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Aliases for FAM195B Gene

Aliases for FAM195B Gene

  • Family With Sequence Similarity 195, Member B 2 3
  • MAPK-Regulated Co-Repressor Interacting Protein 1 3
  • MCRIP1 Protein 3
  • MCRIP1 3

External Ids for FAM195B Gene

Previous GeneCards Identifiers for FAM195B Gene

  • GC17M079783
  • GC17M075181

Summaries for FAM195B Gene

GeneCards Summary for FAM195B Gene

FAM195B (Family With Sequence Similarity 195, Member B) is a Protein Coding gene. An important paralog of this gene is FAM195A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM195B Gene

Genomics for FAM195B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM195B Gene

Chromosome:
17
Start:
81,822,361 bp from pter
End:
81,833,302 bp from pter
Size:
10,942 bases
Orientation:
Minus strand

Genomic View for FAM195B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM195B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM195B Gene

No data available for Regulatory Elements for FAM195B Gene

Proteins for FAM195B Gene

  • Protein details for FAM195B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLW8-F195B_HUMAN
    Recommended name:
    Protein FAM195B
    Protein Accession:
    C9JLW8
    Secondary Accessions:
    • Q6ZUL0

    Protein attributes for FAM195B Gene

    Size:
    97 amino acids
    Molecular mass:
    10920 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86211.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM195B Gene

Proteomics data for FAM195B Gene at MOPED

Post-translational modifications for FAM195B Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM195B Gene

Domains & Families for FAM195B Gene

Protein Domains for FAM195B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM195B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

C9JLW8

UniProtKB/Swiss-Prot:

F195B_HUMAN :
  • Belongs to the FAM195 family.
Family:
  • Belongs to the FAM195 family.
genes like me logo Genes that share domains with FAM195B: view

No data available for Gene Families for FAM195B Gene

Function for FAM195B Gene

Gene Ontology (GO) - Molecular Function for FAM195B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25728771
genes like me logo Genes that share ontologies with FAM195B: view

Phenotypes for FAM195B Gene

genes like me logo Genes that share phenotypes with FAM195B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM195B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM195B Gene

Localization for FAM195B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM195B Gene COMPARTMENTS Subcellular localization image for FAM195B gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM195B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25728771
genes like me logo Genes that share ontologies with FAM195B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM195B Gene

Pathways & Interactions for FAM195B Gene

SuperPathways for FAM195B Gene

No Data Available

Interacting Proteins for FAM195B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000409009%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: C9JLW8-F195B_HUMAN ENSP00000409009 for FAM195B Gene via I2D STRING

Gene Ontology (GO) - Biological Process for FAM195B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010717 regulation of epithelial to mesenchymal transition IDA 25728771
genes like me logo Genes that share ontologies with FAM195B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM195B Gene

Drugs & Compounds for FAM195B Gene

No Compound Related Data Available

Transcripts for FAM195B Gene

Unigene Clusters for FAM195B Gene

Family with sequence similarity 195, member B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM195B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM195B Gene

No ASD Table

Relevant External Links for FAM195B Gene

GeneLoc Exon Structure for
FAM195B
ECgene alternative splicing isoforms for
FAM195B

Expression for FAM195B Gene

mRNA expression in normal human tissues for FAM195B Gene

Protein differential expression in normal tissues from HIPED for FAM195B Gene

This gene is overexpressed in Fetal Brain (17.4), Fetal ovary (9.1), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM195B Gene



SOURCE GeneReport for Unigene cluster for FAM195B Gene Hs.514632

genes like me logo Genes that share expression patterns with FAM195B: view

Protein tissue co-expression partners for FAM195B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM195B Gene

Orthologs for FAM195B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM195B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM195B 35
  • 91.41 (n)
  • 90.72 (a)
FAM195B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM195B 35
  • 88.89 (n)
  • 85.96 (a)
FAM195B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195b 35
  • 88.66 (n)
  • 90.72 (a)
Fam195b 16
Fam195b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM195B 35
  • 99.72 (n)
  • 100 (a)
FAM195B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam195b 35
  • 87.29 (n)
  • 90.72 (a)
oppossum
(Monodelphis domestica)
Mammalia FAM195B 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195B 35
  • 81.56 (n)
  • 85.11 (a)
lizard
(Anolis carolinensis)
Reptilia FAM195B 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195b 35
  • 70.1 (n)
  • 78.35 (a)
Str.12007 35
zebrafish
(Danio rerio)
Actinopterygii fam195b 35
  • 63.51 (n)
  • 60 (a)
fam195b 36
  • 58 (a)
OneToOne
Species with no ortholog for FAM195B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM195B Gene

ENSEMBL:
Gene Tree for FAM195B (if available)
TreeFam:
Gene Tree for FAM195B (if available)

Paralogs for FAM195B Gene

Paralogs for FAM195B Gene

(1) SIMAP similar genes for FAM195B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FAM195B: view

Variants for FAM195B Gene

Sequence variations from dbSNP and Humsavar for FAM195B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1047441 -- 81,822,805(-) GCCCC(A/C)CCCCA utr-variant-3-prime
rs1047559 -- 81,822,531(-) TGGCT(C/T)TGGGG utr-variant-3-prime
rs1047580 -- 81,822,467(-) AGTGT(C/T)TGTGT utr-variant-3-prime
rs3187588 -- 81,822,482(-) GCCCT(C/T)TGAAA utr-variant-3-prime
rs4013609 -- 81,826,522(-) TTTTT(-/TT)GACAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM195B Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294

Variation tolerance for FAM195B Gene

Gene Damage Index Score: 0.28; 6.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM195B Gene

HapMap Linkage Disequilibrium report
FAM195B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM195B Gene

Disorders for FAM195B Gene

Relevant External Links for FAM195B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM195B
genes like me logo Genes that share disorders with FAM195B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM195B Gene

Publications for FAM195B Gene

  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. (PMID: 25728771) Ichikawa K. … Takekawa M. (Mol. Cell 2015) 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for FAM195B Gene

Sources for FAM195B Gene

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