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FAM189B Gene

protein-coding   GIFtS: 48
GCID: GC01M155216

Family With Sequence Similarity 189, Member B

(Previous name: chromosome 1 open reading frame 2)
(Previous symbol: C1orf2)
  Search for FAM189B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 189, Member B1 2
C1orf21 2 3
COTE12 3
Chromosome 1 Open Reading Frame 21
Protein FAM189B2
Protein COTE13

External Ids:    HGNC: 12331   Entrez Gene: 107122   Ensembl: ENSG000001607677   UniProtKB: P814083   

Export aliases for FAM189B gene to outside databases

Previous GC identifers: GC01M153484 GC01M126579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM189B Gene:
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is
associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW
domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for FAM189B Gene:
FAM189B (family with sequence similarity 189, member B) is a protein-coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is FAM189A1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM189B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM189B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM189B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

FAM189B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM189B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155216:  view genomic region     (about GC identifiers)

Start:
155,216,996 bp from pter      End:
155,225,274 bp from pter
Size:
8,279 bases      Orientation:
minus strand

1 alternative location:
Chr1-,NW_003315906 52,228-60,506     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: F189B_HUMAN, P81408 (See protein sequence)
Recommended Name: Protein FAM189B  
Size: 668 amino acids; 71355 Da
Subunit: May interact with WWOX
Secondary accessions: B1AVS5 Q8IXL3 Q9BR66
Alternative splicing: 4 isoforms:  P81408-1   P81408-2   P81408-3   P81408-4   

Explore the universe of human proteins at neXtProt for FAM189B: NX_P81408

Explore proteomics data for FAM189B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys579
  • Glycosylation2 at Asn160
  • Modification sites at PhosphoSitePlus

  • See FAM189B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254537.1  NP_006580.2  NP_937995.1  

    ENSEMBL proteins: 
     ENSP00000307128   ENSP00000357352   ENSP00000354958   ENSP00000427520   ENSP00000427011  

    FAM189B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FAM189B
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    Novus Biologicals FAM189B Protein
    Novus Biologicals FAM189B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FAM189B

     
    Search eBioscience for Proteins for FAM189B 

    FAM189B Antibody Products:

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    Abcam antibodies for FAM189B
    Cloud-Clone Corp. Antibodies for FAM189B
    Search ThermoFisher Antibodies for FAM189B
    LSBio Antibodies in human, mouse, rat for FAM189B

    FAM189B Assay Products:

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    Cloud-Clone Corp. CLIAs for FAM189B
    Search eBioscience for ELISAs for FAM189B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry P81408

    ProtoNet protein and cluster: P81408

    UniProtKB/Swiss-Prot: F189B_HUMAN, P81408
    Similarity: Belongs to the FAM189 family


    Find genes that share domains with FAM189B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15064722
    GO:0050699WW domain binding IPI15064722
         
    Find genes that share ontologies with FAM189B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM189B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FAM189B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM189B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM189B

    miRNA
    Products:
        
    miRTarBase miRNAs that target FAM189B:
    hsa-mir-532-3p (MIRT037920), hsa-mir-423-5p (MIRT038131), hsa-mir-92a-3p (MIRT049466), hsa-mir-16-5p (MIRT032049)

    Block miRNA regulation of human, mouse, rat FAM189B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM189B (see all 15):
    hsa-miR-3194-5p hsa-miR-550a hsa-miR-15a hsa-miR-575 hsa-miR-1301 hsa-miR-497 hsa-miR-103a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFAM189B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FAM189B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM189B

    Gene Editing
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    OriGene ORF clones in mouse, rat for FAM189B
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    GenScript: all cDNA clones in your preferred vector (see all 2): FAM189B (NM_198264)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM189B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM189B

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    Browse ESI BIO Cell Lines and PureStem Progenitors for FAM189B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM189B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F189B_HUMAN, P81408: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FAM189B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM189B
    Interactions:

        Search GeneGlobe Interaction Network for FAM189B

    3 Interacting proteins for FAM189B (P814081, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134243I2D: score=1 
    YWHAZP631043I2D: score=1 
    WWOXQ9NZC71EBI-6366314,EBI-4320739
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with FAM189B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM189B (F189B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM189B gene (3 alternative transcripts): 
    NM_001267608.1  NM_006589.2  NM_198264.1  

    Unigene Cluster for FAM189B:

    Family with sequence similarity 189, member B
    Hs.348308  [show with all ESTs]
    Unigene Representative Sequence: NM_006589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350210(uc009wql.3) ENST00000368366 ENST00000368368 ENST00000361361(uc001fjm.3 uc001fjn.3 uc001fjo.3 uc001fjp.3)
    ENST00000487649 ENST00000491082 ENST00000497941 ENST00000472550 ENST00000481822(uc001fjq.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FAM189B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FAM189B (see all 15):
    hsa-miR-3194-5p hsa-miR-550a hsa-miR-15a hsa-miR-575 hsa-miR-1301 hsa-miR-497 hsa-miR-103a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFAM189B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM189B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM189B
    Clone
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    OriGene clones in human, mouse for FAM189B (see all 13)
    OriGene ORF clones in mouse, rat for FAM189B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FAM189B (NM_198264)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FAM189B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM189B
    Primer
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    OriGene qPCR primer pairs and template standards for FAM189B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM189B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM189B
      QuantiFast Probe-based Assays in human, mouse, rat FAM189B

