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Aliases for FAM188A Gene

Aliases for FAM188A Gene

  • Family With Sequence Similarity 188 Member A 2 3 5
  • Caspase Recruitment Domain Containing Pro-Apoptotic Protein 2 3
  • Family With Sequence Similarity 188, Member A 2 3
  • Dermal Papilla-Derived Protein 5 3 4
  • CARD-Containing Protein 2 3
  • C10orf97 3 4
  • DERP5 3 4
  • CARP 3 4
  • Chromosome 10 Open Reading Frame 97 2
  • Protein CARP 4
  • MSTP126 3
  • MST126 3
  • My042 3

External Ids for FAM188A Gene

Previous HGNC Symbols for FAM188A Gene

  • C10orf97

Summaries for FAM188A Gene

Entrez Gene Summary for FAM188A Gene

  • The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for FAM188A Gene

FAM188A (Family With Sequence Similarity 188 Member A) is a Protein Coding gene. Diseases associated with FAM188A include Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 3. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAM188B.

UniProtKB/Swiss-Prot for FAM188A Gene

  • May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM188A Gene

Genomics for FAM188A Gene

Regulatory Elements for FAM188A Gene

Enhancers for FAM188A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM188A on UCSC Golden Path with GeneCards custom track

Promoters for FAM188A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM188A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM188A Gene

Chromosome:
10
Start:
15,778,169 bp from pter
End:
15,860,520 bp from pter
Size:
82,352 bases
Orientation:
Minus strand

Genomic View for FAM188A Gene

Genes around FAM188A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM188A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM188A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM188A Gene

Proteins for FAM188A Gene

  • Protein details for FAM188A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M7-F188A_HUMAN
    Recommended name:
    Protein FAM188A
    Protein Accession:
    Q9H8M7
    Secondary Accessions:
    • Q5SZ68
    • Q5SZ69
    • Q5SZ70
    • Q6IA40
    • Q6P7P0
    • Q7Z2S1
    • Q8WUF1
    • Q9H3I4

    Protein attributes for FAM188A Gene

    Size:
    445 amino acids
    Molecular mass:
    49725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61585.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13660.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305}; Sequence=CAI13817.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13819.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW86233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM188A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM188A Gene

Proteomics data for FAM188A Gene at MOPED

Post-translational modifications for FAM188A Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM188A Gene

No data available for DME Specific Peptides for FAM188A Gene

Domains & Families for FAM188A Gene

Protein Domains for FAM188A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM188A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8M7

UniProtKB/Swiss-Prot:

F188A_HUMAN :
  • Belongs to the FAM188 family.
Family:
  • Belongs to the FAM188 family.
genes like me logo Genes that share domains with FAM188A: view

No data available for Gene Families for FAM188A Gene

Function for FAM188A Gene

Molecular function for FAM188A Gene

UniProtKB/Swiss-Prot Function:
May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines.
genes like me logo Genes that share phenotypes with FAM188A: view

Animal Model Products

CRISPR Products

miRNA for FAM188A Gene

miRTarBase miRNAs that target FAM188A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM188A Gene

Localization for FAM188A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM188A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM188A Gene COMPARTMENTS Subcellular localization image for FAM188A gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FAM188A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with FAM188A: view

Pathways & Interactions for FAM188A Gene

SuperPathways for FAM188A Gene

No Data Available

Interacting Proteins for FAM188A Gene

Gene Ontology (GO) - Biological Process for FAM188A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM188A Gene

Drugs & Compounds for FAM188A Gene

No Compound Related Data Available

Transcripts for FAM188A Gene

Unigene Clusters for FAM188A Gene

Family with sequence similarity 188, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM188A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - -
SP11: - - -
SP12: - - - -
SP13: -
SP14:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -

Relevant External Links for FAM188A Gene

GeneLoc Exon Structure for
FAM188A
ECgene alternative splicing isoforms for
FAM188A

