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FAM189A2 Gene

protein-coding   GIFtS: 46
GCID: GC09P071939

Family With Sequence Similarity 189, Member A2

(Previous name: chromosome 9 open reading frame 61)
(Previous symbol: C9orf61)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 189, Member A21 2     Friedreich Ataxia Region Gene X1232
C9orf611 2 3     Protein FAM189A22
X1232 3 5     Protein X1233
Chromosome 9 Open Reading Frame 611     

External Ids:    HGNC: 248201   Entrez Gene: 94132   Ensembl: ENSG000001350637   OMIM: 6077105   UniProtKB: Q158843   

Export aliases for FAM189A2 gene to outside databases

Previous GC identifers: GC09P071134 GC09P041778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM189A2 Gene:
FAM189A2 (family with sequence similarity 189, member A2) is a protein-coding gene. Diseases associated with FAM189A2 include corneal ectasia, and friedreich ataxia. An important paralog of this gene is FAM189A1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM189A2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM189A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM189A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.11   Ensembl cytogenetic band:  9q21.11   HGNC cytogenetic band: 9q21.11

FAM189A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM189A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P071939:  view genomic region     (about GC identifiers)

Start:
71,939,488 bp from pter      End:
72,007,371 bp from pter
Size:
67,884 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F1892_HUMAN, Q15884 (See protein sequence)
Recommended Name: Protein FAM189A2 precursor  
Size: 450 amino acids; 49703 Da
Sequence caution: Sequence=AAA61301.1; Type=Erroneous initiation; Sequence=CAI15446.1; Type=Erroneous initiation;
Secondary accessions: Q14CN5 Q5T6C8 Q5T6C9 Q6ZTX4 Q96N10
Alternative splicing: 3 isoforms:  Q15884-3   Q15884-1   Q15884-2   (Ref.1 (AAA61301) sequence is in conflict in position: 19:C->CYS)

Explore the universe of human proteins at neXtProt for FAM189A2: NX_Q15884

Explore proteomics data for FAM189A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM189A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121080.1  NP_004807.3  

    ENSEMBL proteins: 
     ENSP00000257515   ENSP00000304435   ENSP00000366422   ENSP00000395675  

    FAM189A2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for FAM189A2

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    Cloud-Clone Corp. CLIAs for FAM189A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q15884

    ProtoNet protein and cluster: Q15884

    UniProtKB/Swiss-Prot: F1892_HUMAN, Q15884
    Similarity: Belongs to the FAM189 family


    FAM189A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    FAM189A2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM189A2
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    miRNA
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    miRTarBase miRNAs that target FAM189A2:
    hsa-mir-215-5p (MIRT024593), hsa-mir-192-5p (MIRT026758)

    Block miRNA regulation of human, mouse, rat FAM189A2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FAM189A2:
    hsa-miR-3121-3p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidFAM189A2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM189A2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    F1892_HUMAN, Q15884: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    FAM189A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM189A2
    Interactions:

        Search GeneGlobe Interaction Network for FAM189A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for FAM189A2 (Q158843 ENSP000002575154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319473, ENSP000003409894I2D: score=3 STRING: ENSP00000340989
    BAG3O958173, ENSP000003580814I2D: score=3 STRING: ENSP00000358081
    CALCOCO2Q131373I2D: score=1 
    OPTNQ96CV93I2D: score=1 
    STAM2O758863I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    FAM189A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM189A2 (F1892)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM189A2 gene (2 alternative transcripts): 
    NM_001127608.1  NM_004816.3  

    Unigene Cluster for FAM189A2:

    Family with sequence similarity 189, member A2
    Hs.118003  [show with all ESTs]
    Unigene Representative Sequence: NM_004816
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257515(uc004ahg.2) ENST00000303068(uc010moo.1) ENST00000460871
    ENST00000469179 ENST00000377216 ENST00000455972(uc010mon.1)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FAM189A2:
    hsa-miR-3121-3p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidFAM189A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM189A2
    Predesigned siRNA for gene silencing in human, mouse, rat FAM189A2
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FAM189A2

    Additional mRNA sequence: 

    AK056152.1 AK126127.1 BC021685.1 BC113683.1 BC113685.1 L27479.1 

    7 DOTS entries:

    DT.100661319  DT.101981483  DT.444402  DT.96085237  DT.121189933  DT.437053  DT.95310922 

    Selected AceView cDNA sequences (see all 48):

