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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM194B Gene

protein-coding   GIFtS: 33
GCID: GC13M046115          (predicted)

Family With Sequence Similarity 194, Member B

  Search for FAM194B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 194, Member B1 2
Protein FAM194B2

External Ids:    HGNC: 265231   Entrez Gene: 2200812   Ensembl: ENSG000001658377   UniProtKB: Q5W0A03   

Export aliases for FAM194B gene to outside databases

Previous GC identifers: GC13M045014 GC13M026911


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM194B Gene: 
FAM194B (family with sequence similarity 194, member B) is a protein-coding gene. An important paralog of this gene is FAM194A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM194B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM194B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM194B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.13   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.13

FAM194B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM194B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M046115:  view genomic region     (about GC identifiers)

Start:
46,108,657 bp from pter      End:
46,189,874 bp from pter
Size:
81,218 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F194B_HUMAN, Q5W0A0 (See protein sequence)
Recommended Name: Protein FAM194B  
Size: 696 amino acids; 81686 Da
Secondary accessions: Q96MB5
Alternative splicing: 2 isoforms:  Q5W0A0-1   Q5W0A0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FAM194B: NX_Q5W0A0

Explore proteomics data for FAM194B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5W0A0

  • FAM194B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FAM194B Protein Expression
    REFSEQ proteins: NP_872348.2  
    ENSEMBL proteins: 
     ENSP00000298738  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5W0A0

    UniProtKB/Swiss-Prot: F194B_HUMAN, Q5W0A0
    Similarity: Belongs to the FAM194 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM194B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM194B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM194B (F194B)

    Search CenterWatch for drugs/clinical trials and news about FAM194B / F194B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FAM194B gene: 
    NM_182542.2  

    Unigene Cluster for FAM194B:

    Family with sequence similarity 194, member B
    Hs.668747  [show with all ESTs]
    Unigene Representative Sequence: NM_182542
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504261 ENST00000298738(uc001val.2) ENST00000482992 ENST00000378977(uc001vam.1)

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    Additional mRNA sequence: 

    AK057244.1 BC131494.1 

    2 DOTS entries:

    DT.75156438  DT.100776939 

    3 AceView cDNA sequences:

    BM666456 AK057244 AI377871 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM194B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                     
    SP2:              -                           
    SP3:              -     -                     


    ECgene alternative splicing isoforms for FAM194B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM194B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM194B Expression
    About this image


    See FAM194B Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.668747
        SABiosciences Custom PCR Arrays for FAM194B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM194B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FAM194B gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FAM194B1 family with sequence similarity 194, member B 67.43(n)
    51.14(a)
      100683849  XM_003433035.1  XP_003433083.1 
    chicken
    (Gallus gallus)
    Aves FAM194B1 family with sequence similarity 194, member B 43.78(n)
    30.71(a)
      418847  XM_417042.3  XP_417042.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM194B6
    Uncharacterized protein
    45(a)
    1 ↔ 1
    GL343297.1(1280694-1286707)


    ENSEMBL Gene Tree for FAM194B (if available)
    TreeFam Gene Tree for FAM194B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM194B gene
    FAM194A2  
    1 SIMAP similar gene for FAM194B using alignment to 1 protein entry:     F194B_HUMAN:
    FLJ32682

    FAM194B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1676 SNPs in FAM194B are shown (see all 1676)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931639531,2
    C--46114943(+) GGCCTA/GAGGAA 1 -- ds50010--------
    rs46208611,2
    H--46114995(+) ACTCAG/ACCTAC 1 -- ds50014Minor allele frequency- A:0.00NS EA 416
    rs15362081,2
    C,F,O,A,H--46115014(-) GGGTCC/TGTGAG 1 -- ds500128Minor allele frequency- T:0.30NS EA NA WA CSA 2495
    rs1847090311,2
    --46115077(+) GTGACA/GCTGAG 1 -- ds50010--------
    rs614832411,2
    C,F--46115129(+) CATTAT/ACTAAT 1 -- ds50018Minor allele frequency- A:0.32WA CSA NA EA 366
    rs1871811691,2
    --46115266(+) ACAGTC/TGTTGT 1 -- ds50010--------
    rs1470971651,2
    --46115284(+) CAAGGA/CCCGTA 1 -- ds50010--------
    rs1161554241,2
    F--46115287(+) GGCCCG/ATACTG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs602506501,2
    C,F--46115306(+) AAAAGT/AACTGA 1 -- ds50015Minor allele frequency- A:0.47WA CSA 126
    rs1911892101,2
    --46115376(+) CTTCCC/GTGCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FAM194B (46108657 - 46189874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM194B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv250e201CNV Deletion23290073
    esv2747349CNV Deletion23290073
    esv2747350CNV Deletion23290073
    esv1002062CNV Loss20482838
    esv275007CNV Loss21479260
    nsv510583CNV Loss20534489
    dgv325n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FAM194B for disorders           About MalaCards

    FAM194B for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM194B
    Human Genome Epidemiology (HuGE) Navigator: FAM194B (1 document)

    Export disorders for FAM194B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM194B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM194B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220081 HGNC: 26523 AceView: FLJ32682 Ensembl:ENSG00000165837 euGenes: HUgn220081
    ECgene: FAM194B H-InvDB: FAM194B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM194B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FAM194B gene:
    Search GeneIP for patents involving FAM194B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM194B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FAM194B
     Browse SwitchGear Promoter luciferase reporter plasmids for FAM194B
     Search ThermoFisher Antibodies for FAM194B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM194B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM194B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM194B
    Customized:
     lentivirus for stable overexpression of FAM194B
     lentivirus expression plasmids for stable overexpression of FAM194B
     adenovirus for overexpression of FAM194B
     Search LSBio for Antibodies for FAM194B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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