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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM195B Gene

protein-coding   GIFtS: 38
GCID: GC17M079783

Family With Sequence Similarity 195, Member B

  Search for FAM195B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 195, Member B1 2
Protein FAM195B2

External Ids:    HGNC: 280071   Entrez Gene: 3482622   Ensembl: ENSG000002256637   UniProtKB: C9JLW83   

Export aliases for FAM195B gene to outside databases

Previous GC identifer: GC17M075181


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM195B Gene: 
FAM195B (family with sequence similarity 195, member B) is a protein-coding gene. An important paralog of this gene is FAM195A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM195B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM195B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM195B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

FAM195B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM195B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079783:  view genomic region     (about GC identifiers)

Start:
79,780,287 bp from pter      End:
79,791,178 bp from pter
Size:
10,892 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F195B_HUMAN, C9JLW8 (See protein sequence)
Recommended Name: Protein FAM195B  
Size: 97 amino acids; 10920 Da
Sequence caution: Sequence=BAC86211.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q6ZUL0

Explore the universe of human proteins at neXtProt for FAM195B: NX_C9JLW8

Explore proteomics data for FAM195B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_C9JLW8

  • FAM195B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM195B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001087236.1  NP_997251.2  

    ENSEMBL proteins: 
     ENSP00000409009   ENSP00000458707   ENSP00000461433   ENSP00000445543   ENSP00000460299  
     ENSP00000458720   ENSP00000459769   ENSP00000460329   ENSP00000460100   ENSP00000460461  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: C9JLW8

    UniProtKB/Swiss-Prot: F195B_HUMAN, C9JLW8
    Similarity: Belongs to the FAM195 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for FAM195B:
     Decreased viability with pacli  Small cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM195B 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM195B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM195B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for FAM195B (C9JLW83 ENSP000004090094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ULK2Q8IYT83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM195B (F195B)

    Search CenterWatch for drugs/clinical trials and news about FAM195B / F195B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM195B gene (2 alternative transcripts): 
    NM_001093767.1  NM_207368.3  

    Unigene Cluster for FAM195B:

    Family with sequence similarity 195, member B
    Hs.514632  [show with all ESTs]
    Unigene Representative Sequence: BI194770
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455127(uc010wuz.1) ENST00000576730 ENST00000572645(uc002kjd.2)
    ENST00000538396(uc010wuy.1) ENST00000573478 ENST00000574190 ENST00000570507
    ENST00000575090 ENST00000576679 ENST00000576431 ENST00000575061
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FAM195B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM195B
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FAM195B (NM_207368)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM195B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM195B
    Sirion Biotech Customized lentivirus for stable overexpression of FAM195B 
                         Customized lentivirus expression plasmids for stable overexpression of FAM195B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM195B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM195B

    Additional mRNA sequence: 

    AK000852.1 BC017108.1 BC019318.1 BC041068.1 BC063557.1 BC094876.1 BX649156.1 

    15 DOTS entries:

    DT.101984683  DT.100792577  DT.100029078  DT.99940839  DT.99953542  DT.100792576  DT.121645511  DT.95309472 
    DT.100792571  DT.92049654  DT.95211890  DT.95309473  DT.91868370  DT.91976817  DT.95309464 

    24/73 AceView cDNA sequences (see all 73):

    BM915459 CK826354 BU622806 BU787922 BQ718348 BM913316 AI283881 BE336921 
    BX464731 BE407283 AA773845 BV203147 BM671726 BE385782 BU682755 BM728382 
    BC041068 BX329462 BI910774 BU742902 BQ431839 BQ944273 BM710298 AI674207 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM195B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCTGGG
    FAM195B Expression
    About this image


    See FAM195B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM195B

    SOURCE GeneReport for Unigene cluster: Hs.514632
        SABiosciences Custom PCR Arrays for FAM195B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM195B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM195B gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam195b1 , 5 family with sequence similarity 195, member B1, 5 88.66(n)1
    90.72(a)1
      11 (84.25 cM)5
    1921731  NM_001033231.21  NP_001028403.11 
     1205428885 
    lizard
    (Anolis carolinensis)
    Reptilia FAM195B6
    family with sequence similarity 195, member B
    89(a)
    1 ↔ 1
    2(118662186-118667480)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB206813.12   -- 71.61(n)    CB206813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam195b1 family with sequence similarity 195, member B 62.81(n)
    60(a)
      751762  NM_001045471.2  NP_001038936.1 


    ENSEMBL Gene Tree for FAM195B (if available)
    TreeFam Gene Tree for FAM195B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM195B gene
    FAM195A2  
    1 SIMAP similar gene for FAM195B using alignment to 6 protein entries:     F195B_HUMAN (see all proteins):
    FAM195A

    FAM195B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 SNPs in FAM195B are shown (see all 196)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924218471,2
    --79779863(+) TTCCAA/GCAGGA 2 -- int1 ds50010--------
    rs1423256911,2
    --79779932(+) TGCACA/GTGGCT 2 -- int1 ds50010--------
    rs1843834961,2
    --79779954(+) CCAGCA/GGCACC 2 -- int1 ds50010--------
    rs1465719721,2
    C--79780059(+) CTGGGC/GAGCCC 2 -- int1 ds50010--------
    rs1872710301,2
    --79780110(+) TCTCCC/TTCCAG 2 -- int1 ds50010--------
    rs1390958261,2
    --79780157(+) GAGCAC/TGCCCA 2 -- int1 ds50010--------
    rs1404980121,2
    C--79780158(+) AGCACA/GCCCAG 2 -- int1 ds50010--------
    rs1503607901,2
    --79780302(+) GTGCCA/GCCGCC 2 -- ut310--------
    rs1380265301,2
    C--79780416(+) CAAGAC/GAGACC 2 -- ut310--------
    rs1495442181,2
    C--79780594(+) GGCTGC/GACGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM195B (79780287 - 79791178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FAM195B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3330n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3332n71CNV Loss21882294
    nsv470620CNV Loss18288195
    nsv428351CNV Gain18775914
    esv21913CNV Gain+Loss19812545
    nsv909128CNV Gain+Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM195B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM195B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348262 HGNC: 28007 AceView: LOC348262 Ensembl:ENSG00000225663 euGenes: HUgn348262
    ECgene: FAM195B H-InvDB: FAM195B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM195B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM195B gene:
    Search GeneIP for patents involving FAM195B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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