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Aliases for FAM196A Gene

Aliases for FAM196A Gene

  • Family With Sequence Similarity 196, Member A 2 3
  • C10orf141 3 4
  • Chromosome 10 Open Reading Frame 141 2

External Ids for FAM196A Gene

Previous HGNC Symbols for FAM196A Gene

  • C10orf141

Previous GeneCards Identifiers for FAM196A Gene

  • GC10M128827
  • GC10M128934
  • GC10M122505

Summaries for FAM196A Gene

GeneCards Summary for FAM196A Gene

FAM196A (Family With Sequence Similarity 196, Member A) is a Protein Coding gene. An important paralog of this gene is FAM196B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM196A Gene

Genomics for FAM196A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM196A Gene

127,135,426 bp from pter
127,196,216 bp from pter
60,791 bases
Minus strand

Genomic View for FAM196A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM196A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM196A Gene

No data available for Regulatory Elements for FAM196A Gene

Proteins for FAM196A Gene

  • Protein details for FAM196A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM196A
    Protein Accession:
    Secondary Accessions:
    • B2RNT4
    • B7ZME7

    Protein attributes for FAM196A Gene

    479 amino acids
    Molecular mass:
    52909 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM196A Gene


neXtProt entry for FAM196A Gene

Proteomics data for FAM196A Gene at MOPED

Post-translational modifications for FAM196A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM196A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM196A Gene

Domains & Families for FAM196A Gene

Protein Domains for FAM196A Gene


Suggested Antigen Peptide Sequences for FAM196A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM196 family.
  • Belongs to the FAM196 family.
genes like me logo Genes that share domains with FAM196A: view

No data available for Gene Families for FAM196A Gene

Function for FAM196A Gene

Animal Model Products

CRISPR Products

miRNA for FAM196A Gene

miRTarBase miRNAs that target FAM196A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM196A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM196A Gene

Localization for FAM196A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM196A Gene

Pathways & Interactions for FAM196A Gene

SuperPathways for FAM196A Gene

No Data Available

Interacting Proteins for FAM196A Gene

Gene Ontology (GO) - Biological Process for FAM196A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM196A Gene

Drugs & Compounds for FAM196A Gene

No Compound Related Data Available

Transcripts for FAM196A Gene

mRNA/cDNA for FAM196A Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM196A Gene

Family with sequence similarity 196, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM196A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM196A Gene

No ASD Table

Relevant External Links for FAM196A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM196A Gene

mRNA expression in normal human tissues for FAM196A Gene

mRNA differential expression in normal tissues according to GTEx for FAM196A Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.8), Brain - Putamen (basal ganglia) (x6.6), Brain - Caudate (basal ganglia) (x6.3), and Brain - Hypothalamus (x4.3).

Protein differential expression in normal tissues from HIPED for FAM196A Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM196A Gene

SOURCE GeneReport for Unigene cluster for FAM196A Gene Hs.613882

genes like me logo Genes that share expression patterns with FAM196A: view

Protein tissue co-expression partners for FAM196A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM196A Gene

Orthologs for FAM196A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM196A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM196A 35
  • 83.44 (n)
  • 79.96 (a)
FAM196A 36
  • 79 (a)
(Canis familiaris)
Mammalia FAM196A 35
  • 80.45 (n)
  • 73.21 (a)
FAM196A 36
  • 71 (a)
(Mus musculus)
Mammalia Fam196a 35
  • 83.12 (n)
  • 85.53 (a)
Fam196a 16
Fam196a 36
  • 83 (a)
(Pan troglodytes)
Mammalia FAM196A 35
  • 99.23 (n)
  • 99.58 (a)
FAM196A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam196a 35
  • 82.77 (n)
  • 84.26 (a)
(Monodelphis domestica)
Mammalia FAM196A 36
  • 58 (a)
(Gallus gallus)
Aves FAM196A 35
  • 72.11 (n)
  • 71.75 (a)
FAM196A 36
  • 69 (a)
(Anolis carolinensis)
Reptilia FAM196A 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam196a 35
  • 66.1 (n)
  • 62.16 (a)
(Danio rerio)
Actinopterygii LOC100333552 35
  • 57.44 (n)
  • 54.25 (a)
FAM196A (1 of 3) 36
  • 37 (a)
FAM196A (3 of 3) 36
  • 49 (a)
fam196ab 36
  • 45 (a)
Species with no ortholog for FAM196A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM196A Gene

Gene Tree for FAM196A (if available)
Gene Tree for FAM196A (if available)

Paralogs for FAM196A Gene

Paralogs for FAM196A Gene

(1) SIMAP similar genes for FAM196A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM196A: view

Variants for FAM196A Gene

Sequence variations from dbSNP and Humsavar for FAM196A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_042679 -

Structural Variations from Database of Genomic Variants (DGV) for FAM196A Gene

Variant ID Type Subtype PubMed ID
nsv896093 CNV Loss 21882294
essv14789 CNV CNV 17122850
nsv896094 CNV Gain 21882294
nsv511443 CNV Gain 21212237
esv24572 CNV Gain 19812545
nsv821275 CNV Deletion 20802225
essv13354 CNV CNV 17122850

Variation tolerance for FAM196A Gene

Residual Variation Intolerance Score: 41.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM196A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM196A Gene

Disorders for FAM196A Gene

Relevant External Links for FAM196A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM196A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM196A Gene

Publications for FAM196A Gene

  1. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 67
  2. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PMID: 17362836) Schymick J.C. … Traynor B.J. (Lancet Neurol 2007) 67
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for FAM196A Gene

Sources for FAM196A Gene

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