    Additional mRNA sequence: 

    AF070550.1 BC006297.1 BC006493.2 BC007444.2 BC008854.2 BC010471.1 BC017262.2 BC033707.1 
    BC040136.1 

    14 DOTS entries:

    DT.100811718  DT.415458  DT.100811721  DT.91742385  DT.100754265  DT.91910649  DT.121439076  DT.91946107 
    DT.100739718  DT.121439094  DT.92020817  DT.97805151  DT.99965722  DT.100754264 

    Selected AceView cDNA sequences (see all 369):

    CA440266 CF529949 AW004948 BG254314 Z38316 CR607925 BF347349 AW170535 
    BQ898611 BC006493 BM763530 AL353941 BC014067 CD742665 NM_006589 BM547428 
    BU162233 BM995877 BM703689 BC006274 AW410495 AI440441 CA417291 BE741472 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM189B (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                                        -                                   -                                                         
    SP2:                          -     -     -     -           -                                   -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                        -                                                                                             
    SP5:                                                        -                                   -                                                         


    ECgene alternative splicing isoforms for FAM189B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM189B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTGGGCA
    FAM189B Expression
    About this image


    FAM189B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Lymph (Hematopoietic System)
    FAM189B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM189B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348308

    UniProtKB/Swiss-Prot: F189B_HUMAN, P81408
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM189B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM189B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam189b1 , 5 family with sequence similarity 189, member B1, 5 88.62(n)1
    94.16(a)1
      3 (39.01 cM)5
    685211  NM_001014995.11  NP_001014995.11 
     891831435 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018827681 protein FAM189B-like 57.65(n)
    53.06(a)
      101882768  XM_005158145.1  XP_005158202.1 


    ENSEMBL Gene Tree for FAM189B (if available)
    TreeFam Gene Tree for FAM189B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM189B gene
    FAM189A12  FAM189A22  
    2 SIMAP similar genes for FAM189B using alignment to 2 protein entries:     F189B_HUMAN (see all proteins):
    C1orf2    FAM189A1

    Find genes that share paralogs with FAM189B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM189B (see all 237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356844
    A breast cancer sample4--see VAR_0356842 S F mis40--------
    rs21788151,2
    C,F,H--155216719(-) tccagG/Tctgca 3 -- int15Minor allele frequency- T:0.10NS NA 636
    rs1862214241,2
    --155216782(+) ACAGGC/TGTGTC 3 -- int10--------
    rs1906970191,2
    --155216874(+) TCAGGC/TGATCC 3 -- int10--------
    rs1827300391,2
    --155217139(+) GAGGTA/GGCAGA 3 -- ut310--------
    rs1150207761,2
    C,F--155217143(+) TGGCAG/AAGCTG 3 -- ut311Minor allele frequency- A:0.04WA 118
    rs1461920471,2
    --155217211(+) GCACAC/TGTCAC 3 -- ut310--------
    rs2015155711,2
    C--155217435(+) AGGTA-/ATT   
       
    /ATTG
    GGAGG
    6 -- cds1 ut310--------
    rs767185271,2
    C--155217436(+) AGGTAA/GGAGGG 3 -- ut310--------
    rs1163520801,2
    C,F--155217437(+) GGTAGG/TAGGGA 3 -- ut313Minor allele frequency- T:0.44WA NA EA 358

    HapMap Linkage Disequilibrium report for FAM189B (155216996 - 155225274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FAM189B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3n68CNV Loss17160897
    nsv470741CNV Loss18288195
    nsv872457CNV Loss21882294
    nsv831636CNV Loss17160897
    esv33869CNV Loss17666407
    esv28935CNV Gain19812545
    dgv132e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM189B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM189B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    Find genes that share disorders with FAM189B           About GenesLikeMe

    Genetic Association Database (GAD): FAM189B
    Human Genome Epidemiology (HuGE) Navigator: FAM189B (3 documents)

    Export disorders for FAM189B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM189B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FAM189B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PubMed id 9331372)1, 2, 3 Winfield S.L.... Sidransky E. (Genome Res. 1997)
    2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PubMed id 15064722)1, 2 Ludes-Meyers J.H....Aldaz C.M. (Oncogene 2004)
    3. Ectopic overexpression of COTE1 promotes cellular invasion of hepatocellular carcinoma. (PubMed id 23317259)1 Zhang H....Li X.C. (Asian Pac. J. Cancer Prev. 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. (PubMed id 17452746)1 Kallin A....Demoulin J.B. (J. Lipid Res. 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10712 HGNC: 1233 AceView: CLK2andC1orf2 Ensembl:ENSG00000160767 euGenes: HUgn10712
    ECgene: FAM189B H-InvDB: FAM189B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM189B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FAM189B gene:
    Search GeneIP for patents involving FAM189B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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