Expression for FAM188A Gene

mRNA expression in normal human tissues for FAM188A Gene

Protein differential expression in normal tissues from HIPED for FAM188A Gene

This gene is overexpressed in Testis (8.8) and Urinary Bladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM188A Gene



SOURCE GeneReport for Unigene cluster for FAM188A Gene Hs.158870

mRNA Expression by UniProt/SwissProt for FAM188A Gene

Q9H8M7-F188A_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and kidney, with weak expression in liver and brain.
genes like me logo Genes that share expression patterns with FAM188A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FAM188A Gene

Orthologs for FAM188A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM188A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM188A 35
  • 94.61 (n)
  • 97.53 (a)
FAM188A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM188A 35
  • 95.34 (n)
  • 98.07 (a)
FAM188A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam188a 35
  • 92.72 (n)
  • 95.95 (a)
Fam188a 16
Fam188a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM188A 35
  • 99.7 (n)
  • 99.78 (a)
FAM188A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam188a 35
  • 92.49 (n)
  • 95.27 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FAM188A 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM188A 35
  • 82.13 (n)
  • 87.16 (a)
FAM188A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM188A 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam188a 35
  • 73.48 (n)
  • 77.27 (a)
zebrafish
(Danio rerio)
Actinopterygii fam188a 35
  • 69.74 (n)
  • 74.38 (a)
fam188a 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000412 35
  • 48.05 (n)
  • 46.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7332 35
  • 51.83 (n)
  • 48.17 (a)
CG7332 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G43690 35
  • 48.57 (n)
  • 36.36 (a)
rice
(Oryza sativa)
Liliopsida Os04g0421800 35
  • 50.49 (n)
  • 39.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2416 36
  • 42 (a)
OneToOne
Species with no ortholog for FAM188A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM188A Gene

ENSEMBL:
Gene Tree for FAM188A (if available)
TreeFam:
Gene Tree for FAM188A (if available)

Paralogs for FAM188A Gene

Paralogs for FAM188A Gene

genes like me logo Genes that share paralogs with FAM188A: view

Variants for FAM188A Gene

Sequence variations from dbSNP and Humsavar for FAM188A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2297882 -- 15,860,304(+) TGATG(A/G)GGAAC nc-transcript-variant, utr-variant-5-prime
rs7476607 -- 15,856,492(+) GAGAA(A/C)CAATA intron-variant
rs7895562 -- 15,860,506(+) CGGAA(C/G)TGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs7898385 -- 15,857,356(+) aaCTC(C/T)GTATT intron-variant
rs12218978 -- 15,853,957(+) tgttc(C/T)gatga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM188A Gene

Variant ID Type Subtype PubMed ID
nsv894900 CNV Gain 21882294
nsv831795 CNV Gain 17160897

Variation tolerance for FAM188A Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM188A Gene

Human Gene Mutation Database (HGMD)
FAM188A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM188A Gene

Disorders for FAM188A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM188A Gene - From: OMIM

Disorder Aliases PubMed IDs
cerebellar ataxia and mental retardation with or without quadrupedal locomotion 3
  • congenital cerebellar ataxia and mental retardation autosomal recessive
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM188A

Genetic Association Database (GAD)
FAM188A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM188A
genes like me logo Genes that share disorders with FAM188A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM188A Gene

Publications for FAM188A Gene

  1. CARP is a novel caspase recruitment domain containing pro-apoptotic protein. (PMID: 12054670) Liu B. … Hui R.T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. (PMID: 17652099) Daw E.W. … Marian A.J. (Hum. Mol. Genet. 2007) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3
  5. CARP is a potential tumor suppressor in gastric carcinoma and a single-nucleotide polymorphism in CARP gene might increase the risk of gastric carcinoma. (PMID: 24870804) Lu F. … Wei Y.Q. (PLoS ONE 2014) 3

Products for FAM188A Gene

Sources for FAM188A Gene

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