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Aliases for FAM195A Gene

Aliases for FAM195A Gene

  • Family With Sequence Similarity 195, Member A 2 3
  • C16orf14 3 4
  • Chromosome 16 Open Reading Frame 14 2
  • C349E10.1 3

External Ids for FAM195A Gene

Previous HGNC Symbols for FAM195A Gene

  • C16orf14

Previous GeneCards Identifiers for FAM195A Gene

  • GC16P000633
  • GC16P000692
  • GC16P000613
  • GC16P000694
  • GC16P000696
  • GC16P000698
  • GC16P000704
  • GC16P000729
  • GC16P000824
  • GC16P000845
  • GC16P000814

Summaries for FAM195A Gene

GeneCards Summary for FAM195A Gene

FAM195A (Family With Sequence Similarity 195, Member A) is a Protein Coding gene. Diseases associated with FAM195A include hepatic tuberculosis and granulomatous hepatitis. An important paralog of this gene is FAM195B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM195A Gene

Genomics for FAM195A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM195A Gene

Chromosome:
16
Start:
636,817 bp from pter
End:
648,474 bp from pter
Size:
11,658 bases
Orientation:
Plus strand

Genomic View for FAM195A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM195A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM195A Gene

No data available for Regulatory Elements for FAM195A Gene

Proteins for FAM195A Gene

  • Protein details for FAM195A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUT9-F195A_HUMAN
    Recommended name:
    Protein FAM195A
    Protein Accession:
    Q9BUT9
    Secondary Accessions:
    • Q969E9
    • Q96KV8

    Protein attributes for FAM195A Gene

    Size:
    160 amino acids
    Molecular mass:
    17828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM195A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM195A Gene

Proteomics data for FAM195A Gene at MOPED

Post-translational modifications for FAM195A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM195A Gene

No data available for DME Specific Peptides for FAM195A Gene

Domains & Families for FAM195A Gene

Protein Domains for FAM195A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM195A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUT9

UniProtKB/Swiss-Prot:

F195A_HUMAN :
  • Belongs to the FAM195 family.
Family:
  • Belongs to the FAM195 family.
genes like me logo Genes that share domains with FAM195A: view

No data available for Gene Families for FAM195A Gene

Function for FAM195A Gene

Gene Ontology (GO) - Molecular Function for FAM195A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FAM195A: view

Phenotypes for FAM195A Gene

GenomeRNAi human phenotypes for FAM195A:
genes like me logo Genes that share phenotypes with FAM195A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM195A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM195A Gene

Localization for FAM195A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM195A Gene COMPARTMENTS Subcellular localization image for FAM195A gene
Compartment Confidence
cytoskeleton 1
extracellular 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM195A Gene

Pathways & Interactions for FAM195A Gene

SuperPathways for FAM195A Gene

No Data Available

Interacting Proteins for FAM195A Gene

Selected Interacting proteins: Q9BUT9-F195A_HUMAN for FAM195A Gene via I2D

Symbol External ID(s) Details
EEF1G
PIK3CD
--
  • O00334 21

Gene Ontology (GO) - Biological Process for FAM195A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM195A Gene

Drugs & Compounds for FAM195A Gene

No Compound Related Data Available

Transcripts for FAM195A Gene

Unigene Clusters for FAM195A Gene

Family with sequence similarity 195, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM195A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM195A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6: - - - -
SP7: - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - -

Relevant External Links for FAM195A Gene

GeneLoc Exon Structure for
FAM195A
ECgene alternative splicing isoforms for
FAM195A

Expression for FAM195A Gene

mRNA expression in normal human tissues for FAM195A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM195A Gene

This gene is overexpressed in Fetal Liver (58.6) and Skin (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FAM195A Gene



SOURCE GeneReport for Unigene cluster for FAM195A Gene Hs.706105

genes like me logo Genes that share expression patterns with FAM195A: view

Protein tissue co-expression partners for FAM195A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM195A Gene

Orthologs for FAM195A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM195A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM195A 35
  • 91.18 (n)
  • 91.61 (a)
FAM195A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195a 35
  • 85.83 (n)
  • 85 (a)
Fam195a 16
Fam195a 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM195A 35
  • 99.37 (n)
  • 99.37 (a)
FAM195A 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam195a 35
  • 87.5 (n)
  • 85 (a)
dog
(Canis familiaris)
Mammalia FAM195A 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM195A 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195A 35
  • 73.43 (n)
  • 65.73 (a)
FAM195A 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195a 35
  • 57.41 (n)
  • 54.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-44g23.5 35
  • 67.38 (n)
  • 62.86 (a)
FAM195A 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10574 35
Species with no ortholog for FAM195A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM195A Gene

ENSEMBL:
Gene Tree for FAM195A (if available)
TreeFam:
Gene Tree for FAM195A (if available)

Paralogs for FAM195A Gene

Paralogs for FAM195A Gene

(1) SIMAP similar genes for FAM195A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FAM195A Gene

genes like me logo Genes that share paralogs with FAM195A: view

Variants for FAM195A Gene

Sequence variations from dbSNP and Humsavar for FAM195A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1810458 -- 645,287(+) AGTCT(C/T)GCTCT intron-variant
rs2384971 -- 647,249(-) CAGGC(A/C)TCTCT intron-variant
rs7203410 -- 646,111(+) CCCCT(C/G)GGGCG intron-variant
rs8049999 -- 644,428(+) ACCTC(C/G)CTGTT intron-variant
rs9940108 -- 646,499(+) ACCGA(A/G)AGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM195A Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv833114 CNV Gain+Loss 17160897
nsv471063 CNV Loss 18288195
dgv2484n71 CNV Loss 21882294
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv334n27 CNV Loss 19166990
nsv904760 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904779 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
dgv2489n71 CNV Loss 21882294
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
esv2663331 CNV Deletion 23128226

Variation tolerance for FAM195A Gene

Gene Damage Index Score: 0.32; 7.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM195A Gene

HapMap Linkage Disequilibrium report
FAM195A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM195A Gene

Disorders for FAM195A Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM195A Gene - From: DISEASES

Disorder Aliases PubMed IDs
hepatic tuberculosis
  • tuberculosis of liver
granulomatous hepatitis
- elite association

Relevant External Links for FAM195A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM195A
genes like me logo Genes that share disorders with FAM195A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM195A Gene

Publications for FAM195A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67

Products for FAM195A Gene

Sources for FAM195A Gene

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