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Aliases for FAM189A1 Gene

Aliases for FAM189A1 Gene

  • Family With Sequence Similarity 189 Member A1 2 3 5
  • Transmembrane Protein 228 2 3 4
  • Family With Sequence Similarity 189, Member A1 2 3
  • TMEM228 3 4
  • KIAA0574 4

External Ids for FAM189A1 Gene

Previous GeneCards Identifiers for FAM189A1 Gene

  • GC15M029412
  • GC15M007069

Summaries for FAM189A1 Gene

GeneCards Summary for FAM189A1 Gene

FAM189A1 (Family With Sequence Similarity 189 Member A1) is a Protein Coding gene. An important paralog of this gene is FAM189A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM189A1 Gene

Genomics for FAM189A1 Gene

Regulatory Elements for FAM189A1 Gene

Enhancers for FAM189A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM189A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM189A1 Gene

29,120,252 bp from pter
29,570,723 bp from pter
450,472 bases
Minus strand

Genomic View for FAM189A1 Gene

Genes around FAM189A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM189A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM189A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM189A1 Gene

Proteins for FAM189A1 Gene

  • Protein details for FAM189A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM189A1
    Protein Accession:
    Secondary Accessions:
    • A0PK09

    Protein attributes for FAM189A1 Gene

    539 amino acids
    Molecular mass:
    56544 Da
    Quaternary structure:
    No Data Available
    • Sequence=BC127817; Type=Frameshift; Positions=177; Evidence={ECO:0000305}; Sequence=BG752856; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM189A1 Gene


neXtProt entry for FAM189A1 Gene

Proteomics data for FAM189A1 Gene at MOPED

Post-translational modifications for FAM189A1 Gene

No Post-translational modifications

Other Protein References for FAM189A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM189A1 Gene

Domains & Families for FAM189A1 Gene

Protein Domains for FAM189A1 Gene


Suggested Antigen Peptide Sequences for FAM189A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



F1891_HUMAN :
  • Belongs to the FAM189 family.
  • Belongs to the FAM189 family.
genes like me logo Genes that share domains with FAM189A1: view

No data available for Gene Families for FAM189A1 Gene

Function for FAM189A1 Gene

Phenotypes for FAM189A1 Gene

GenomeRNAi human phenotypes for FAM189A1:
genes like me logo Genes that share phenotypes with FAM189A1: view

Animal Model Products

CRISPR Products

miRNA for FAM189A1 Gene

miRTarBase miRNAs that target FAM189A1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM189A1 Gene

Localization for FAM189A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM189A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FAM189A1 Gene COMPARTMENTS Subcellular localization image for FAM189A1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FAM189A1 Gene

Pathways & Interactions for FAM189A1 Gene

SuperPathways for FAM189A1 Gene

No Data Available

Interacting Proteins for FAM189A1 Gene

Gene Ontology (GO) - Biological Process for FAM189A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM189A1 Gene

Drugs & Compounds for FAM189A1 Gene

No Compound Related Data Available

Transcripts for FAM189A1 Gene

mRNA/cDNA for FAM189A1 Gene

(10) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM189A1 Gene

Family with sequence similarity 189, member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM189A1 Gene

No ASD Table

Relevant External Links for FAM189A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM189A1 Gene

mRNA expression in normal human tissues for FAM189A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM189A1 Gene

This gene is overexpressed in Brain - Hippocampus (x6.5), Brain - Cortex (x5.4), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Amygdala (x5.0), and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM189A1 Gene

This gene is overexpressed in Bone (46.8) and Colon muscle (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM189A1 Gene

SOURCE GeneReport for Unigene cluster for FAM189A1 Gene Hs.383564

genes like me logo Genes that share expression patterns with FAM189A1: view

Protein tissue co-expression partners for FAM189A1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM189A1 Gene

