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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM195A Gene

protein-coding GIFtS: 40
GCID: GC16P000729

family with sequence similarity 195, member A

(Previous name: chromosome 16 open reading frame 14 )
(Previous symbol: C16orf14)

Search for FAM195A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 195, Member A¹ ²
C16orf14¹ ² ³
MGC15416¹
Chromosome 16 Open Reading Frame 14¹
C349E10.1¹
Protein FAM195A²

External Ids:	HGNC: 14142¹	Entrez Gene: 84331²	Ensembl: ENSG00000172366⁷	UniProtKB: Q9BUT9³

Export aliases for FAM195A gene to outside databases

Previous GC identifers: GC16P000633 GC16P000692 GC16P000613 GC16P000694 GC16P000696 GC16P000698 GC16P000704

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for FAM195A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM195A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM195A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM195A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

FAM195A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM195A gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000729: view genomic region (about GC identifiers)

Start:	691,813 bp from pter	End:	698,474 bp from pter
Size:	6,662 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F195A_HUMAN, Q9BUT9 (See protein sequence)

Recommended Name: Protein FAM195A

Size: 160 amino acids; 17828 Da

Secondary accessions: Q969E9 Q96KV8

Alternative splicing: 2 isoforms: Q9BUT9-1 Q9BUT9-2 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FAM195A: NX_Q9BUT9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BUT9

FAM195A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_612427.2

ENSEMBL proteins:

ENSP00000305138 ENSP00000458625 ENSP00000433876

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9BUT9

UniProtKB/Swiss-Prot: F195A_HUMAN, Q9BUT9

Similarity: Belongs to the FAM195 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FAM195A

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

FAM195A for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM195A

3 Interacting proteins for FAM195A (Q9BUT9³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EEF1G	P26641³	I2D: score=4
PIK3CD	O00329³	I2D: score=2
--	O00334³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM195A
Search CenterWatch for drugs/clinical trials and news about FAM195A / F195A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for FAM195A gene (2 alternative transcripts):

NM_138418.2 NM_032371.2

Unigene Cluster for FAM195A:

Family with sequence similarity 195, member A

Hs.706105 [show with all ESTs]

Unigene Representative Sequence: AK054811

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000307650(uc002cic.1 uc002cid.1) ENST00000491999(uc021szz.1)

ENST00000474840 ENST00000575894

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Additional cDNA sequence:

AF386504.1 AK054811.1 BC001912.1 BC111391.1

15 DOTS entries:

DT.211081 DT.97856108 DT.75191244 DT.100756825 DT.95287595 DT.120676477 DT.100792924 DT.100036501

DT.120676463 DT.91935816 DT.120676435 DT.97858975 DT.120676487 DT.120676498 DT.91704278

24/153 AceView cDNA sequences (see all 153):

CA391514 BM696776 AK054811 BU622436 BF591335 CR608790 BC007346 CB155234

AW079526 BM553275 CB242316 BG574597 BC010562 AV683103 AJ709169 AW134724

CR602676 BU857054 BM849544 BM769242 BQ686073 NM_032371 NM_138418 BU627249

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for FAM195A (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:											-				-
SP2:											-				-		-
SP3:											-		-		-
SP4:											-				-
SP5:

ECgene alternative splicing isoforms for FAM195A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM195A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAGGGCC

About this image

FAM195A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM195A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM195A

SOURCE GeneReport for Unigene cluster: Hs.706105

SABiosciences Custom PCR Arrays for FAM195A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM195A gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Fam195a^{1 , 5}	family with sequence similarity 195, member A^{1, 5}	85.83(n)¹ 85(a)¹	17 (12.96 cM)⁵ 68241¹ NM_026633.3¹ NP_080909.1¹ 25863698⁵
chicken (Gallus gallus)	Aves	FAM195A¹	family with sequence similarity 195, member A	73.43(n) 65.73(a)	425184 XM_422971.3 XP_422971.3
zebrafish (Danio rerio)	Actinopterygii	si:dkey-44g23.5¹	si:dkey-44g23.5	66.67(n) 61.43(a)	567109 NM_001045127.3 NP_001038592.1

