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Aliases for FAM196A Gene

Aliases for FAM196A Gene

  • Family With Sequence Similarity 196 Member A 2 3 5
  • Inhibitory Synaptic Protein 2 2 3
  • C10orf141 3 4
  • Family With Sequence Similarity 196, Member A 2
  • Chromosome 10 Open Reading Frame 141 2
  • Protein FAM196A 3
  • INSYN2 3

External Ids for FAM196A Gene

Previous HGNC Symbols for FAM196A Gene

  • C10orf141

Previous GeneCards Identifiers for FAM196A Gene

  • GC10M128827
  • GC10M128934
  • GC10M122505

Summaries for FAM196A Gene

GeneCards Summary for FAM196A Gene

FAM196A (Family With Sequence Similarity 196 Member A) is a Protein Coding gene. An important paralog of this gene is FAM196B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM196A Gene

Genomics for FAM196A Gene

Regulatory Elements for FAM196A Gene

Enhancers for FAM196A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G127147 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +47.2 47173 3.6 JUN BHLHE40 TEAD4 EP300 FOSL1 JUND ZNF316 FOS NFE2 MAFK FAM196A ENSG00000232935 PIR41263 GC10P127176
GH10G127144 1.1 FANTOM5 ENCODE dbSUPER 17.8 +50.6 50611 1.3 JUND IKZF1 MNT FOS MAFK ZEB1 FAM196A PIR41263 PIR45795
GH10G127279 0.9 ENCODE 15.6 -83.1 -83059 1.4 ELF3 TBP FOXA2 ATF1 MLX RAD21 RARA SLC30A9 CREM MIXL1 FAM196A GC10M127308
GH10G127156 0.5 ENCODE 18.2 +38.6 38558 1.3 MAFF ZNF316 ATF2 MAFK FAM196A PIR41263 GC10P127176
GH10G127278 0.7 ENCODE 10.6 -82.0 -81956 0.2 ELF3 SOX5 SOX13 CTCF FOXA2 SAP130 TEAD1 NFIA FOS ZNF652 FAM196A GC10M127308
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM196A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM196A Gene

Chromosome:
10
Start:
127,135,426 bp from pter
End:
127,196,216 bp from pter
Size:
60,791 bases
Orientation:
Minus strand

Genomic View for FAM196A Gene

Genes around FAM196A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM196A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM196A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM196A Gene

Proteins for FAM196A Gene

  • Protein details for FAM196A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSG2-F196A_HUMAN
    Recommended name:
    Protein FAM196A
    Protein Accession:
    Q6ZSG2
    Secondary Accessions:
    • B2RNT4
    • B7ZME7

    Protein attributes for FAM196A Gene

    Size:
    479 amino acids
    Molecular mass:
    52909 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM196A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM196A Gene

Post-translational modifications for FAM196A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM196A Gene

Domains & Families for FAM196A Gene

Protein Domains for FAM196A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM196A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZSG2

UniProtKB/Swiss-Prot:

F196A_HUMAN :
  • Belongs to the FAM196 family.
Family:
  • Belongs to the FAM196 family.
genes like me logo Genes that share domains with FAM196A: view

No data available for Gene Families for FAM196A Gene

Function for FAM196A Gene

Phenotypes for FAM196A Gene

GenomeRNAi human phenotypes for FAM196A:
genes like me logo Genes that share phenotypes with FAM196A: view

Animal Model Products

CRISPR Products

miRNA for FAM196A Gene

miRTarBase miRNAs that target FAM196A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM196A Gene

Localization for FAM196A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM196A Gene

Pathways & Interactions for FAM196A Gene

SuperPathways for FAM196A Gene

No Data Available

Interacting Proteins for FAM196A Gene

Gene Ontology (GO) - Biological Process for FAM196A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM196A Gene

Drugs & Compounds for FAM196A Gene

No Compound Related Data Available

Transcripts for FAM196A Gene

mRNA/cDNA for FAM196A Gene

(9) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM196A Gene

Family with sequence similarity 196, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM196A Gene

No ASD Table

Relevant External Links for FAM196A Gene

GeneLoc Exon Structure for
FAM196A
ECgene alternative splicing isoforms for
FAM196A

Expression for FAM196A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM196A Gene

mRNA differential expression in normal tissues according to GTEx for FAM196A Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.8), Brain - Putamen (basal ganglia) (x6.6), Brain - Caudate (basal ganglia) (x6.3), and Brain - Hypothalamus (x4.3).

Protein differential expression in normal tissues from HIPED for FAM196A Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM196A Gene



Protein tissue co-expression partners for FAM196A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM196A Gene:

FAM196A

SOURCE GeneReport for Unigene cluster for FAM196A Gene:

Hs.613882
genes like me logo Genes that share expression patterns with FAM196A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM196A Gene

Orthologs for FAM196A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM196A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM196A 34 35
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia FAM196A 34 35
  • 83.44 (n)
mouse
(Mus musculus)
Mammalia Fam196a 34 16 35
  • 83.12 (n)
rat
(Rattus norvegicus)
Mammalia Fam196a 34
  • 82.77 (n)
dog
(Canis familiaris)
Mammalia FAM196A 34 35
  • 80.45 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM196A 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM196A 34 35
  • 72.11 (n)
lizard
(Anolis carolinensis)
Reptilia FAM196A 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam196a 34
  • 66.1 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333552 34
  • 57.44 (n)
FAM196A (3 of 3) 35
  • 49 (a)
OneToMany
fam196ab 35
  • 45 (a)
OneToMany
FAM196A (1 of 3) 35
  • 37 (a)
OneToMany
Species where no ortholog for FAM196A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM196A Gene

ENSEMBL:
Gene Tree for FAM196A (if available)
TreeFam:
Gene Tree for FAM196A (if available)

Paralogs for FAM196A Gene

Paralogs for FAM196A Gene

(1) SIMAP similar genes for FAM196A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM196A: view

Variants for FAM196A Gene

Sequence variations from dbSNP and Humsavar for FAM196A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000042798 -- 127,169,157(+) GCTGT(C/T)ATATA intron-variant
rs1000058451 -- 127,149,118(+) ACCCT(C/T)CTGTG intron-variant
rs1000096551 -- 127,162,748(+) GGAGC(C/T)GACAT intron-variant
rs1000137185 -- 127,180,783(+) TTATA(G/T)AGATT intron-variant, upstream-variant-2KB
rs1000170598 -- 127,162,955(+) AGAAC(C/T)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM196A Gene

Variant ID Type Subtype PubMed ID
dgv1418n54 CNV loss 21841781
esv24572 CNV gain 19812545
esv2759789 CNV gain 17122850
esv3624875 CNV loss 21293372
nsv1045509 CNV gain 25217958
nsv1147260 CNV insertion 26484159
nsv477772 CNV novel sequence insertion 20440878
nsv511443 CNV gain 21212237
nsv821275 CNV deletion 20802225

Variation tolerance for FAM196A Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM196A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM196A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM196A Gene

Disorders for FAM196A Gene

Relevant External Links for FAM196A

Genetic Association Database (GAD)
FAM196A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM196A

No disorders were found for FAM196A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM196A Gene

Publications for FAM196A Gene

  1. Identification of an elaborate complex mediating postsynaptic inhibition. (PMID: 27609886) Uezu A. … Soderling S.H. (Science 2016) 2 3 64
  2. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PMID: 17362836) Schymick J.C. … Traynor B.J. (Lancet Neurol 2007) 46 64
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for FAM196A Gene

Sources for FAM196A Gene

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