Orthologs for FAM189A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM189A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM189A1 35
  • 81.06 (n)
  • 78.32 (a)
FAM189A1 36
  • 52 (a)
(Canis familiaris)
Mammalia FAM189A1 35
  • 82.99 (n)
  • 79.55 (a)
FAM189A1 36
  • 41 (a)
(Mus musculus)
Mammalia Fam189a1 35
  • 81.19 (n)
  • 81.32 (a)
Fam189a1 16
Fam189a1 36
  • 77 (a)
(Pan troglodytes)
Mammalia FAM189A1 35
  • 90.95 (n)
  • 88.2 (a)
FAM189A1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fam189a1 35
  • 81.91 (n)
  • 81.91 (a)
(Monodelphis domestica)
Mammalia FAM189A1 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia FAM189A1 36
  • 35 (a)
(Gallus gallus)
Aves FAM189A1 35
  • 68.14 (n)
  • 67.81 (a)
FAM189A1 36
  • 42 (a)
(Anolis carolinensis)
Reptilia FAM189A1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam189a1 35
  • 67.13 (n)
  • 68.76 (a)
(Danio rerio)
Actinopterygii fam189a1 35
  • 62.72 (n)
  • 63.65 (a)
fam189a1 36
  • 64 (a)
Species with no ortholog for FAM189A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM189A1 Gene

Gene Tree for FAM189A1 (if available)
Gene Tree for FAM189A1 (if available)

Paralogs for FAM189A1 Gene

Paralogs for FAM189A1 Gene

(1) SIMAP similar genes for FAM189A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM189A1: view

Variants for FAM189A1 Gene

Sequence variations from dbSNP and Humsavar for FAM189A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2256277 - 29,126,371(-) TGGCC(A/G)TGTGT reference, missense
rs2256273 - 29,126,317(-) CGGGC(A/G)TGTGT reference, missense
rs2292628 - 29,137,143(-) CTCAC(A/C/G)GCACC reference, missense
rs2306933 - 29,128,851(-) TATAG(A/G)TCAGC reference, missense
rs2279482 - 29,124,698(-) GGCTG(A/C/T)GCCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM189A1 Gene

Variant ID Type Subtype PubMed ID
nsv522597 CNV Loss 19592680
esv2751526 CNV Loss 17911159
nsv527255 CNV Gain 19592680
dgv2289n71 CNV Loss 21882294
nsv515798 CNV Gain+Loss 19592680
nsv903747 CNV Gain 21882294
dgv2290n71 CNV Loss 21882294
nsv471232 CNV Loss 18288195
nsv524362 CNV Loss 19592680
dgv2291n71 CNV Loss 21882294
nsv903753 CNV Loss 21882294
nsv9228 CNV Loss 18304495
esv2525505 CNV Deletion 19546169
esv2560892 CNV Insertion 19546169
nsv513425 CNV Insertion 21212237
nsv9229 CNV Gain 18304495
esv2676098 CNV Deletion 23128226
nsv515660 CNV Gain 19592680
nsv525604 CNV Gain 19592680
nsv94404 CNV Loss 16902084
esv2668832 CNV Deletion 23128226
esv2669303 CNV Deletion 23128226
esv33949 CNV Loss 17666407
esv2658156 CNV Deletion 23128226
nsv832943 CNV Gain+Loss 17160897
esv8630 CNV Gain 19470904
dgv303n27 CNV Loss 19166990
esv270017 CNV Insertion 20981092
esv2514398 CNV Insertion 19546169
nsv1474 CNV Insertion 18451855
nsv511043 CNV Complex 20534489
nsv99 CNV Insertion 15895083
esv2527875 CNV Loss 19546169
nsv513426 CNV Insertion 21212237
esv987980 CNV Insertion 20482838
esv1396021 CNV Insertion 17803354
nsv827268 CNV Gain 20364138
dgv429n67 CNV Gain 20364138
nsv827271 CNV Gain 20364138
nsv832944 CNV Gain+Loss 17160897

Variation tolerance for FAM189A1 Gene

Gene Damage Index Score: 6.61; 78.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM189A1 Gene

Disorders for FAM189A1 Gene

Relevant External Links for FAM189A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM189A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM189A1 Gene

Publications for FAM189A1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias. (PMID: 22247754) Murray S.S. … Topol E.J. (PLoS ONE 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for FAM189A1 Gene

Sources for FAM189A1 Gene