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FAM186B Gene

protein-coding   GIFtS: 39
GCID: GC12M049981

Family With Sequence Similarity 186, Member B

(Previous name: chromosome 12 open reading frame 25)
(Previous symbol: C12orf25)
  Search for FAM186B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 186, Member B1 2
C12orf251 2 3
Chromosome 12 Open Reading Frame 251
Protein FAM186B2

External Ids:    HGNC: 252961   Entrez Gene: 840702   Ensembl: ENSG000001354367   UniProtKB: Q8IYM03   

Export aliases for FAM186B gene to outside databases

Previous GC identifers: GC12M048270 GC12M047007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FAM186B Gene:
This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for FAM186B Gene:
FAM186B (family with sequence similarity 186, member B) is a protein-coding gene. An important paralog of this gene is FAM186A.

Gene Wiki entry for FAM186B (Protein FAM186B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM186B gene promoter:
         RFX1   p300   Bach2   Egr-1   AP-2gamma   YY1   FOXJ2 (long isoform)   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM186B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM186B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

FAM186B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM186B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049981:  view genomic region     (about GC identifiers)

Start:
49,976,658 bp from pter      End:
49,999,433 bp from pter
Size:
22,776 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: F186B_HUMAN, Q8IYM0 (See protein sequence)
Recommended Name: Protein FAM186B  
Size: 893 amino acids; 103722 Da
Secondary accessions: Q8TCP7 Q9H0L3

Explore the universe of human proteins at neXtProt for FAM186B: NX_Q8IYM0

Explore proteomics data for FAM186B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM186B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115506.1  
    ENSEMBL proteins: 
     ENSP00000448989   ENSP00000433047   ENSP00000448656   ENSP00000436995   ENSP00000257894  
     ENSP00000438569  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IYM0

    UniProtKB/Swiss-Prot: F186B_HUMAN, Q8IYM0
    Similarity: Belongs to the FAM186 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM186B:
     Increased G1 DNA content 

         1 MGI phenotypic allele for Fam186b (no phenotypes)

    FAM186B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM186B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043234protein complex IDA--

    FAM186B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM186B
    Interactions:

        Search GeneGlobe Interaction Network for FAM186B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM186B (F186B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FAM186B gene: 
    NM_032130.2  

    Unigene Cluster for FAM186B:

    Family with sequence similarity 186, member B
    Hs.524406  [show with all ESTs]
    Unigene Representative Sequence: NR_027450
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548841 ENST00000533372 ENST00000551047 ENST00000532262 ENST00000257894(uc001ruo.3)
    ENST00000544141(uc010smk.2)
    miRNA
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    Additional mRNA sequence: 

    AK093242.1 AK302702.1 AL136748.1 AL713673.1 BC035621.1 NR_027450.1 

    6 DOTS entries:

    DT.91812096  DT.75112058  DT.91933150  DT.300328  DT.444408  DT.100773144 

    Selected AceView cDNA sequences (see all 27):

    BC035621 AL136748 AL713673 AX748009 BI827313 NM_032130 AK093242 AI684621 
    CD359787 BG772526 CD557138 BM563499 BI830242 CD244460 BX111560 AI829695 
    BI828202 AA883866 AA641965 BF062125 AA641912 AA764768 BX455501 BI521009 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM186B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCCCCTG
    FAM186B Expression
    About this image

    FAM186B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM186B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524406
        Custom PCR Arrays for FAM186B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM186B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM186B gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam186b1 , 5 family with sequence similarity 186, member B1, 5 72.97(n)1
    61.17(a)1
      15 (56.11 cM)5
    5451361  NM_001081254.11  NP_001074723.11 
     992710185 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    20(a)
    1 → many
    2(91421285-91437082)


    ENSEMBL Gene Tree for FAM186B (if available)
    TreeFam Gene Tree for FAM186B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM186B gene
    FAM186A2  
    1 SIMAP similar gene for FAM186B using alignment to 5 protein entries:     F186B_HUMAN (see all proteins):
    FAM186A

    FAM186B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM186B (see all 561)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111690771,2
    C,H--49976242(+) ATCTTC/GCACAT 1 -- ds50015Minor allele frequency- G:0.00NS EA WA 536
    rs1414127621,2
    --49976272(+) AGGCT-/GGGTGGG 1 -- ds50010--------
    rs1179250621,2
    C,F--49976306(+) GTCCCC/TGAATA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs106276811,2
    C--49976474(+) CACAC-/ACTTACA 1 -- ds50011Minor allele frequency- AC:0.50CSA 2
    rs339668931,2
    C--49976475(+) CCCGA-/ACCACAC 1 -- ds50010--------
    rs1476869281,2
    --49976504(+) ACACAC/TATATA 1 -- ds50010--------
    rs1908279691,2
    C--49976571(+) TATACA/CCACAT 1 -- ds50010--------
    rs787206761,2
    C,F--49976616(+) ATAAAT/AACATA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1820680041,2
    C--49976839(+) AGTCCA/TCCATC 1 -- nc-transcript-variant0--------
    rs123045351,2
    H--49976872(+) GGCCCC/GTTAAG 1 -- nc-transcript-variant4Minor allele frequency- G:0.00NS EA 420

    HapMap Linkage Disequilibrium report for FAM186B (49976658 - 49999433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FAM186B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832406CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM186B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM186B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM186B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM186B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    10. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84070 HGNC: 25296 AceView: DKFZP434J0113 Ensembl:ENSG00000135436 euGenes: HUgn84070
    ECgene: FAM186B H-InvDB: FAM186B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM186B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM186B gene:
    Search GeneIP for patents involving FAM186B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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