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Aliases for FAM193A Gene

Aliases for FAM193A Gene

  • Family With Sequence Similarity 193, Member A 2 3
  • C4orf8 3 4
  • Chromosome 4 Open Reading Frame 8 2
  • Protein FAM193A 3
  • Protein IT14 4
  • RES4-22 3

External Ids for FAM193A Gene

Previous Symbols for FAM193A Gene

  • C4orf8

Summaries for FAM193A Gene

GeneCards Summary for FAM193A Gene

FAM193A (Family With Sequence Similarity 193, Member A) is a Protein Coding gene. An important paralog of this gene is FAM193B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM193A Gene

Genomics for FAM193A Gene

Genomic Location for FAM193A Gene

Start:
2,596,003 bp from pter
End:
2,732,575 bp from pter
Size:
136,573 bases
Orientation:
Plus strand

Genomic View for FAM193A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM193A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM193A Gene

No data available for Regulatory Elements for FAM193A Gene

Proteins for FAM193A Gene

  • Protein details for FAM193A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78312-F193A_HUMAN
    Recommended name:
    Protein FAM193A
    Protein Accession:
    P78312
    Secondary Accessions:
    • B7ZM85
    • B9EGR0
    • E9PFA1
    • O43607
    • P78311
    • P78313
    • Q9UEG8

    Protein attributes for FAM193A Gene

    Size:
    1265 amino acids
    Molecular mass:
    139988 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM193A Gene

neXtProt entry for FAM193A Gene

Proteomics data for FAM193A Gene at MOPED

Post-translational modifications for FAM193A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM193A Gene

Domains for FAM193A Gene

Protein Domains for FAM193A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F193A_HUMAN
Family:
  • Belongs to the FAM193 family.:
    • P78312
genes like me logo Genes that share domains with FAM193A: view

No data available for Gene Families for FAM193A Gene

Function for FAM193A Gene

Phenotypes for FAM193A Gene

GenomeRNAi human phenotypes for FAM193A:
genes like me logo Genes that share phenotypes with FAM193A: view

miRNA for FAM193A Gene

miRTarBase miRNAs that target FAM193A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM193A Gene

Localization for FAM193A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM193A Gene COMPARTMENTS Subcellular localization image for FAM193A gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FAM193A Gene

Pathways for FAM193A Gene

SuperPathways for FAM193A Gene

No Data Available

Interacting Proteins for FAM193A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000372290%0d%0a9606.ENSP00000382379%0d%0a
Selected Interacting proteins: ENSP00000372290 P78312-F193A_HUMAN for FAM193A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FAM193A Gene

None

No data available for Pathways by source for FAM193A Gene

Transcripts for FAM193A Gene

Unigene Clusters for FAM193A Gene

Family with sequence similarity 193, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM193A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6: -
SP7: - - -

ExUns: 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for FAM193A Gene

GeneLoc Exon Structure for
FAM193A
ECgene alternative splicing isoforms for
FAM193A

Expression for FAM193A Gene

mRNA expression in normal human tissues for FAM193A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM193A Gene

SOURCE GeneReport for Unigene cluster for FAM193A Gene Hs.652364

genes like me logo Genes that share expressions with FAM193A: view

Orthologs for FAM193A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM193A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM193A 36
  • 99.18 (n)
  • 98.97 (a)
FAM193A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM193A 36
  • 81.45 (n)
  • 83.63 (a)
FAM193A 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM193A 36
  • 87.02 (n)
  • 89.81 (a)
FAM193A 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam193a 36
  • 86.22 (n)
  • 89.09 (a)
Fam193a 16
Fam193a 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM193A 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM193A 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam193a 36
  • 82.82 (n)
  • 84.88 (a)
chicken
(Gallus gallus)
Aves FAM193A 36
  • 76.11 (n)
  • 79.93 (a)
FAM193A 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM193A 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3384 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fam193a 36
  • 71.32 (n)
  • 72.85 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11568 36
fam193a 37
  • 46 (a)
OneToOne
LOC100534836 36
  • 68.68 (n)
  • 68.79 (a)
Species with no ortholog for FAM193A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM193A Gene

ENSEMBL:
Gene Tree for FAM193A (if available)
TreeFam:
Gene Tree for FAM193A (if available)

Paralogs for FAM193A Gene

Paralogs for FAM193A Gene

Selected SIMAP similar genes for FAM193A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM193A: view

Variants for FAM193A Gene

Sequence variations from dbSNP and Humsavar for FAM193A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8426 -- 2,732,448(-) ACAGA(C/T)TTGAT utr-variant-3-prime, nc-transcript-variant
rs10311 -- 2,732,405(+) CAGAA(C/T)GAGAA utr-variant-3-prime, nc-transcript-variant
rs28483 -- 2,692,169(+) attga(C/G)tcaca intron-variant
rs170784 -- 2,685,364(-) TTTAA(C/T)TGAAT intron-variant
rs179695 -- 2,694,518(+) TTCCT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM193A Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv878443 CNV Gain 21882294
nsv829839 CNV Loss 17160897
esv2726856 CNV Deletion 23290073
esv2678225 CNV Deletion 23128226
esv275488 CNV Loss 21479260
nsv470001 CNV Gain 18288195
nsv878444 CNV Loss 21882294
nsv470002 CNV Loss 18288195
dgv5426n71 CNV Loss 21882294
nsv516797 CNV Loss 19592680

Relevant External Links for FAM193A Gene

HapMap Linkage Disequilibrium report
FAM193A

Disorders for FAM193A Gene

(1) University of Copenhagen DISEASES for FAM193A Gene

Relevant External Links for FAM193A

Genetic Association Database (GAD)
FAM193A
Human Genome Epidemiology (HuGE) Navigator
FAM193A
genes like me logo Genes that share disorders with FAM193A: view

No data available for UniProtKB/Swiss-Prot for FAM193A Gene

Publications for FAM193A Gene

  1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PMID: 9734812) Hadano S. … Ikeda J.-E. (DNA Res. 1998) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for FAM193A Gene

Sources for FAM193A Gene

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