    NM_004816 AK126127 BF516006 BX282233 BI771919 BC021685 AW205253 AA442973 
    AI240080 F26848 H24769 CN479062 AA478205 BX641153 BM829134 R15436 
    AW779892 AW000728 CD366853 AK056152 AI961387 AA573429 AI682993 AI198786 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FAM189A2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
    SP1:              -                                   -     -                                   -                     
    SP2:                    -                             -     -                                   -                     
    SP3:                                                  -     -                                   -     -     -         
    SP4:              -                                                                                                   
    SP5:                                                  -     -                                                         


    ECgene alternative splicing isoforms for FAM189A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM189A2 expression in normal human tissues (normalized intensities)      FAM189A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTTTGG
    FAM189A2 Expression
    About this image


    FAM189A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Thyroid (Endocrine System)
    FAM189A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM189A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118003

    UniProtKB/Swiss-Prot: F1892_HUMAN, Q15884
    Tissue specificity: Prominently expressed in muscle

        Custom PCR Arrays for FAM189A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM189A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM189A2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam189a21 , 5 family with sequence similarity 189, member A21, 5 82.96(n)1
    86(a)1
      19 (19.00 cM)5
    3812171  NM_001114174.11  NP_001107646.11 
     239727515 
    chicken
    (Gallus gallus)
    Aves FAM189A21 family with sequence similarity 189, member A2 69.81(n)
    72.81(a)
      427245  XM_424828.4  XP_424828.4 
    lizard
    (Anolis carolinensis)
    Reptilia FAM189A26
    family with sequence similarity 189, member A2
    70(a)
    1 ↔ 1
    2(49552932-49596012)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam189a21 family with sequence similarity 189, member A2 66.92(n)
    67.55(a)
      100487300  XM_002935596.2  XP_002935642.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fam189a21 family with sequence similarity 189, member A2 59.16(n)
    56.32(a)
      503960  XM_005165476.1  XP_005165533.1 


    ENSEMBL Gene Tree for FAM189A2 (if available)
    TreeFam Gene Tree for FAM189A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM189A2 gene
    FAM189A12  FAM189B2  
    1 SIMAP similar gene for FAM189A2 using alignment to 1 protein entry:     F1892_HUMAN:
    DKFZp686J24109

    FAM189A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM189A2 (see all 1586)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1939210101,2
    Cuntested172000704(+) TTTTT-/A/TA  
            
    AATCA
    2 -- int10--------
    rs348841901,2
    C--41811302(+) TCTAC-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs339188231,2
    C--71896825(+) GTCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1820407691,2
    --71937491(+) CAAATG/TACAAC 1 -- us2k10--------
    rs114592231,2
    C--71937551(+) TTTTT-/T/TT  
            
    ATTAA
    1 -- us2k1 trp30--------
    rs680254431,2
    C--71937569(+) TTTTT-/A/AT  
            
    TTAAG
    1 -- us2k11NA 2
    rs736496481,2
    C--71937569(+) TTTTTT/ATTAAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1455544261,2
    --71937676(+) GGAGAC/TGCAAA 1 -- us2k10--------
    rs610419641,2
    C--71937677(+) GAGATG/ACAAAG 1 -- us2k13Minor allele frequency- A:0.15CSA WA NA 240
    rs1491776881,2
    --71937689(+) ATCAAG/TCTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FAM189A2 (71939488 - 72007371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FAM189A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738536CNV Deletion23290073
    esv2738537CNV Deletion23290073
    esv1110839CNV Deletion17803354
    nsv893431CNV Loss21882294
    nsv415460CNV Loss16902084
    nsv893428CNV Gain21882294
    dgv8247n71CNV Gain21882294
    nsv831610CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM189A2
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM189A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607710    OMIM disorders: --

    5 diseases for FAM189A2:    About MalaCards
    corneal ectasia    friedreich ataxia    ataxia    keratoconus
    bipolar disorder


    FAM189A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FAM189A2

    Export disorders for FAM189A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM189A2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM189A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb. (PubMed id 7951235)1, 2, 3 Duclos F.... Koenig M. (Hum. Mol. Genet. 1994)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. (PubMed id 22925353)1 Lee H.J....Kelsoe J.R. (J Affect Disord 2013)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9413 HGNC: 24820 AceView: C9orf61 Ensembl:ENSG00000135063 euGenes: HUgn9413
    ECgene: FAM189A2 H-InvDB: FAM189A2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FAM189A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM189A2 gene:
    Search GeneIP for patents involving FAM189A2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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