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Aliases for FAM198A Gene

Aliases for FAM198A Gene

  • Family With Sequence Similarity 198 Member A 2 3 5
  • C3orf41 3 4
  • Family With Sequence Similarity 198, Member A 2
  • Chromosome 3 Open Reading Frame 41 2
  • Protein FAM198A 3

External Ids for FAM198A Gene

Previous HGNC Symbols for FAM198A Gene

  • C3orf41

Previous GeneCards Identifiers for FAM198A Gene

  • GC03P042998

Summaries for FAM198A Gene

GeneCards Summary for FAM198A Gene

FAM198A (Family With Sequence Similarity 198 Member A) is a Protein Coding gene. An important paralog of this gene is FAM198B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198A Gene

Genomics for FAM198A Gene

Regulatory Elements for FAM198A Gene

Enhancers for FAM198A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G042999 1.3 FANTOM5 Ensembl ENCODE 18.6 +21.7 21670 3.3 ELF3 SOX13 FOXA2 SAP130 MAX CEBPG RAD21 YY1 TEAD3 HNF4G FAM198A POMGNT2 PIR49761 PIR62180
GH03G043036 0.8 ENCODE dbSUPER 17.8 +57.8 57797 0.7 MTA2 BHLHE40 NR2F1 CEBPB RELB CEBPG TBX21 FAM198A POMGNT2 PIR62180 ENSG00000232375
GH03G043031 0.5 dbSUPER 18.3 +52.6 52626 0.7 MAX MYC EGR2 FAM198A PIR62180 PIR49761
GH03G042850 1.5 Ensembl ENCODE dbSUPER 4.8 -125.4 -125443 5.9 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 ZNF766 SP5 ACKR2 CCDC13 CYP8B1 CCDC13-AS1 FAM198A GC03P042856 GC03P042857
GH03G043011 1.3 Ensembl ENCODE dbSUPER 5.2 +39.4 39403 14.5 ZBTB21 ZFP64 TAL1 ZBTB40 ZIC2 FOSL1 TCF12 NFE2 TRIM24 MAFK POMGNT2 FAM198A HIGD1A PIR62180 PIR49761
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM198A on UCSC Golden Path with GeneCards custom track

Promoters for FAM198A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151432 333 800 NFIB ZNF76 ZNF2 GLIS2 SCRT2 EGR2 REST ZNF398 GLIS1 MYNN

Genomic Location for FAM198A Gene

Chromosome:
3
Start:
42,979,267 bp from pter
End:
43,060,211 bp from pter
Size:
80,945 bases
Orientation:
Plus strand

Genomic View for FAM198A Gene

Genes around FAM198A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM198A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM198A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198A Gene

Proteins for FAM198A Gene

  • Protein details for FAM198A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFP1-F198A_HUMAN
    Recommended name:
    Protein FAM198A
    Protein Accession:
    Q9UFP1
    Secondary Accessions:
    • B3KR48

    Protein attributes for FAM198A Gene

    Size:
    575 amino acids
    Molecular mass:
    63637 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM198A Gene

Post-translational modifications for FAM198A Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at isoforms=123, isoforms=192, and isoforms=566
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM198A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM198A Gene

Domains & Families for FAM198A Gene

Protein Domains for FAM198A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM198A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFP1

UniProtKB/Swiss-Prot:

F198A_HUMAN :
  • Belongs to the FAM198 family.
Family:
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198A: view

No data available for Gene Families for FAM198A Gene

Function for FAM198A Gene

Phenotypes for FAM198A Gene

genes like me logo Genes that share phenotypes with FAM198A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM198A Gene

Localization for FAM198A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM198A gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM198A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM198A: view

Pathways & Interactions for FAM198A Gene

SuperPathways for FAM198A Gene

No Data Available

Interacting Proteins for FAM198A Gene

Gene Ontology (GO) - Biological Process for FAM198A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM198A Gene

Drugs & Compounds for FAM198A Gene

No Compound Related Data Available

Transcripts for FAM198A Gene

mRNA/cDNA for FAM198A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM198A Gene

Family with sequence similarity 198, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - - - -
SP3: -
SP4:
SP5: - -
SP6: - - - -

Relevant External Links for FAM198A Gene

GeneLoc Exon Structure for
FAM198A
ECgene alternative splicing isoforms for
FAM198A

Expression for FAM198A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM198A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM198A Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM198A Gene



Protein tissue co-expression partners for FAM198A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM198A Gene:

FAM198A

SOURCE GeneReport for Unigene cluster for FAM198A Gene:

Hs.729533

Evidence on tissue expression from TISSUES for FAM198A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM198A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM198A Gene

Orthologs for FAM198A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM198A 34 35
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia FAM198A 34 35
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Fam198a 34
  • 77.72 (n)
mouse
(Mus musculus)
Mammalia Fam198a 34 16 35
  • 76.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM198A 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM198A 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM198A 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM198A 35
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR627484.1 35
  • 38 (a)
OneToOne
Species where no ortholog for FAM198A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198A Gene

ENSEMBL:
Gene Tree for FAM198A (if available)
TreeFam:
Gene Tree for FAM198A (if available)

Paralogs for FAM198A Gene

Paralogs for FAM198A Gene

(2) SIMAP similar genes for FAM198A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM198A: view

Variants for FAM198A Gene

Sequence variations from dbSNP and Humsavar for FAM198A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000007223 -- 43,052,494(+) TCATT(A/G)AGGTA intron-variant
rs1000023640 -- 42,988,713(+) TTCGT(C/T)AGTGT intron-variant
rs1000039735 -- 43,041,516(+) CATAA(A/G)TGTCT intron-variant
rs1000060161 -- 42,989,244(+) AACAC(A/G)TTTCC intron-variant
rs1000134447 -- 43,016,568(+) GCTGT(A/G)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM198A Gene

Variant ID Type Subtype PubMed ID
dgv2515n106 CNV deletion 24896259
esv1005787 CNV deletion 20482838
esv1510992 CNV deletion 17803354
esv2200110 CNV deletion 18987734
esv2496441 CNV deletion 19546169
esv2657871 CNV deletion 23128226
esv2725205 CNV deletion 23290073
esv2725206 CNV deletion 23290073
esv2725208 CNV deletion 23290073
esv27501 CNV gain 19812545
esv3313 CNV loss 18987735
esv3561798 CNV deletion 23714750
esv7584 CNV loss 19470904
nsv1074587 CNV deletion 25765185
nsv1110409 CNV duplication 24896259
nsv1147238 CNV duplication 26484159
nsv1153575 CNV deletion 26484159
nsv236200 CNV deletion 16902084
nsv237088 CNV deletion 16902084
nsv460523 CNV loss 19166990
nsv513044 CNV loss 21212237
nsv590149 CNV gain 21841781
nsv590150 CNV loss 21841781
nsv955562 CNV deletion 24416366
nsv979824 CNV duplication 23825009

Variation tolerance for FAM198A Gene

Gene Damage Index Score: 9.10; 87.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM198A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM198A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198A Gene

Disorders for FAM198A Gene

Relevant External Links for FAM198A

Genetic Association Database (GAD)
FAM198A
Human Genome Epidemiology (HuGE) Navigator
FAM198A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM198A

No disorders were found for FAM198A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM198A Gene

Publications for FAM198A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for FAM198A Gene

Sources for FAM198A Gene

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