ENSEMBL Gene Tree for FAM195A (if available)
TreeFam Gene Tree for FAM195A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM195A gene

FAM195B²

1 SIMAP similar gene for FAM195A using alignment to 2 protein entries: F195A_HUMAN (see all proteins):

FAM195B

FAM195A for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for FAM195A
PGOHUM00000245123 PGOHUM00000241547

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71378528^1,2	C,	--	689967(+)	`TCCACT/CTCCTG`	1	--	us2k¹		2		NA	4
rs12050977^1,2		--	689993(+)	`cctgtC/G/Ttcagc`	1	--	us2k¹		0	--	--	--	--
rs186438966^1,2		--	690022(+)	`TACAGC/GTGTGT`	1	--	us2k¹		0	--	--	--	--
rs57161108^1,2		--	690068(+)	`GAGACA/GGAGTC`	1	--	us2k¹		0	--	--	--	--
rs138084967^1,2		--	690188(+)	`TATAGG/TCACCT`	1	--	us2k¹		0	--	--	--	--
rs71391144^1,2	C	--	690212(+)	`TTTTTT/-GTATT`	1	--	us2k¹		1		NA	2
rs189292829^1,2		--	690326(+)	`CAAAGC/TGCTGG`	1	--	us2k¹		0	--	--	--	--
rs182169254^1,2		--	690341(+)	`ACAGGA/TGTAAA`	1	--	us2k¹		0	--	--	--	--
rs78251364^1,2	F,	--	690505(+)	`CACGTC/TGGGCC`	1	--	us2k¹		1		WA	118
rs143865501^1,2		--	690624(+)	`CCAGGA/GGGATG`	2	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM195A (691813 - 698474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FAM195A
11 CNVs: 49727 53069 29986 49728 3987 29982 5329 30732 29983 4914 29985

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FAM195A for disorders About MalaCards

FAM195A for disorders About GeneDecksing

1 disease from the University of Copenhagen DISEASES database for FAM195A:

Cancer

Export disorders for FAM195A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM195A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM195A)

Utopia: connect your pdf to the dynamic
world of online information

The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84331	HGNC: 14142	AceView: MGC15416	Ensembl:ENSG00000172366	euGenes: HUgn84331
ECgene: FAM195A	H-InvDB: FAM195A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM195A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM195A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM195A gene:
Search GeneIP for patents involving FAM195A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FAM195A gene at Home site.

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FAM195A Gene

family with sequence similarity 195, member A

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for FAM195A gene

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Export list of displayed genes

FAM195A Gene

family with sequence similarity 195, member A

Aliasesfor FAM195A gene

Summariesfor FAM195A gene

Genomic Viewsfor FAM195A gene

Proteinsfor FAM195A gene

Protein Domains /Familiesfor FAM195A gene

Functionfor FAM195A gene

Pathways & Interactionsfor FAM195A gene

Drugs & Compoundsfor FAM195A gene

Transcriptsfor FAM195A gene

Expression for FAM195A gene

Orthologsfor FAM195A gene

Paralogsfor FAM195A gene

Genomic Variantsfor FAM195A gene

Disorders / Diseasesfor FAM195A gene

Publicationsfor FAM195A gene

External Searches for FAM195A gene

Genome Databases showing FAM195A gene

Other Databases showing FAM195A gene

Specialized Databases showing FAM195A gene

Intellectual Propertyfor FAM195A gene

Productsfor FAM195A gene

View Random Gene

Aliases
for FAM195A gene

Summaries
for FAM195A gene

Genomic Views
for FAM195A gene

Proteins
for FAM195A gene

Protein Domains /
Families
for FAM195A gene

Function
for FAM195A gene

Pathways & Interactions
for FAM195A gene

Drugs & Compounds
for FAM195A gene

Transcripts
for FAM195A gene

Expression
for FAM195A gene

Orthologs
for FAM195A gene

Paralogs
for FAM195A gene

Genomic Variants
for FAM195A gene

Disorders / Diseases
for FAM195A gene

Publications
for FAM195A gene

Intellectual Property
for FAM195A gene

Products
for FAM195A gene