Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM188A Gene

Aliases for FAM188A Gene

  • Family With Sequence Similarity 188 Member A 2 3 5
  • Caspase Recruitment Domain Containing Pro-Apoptotic Protein 2 3
  • Dermal Papilla-Derived Protein 5 3 4
  • CARD-Containing Protein 2 3
  • C10orf97 3 4
  • DERP5 3 4
  • CARP 3 4
  • Family With Sequence Similarity 188, Member A 2
  • Ubiquitin Carboxyl-Terminal Hydrolase FAM188A 3
  • Chromosome 10 Open Reading Frame 97 2
  • Protein FAM188A 3
  • Protein CARP 4
  • EC 3.4.19.12 4
  • MSTP126 3
  • MST126 3
  • My042 3

External Ids for FAM188A Gene

Previous HGNC Symbols for FAM188A Gene

  • C10orf97

Summaries for FAM188A Gene

Entrez Gene Summary for FAM188A Gene

  • The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for FAM188A Gene

FAM188A (Family With Sequence Similarity 188 Member A) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAM188B.

UniProtKB/Swiss-Prot for FAM188A Gene

  • Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM188A Gene

Genomics for FAM188A Gene

Regulatory Elements for FAM188A Gene

Enhancers for FAM188A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F015859 1 ENCODE 14.7 +0.2 163 1.8 PKNOX1 ARID4B SIN3A DMAP1 YY1 ETS1 GLIS2 ELK1 KLF7 KDM4B FAM188A ENSG00000272853 LOC101928678
GH10F014950 1 ENCODE 12.8 +907.6 907582 4.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 FAM188A MEIG1 GC10P014933
GH10F015831 0.2 Ensembl 11.6 +28.6 28620 0.2 JUNB ETV6 FAM188A LOC101928678
GH10F015902 0.4 ENCODE 11 -41.6 -41557 0.1 JUND TEAD4 FAM188A GC10P015862 ENSG00000252537
GH10F015088 0.9 ENCODE 10.8 +771.6 771648 1.1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 FOS KLF13 ZNF263 C10orf111 FAM188A ACBD7 RPP38 GAPDHP45
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM188A on UCSC Golden Path with GeneCards custom track

Promoters for FAM188A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003211 820 3400 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 ETS1 GLIS2 ELK1 KLF7

Genomic Location for FAM188A Gene

Chromosome:
10
Start:
15,778,169 bp from pter
End:
15,860,520 bp from pter
Size:
82,352 bases
Orientation:
Minus strand

Genomic View for FAM188A Gene

Genes around FAM188A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM188A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM188A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM188A Gene

Proteins for FAM188A Gene

  • Protein details for FAM188A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M7-F188A_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase FAM188A
    Protein Accession:
    Q9H8M7
    Secondary Accessions:
    • Q5SZ68
    • Q5SZ69
    • Q5SZ70
    • Q6IA40
    • Q6P7P0
    • Q7Z2S1
    • Q8WUF1
    • Q9H3I4

    Protein attributes for FAM188A Gene

    Size:
    445 amino acids
    Molecular mass:
    49725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61585.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13660.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305}; Sequence=CAI13817.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13819.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW86233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM188A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM188A Gene

Post-translational modifications for FAM188A Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM188A Gene

Domains & Families for FAM188A Gene

Protein Domains for FAM188A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM188A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8M7

UniProtKB/Swiss-Prot:

F188A_HUMAN :
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
Family:
  • Belongs to the peptidase MINDY family. FAM188 subfamily.
genes like me logo Genes that share domains with FAM188A: view

No data available for Gene Families for FAM188A Gene

Function for FAM188A Gene

Molecular function for FAM188A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Hydrolase that can specifically remove Lys-48-linked conjugated ubiquitin from proteins. May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines.

