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Aliases for FAM189B Gene

Aliases for FAM189B Gene

  • Family With Sequence Similarity 189, Member B 2 3
  • C1orf2 3 4
  • COTE1 3 4
  • Chromosome 1 Open Reading Frame 2 2
  • Protein FAM189B 3
  • Protein COTE1 4

External Ids for FAM189B Gene

Previous HGNC Symbols for FAM189B Gene

  • C1orf2

Previous GeneCards Identifiers for FAM189B Gene

  • GC01M153484
  • GC01M155216
  • GC01M126579

Summaries for FAM189B Gene

Entrez Gene Summary for FAM189B Gene

  • This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for FAM189B Gene

FAM189B (Family With Sequence Similarity 189, Member B) is a Protein Coding gene. GO annotations related to this gene include WW domain binding. An important paralog of this gene is FAM189A2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM189B Gene

Genomics for FAM189B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FAM189B Gene

155,247,205 bp from pter
155,255,483 bp from pter
8,279 bases
Minus strand

Genomic View for FAM189B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM189B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM189B Gene

No data available for Regulatory Elements for FAM189B Gene

Proteins for FAM189B Gene

  • Protein details for FAM189B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM189B
    Protein Accession:
    Secondary Accessions:
    • B1AVS5
    • Q8IXL3
    • Q9BR66

    Protein attributes for FAM189B Gene

    668 amino acids
    Molecular mass:
    71355 Da
    Quaternary structure:
    • May interact with WWOX

    Alternative splice isoforms for FAM189B Gene


neXtProt entry for FAM189B Gene

Proteomics data for FAM189B Gene at MOPED

Post-translational modifications for FAM189B Gene

Other Protein References for FAM189B Gene

Antibody Products

No data available for DME Specific Peptides for FAM189B Gene

Domains for FAM189B Gene

Protein Domains for FAM189B Gene


Suggested Antigen Peptide Sequences for FAM189B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P81408
  • Belongs to the FAM189 family.
genes like me logo Genes that share domains with FAM189B: view

No data available for Gene Families for FAM189B Gene

Function for FAM189B Gene

Gene Ontology (GO) - Molecular Function for FAM189B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15064722
GO:0050699 WW domain binding IPI 15064722
genes like me logo Genes that share ontologies with FAM189B: view

Animal Model Products

CRISPR Products

miRNA for FAM189B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM189B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM189B Gene

Localization for FAM189B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM189B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM189B Gene COMPARTMENTS Subcellular localization image for FAM189B gene
Compartment Confidence
plasma membrane 3
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM189B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM189B: view

Pathways for FAM189B Gene

SuperPathways for FAM189B Gene

No Data Available

Interacting Proteins for FAM189B Gene

Gene Ontology (GO) - Biological Process for FAM189B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM189B: view

No data available for Pathways by source for FAM189B Gene

Transcripts for FAM189B Gene

Unigene Clusters for FAM189B Gene

Family with sequence similarity 189, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM189B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM189B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - -
SP2: - - - - - -
SP4: -
SP5: - -
SP6: -
SP7: - - - - - - - - - - - - - -
SP8: - - - -
SP9: -
SP10: - - - -
SP11: -

Relevant External Links for FAM189B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM189B Gene

mRNA expression in normal human tissues for FAM189B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for FAM189B Gene Hs.348308

mRNA Expression by UniProt/SwissProt for FAM189B Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with FAM189B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for FAM189B Gene

Orthologs for FAM189B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM189B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM189B 35
  • 91.47 (n)
  • 95.66 (a)
FAM189B 36
  • 96 (a)
(Canis familiaris)
Mammalia FAM189B 35
  • 90.62 (n)
  • 94.61 (a)
FAM189B 36
  • 94 (a)
(Mus musculus)
Mammalia Fam189b 35
  • 88.62 (n)
  • 94.16 (a)
Fam189b 16
Fam189b 36
  • 93 (a)
(Pan troglodytes)
Mammalia FAM189B 35
  • 99.65 (n)
  • 99.85 (a)
FAM189B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fam189b 35
  • 87.97 (n)
  • 94.01 (a)
(Monodelphis domestica)
Mammalia FAM189B 36
  • 87 (a)
(Danio rerio)
Actinopterygii LOC101882768 35
  • 57.65 (n)
  • 53.06 (a)
Species with no ortholog for FAM189B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM189B Gene

Gene Tree for FAM189B (if available)
Gene Tree for FAM189B (if available)

Paralogs for FAM189B Gene

Paralogs for FAM189B Gene

Selected SIMAP similar genes for FAM189B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM189B: view

Variants for FAM189B Gene

Sequence variations from dbSNP and Humsavar for FAM189B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs734073 -- 155,248,574(-) GTGGG(A/G)GCTGT intron-variant
rs734074 -- 155,248,655(-) AGTCC(C/T)TGTTG intron-variant
rs741756 -- 155,250,077(-) AAGGA(G/T)AATTT intron-variant
rs878436 -- 155,255,194(+) GCCGG(C/T)CCAGG utr-variant-5-prime, upstream-variant-2KB
rs909108 -- 155,255,234(+) CACCC(C/G)TCCCT utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FAM189B Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
esv28935 CNV Gain 19812545
nsv831636 CNV Loss 17160897
esv33869 CNV Loss 17666407

Relevant External Links for FAM189B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM189B Gene

Disorders for FAM189B Gene

Relevant External Links for FAM189B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FAM189B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FAM189B Gene

Publications for FAM189B Gene

  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield S.L. … Sidransky E. (Genome Res. 1997) 2 3 4
  2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. (PMID: 15064722) Ludes-Meyers J.H. … Aldaz C.M. (Oncogene 2004) 3 4
  3. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PMID: 15123239) Boisguerin P. … Volkmer-Engert R. (Chem. Biol. 2004) 3
  4. SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. (PMID: 17452746) Kallin A. … Demoulin J.B. (J. Lipid Res. 2007) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for FAM189B Gene

Sources for FAM189B Gene

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