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Aliases for FAM188B2 Gene

Aliases for FAM188B2 Gene

  • Family With Sequence Similarity 188 Member B2 2 3 5
  • C3orf76 3 4
  • Family With Sequence Similarity 188, Member B2 2
  • Chromosome 3 Open Reading Frame 76 2
  • Putative UPF0526 Protein B 3
  • Protein FAM188B2 3
  • CLRN1 3

External Ids for FAM188B2 Gene

Previous HGNC Symbols for FAM188B2 Gene

  • C3orf76

Previous GeneCards Identifiers for FAM188B2 Gene

  • GC03M152073
  • GC03M150588
  • GC03M147962

Summaries for FAM188B2 Gene

GeneCards Summary for FAM188B2 Gene

FAM188B2 (Family With Sequence Similarity 188 Member B2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM188B2 Gene

Genomics for FAM188B2 Gene

Regulatory Elements for FAM188B2 Gene

Enhancers for FAM188B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F150724 1.6 FANTOM5 Ensembl ENCODE 10.8 +163.4 163410 5.6 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZNF121 GATA2 ZNF143 FOS JUNB ERICH6-AS1 SIAH2 ERICH6 SIAH2-AS1 ENSG00000243273 FAM188B2 SNRPCP3 LOC101928105
GH03F150925 1.2 FANTOM5 Ensembl ENCODE 11.1 -34.8 -34841 1.0 CTCF ZNF654 PKNOX1 RNF2 REST RAD21 CBX8 GATA2 SMC3 KLF13 FAM188B2 ENSG00000243273 CLRN1 CLRN1-AS1 MED12L P2RY14 ENSG00000260234 ENSG00000244382
GH03F150865 1 Ensembl ENCODE 12.3 +25.6 25560 0.6 CTCF MAX ZBTB40 ZNF2 RAD21 RFX5 E2F1 GATA3 SMC3 STAT1 ENSG00000243273 FAM188B2 CLRN1 CLRN1-AS1
GH03F151145 1.1 Ensembl ENCODE 10.8 -255.1 -255147 1.7 GTF2F1 CTCF JUN MAX CEBPG EBF1 RAD21 YY1 GATA3 ZBTB48 MED12L P2RY14 ENSG00000243273 FAM188B2 CLRN1 CLRN1-AS1 GC03M151148
GH03F150797 0.9 Ensembl ENCODE 10.4 +92.7 92733 0.9 GATAD2A HLF CEBPB HMG20A CEBPG ZIC2 KAT2B ZFHX2 CEBPA GLIS1 SIAH2 SIAH2-AS1 ENSG00000243273 FAM188B2 AADACP1 GC03M150810
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM188B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM188B2 Gene

Chromosome:
3
Start:
150,871,045 bp from pter
End:
150,891,060 bp from pter
Size:
20,016 bases
Orientation:
Minus strand

Genomic View for FAM188B2 Gene

Genes around FAM188B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM188B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM188B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM188B2 Gene

Proteins for FAM188B2 Gene

  • Protein details for FAM188B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYZ0-F1882_HUMAN
    Recommended name:
    Protein FAM188B2
    Protein Accession:
    A8MYZ0

    Protein attributes for FAM188B2 Gene

    Size:
    360 amino acids
    Molecular mass:
    41070 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM188B2 Gene

Post-translational modifications for FAM188B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM188B2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for FAM188B2 Gene

Domains & Families for FAM188B2 Gene

Protein Domains for FAM188B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM188B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MYZ0

UniProtKB/Swiss-Prot:

F1882_HUMAN :
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
genes like me logo Genes that share domains with FAM188B2: view

No data available for Gene Families for FAM188B2 Gene

Function for FAM188B2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM188B2 Gene

Localization for FAM188B2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM188B2 gene
Compartment Confidence
mitochondrion 2
peroxisome 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM188B2 Gene

Pathways & Interactions for FAM188B2 Gene

SuperPathways for FAM188B2 Gene

No Data Available

Interacting Proteins for FAM188B2 Gene

Gene Ontology (GO) - Biological Process for FAM188B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM188B2 Gene

Transcripts for FAM188B2 Gene

mRNA/cDNA for FAM188B2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM188B2 Gene

Family with sequence similarity 188, member B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM188B2 Gene

No ASD Table

Relevant External Links for FAM188B2 Gene

GeneLoc Exon Structure for
FAM188B2
ECgene alternative splicing isoforms for
FAM188B2

Expression for FAM188B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM188B2 Gene

mRNA differential expression in normal tissues according to GTEx for FAM188B2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x17.2), Brain - Caudate (basal ganglia) (x12.2), and Brain - Putamen (basal ganglia) (x8.8).

Protein differential expression in normal tissues from HIPED for FAM188B2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM188B2 Gene



Protein tissue co-expression partners for FAM188B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM188B2 Gene:

FAM188B2

SOURCE GeneReport for Unigene cluster for FAM188B2 Gene:

Hs.380222
genes like me logo Genes that share expression patterns with FAM188B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM188B2 Gene

Orthologs for FAM188B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM188B2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM188B2 35
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM188B2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves FAM188B2 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM188B2 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FAM188B2 35
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14142 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToOne
Species where no ortholog for FAM188B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM188B2 Gene

ENSEMBL:
Gene Tree for FAM188B2 (if available)
TreeFam:
Gene Tree for FAM188B2 (if available)

Paralogs for FAM188B2 Gene

No data available for Paralogs for FAM188B2 Gene

Variants for FAM188B2 Gene

Sequence variations from dbSNP and Humsavar for FAM188B2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1055723 -- 150,873,431(+) GCCGA(A/T)ACATG intron-variant
rs10589743 -- 150,878,140(+) AATGA(-/AATGA)CCCAG intron-variant
rs10634706 -- 150,874,549(+) ATATA(-/CACATA)TATCT intron-variant
rs10662442 -- 150,882,494(+) TATTT(-/ATTT/TATT)CTGTG intron-variant
rs10935821 -- 150,892,157(+) cctcc(C/T)taagg upstream-variant-2KB

Variation tolerance for FAM188B2 Gene

Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM188B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM188B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM188B2 Gene

Disorders for FAM188B2 Gene

Relevant External Links for FAM188B2

Genetic Association Database (GAD)
FAM188B2
Human Genome Epidemiology (HuGE) Navigator
FAM188B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM188B2

No disorders were found for FAM188B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM188B2 Gene

Publications for FAM188B2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Alternative splice variants of the USH3A gene Clarin 1 (CLRN1). (PMID: 20717163) Vastinsalo H. … Sankila E.M. (Eur. J. Hum. Genet. 2011) 3 64

Products for FAM188B2 Gene

Sources for FAM188B2 Gene

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