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Aliases for FAM193B Gene

Aliases for FAM193B Gene

  • Family With Sequence Similarity 193, Member B 2 3
  • IRIZIO 3 4
  • Protein FAM193B 3
  • KIAA1931 4

External Ids for FAM193B Gene

Previous GeneCards Identifiers for FAM193B Gene

  • GC05M176880
  • GC05M176946
  • GC05M171867

Summaries for FAM193B Gene

GeneCards Summary for FAM193B Gene

FAM193B (Family With Sequence Similarity 193, Member B) is a Protein Coding gene. An important paralog of this gene is FAM193A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM193B Gene

Genomics for FAM193B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM193B Gene

Start:
177,519,788 bp from pter
End:
177,554,547 bp from pter
Size:
34,760 bases
Orientation:
Minus strand

Genomic View for FAM193B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM193B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM193B Gene

No data available for Regulatory Elements for FAM193B Gene

Proteins for FAM193B Gene

  • Protein details for FAM193B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PV7-F193B_HUMAN
    Recommended name:
    Protein FAM193B
    Protein Accession:
    Q96PV7
    Secondary Accessions:
    • E9PET5
    • Q9NW00

    Protein attributes for FAM193B Gene

    Size:
    902 amino acids
    Molecular mass:
    96543 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67824.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM193B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM193B Gene

Proteomics data for FAM193B Gene at MOPED

Post-translational modifications for FAM193B Gene

  • Ubiquitination at Lys680
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM193B Gene

Domains for FAM193B Gene

Protein Domains for FAM193B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM193B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PV7

UniProtKB/Swiss-Prot:

F193B_HUMAN :
  • Q96PV7
Family:
  • Belongs to the FAM193 family.
genes like me logo Genes that share domains with FAM193B: view

No data available for Gene Families for FAM193B Gene

Function for FAM193B Gene

Gene Ontology (GO) - Molecular Function for FAM193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM193B: view

Phenotypes for FAM193B Gene

GenomeRNAi human phenotypes for FAM193B:
genes like me logo Genes that share phenotypes with FAM193B: view

Animal Model Products

CRISPR Products

miRNA for FAM193B Gene

miRTarBase miRNAs that target FAM193B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM193B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM193B Gene

Localization for FAM193B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM193B Gene

Cytoplasm. Nucleus. Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM193B Gene COMPARTMENTS Subcellular localization image for FAM193B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM193B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 21177767
genes like me logo Genes that share ontologies with FAM193B: view

Pathways for FAM193B Gene

SuperPathways for FAM193B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM193B Gene

None

No data available for Pathways by source for FAM193B Gene

Transcripts for FAM193B Gene

Unigene Clusters for FAM193B Gene

Family with sequence similarity 193, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM193B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM193B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^ 12 ^
SP1:
SP2: - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8: - -
SP9: - -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15: - - - -
SP16:

ExUns: 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - -
SP10:
SP11: - -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for FAM193B Gene

GeneLoc Exon Structure for
FAM193B
ECgene alternative splicing isoforms for
FAM193B

Expression for FAM193B Gene

mRNA expression in normal human tissues for FAM193B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FAM193B Gene

This gene is overexpressed in Heart (43.8) and Peripheral blood mononuclear cells (22.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FAM193B Gene

SOURCE GeneReport for Unigene cluster for FAM193B Gene Hs.484289

mRNA Expression by UniProt/SwissProt for FAM193B Gene

Q96PV7-F193B_HUMAN
Tissue specificity: Isoform 1 is up-regulated in both embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma cell lines.
genes like me logo Genes that share expressions with FAM193B: view

Expression partners for FAM193B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FAM193B Gene

Orthologs for FAM193B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM193B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM193B 35
  • 90.5 (n)
  • 90.13 (a)
FAM193B 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM193B 35
  • 99.64 (n)
  • 99.64 (a)
FAM193B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam193b 16
Fam193b 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM193B 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM193B 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM193B 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM193B 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3763 35
zebrafish
(Danio rerio)
Actinopterygii fam193b 36
  • 31 (a)
OneToOne
Species with no ortholog for FAM193B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM193B Gene

ENSEMBL:
Gene Tree for FAM193B (if available)
TreeFam:
Gene Tree for FAM193B (if available)

Paralogs for FAM193B Gene

Paralogs for FAM193B Gene

genes like me logo Genes that share paralogs with FAM193B: view

Variants for FAM193B Gene

Sequence variations from dbSNP and Humsavar for FAM193B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8900 -- 177,520,106(-) CCCTC(C/T)GTGTG utr-variant-3-prime, nc-transcript-variant
rs163009 -- 177,541,989(-) tctat(A/G)ctgaa intron-variant
rs163010 -- 177,541,652(+) ctgac(C/T)tcgtg intron-variant
rs163196 -- 177,546,879(-) TGCAC(C/G/T)CAGGA intron-variant
rs163197 -- 177,543,434(+) CTACA(C/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM193B Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv6381n71 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv883177 CNV Loss 21882294
nsv5147 CNV Loss 18451855
esv1002656 CNV Deletion 20482838
nsv5148 CNV Insertion 18451855
nsv883181 CNV Loss 21882294
nsv883182 CNV Gain 21882294

Relevant External Links for FAM193B Gene

HapMap Linkage Disequilibrium report
FAM193B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM193B Gene

Disorders for FAM193B Gene

(1) University of Copenhagen DISEASES for FAM193B Gene

genes like me logo Genes that share disorders with FAM193B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for FAM193B Gene

Publications for FAM193B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). (PMID: 21177767) Picchione F. … Grosveld G.C. (Carcinogenesis 2011) 3 4
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for FAM193B Gene

Sources for FAM193B Gene

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