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FAM195B Gene

protein-coding   GIFtS: 40
GCID: GC17M079783

Family With Sequence Similarity 195, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 195, Member B1 2
Protein FAM195B2

External Ids:    HGNC: 280071   Entrez Gene: 3482622   Ensembl: ENSG000002256637   UniProtKB: C9JLW83   
ORGUL members:         

Export aliases for FAM195B gene to outside databases

Previous GC identifer: GC17M075181


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM195B Gene:
FAM195B (family with sequence similarity 195, member B) is a protein-coding gene. An important paralog of this gene is FAM195A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM195B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM195B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM195B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

FAM195B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM195B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079783:  view genomic region     (about GC identifiers)

Start:
79,780,287 bp from pter      End:
79,791,178 bp from pter
Size:
10,892 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F195B_HUMAN, C9JLW8 (See protein sequence)
Recommended Name: Protein FAM195B  
Size: 97 amino acids; 10920 Da
Sequence caution: Sequence=BAC86211.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q6ZUL0

Explore the universe of human proteins at neXtProt for FAM195B: NX_C9JLW8

Explore proteomics data for FAM195B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus

  • See FAM195B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001087236.1  NP_001275727.1  NP_001275728.1  NP_997251.2  

    ENSEMBL proteins: 
     ENSP00000409009   ENSP00000458707   ENSP00000461433   ENSP00000445543   ENSP00000460299  
     ENSP00000458720   ENSP00000459769   ENSP00000460329   ENSP00000460100   ENSP00000460461  

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    antibodies-online proteins for FAM195B (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: C9JLW8

    UniProtKB/Swiss-Prot: F195B_HUMAN, C9JLW8
    Similarity: Belongs to the FAM195 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM195B:
     Decreased viability with pacli  Small cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM195B

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    extracellular1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM195B
    Interactions:

        Search GeneGlobe Interaction Network for FAM195B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM195B (C9JLW83 ENSP000004090094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ULK2Q8IYT83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM195B (F195B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM195B gene (4 alternative transcripts): 
    NM_001093767.2  NM_001288798.1  NM_001288799.1  NM_207368.4  

    Unigene Cluster for FAM195B:

    Family with sequence similarity 195, member B
    Hs.514632  [show with all ESTs]
    Unigene Representative Sequence: BI194770
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455127(uc010wuz.1) ENST00000576730 ENST00000572645(uc002kjd.2)
    ENST00000538396(uc010wuy.1) ENST00000573478 ENST00000574190 ENST00000570507
    ENST00000575090 ENST00000576679 ENST00000576431 ENST00000575061
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat FAM195B

    Additional mRNA sequence: 

    AK000852.1 BC017108.1 BC019318.1 BC041068.1 BC063557.1 BC094876.1 BX649156.1 

    15 DOTS entries:

    DT.101984683  DT.100792577  DT.100029078  DT.99940839  DT.99953542  DT.100792576  DT.121645511  DT.95309472 
    DT.100792571  DT.92049654  DT.95211890  DT.95309473  DT.91868370  DT.91976817  DT.95309464 

    Selected AceView cDNA sequences (see all 73):

    AI283881 AA773845 BM671726 BU682755 BM915459 BV203147 BQ944273 BU622806 
    BU787922 BQ718348 BX464731 BE407283 BX329462 BU742902 CK826354 BI910774 
    BC041068 BM728382 BQ431839 BM913316 BE385782 BE336921 NM_207368 BE390064 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM195B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCTGGG
    FAM195B Expression
    About this image

    FAM195B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM195B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514632
        Custom PCR Arrays for FAM195B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM195B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM195B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam195b1 , 5 family with sequence similarity 195, member B1, 5 88.66(n)1
    90.72(a)1
      11 (84.25 cM)5
    1921731  NM_001033231.21  NP_001028403.11 
     1205428885 
    chicken
    (Gallus gallus)
    Aves FAM195B1 family with sequence similarity 195, member B 81.56(n)
    85.11(a)
      101749776  XM_004946381.1  XP_004946438.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM195B6
    family with sequence similarity 195, member B
    89(a)
    1 ↔ 1
    2(118662186-118667480)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB206813.12   -- 71.61(n)    CB206813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam195b1 family with sequence similarity 195, member B 63.51(n)
    60(a)
      751762  NM_001045471.2  NP_001038936.1 


    ENSEMBL Gene Tree for FAM195B (if available)
    TreeFam Gene Tree for FAM195B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM195B gene
    FAM195A2  
    1 SIMAP similar gene for FAM195B using alignment to 6 protein entries:     F195B_HUMAN (see all proteins):
    FAM195A

    Find genes that share paralogs with FAM195B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM195B (see all 196)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924218471,2
    --79779863(+) TTCCAA/GCAGGA 2 -- int1 ds50010--------
    rs1423256911,2
    --79779932(+) TGCACA/GTGGCT 2 -- int1 ds50010--------
    rs1843834961,2
    --79779954(+) CCAGCA/GGCACC 2 -- int1 ds50010--------
    rs1465719721,2
    C--79780059(+) CTGGGC/GAGCCC 2 -- int1 ds50010--------
    rs1872710301,2
    --79780110(+) TCTCCC/TTCCAG 2 -- int1 ds50010--------
    rs1390958261,2
    --79780157(+) GAGCAC/TGCCCA 2 -- int1 ds50010--------
    rs1404980121,2
    C--79780158(+) AGCACA/GCCCAG 2 -- int1 ds50010--------
    rs1503607901,2
    --79780302(+) GTGCCA/GCCGCC 2 -- ut310--------
    rs1380265301,2
    C--79780416(+) CAAGAC/GAGACC 2 -- ut310--------
    rs1495442181,2
    C--79780594(+) GGCTGC/GACGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM195B (79780287 - 79791178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FAM195B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3330n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3332n71CNV Loss21882294
    nsv470620CNV Loss18288195
    nsv428351CNV Gain18775914
    esv21913CNV Gain+Loss19812545
    nsv909128CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM195B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM195B gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with FAM195B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 348262 HGNC: 28007 AceView: LOC348262 Ensembl:ENSG00000225663 euGenes: HUgn348262
    ECgene: FAM195B H-InvDB: FAM195B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM195B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM195B gene:
    Search GeneIP for patents involving FAM195B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Custom Antibody Services for FAM195B   OriGene Custom Protein Services for FAM195B  

     
     
     Block miRNA regulation of human, mouse, rat FAM195B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FAM195B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM195B Predesigned siRNA for gene silencing in human, mouse, rat FAM195B
     QuantiFast Probe-based Assays in human, mouse, rat FAM195B QuantiTect SYBR Green Assays in human, mouse, rat FAM195B
     Custom PCR Arrays for FAM195B Search Chromatin IP Primers for FAM195B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM195B  Search GeneGlobe Interaction Network for FAM195B
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     GenScript Custom Purified and Recombinant Proteins Services for FAM195B GenScript cDNA clones with any tag delivered in your preferred vector for FAM195B
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     Search for Antibodies & Assays

     Search Tocris compounds for FAM195B (F195B)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for FAM195B
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM195B
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     Search ThermoFisher Antibodies for FAM195B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM195B
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     Search Addgene for plasmids for FAM195B
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM195B
      Search antibodies-online for antibodies for FAM195B
     antibodies-online kits for FAM195B (5 products)
      Search antibodies-online for peptides for FAM195B
     antibodies-online proteins for FAM195B (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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