Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM198A Gene

Aliases for FAM198A Gene

  • Family With Sequence Similarity 198 Member A 2 3 5
  • Family With Sequence Similarity 198, Member A 2 3
  • C3orf41 3 4
  • Chromosome 3 Open Reading Frame 41 2

External Ids for FAM198A Gene

Previous HGNC Symbols for FAM198A Gene

  • C3orf41

Previous GeneCards Identifiers for FAM198A Gene

  • GC03P042998

Summaries for FAM198A Gene

GeneCards Summary for FAM198A Gene

FAM198A (Family With Sequence Similarity 198 Member A) is a Protein Coding gene. An important paralog of this gene is FAM198B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198A Gene

Genomics for FAM198A Gene

Regulatory Elements for FAM198A Gene

Promoters for FAM198A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM198A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM198A Gene

Chromosome:
3
Start:
42,979,267 bp from pter
End:
43,060,211 bp from pter
Size:
80,945 bases
Orientation:
Plus strand

Genomic View for FAM198A Gene

Genes around FAM198A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM198A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM198A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198A Gene

Proteins for FAM198A Gene

  • Protein details for FAM198A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFP1-F198A_HUMAN
    Recommended name:
    Protein FAM198A
    Protein Accession:
    Q9UFP1
    Secondary Accessions:
    • B3KR48

    Protein attributes for FAM198A Gene

    Size:
    575 amino acids
    Molecular mass:
    63637 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM198A Gene

Proteomics data for FAM198A Gene at MOPED

Post-translational modifications for FAM198A Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Thr 123, Thr 192, and Asn 566
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM198A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM198A Gene

Domains & Families for FAM198A Gene

Protein Domains for FAM198A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM198A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFP1

UniProtKB/Swiss-Prot:

F198A_HUMAN :
  • Belongs to the FAM198 family.
Family:
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198A: view

No data available for Gene Families for FAM198A Gene

Function for FAM198A Gene

Phenotypes for FAM198A Gene

genes like me logo Genes that share phenotypes with FAM198A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM198A Gene

Localization for FAM198A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM198A Gene COMPARTMENTS Subcellular localization image for FAM198A gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FAM198A Gene

Pathways & Interactions for FAM198A Gene

SuperPathways for FAM198A Gene

No Data Available

Interacting Proteins for FAM198A Gene

Gene Ontology (GO) - Biological Process for FAM198A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM198A Gene

Drugs & Compounds for FAM198A Gene

No Compound Related Data Available

Transcripts for FAM198A Gene

mRNA/cDNA for FAM198A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM198A Gene

Family with sequence similarity 198, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - - - -
SP3: -
SP4:
SP5: - -
SP6: - - - -

Relevant External Links for FAM198A Gene

GeneLoc Exon Structure for
FAM198A
ECgene alternative splicing isoforms for
FAM198A

Expression for FAM198A Gene

mRNA expression in normal human tissues for FAM198A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM198A Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM198A Gene



SOURCE GeneReport for Unigene cluster for FAM198A Gene Hs.729533

genes like me logo Genes that share expression patterns with FAM198A: view

Protein tissue co-expression partners for FAM198A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM198A Gene

Orthologs for FAM198A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM198A 35
  • 83.86 (n)
  • 77.8 (a)
FAM198A 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam198a 35
  • 76.72 (n)
  • 70.77 (a)
Fam198a 16
Fam198a 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM198A 35
  • 98.95 (n)
  • 98.08 (a)
FAM198A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam198a 35
  • 77.72 (n)
  • 71.12 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM198A 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM198A 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM198A 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM198A 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR627484.1 36
  • 38 (a)
OneToOne
Species with no ortholog for FAM198A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198A Gene

ENSEMBL:
Gene Tree for FAM198A (if available)
TreeFam:
Gene Tree for FAM198A (if available)

Paralogs for FAM198A Gene

Paralogs for FAM198A Gene

(2) SIMAP similar genes for FAM198A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM198A: view

Variants for FAM198A Gene

Sequence variations from dbSNP and Humsavar for FAM198A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2936817 - 43,032,942(+) GAGCT(C/T)ATCAG reference, missense
rs536119 - 43,053,609(-) GGTTC(C/T)GGCAT reference, missense
rs489117 -- 43,047,245(+) ctcta(C/T)cctgc intron-variant
rs496436 -- 43,037,898(+) AGACT(C/T)TGATT intron-variant
rs531888 -- 43,031,493(+) TCCCA(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM198A Gene

Variant ID Type Subtype PubMed ID
nsv460523 CNV Loss 19166990
nsv236200 CNV Loss 16902084
nsv513044 CNV Loss 21212237
esv2200110 CNV Deletion 18987734
esv2496441 CNV Deletion 19546169
esv3313 CNV Deletion 18987735
esv1005787 CNV Deletion 20482838
esv2725205 CNV Deletion 23290073
esv1510992 CNV Deletion 17803354
nsv237088 CNV Loss 16902084
esv7584 CNV Loss 19470904
esv2725206 CNV Deletion 23290073
esv27501 CNV Gain 19812545
esv2657871 CNV Deletion 23128226
esv2725208 CNV Deletion 23290073

Variation tolerance for FAM198A Gene

Gene Damage Index Score: 9.10; 87.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM198A Gene

HapMap Linkage Disequilibrium report
FAM198A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198A Gene

Disorders for FAM198A Gene

Relevant External Links for FAM198A

Genetic Association Database (GAD)
FAM198A
Human Genome Epidemiology (HuGE) Navigator
FAM198A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM198A

No disorders were found for FAM198A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM198A Gene

Publications for FAM198A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM198A Gene

Sources for FAM198A Gene

Back to Top

Content