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Aliases for FAM188B Gene

Aliases for FAM188B Gene

  • Family With Sequence Similarity 188 Member B 2 3 5
  • C7orf67 3 4
  • Probable Ubiquitin Carboxyl-Terminal Hydrolase FAM188B 3
  • Family With Sequence Similarity 188, Member B 2
  • Chromosome 7 Open Reading Frame 67 2
  • Protein FAM188B 3
  • EC 3.4.19.12 4

External Ids for FAM188B Gene

Previous HGNC Symbols for FAM188B Gene

  • C7orf67

Previous GeneCards Identifiers for FAM188B Gene

  • GC07P030779
  • GC07P030812

Summaries for FAM188B Gene

GeneCards Summary for FAM188B Gene

FAM188B (Family With Sequence Similarity 188 Member B) is a Protein Coding gene. An important paralog of this gene is FAM188A.

UniProtKB/Swiss-Prot for FAM188B Gene

  • Probable hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins.

Gene Wiki entry for FAM188B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM188B Gene

Genomics for FAM188B Gene

Regulatory Elements for FAM188B Gene

Enhancers for FAM188B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F030798 1.1 Ensembl ENCODE 29.8 +28.9 28919 3.2 INSM2 KLF17 BMI1 RAD21 GLIS2 SCRT2 ZNF143 ETV6 FOS ZNF654 FAM188B ENSG00000250424 AQP1 ENSG00000229263 INMT
GH07F030740 1.1 Ensembl ENCODE 28.8 -30.7 -30690 0.7 CTCF MAX RAD21 ZKSCAN1 GATA3 CTBP1 SCRT2 HSF1 ZNF143 SMC3 FAM188B CRHR2 ENSG00000223419 LOC105375219
GH07F030794 0.8 Ensembl ENCODE 31.4 +25.1 25064 4.0 JUND CTBP1 ZNF585B JUN NR2F6 ZKSCAN1 FAM188B ENSG00000250424 AQP1 FKBP14 ENSG00000229263 INMT ZNRF2
GH07F030760 1 ENCODE 20.4 -9.8 -9837 1.8 ATF1 PKNOX1 ARNT CREB3L1 ELK1 GATA2 NCOA1 REST SMARCB1 NFIL3 FAM188B ENSG00000244480 INMT-FAM188B
GH07F030748 0.7 ENCODE 28.6 -20.3 -20252 5.8 CTCF CBX3 BHLHE40 CEBPG REST RAD21 NR2F2 ATF3 SCRT2 IKZF1 FAM188B CRHR2 INMT ENSG00000244480 INMT-FAM188B ENSG00000223419
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM188B on UCSC Golden Path with GeneCards custom track

Promoters for FAM188B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000065856 283 1801 TBP HDAC1 ATF1 TBL1XR1 NFRKB ZNF76 SIN3A BMI1 ZBTB40 ETS1

Genomic Location for FAM188B Gene

Chromosome:
7
Start:
30,771,417 bp from pter
End:
30,892,387 bp from pter
Size:
120,971 bases
Orientation:
Plus strand

Genomic View for FAM188B Gene

Genes around FAM188B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM188B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM188B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM188B Gene

Proteins for FAM188B Gene

  • Protein details for FAM188B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0A6-F188B_HUMAN
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase FAM188B
    Protein Accession:
    Q4G0A6
    Secondary Accessions:
    • Q71AZ7
    • Q9H6D2

    Protein attributes for FAM188B Gene

    Size:
    757 amino acids
    Molecular mass:
    84372 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ10898.1; Type=Frameshift; Positions=617; Evidence={ECO:0000305}; Sequence=BAB15327.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for FAM188B Gene

Post-translational modifications for FAM188B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM188B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM188B Gene

Domains & Families for FAM188B Gene

Protein Domains for FAM188B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM188B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0A6

UniProtKB/Swiss-Prot:

F188B_HUMAN :
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
genes like me logo Genes that share domains with FAM188B: view

No data available for Gene Families for FAM188B Gene

Function for FAM188B Gene

Molecular function for FAM188B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Probable hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins.

