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Aliases for FAM186B Gene

Aliases for FAM186B Gene

  • Family With Sequence Similarity 186, Member B 2 3
  • C12orf25 3 4
  • Chromosome 12 Open Reading Frame 25 2
  • Protein FAM186B 3

External Ids for FAM186B Gene

Previous HGNC Symbols for FAM186B Gene

  • C12orf25

Previous GeneCards Identifiers for FAM186B Gene

  • GC12M048270
  • GC12M049981
  • GC12M047007

Summaries for FAM186B Gene

Entrez Gene Summary for FAM186B Gene

  • This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for FAM186B Gene

FAM186B (Family With Sequence Similarity 186, Member B) is a Protein Coding gene. An important paralog of this gene is FAM186A.

Gene Wiki entry for FAM186B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM186B Gene

Genomics for FAM186B Gene

Regulatory Elements for FAM186B Gene

Genomic Location for FAM186B Gene

Start:
49,582,870 bp from pter
End:
49,605,650 bp from pter
Size:
22,781 bases
Orientation:
Minus strand

Genomic View for FAM186B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM186B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186B Gene

Proteins for FAM186B Gene

  • Protein details for FAM186B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM0-F186B_HUMAN
    Recommended name:
    Protein FAM186B
    Protein Accession:
    Q8IYM0
    Secondary Accessions:
    • B4DZ15
    • Q8TCP7
    • Q9H0L3

    Protein attributes for FAM186B Gene

    Size:
    893 amino acids
    Molecular mass:
    103722 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM186B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM186B Gene

Proteomics data for FAM186B Gene at MOPED

Post-translational modifications for FAM186B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM186B Gene

No data available for DME Specific Peptides for FAM186B Gene

Domains for FAM186B Gene

Protein Domains for FAM186B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM186B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM0

UniProtKB/Swiss-Prot:

F186B_HUMAN :
  • Q8IYM0
Family:
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186B: view

No data available for Gene Families for FAM186B Gene

Function for FAM186B Gene

Phenotypes for FAM186B Gene

GenomeRNAi human phenotypes for FAM186B:
genes like me logo Genes that share phenotypes with FAM186B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FAM186B Gene

Localization for FAM186B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM186B Gene COMPARTMENTS Subcellular localization image for FAM186B gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FAM186B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with FAM186B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM186B Gene

Pathways for FAM186B Gene

SuperPathways for FAM186B Gene

No Data Available

Interacting Proteins for FAM186B Gene

Gene Ontology (GO) - Biological Process for FAM186B Gene

None

No data available for Pathways by source for FAM186B Gene

Transcripts for FAM186B Gene

Unigene Clusters for FAM186B Gene

Family with sequence similarity 186, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186B Gene

No ASD Table

Relevant External Links for FAM186B Gene

GeneLoc Exon Structure for
FAM186B
ECgene alternative splicing isoforms for
FAM186B

Expression for FAM186B Gene

mRNA expression in normal human tissues for FAM186B Gene

mRNA differential expression in normal tissues according to GTEx for FAM186B Gene

This gene is overexpressed in Testis (41.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FAM186B Gene

SOURCE GeneReport for Unigene cluster for FAM186B Gene Hs.524406

genes like me logo Genes that share expressions with FAM186B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM186B Gene

Orthologs for FAM186B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM186B 35
  • 98.6 (n)
  • 97.49 (a)
FAM186B 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM186B 35
  • 80.56 (n)
  • 69.38 (a)
FAM186B 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
FAM186B 35
  • 81.21 (n)
  • 69.75 (a)
mouse
(Mus musculus)
Mammalia Fam186b 35
  • 72.97 (n)
  • 61.17 (a)
Fam186b 16
Fam186b 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM186B 36
  • 27 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam186b 35
  • 74.59 (n)
  • 61.82 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
OneToMany
Species with no ortholog for FAM186B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186B Gene

ENSEMBL:
Gene Tree for FAM186B (if available)
TreeFam:
Gene Tree for FAM186B (if available)

Paralogs for FAM186B Gene

Paralogs for FAM186B Gene

Selected SIMAP similar genes for FAM186B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM186B: view

Variants for FAM186B Gene

Sequence variations from dbSNP and Humsavar for FAM186B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs876889 -- 49,589,595(-) AAACA(A/G)GAACC intron-variant
rs1150059 -- 49,585,313(+) atgcc(C/T)ggccT intron-variant
rs1248366 -- 49,592,060(+) tagag(A/G)caaaa intron-variant
rs1261976 -- 49,602,665(+) TTGTG(C/G)TCCCT intron-variant
rs1269814 -- 49,594,524(+) acaat(G/T)ttaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM186B Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897

Relevant External Links for FAM186B Gene

HapMap Linkage Disequilibrium report
FAM186B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186B Gene

Disorders for FAM186B Gene

No disorders were found for FAM186B Gene.

No data available for UniProtKB/Swiss-Prot for FAM186B Gene

Publications for FAM186B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FAM186B Gene

Sources for FAM186B Gene

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