B Gene

Sequence variations from dbSNP and Humsavar for FAM198B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17857283 - 158,130,844(+) GAAAC(A/C/T)CTTGT reference, missense
rs7384 -- 158,124,691(-) ATCAT(C/T)ATATT utr-variant-3-prime
rs8370 -- 158,124,814(-) TGCTT(C/T)TGTAG utr-variant-3-prime
rs14202 -- 158,125,126(+) AAAGC(C/T)TGGCC utr-variant-3-prime
rs1544089 -- 158,173,925(+) CACAA(C/T)AGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM198B Gene

Variant ID Type Subtype PubMed ID
nsv880293 CNV Loss 21882294
esv272057 CNV Insertion 20981092

Variation tolerance for FAM198B Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM198B Gene

HapMap Linkage Disequilibrium report
FAM198B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198B Gene

Disorders for FAM198B Gene

Relevant External Links for FAM198B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM198B

No disorders were found for FAM198B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM198B Gene

Publications for FAM198B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for FAM198B Gene

Sources for FAM198B Gene

Back to Top

Content