Enzyme Numbers (IUBMB) for FAM188B Gene

Gene Ontology (GO) - Molecular Function for FAM188B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with FAM188B: view

Animal Model Products

miRNA for FAM188B Gene

miRTarBase miRNAs that target FAM188B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM188B Gene

Localization for FAM188B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM188B Gene

Pathways & Interactions for FAM188B Gene

SuperPathways for FAM188B Gene

No Data Available

Interacting Proteins for FAM188B Gene

Selected Interacting proteins: Q4G0A6-F188B_HUMAN for FAM188B Gene via IID

Gene Ontology (GO) - Biological Process for FAM188B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with FAM188B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM188B Gene

Transcripts for FAM188B Gene

mRNA/cDNA for FAM188B Gene

Unigene Clusters for FAM188B Gene

Family with sequence similarity 188, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM188B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2:
SP3: - - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for FAM188B Gene

GeneLoc Exon Structure for
FAM188B
ECgene alternative splicing isoforms for
FAM188B

Expression for FAM188B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM188B Gene

Protein differential expression in normal tissues from HIPED for FAM188B Gene

This gene is overexpressed in Serum (48.6) and Platelet (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM188B Gene



Protein tissue co-expression partners for FAM188B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM188B Gene:

FAM188B

SOURCE GeneReport for Unigene cluster for FAM188B Gene:

Hs.660192
genes like me logo Genes that share expression patterns with FAM188B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM188B Gene

Orthologs for FAM188B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM188B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM188B 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia FAM188B 34 35
  • 85.28 (n)
cow
(Bos Taurus)
Mammalia FAM188B 34 35
  • 82.32 (n)
mouse
(Mus musculus)
Mammalia Fam188b 34 16 35
  • 80.8 (n)
rat
(Rattus norvegicus)
Mammalia Fam188b 34
  • 79.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM188B 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM188B 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM188B 34 35
  • 61.72 (n)
lizard
(Anolis carolinensis)
Reptilia FAM188B 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188b 34
  • 57.93 (n)
Str.11231 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14505 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-30h22.11 34
  • 55.59 (n)
FAM188B 35
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13006 34
Species where no ortholog for FAM188B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM188B Gene

ENSEMBL:
Gene Tree for FAM188B (if available)
TreeFam:
Gene Tree for FAM188B (if available)

Paralogs for FAM188B Gene

Paralogs for FAM188B Gene

genes like me logo Genes that share paralogs with FAM188B: view

Variants for FAM188B Gene

Sequence variations from dbSNP and Humsavar for FAM188B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10155853 -- 30,820,201(+) cggcc(A/G)ATAAT intron-variant
rs10155856 -- 30,820,602(+) aactt(A/C)cggtg intron-variant
rs10156053 -- 30,820,193(+) accgc(A/G)cccgg intron-variant
rs1017012 -- 30,797,387(+) gggac(A/G)gagct intron-variant
rs10215211 -- 30,863,273(+) CAGCT(C/G)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM188B Gene

Variant ID Type Subtype PubMed ID
nsv955992 CNV deletion 24416366
nsv830939 CNV loss 17160897
nsv830938 CNV gain 17160897
nsv606509 CNV loss 21841781
nsv606508 CNV loss 21841781
nsv606507 CNV loss 21841781
nsv527038 CNV gain 19592680
nsv526591 CNV loss 19592680
nsv464416 CNV loss 19166990
nsv436557 CNV deletion 17901297
nsv1148830 OTHER inversion 26484159
nsv1146524 CNV deletion 26484159
nsv1074084 CNV deletion 25765185
nsv1068321 OTHER inversion 25765185
nsv1025945 CNV loss 25217958
esv993279 CNV deletion 20482838
esv5499 CNV loss 19470904
esv5109 CNV loss 18987735
esv3612714 CNV loss 21293372
esv3571725 CNV loss 25503493
esv3541409 CNV deletion 23714750
esv3356059 CNV insertion 20981092
esv3305464 CNV mobile element insertion 20981092
esv2761316 CNV gain 21179565
esv2734204 CNV deletion 23290073
esv2734203 CNV deletion 23290073
esv2678752 CNV deletion 23128226
esv2678492 CNV deletion 23128226
esv2390406 CNV deletion 18987734
esv22626 CNV gain 19812545
dgv6316n100 CNV gain 25217958
dgv1879e212 CNV loss 25503493

Variation tolerance for FAM188B Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM188B Gene

Human Gene Mutation Database (HGMD)
FAM188B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM188B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM188B Gene

Disorders for FAM188B Gene

Relevant External Links for FAM188B

Genetic Association Database (GAD)
FAM188B
Human Genome Epidemiology (HuGE) Navigator
FAM188B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM188B

No disorders were found for FAM188B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM188B Gene

Publications for FAM188B Gene

  1. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. (PMID: 22396660) Urabe Y. … Matsuda K. (PLoS Genet. 2012) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64

Products for FAM188B Gene

Sources for FAM188B Gene

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