Enzyme Numbers (IUBMB) for FAM188A Gene

Gene Ontology (GO) - Molecular Function for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21499297
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016807 cysteine-type carboxypeptidase activity IDA 27292798
genes like me logo Genes that share ontologies with FAM188A: view
genes like me logo Genes that share phenotypes with FAM188A: view

Animal Model Products

miRNA for FAM188A Gene

miRTarBase miRNAs that target FAM188A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM188A Gene

Localization for FAM188A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM188A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM188A Gene COMPARTMENTS Subcellular localization image for FAM188A gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FAM188A: view

Pathways & Interactions for FAM188A Gene

SuperPathways for FAM188A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006915 apoptotic process IEA --
GO:0071108 protein K48-linked deubiquitination IEA --
genes like me logo Genes that share ontologies with FAM188A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM188A Gene

Transcripts for FAM188A Gene

Unigene Clusters for FAM188A Gene

Family with sequence similarity 188, member A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM188A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -

Relevant External Links for FAM188A Gene

GeneLoc Exon Structure for
FAM188A
ECgene alternative splicing isoforms for
FAM188A

Expression for FAM188A Gene

mRNA expression in normal human tissues for FAM188A Gene

Protein differential expression in normal tissues from HIPED for FAM188A Gene

This gene is overexpressed in Testis (8.8) and Urinary Bladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM188A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM188A Gene:

FAM188A

SOURCE GeneReport for Unigene cluster for FAM188A Gene:

Hs.158870

mRNA Expression by UniProt/SwissProt for FAM188A Gene:

Q9H8M7-F188A_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and kidney, with weak expression in liver and brain.
genes like me logo Genes that share expression patterns with FAM188A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM188A Gene

Orthologs for FAM188A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM188A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM188A 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia FAM188A 34 35
  • 95.34 (n)
cow
(Bos Taurus)
Mammalia FAM188A 34 35
  • 94.61 (n)
mouse
(Mus musculus)
Mammalia Fam188a 34 16 35
  • 92.72 (n)
rat
(Rattus norvegicus)
Mammalia Fam188a 34
  • 92.49 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM188A 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM188A 34 35
  • 82.13 (n)
lizard
(Anolis carolinensis)
Reptilia FAM188A 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188a 34
  • 73.48 (n)
zebrafish
(Danio rerio)
Actinopterygii fam188a 34 35
  • 69.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7332 34 35
  • 51.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000412 34
  • 48.05 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G43690 34
  • 48.57 (n)
rice
(Oryza sativa)
Liliopsida Os04g0421800 34
  • 50.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2416 35
  • 42 (a)
OneToOne
Species where no ortholog for FAM188A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM188A Gene

ENSEMBL:
Gene Tree for FAM188A (if available)
TreeFam:
Gene Tree for FAM188A (if available)

Paralogs for FAM188A Gene

Paralogs for FAM188A Gene

genes like me logo Genes that share paralogs with FAM188A: view

Variants for FAM188A Gene

Sequence variations from dbSNP and Humsavar for FAM188A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10508494 -- 15,779,779(+) AGAGA(C/G)GTTGA intron-variant, utr-variant-3-prime
rs10508495 -- 15,811,762(+) TTATT(A/T)CTAGG intron-variant
rs10690053 -- 15,795,004(+) ACTCC(-/CA)GTTTC intron-variant
rs10716234 -- 15,831,693(+) TTTTT(-/T)GAGAT intron-variant
rs10719399 -- 15,848,634(+) ATCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM188A Gene

Variant ID Type Subtype PubMed ID
nsv1036973 CNV loss 25217958
nsv1045879 CNV gain 25217958
nsv831795 CNV gain 17160897

Variation tolerance for FAM188A Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM188A Gene

Human Gene Mutation Database (HGMD)
FAM188A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM188A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM188A Gene

Disorders for FAM188A Gene

Relevant External Links for FAM188A

Genetic Association Database (GAD)
FAM188A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM188A

No disorders were found for FAM188A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM188A Gene

Publications for FAM188A Gene

  1. MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. (PMID: 27292798) Abdul Rehman S.A. … Kulathu Y. (Mol. Cell 2016) 2 3 4 64
  2. CARP is a novel caspase recruitment domain containing pro-apoptotic protein. (PMID: 12054670) Liu B. … Hui R.T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 64
  3. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. (PMID: 17652099) Daw E.W. … Marian A.J. (Hum. Mol. Genet. 2007) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FAM188A Gene

Sources for FAM188A Gene

Content
Loading form....