Aliases for FAM188A Gene
External Ids for FAM188A Gene
Previous HGNC Symbols for FAM188A Gene
The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for FAM188A Gene
FAM188A (Family With Sequence Similarity 188 Member A) is a Protein Coding gene. Diseases associated with FAM188A include Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 3. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAM188B.
UniProtKB/Swiss-Prot for FAM188A Gene
May have pro-apoptotic function. Overexpression significantly inhibits cell proliferation in several tumor cell lines.