FAM198B Gene
protein-coding GIFtS : 41
GCID: GC04 M159048
family with sequence similarity 198, member B (Previous name: chromosome 4 open reading frame 18 ) (Previous symbol: C4orf18 )
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Aliasesfor FAM198B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Family With Sequence Similarity 198, Member B 1 2 Chromosome 4 Open Reading Frame 181 C4orf181 2 3 AD0362 Expressed In Nerve And Epithelium During Development2 3 Protein FAM198B2 DKFZp434L1421 ENED3 FLJ381551
Export aliases for FAM198B gene to outside databases Previous GC identifers: GC04M159266 GC04M154797
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Summariesfor FAM198B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for FAM198B (C4orf18)
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Genomic Viewsfor FAM198B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for FAM198B Other transcription factors Search SABiosciences Chromatin IP Primers for FAM198B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM198B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q32.1 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32.1 FAM198B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M159048: view genomic region
(about GC identifiers )
Start:
159,045,626 bp from pter
End:
159,094,470 bp from pter
Size:
48,845 bases
Orientation:
minus strand
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Proteinsfor FAM198B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: F198B_HUMAN, Q6UWH4 (See
protein sequence )Recommended Name: Protein FAM198B Size : 519 amino acids; 57552 Da
Subcellular location : Golgi apparatus membrane; Single-pass type II membrane protein (Probable)
Secondary accessions : Q498Z3 Q6IAF9 Q6ZMF2 Q86XL0Alternative splicing : 3 isoforms : Q6UWH4-1 Q6UWH4-2 Q6UWH4-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FAM198B: NX_Q6UWH4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6UWH4 FAM198B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001026870.2 NP_001121896.1 NP_057697.2 ENSEMBL proteins: ENSP00000465976 ENSP00000296530 ENSP00000377396 ENSP00000466811 ENSP00000465491 ENSP00000468648 ENSP00000466873 ENSP00000466595 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
FAM198B for ontologies About GeneDecksing FAM198B Antibody Products: Assay Products for FAM198B:
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Protein
Domains / Familiesfor FAM198B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q6UWH4
UniProtKB/Swiss-Prot: F198B_HUMAN, Q6UWH4 Similarity : Belongs to the FAM198 family
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Functionfor FAM198B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): FAM198B (NM_016613 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM198B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM198B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM198B
1 GenomeRNAi human phenotype for FAM198B :Animal Models: Mouse knock-out Fam198b tm1Lex for FAM198B 1 MGI phenotypic allele for Fam198b (no phenotypes)
FAM198B for phenotypes About GeneDecksing
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Pathways & Interactionsfor FAM198B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM198B
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Drugs & Compoundsfor FAM198B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FAM198B Search CenterWatch for drugs/clinical trials and news about FAM198B / F198B
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Transcriptsfor FAM198B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FAM198B gene (3 alternative transcripts): NM_001031700.2 NM_001128424.1 NM_016613.6 Unigene Cluster for FAM198B:
Family with sequence similarity 198, member B Hs.567498 [show with all ESTs ] Unigene Representative Sequence: NM_016613 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000585682 ENST00000296530 (uc003ipp.4 ) ENST00000393807 (uc003ipq.4 uc003ipr.4 uc003ips.3 )ENST00000590648 ENST00000592586 ENST00000593260 ENST00000589306 ENST00000592057 ENST00000587787 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): FAM198B (NM_016613 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM198B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FAM198B
Additional cDNA sequence: AF223468.1 AF260333.1 AK095474.1 AK172805.1 AK304112.1 AK315768.1 AL832589.1 AL834177.1 AY358785.1 BC017701.1 BC043193.2 BC045710.1 BC100016.1 CR457196.1
12 DOTS entries : DT.86836149 DT.100792597
DT.91704726 DT.318315 DT.97774129 DT.100758763 DT.91939711 DT.91704742 DT.95274719 DT.99936244 DT.101976699 DT.87015919 24/233 AceView cDNA sequences (see all 233 ):
BM806946 CB160158 AV708836 Z39445 AA228114 AI016882 BX371744 BM555764 BM728724 AA055186 AA613890 BM564470 AI251865 AI280560 F04712 CR622045 CB120439 AA463361 AV709675 BM823133 AW516308 CR457196 BG682304 CN484354 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FAM198B (see all 6 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c SP1 :     -     -     -   -   -             SP2 :     -     -   -   -   -               SP3 :         -   -   -   -               SP4 :                             SP5 :               -              
ECgene alternative splicing isoforms for FAM198B
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Expression for FAM198B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FAM198B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAAAAGCTTA
About this image FAM198B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FAM198B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FAM198B SOURCE GeneReport for Unigene cluster: Hs.567498 SABiosciences Custom PCR Arrays for FAM198B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM198BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FAM198B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM198B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM198B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM198B
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Orthologsfor FAM198B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for FAM198B gene from 4/8 species (see all 8 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Fam198b1 , 5
family with sequence similarity 198, member B1, 5
81.01(n) 1 79.84(a) 1
 
3 (35.13 cM) 5 68659 1 NM_133187.3 1 NP_573450.2 1 79884533 5
chicken (Gallus gallus)
Aves
FAM198B1
family with sequence similarity 198, member B
65.68(n) 63.04(a)
 
422413 XM_420382.3 XP_420382.3
lizard (Anolis carolinensis)
Reptilia
FAM198B6
--
57(a)
1 ↔ 1
5(128515806-128536975)
zebrafish (Danio rerio)
Actinopterygii
fam198b6
family with sequence similarity 198, member B
48(a)
1 ↔ 1
14(37097650-37103245)
ENSEMBL Gene Tree for FAM198B (if available)TreeFam Gene Tree for FAM198B (if available)
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Paralogsfor FAM198B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FAM198B gene FAM198A 2 2 SIMAP similar genes for FAM198B using alignment to 5 protein entries: F198B_HUMAN (see all proteins ):AD021 FAM198A
FAM198B for paralogs About GeneDecksing
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Genomic Variantsfor FAM198B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM198B
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Disorders
/ Diseasesfor FAM198B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor FAM198B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FAM198B gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with FAM198B) Utopia : connect your pdf to the dynamic world of online information
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614) 1 , 2 Simpson J.C.... Wiemann S. (2000) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The LIFEdb database in 2006. (PubMed id 16381901) 1 Mehrle A....Wiemann S. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 1 Wiemann S....Poustka A. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 Wiemann S.... Poustka A. (2001)
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External Searches for FAM198B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FAM198B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FAM198B gene
(According to HUGE )
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Specialized Databases showing FAM198B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FAM198B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FAM198B gene: Search GeneIP for patents involving FAM198B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FAM198B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FAM198B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FAM198B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FAM198B OriGene Protein Over-expression Lysate for FAM198B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FAM198B OriGene 3'-UTR Clone for FAM198B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FAM198B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FAM198B OriGene Custom Protein Services for FAM198B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM198B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FAM198B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM198B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FAM198B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FAM198B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FAM198B
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FAM198B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM198B
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Aliases for FAM198B
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Expression for FAM198B
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