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Aliases for FAM198B Gene

Aliases for FAM198B Gene

  • Family With Sequence Similarity 198, Member B 2 3
  • Expressed In Nerve And Epithelium During Development 3 4
  • C4orf18 3 4
  • Chromosome 4 Open Reading Frame 18 2
  • Protein FAM198B 3
  • AD021 3
  • AD036 3
  • ENED 4

External Ids for FAM198B Gene

Previous HGNC Symbols for FAM198B Gene

  • C4orf18

Previous GeneCards Identifiers for FAM198B Gene

  • GC04M159266
  • GC04M159048
  • GC04M154797

Summaries for FAM198B Gene

GeneCards Summary for FAM198B Gene

FAM198B (Family With Sequence Similarity 198, Member B) is a Protein Coding gene. An important paralog of this gene is FAM198A.

Gene Wiki entry for FAM198B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198B Gene

Genomics for FAM198B Gene

Genomic Location for FAM198B Gene

158,124,474 bp from pter
158,173,318 bp from pter
48,845 bases
Minus strand

Genomic View for FAM198B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM198B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198B Gene

No data available for Regulatory Elements for FAM198B Gene

Proteins for FAM198B Gene

  • Protein details for FAM198B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM198B
    Protein Accession:
    Secondary Accessions:
    • Q498Z3
    • Q6IAF9
    • Q6ZMF2
    • Q86XL0

    Protein attributes for FAM198B Gene

    519 amino acids
    Molecular mass:
    57552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM198B Gene


neXtProt entry for FAM198B Gene

Proteomics data for FAM198B Gene at MOPED

Post-translational modifications for FAM198B Gene

  • Glycosylation at Ser137, Ser149, and Asn289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM198B Gene

Domains for FAM198B Gene

Protein Domains for FAM198B Gene


Suggested Antigen Peptide Sequences for FAM198B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6UWH4
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198B: view

No data available for Gene Families for FAM198B Gene

Function for FAM198B Gene

Phenotypes for FAM198B Gene

GenomeRNAi human phenotypes for FAM198B:
genes like me logo Genes that share phenotypes with FAM198B: view

Animal Model Products

CRISPR Products

miRNA for FAM198B Gene

miRTarBase miRNAs that target FAM198B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM198B Gene

Localization for FAM198B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for FAM198B Gene COMPARTMENTS Subcellular localization image for FAM198B gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM198B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM198B: view

Pathways for FAM198B Gene

SuperPathways for FAM198B Gene

No Data Available

Interacting Proteins for FAM198B Gene

Gene Ontology (GO) - Biological Process for FAM198B Gene


No data available for Pathways by source for FAM198B Gene

Transcripts for FAM198B Gene

Unigene Clusters for FAM198B Gene

Family with sequence similarity 198, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM198B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP5: -
SP6: - -

Relevant External Links for FAM198B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM198B Gene

mRNA expression in normal human tissues for FAM198B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM198B Gene

This gene is overexpressed in Adrenal Gland (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FAM198B Gene

SOURCE GeneReport for Unigene cluster for FAM198B Gene Hs.567498

genes like me logo Genes that share expressions with FAM198B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM198B Gene

Orthologs for FAM198B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM198B 35
  • 99.81 (n)
  • 99.62 (a)
FAM198B 36
  • 100 (a)
(Bos Taurus)
Mammalia FAM198B 36
  • 70 (a)
(Canis familiaris)
Mammalia FAM198B 36
  • 74 (a)
(Mus musculus)
Mammalia Fam198b 35
  • 81.23 (n)
  • 80.39 (a)
Fam198b 16
Fam198b 36
  • 80 (a)
(Monodelphis domestica)
Mammalia FAM198B 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia FAM198B 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Fam198b 35
  • 80.74 (n)
  • 79.57 (a)
(Gallus gallus)
Aves FAM198B 35
  • 65.68 (n)
  • 63.04 (a)
FAM198B 36
  • 59 (a)
(Anolis carolinensis)
Reptilia FAM198B 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam198b 35
  • 58.93 (n)
  • 55.85 (a)
(Danio rerio)
Actinopterygii fam198b 35
  • 55.51 (n)
  • 52.49 (a)
fam198b 36
  • 48 (a)
Species with no ortholog for FAM198B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198B Gene

Gene Tree for FAM198B (if available)
Gene Tree for FAM198B (if available)

Paralogs for FAM198B Gene

Paralogs for FAM198B Gene

Selected SIMAP similar genes for FAM198B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM198B: view

Variants for FAM198B Gene

Sequence variations from dbSNP and Humsavar for FAM198B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7384 -- 158,124,691(-) ATCAT(C/T)ATATT utr-variant-3-prime
rs8370 -- 158,124,814(-) TGCTT(C/T)TGTAG utr-variant-3-prime
rs14202 -- 158,125,126(+) AAAGC(C/T)TGGCC utr-variant-3-prime
rs1544089 -- 158,173,925(+) CACAA(C/T)AGGGA upstream-variant-2KB
rs2245735 -- 158,127,868(-) TTGAG(C/T)GTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM198B Gene

Variant ID Type Subtype PubMed ID
nsv880293 CNV Loss 21882294
esv272057 CNV Insertion 20981092

Relevant External Links for FAM198B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198B Gene

Disorders for FAM198B Gene

No disorders were found for FAM198B Gene.

No data available for UniProtKB/Swiss-Prot for FAM198B Gene

Publications for FAM198B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for FAM198B Gene

Sources for FAM198B Gene

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