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Aliases for FAM198B Gene

Aliases for FAM198B Gene

  • Family With Sequence Similarity 198 Member B 2 3 5
  • Expressed In Nerve And Epithelium During Development 2 3 4
  • C4orf18 3 4
  • ENED 3 4
  • Family With Sequence Similarity 198, Member B 2
  • Chromosome 4 Open Reading Frame 18 2
  • Protein FAM198B 3
  • AD021 3
  • AD036 3

External Ids for FAM198B Gene

Previous HGNC Symbols for FAM198B Gene

  • C4orf18

Previous GeneCards Identifiers for FAM198B Gene

  • GC04M159266
  • GC04M159048
  • GC04M154797

Summaries for FAM198B Gene

GeneCards Summary for FAM198B Gene

FAM198B (Family With Sequence Similarity 198 Member B) is a Protein Coding gene. An important paralog of this gene is FAM198A.

Gene Wiki entry for FAM198B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198B Gene

Genomics for FAM198B Gene

Regulatory Elements for FAM198B Gene

Enhancers for FAM198B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G158032 1.3 FANTOM5 Ensembl ENCODE 6.2 +139.7 139723 1.9 TFAP4 SMAD5 JUN RAD21 JUND POLR2A GATA2 CEBPA HNF4G HNF4A FAM198B ENSG00000248429 LOC105377509 ENSG00000250475
GH04G158006 1.3 FANTOM5 Ensembl ENCODE 6 +165.0 164965 4.5 HDAC1 IRF2 PKNOX1 JUN TAL1 CEBPG BMI1 YY1 ZNF507 FOSL1 ENSG00000248429 TMEM144 FAM198B ENSG00000250475 LOC105377509
GH04G158168 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.7 +1.4 1449 6.7 ELF3 TBP ATF1 ARID4B SIN3A DMAP1 THRB ZNF48 RAD21 GATA2 ENSG00000248429 TMEM144 FAM198B
GH04G158176 1 Ensembl ENCODE dbSUPER 0.7 -3.0 -2983 0.2 GATA3 JUND NFIB FOS DPF2 FAM198B LOC101928007
GH04G158181 1 dbSUPER 0.4 -8.9 -8941 0.6 ATF1 PKNOX1 ARID4B SIN3A ZNF48 YY1 GLIS2 ELK1 ZNF207 ZNF263 LOC101928007 FAM198B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM198B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM198B Gene

Chromosome:
4
Start:
158,124,474 bp from pter
End:
158,173,318 bp from pter
Size:
48,845 bases
Orientation:
Minus strand

Genomic View for FAM198B Gene

Genes around FAM198B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM198B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM198B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198B Gene

Proteins for FAM198B Gene

  • Protein details for FAM198B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWH4-F198B_HUMAN
    Recommended name:
    Protein FAM198B
    Protein Accession:
    Q6UWH4
    Secondary Accessions:
    • Q498Z3
    • Q6IAF9
    • Q6ZMF2
    • Q86XL0

    Protein attributes for FAM198B Gene

    Size:
    519 amino acids
    Molecular mass:
    57552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM198B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM198B Gene

Post-translational modifications for FAM198B Gene

  • Glycosylation at Ser137 and Asn289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM198B Gene

Domains & Families for FAM198B Gene

Protein Domains for FAM198B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM198B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWH4

UniProtKB/Swiss-Prot:

F198B_HUMAN :
  • Belongs to the FAM198 family.
Family:
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198B: view

No data available for Gene Families for FAM198B Gene

Function for FAM198B Gene

genes like me logo Genes that share phenotypes with FAM198B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM198B

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM198B Gene

Localization for FAM198B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM198B gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM198B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM198B: view

Pathways & Interactions for FAM198B Gene

SuperPathways for FAM198B Gene

No Data Available

Interacting Proteins for FAM198B Gene

Gene Ontology (GO) - Biological Process for FAM198B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM198B Gene

Drugs & Compounds for FAM198B Gene

No Compound Related Data Available

Transcripts for FAM198B Gene

Unigene Clusters for FAM198B Gene

Family with sequence similarity 198, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for FAM198B Gene

GeneLoc Exon Structure for
FAM198B
ECgene alternative splicing isoforms for
FAM198B

Expression for FAM198B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM198B Gene

mRNA differential expression in normal tissues according to GTEx for FAM198B Gene

This gene is overexpressed in Adrenal Gland (x7.9).

Protein differential expression in normal tissues from HIPED for FAM198B Gene

This gene is overexpressed in Fetal testis (41.9), Liver (10.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM198B Gene



Protein tissue co-expression partners for FAM198B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM198B Gene:

FAM198B

SOURCE GeneReport for Unigene cluster for FAM198B Gene:

Hs.567498

Evidence on tissue expression from TISSUES for FAM198B Gene

  • Nervous system(4.7)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with FAM198B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM198B Gene

Orthologs for FAM198B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM198B 34 35
  • 99.81 (n)
mouse
(Mus musculus)
Mammalia Fam198b 34 16 35
  • 81.23 (n)
rat
(Rattus norvegicus)
Mammalia Fam198b 34
  • 80.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM198B 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM198B 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM198B 35
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM198B 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM198B 34 35
  • 65.68 (n)
lizard
(Anolis carolinensis)
Reptilia FAM198B 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam198b 34
  • 58.93 (n)
zebrafish
(Danio rerio)
Actinopterygii fam198b 34 35
  • 55.51 (n)
Species where no ortholog for FAM198B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198B Gene

ENSEMBL:
Gene Tree for FAM198B (if available)
TreeFam:
Gene Tree for FAM198B (if available)

Paralogs for FAM198B Gene

Paralogs for FAM198B Gene

(2) SIMAP similar genes for FAM198B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM198B: view

Variants for FAM198B Gene

Sequence variations from dbSNP and Humsavar for FAM198B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000039515 -- 158,173,906(+) CACTG(C/T)CCCCT upstream-variant-2KB
rs1000057714 -- 158,129,942(+) AGCTG(A/G)GTTCT intron-variant
rs1000108088 -- 158,129,649(+) CCACA(C/G)TTATT intron-variant
rs1000161623 -- 158,125,874(+) TCTAC(A/G)ATTGT utr-variant-3-prime
rs1000177518 -- 158,160,328(+) ATAGG(A/C)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM198B Gene

Variant ID Type Subtype PubMed ID
esv3307783 CNV mobile element insertion 20981092
esv3388151 CNV insertion 20981092
nsv1021067 CNV gain 25217958

Variation tolerance for FAM198B Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM198B Gene

Human Gene Mutation Database (HGMD)
FAM198B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM198B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198B Gene

Disorders for FAM198B Gene

Relevant External Links for FAM198B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM198B

No disorders were found for FAM198B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM198B Gene

Publications for FAM198B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3 4 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for FAM198B Gene

Sources for FAM198B Gene

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