Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM188A Gene

Aliases for FAM188A Gene

  • Family With Sequence Similarity 188, Member A 2 3
  • C10orf97 3 4 6
  • CARP 3 4 6
  • Caspase Recruitment Domain Containing Pro-Apoptotic Protein 2 3
  • Dermal Papilla-Derived Protein 5 3 4
  • CARD-Containing Protein 2 3
  • DERP5 3 4
  • Chromosome 10 Open Reading Frame 97 2
  • Protein FAM188A 3
  • Protein CARP 4
  • MSTP126 3
  • MST126 3
  • My042 3

External Ids for FAM188A Gene

Previous Symbols for FAM188A Gene

  • C10orf97

Summaries for FAM188A Gene

Entrez Gene Summary for FAM188A Gene

  • C10ORF97 is a member of the caspase-associated recruitment domain (CARD) family of proteins that play a role in apoptosis (Liu et al., 2002 [PubMed 12054670]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FAM188A Gene

FAM188A (Family With Sequence Similarity 188, Member A) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAM188B.

UniProtKB/Swiss-Prot for FAM188A Gene

  • May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM188A Gene

Genomics for FAM188A Gene

Genomic Location for FAM188A Gene

Start:
15,778,169 bp from pter
End:
15,860,520 bp from pter
Size:
82,352 bases
Orientation:
Minus strand

Genomic View for FAM188A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM188A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM188A Gene

No data available for Regulatory Elements for FAM188A Gene

Proteins for FAM188A Gene

  • Protein details for FAM188A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M7-F188A_HUMAN
    Recommended name:
    Protein FAM188A
    Protein Accession:
    Q9H8M7
    Secondary Accessions:
    • Q5SZ68
    • Q5SZ69
    • Q5SZ70
    • Q6IA40
    • Q6P7P0
    • Q7Z2S1
    • Q8WUF1
    • Q9H3I4

    Protein attributes for FAM188A Gene

    Size:
    445 amino acids
    Molecular mass:
    49725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61585.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13660.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305}; Sequence=CAI13817.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13819.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW86233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM188A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM188A Gene

Proteomics data for FAM188A Gene at MOPED

Post-translational modifications for FAM188A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys71

Other Protein References for FAM188A Gene

No data available for DME Specific Peptides for FAM188A Gene

Domains for FAM188A Gene

Protein Domains for FAM188A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

F188A_HUMAN
Family:
  • Belongs to the FAM188 family.:
    • Q9H8M7
genes like me logo Genes that share domains with FAM188A: view

No data available for Gene Families for FAM188A Gene

Function for FAM188A Gene

Molecular function for FAM188A Gene

UniProtKB/Swiss-Prot Function: May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines

Gene Ontology (GO) - Molecular Function for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 21499297
genes like me logo Genes that share ontologies with FAM188A: view

miRNA for FAM188A Gene

miRTarBase miRNAs that target FAM188A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FAM188A Gene

Localization for FAM188A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM188A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM188A Gene COMPARTMENTS Subcellular localization image for FAM188A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FAM188A: view

Pathways for FAM188A Gene

SuperPathways for FAM188A Gene

No Data Available

Interacting Proteins for FAM188A Gene

Gene Ontology (GO) - Biological Process for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with FAM188A: view

No data available for Pathways by source for FAM188A Gene

Transcripts for FAM188A Gene

Unigene Clusters for FAM188A Gene

Family with sequence similarity 188, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM188A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -

Relevant External Links for FAM188A Gene

GeneLoc Exon Structure for
FAM188A
ECgene alternative splicing isoforms for
FAM188A

Expression for FAM188A Gene

mRNA expression in normal human tissues for FAM188A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM188A Gene

SOURCE GeneReport for Unigene cluster for FAM188A Gene Hs.158870

mRNA Expression by UniProt/SwissProt for FAM188A Gene

Q9H8M7-F188A_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and kidney, with weak expression in liver and brain.
genes like me logo Genes that share expressions with FAM188A: view

Orthologs for FAM188A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM188A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM188A 36
  • 99.7 (n)
  • 99.78 (a)
FAM188A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM188A 36
  • 94.61 (n)
  • 97.53 (a)
FAM188A 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM188A 36
  • 95.34 (n)
  • 98.07 (a)
FAM188A 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam188a 36
  • 92.72 (n)
  • 95.95 (a)
Fam188a 16
Fam188a 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM188A 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam188a 36
  • 92.49 (n)
  • 95.27 (a)
chicken
(Gallus gallus)
Aves FAM188A 36
  • 82.13 (n)
  • 87.16 (a)
FAM188A 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM188A 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188a 36
  • 73.48 (n)
  • 77.27 (a)
zebrafish
(Danio rerio)
Actinopterygii fam188a 36
  • 69.74 (n)
  • 74.38 (a)
fam188a 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000412 36
  • 48.05 (n)
  • 46.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7332 36
  • 51.83 (n)
  • 48.17 (a)
CG7332 37
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G43690 36
  • 48.57 (n)
  • 36.36 (a)
rice
(Oryza sativa)
Liliopsida Os04g0421800 36
  • 50.49 (n)
  • 39.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2416 37
  • 42 (a)
OneToOne
Species with no ortholog for FAM188A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM188A Gene

ENSEMBL:
Gene Tree for FAM188A (if available)
TreeFam:
Gene Tree for FAM188A (if available)

Paralogs for FAM188A Gene

Paralogs for FAM188A Gene

genes like me logo Genes that share paralogs with FAM188A: view

Variants for FAM188A Gene

Sequence variations from dbSNP and Humsavar for FAM188A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1538562 -- 15,840,376(-) CATTT(A/G)AACAG intron-variant
rs2297882 -- 15,860,304(+) TGATG(A/G)GGAAC utr-variant-5-prime, nc-transcript-variant
rs2883452 -- 15,859,392(+) ATCAT(C/T)TTTCC intron-variant
rs4266971 -- 15,801,062(+) agcag(C/T)ttctg intron-variant
rs4387254 -- 15,808,184(+) AAGGT(C/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM188A Gene

Variant ID Type Subtype PubMed ID
nsv894900 CNV Gain 21882294
nsv831795 CNV Gain 17160897

Relevant External Links for FAM188A Gene

HapMap Linkage Disequilibrium report
FAM188A
Human Gene Mutation Database (HGMD)
FAM188A

Disorders for FAM188A Gene

Relevant External Links for FAM188A

Genetic Association Database (GAD)
FAM188A
genes like me logo Genes that share disorders with FAM188A: view

No data available for UniProtKB/Swiss-Prot for FAM188A Gene

Publications for FAM188A Gene

  1. CARP is a novel caspase recruitment domain containing pro-apoptotic protein. (PMID: 12054670) Liu B. … Hui R.T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. (PMID: 17652099) Daw E.W. … Marian A.J. (Hum. Mol. Genet. 2007) 2 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for FAM188A Gene

Sources for FAM188A Gene

Back to Top

Content