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FAM195A Gene

protein-coding   GIFtS: 38
GCID: GC16P000845

Family With Sequence Similarity 195, Member A

(Previous name: chromosome 16 open reading frame 14)
(Previous symbol: C16orf14)
  Search for FAM195A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 195, Member A1 2
C16orf141 2 3
Chromosome 16 Open Reading Frame 141
c349E10.12
Protein FAM195A2

External Ids:    HGNC: 141421   Entrez Gene: 843312   Ensembl: ENSG000001723667   UniProtKB: Q9BUT93   

Export aliases for FAM195A gene to outside databases

Previous GC identifers: GC16P000633 GC16P000692 GC16P000613 GC16P000694 GC16P000696 GC16P000698 GC16P000704 GC16P000729 GC16P000824


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM195A Gene:
FAM195A (family with sequence similarity 195, member A) is a protein-coding gene. An important paralog of this gene is FAM195B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM195A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM195A promoter sequence
   Search Chromatin IP Primers for FAM195A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM195A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

FAM195A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM195A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000845:  view genomic region     (about GC identifiers)

Start:
691,813 bp from pter      End:
698,474 bp from pter
Size:
6,662 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F195A_HUMAN, Q9BUT9 (See protein sequence)
Recommended Name: Protein FAM195A  
Size: 160 amino acids; 17828 Da
Secondary accessions: Q969E9 Q96KV8
Alternative splicing: 2 isoforms:  Q9BUT9-1   Q9BUT9-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FAM195A: NX_Q9BUT9

Explore proteomics data for FAM195A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM195A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612427.2  
    ENSEMBL proteins: 
     ENSP00000305138   ENSP00000458625   ENSP00000433876  

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    Cloud-Clone Corp. CLIAs for FAM195A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9BUT9

    UniProtKB/Swiss-Prot: F195A_HUMAN, Q9BUT9
    Similarity: Belongs to the FAM195 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FAM195A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM195A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM195A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM195A

    miRNA
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    miRTarBase miRNAs that target FAM195A:
    hsa-mir-760 (MIRT036773)

    Block miRNA regulation of human, mouse, rat FAM195A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate FAM195A:
    hsa-miR-3934 hsa-miR-644 hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidFAM195A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM195A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: FAM195A (NM_138418)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM195A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM195A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM195A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM195A
    Interactions:

        Search GeneGlobe Interaction Network for FAM195A

    3 Interacting proteins for FAM195A (Q9BUT93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266413I2D: score=4 
    PIK3CDO003293I2D: score=2 
    --O003343I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM195A (F195A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM195A gene (2 alternative transcripts): 
    NM_138418.2  NM_032371.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307650(uc002cic.1 uc002cid.1) ENST00000491999(uc021szz.1)
    ENST00000474840 ENST00000575894
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate FAM195A:
    hsa-miR-3934 hsa-miR-644 hsa-miR-3194-5p
    SwitchGear 3'UTR luciferase reporter plasmidFAM195A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM195A
    Predesigned siRNA for gene silencing in human, mouse, rat FAM195A
    Clone
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    OriGene clones in human, mouse for FAM195A (see all 8)
    OriGene ORF clones in mouse, rat for FAM195A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM195A (NM_138418)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM195A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM195A
    Primer
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    OriGene qPCR primer pairs and template standards for FAM195A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM195A
      QuantiTect SYBR Green Assays in human, mouse, rat FAM195A
      QuantiFast Probe-based Assays in human, mouse, rat FAM195A

    Selected AceView cDNA sequences (see all 153):

    BM676345 BM696776 BM769242 AI805079 AI859283 CB155234 BU857054 AW079526 
    BM849544 CR602674 CR619805 BM773360 BQ686073 BC010562 AJ709169 BC001912 
    CB242316 AV683103 BM553275 AK054811 BU627249 NM_032371 CR602676 CA391514 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM195A (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                -           -                                                                     
    SP2:                                -           -     -                                                               
    SP3:                                -     -     -                                                                     
    SP4:                                -           -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FAM195A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM195A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGGCC
    FAM195A Expression
    About this image


    FAM195A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
    FAM195A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM195A Protein Expression
        Custom PCR Arrays for FAM195A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FAM195A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM195A
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    QuantiFast Probe-based Assays in human, mouse, rat FAM195A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM195A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM195A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam195a1 , 5 family with sequence similarity 195, member A1, 5 85.83(n)1
    85(a)1
      17 (12.96 cM)5
    682411  NM_026633.31  NP_080909.11 
     258636985 
    chicken
    (Gallus gallus)
    Aves FAM195A1 family with sequence similarity 195, member A 73.43(n)
    65.73(a)
      425184  XM_422971.4  XP_422971.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam195a1 family with sequence similarity 195, member A 57.41(n)
    54.86(a)
      733473  NM_001044420.1  NP_001037885.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-44g23.51 si:dkey-44g23.5 67.38(n)
    62.86(a)
      567109  NM_001045127.3  NP_001038592.1 


    ENSEMBL Gene Tree for FAM195A (if available)
    TreeFam Gene Tree for FAM195A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM195A gene
    FAM195B2  
    1 SIMAP similar gene for FAM195A using alignment to 2 protein entries:     F195A_HUMAN (see all proteins):
    FAM195B

    FAM195A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FAM195A
    PGOHUM00000245123 PGOHUM00000241547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM195A (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383943701,2
    --611636(+) TCCTTC/TGGGCT 1 -- us2k10--------
    rs757106531,2
    C,F--611647(+) CCCAAT/GAAACT 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1848930841,2
    --611659(+) GTCTGC/TGGAGG 1 -- us2k10--------
    rs1890124431,2
    --611681(+) TCTTCA/TGACCT 1 -- us2k10--------
    rs782027931,2
    C--611744(+) CTTGTC/TGCGCT 1 -- us2k10--------
    rs767577211,2
    C--611763(+) CAGGAA/GAGGCC 1 -- us2k10--------
    rs713785281,2
    C,F--689967(+) TCCACT/CTCCTG 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs120509771,2
    F--689993(+) cctgtC/G/Ttcagc 1 -- us2k10--------
    rs1864389661,2
    --690022(+) TACAGC/GTGTGT 1 -- us2k10--------
    rs571611081,2
    --690068(+) GAGACA/GGAGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM195A (691813 - 698474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM195A (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663331CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2489n71CNV Loss21882294
    dgv2475n71CNV Loss21882294
    nsv904760CNV Loss21882294
    dgv334n27CNV Loss19166990
    nsv904779CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2487n71CNV Loss21882294
    nsv904759CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM195A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM195A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for FAM195A:
    Cancer

    FAM195A for disorders           About GeneDecksing


    Export disorders for FAM195A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM195A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM195A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84331 HGNC: 14142 AceView: MGC15416 Ensembl:ENSG00000172366 euGenes: HUgn84331
    ECgene: FAM195A H-InvDB: FAM195A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM195A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM195A gene:
    Search GeneIP for patents involving FAM195A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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