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Aliases for FAM186B Gene

Aliases for FAM186B Gene

  • Family With Sequence Similarity 186 Member B 2 3 5
  • C12orf25 3 4
  • Family With Sequence Similarity 186, Member B 2
  • Chromosome 12 Open Reading Frame 25 2
  • Protein FAM186B 3

External Ids for FAM186B Gene

Previous HGNC Symbols for FAM186B Gene

  • C12orf25

Previous GeneCards Identifiers for FAM186B Gene

  • GC12M048270
  • GC12M049981
  • GC12M047007

Summaries for FAM186B Gene

Entrez Gene Summary for FAM186B Gene

  • This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for FAM186B Gene

FAM186B (Family With Sequence Similarity 186 Member B) is a Protein Coding gene. Diseases associated with FAM186B include Oropharynx Cancer. An important paralog of this gene is FAM186A.

Gene Wiki entry for FAM186B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM186B Gene

Genomics for FAM186B Gene

Regulatory Elements for FAM186B Gene

Enhancers for FAM186B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F048865 1.4 Ensembl ENCODE 26.5 +739.3 739321 2.4 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 FOS DDX23 LOC390314 KANSL2 CCNT1 BCDIN3D SENP1 ENSG00000257964 PRPF40B LOC100422296 LOC101927267
GH12F048903 1.1 ENCODE 26.5 +701.8 701789 1.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF416 ZNF548 CCNT1 DDX23 PRPF40B SENP1 LOC390314 BCDIN3D KANSL2 FAM186B ENSG00000257964 LOC101927267
GH12F048923 0.9 ENCODE 26.5 +680.7 680725 2.8 WRNIP1 ZFP64 SIN3A RAD21 ZNF143 CREM ZNF202 ZNF680 SP3 ZBTB11 DDX23 CCNT1 SENP1 LOC390314 BCDIN3D KANSL2 LOC101927267 ENSG00000257964 FAM186B PRPF40B
GH12F049702 1.4 FANTOM5 ENCODE 15.9 -99.5 -99532 6.1 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 FOS LOC390314 DDX23 FAM186B LIMA1 FMNL3 ENSG00000257964 CCNT1 CERS5 PRPF40B LOC100422296
GH12F049230 1.8 FANTOM5 Ensembl ENCODE 10.9 +372.7 372686 5.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 TUBA1C TUBA1A CCNT1 KANSL2 PRKAG1 RHEBL1 FAM186B LOC105369760 TUBA1B LMBR1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM186B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM186B Gene

Chromosome:
12
Start:
49,582,875 bp from pter
End:
49,605,650 bp from pter
Size:
22,776 bases
Orientation:
Minus strand

Genomic View for FAM186B Gene

Genes around FAM186B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM186B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM186B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186B Gene

Proteins for FAM186B Gene

  • Protein details for FAM186B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM0-F186B_HUMAN
    Recommended name:
    Protein FAM186B
    Protein Accession:
    Q8IYM0
    Secondary Accessions:
    • B4DZ15
    • Q8TCP7
    • Q9H0L3

    Protein attributes for FAM186B Gene

    Size:
    893 amino acids
    Molecular mass:
    103722 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM186B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM186B Gene

Post-translational modifications for FAM186B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM186B Gene

Domains & Families for FAM186B Gene

Protein Domains for FAM186B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM186B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM0

UniProtKB/Swiss-Prot:

F186B_HUMAN :
  • Belongs to the FAM186 family.
Family:
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186B: view

No data available for Gene Families for FAM186B Gene

Function for FAM186B Gene

genes like me logo Genes that share phenotypes with FAM186B: view

Animal Models for FAM186B Gene

MGI Knock Outs for FAM186B:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FAM186B Gene

Localization for FAM186B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM186B gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM186B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with FAM186B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM186B Gene

Pathways & Interactions for FAM186B Gene

SuperPathways for FAM186B Gene

No Data Available

Interacting Proteins for FAM186B Gene

Selected Interacting proteins: Q8IYM0-F186B_HUMAN for FAM186B Gene via IID

Symbol External ID(s) Details
EMC8

Gene Ontology (GO) - Biological Process for FAM186B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM186B Gene

Transcripts for FAM186B Gene

Unigene Clusters for FAM186B Gene

Family with sequence similarity 186, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186B Gene

No ASD Table

Relevant External Links for FAM186B Gene

GeneLoc Exon Structure for
FAM186B
ECgene alternative splicing isoforms for
FAM186B

Expression for FAM186B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM186B Gene

mRNA differential expression in normal tissues according to GTEx for FAM186B Gene

This gene is overexpressed in Testis (x41.1).

Protein differential expression in normal tissues from HIPED for FAM186B Gene

This gene is overexpressed in Liver (36.2), Lung (11.5), and Gallbladder (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM186B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM186B Gene:

FAM186B

SOURCE GeneReport for Unigene cluster for FAM186B Gene:

Hs.524406
genes like me logo Genes that share expression patterns with FAM186B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FAM186B Gene

Orthologs for FAM186B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM186B 34 35
  • 98.6 (n)
dog
(Canis familiaris)
Mammalia FAM186B 34
  • 81.21 (n)
-- 35
  • 68 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM186B 34 35
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Fam186b 34
  • 74.59 (n)
mouse
(Mus musculus)
Mammalia Fam186b 34 16 35
  • 72.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM186B 35
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
OneToMany
Species where no ortholog for FAM186B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186B Gene

ENSEMBL:
Gene Tree for FAM186B (if available)
TreeFam:
Gene Tree for FAM186B (if available)

Paralogs for FAM186B Gene

Paralogs for FAM186B Gene

(1) SIMAP similar genes for FAM186B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM186B: view

Variants for FAM186B Gene

Sequence variations from dbSNP and Humsavar for FAM186B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10467104 -- 49,588,421(+) CCATA(C/T)AGCTG intron-variant
rs10627681 -- 49,582,691(+) CACAC(-/AC)TTACA downstream-variant-500B
rs111484322 -- 49,601,244(+) TTGGC(A/G)AGAGT intron-variant
rs111488009 -- 49,593,506(+) GCAGG(C/T)ATTTG intron-variant
rs11169077 -- 49,582,459(+) ATCTT(C/G)CACAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM186B Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV loss 17160897

Variation tolerance for FAM186B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM186B Gene

Human Gene Mutation Database (HGMD)
FAM186B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM186B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186B Gene

Disorders for FAM186B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM186B Gene - From: DISEASES

Disorder Aliases PubMed IDs
oropharynx cancer
  • malignant neoplasm of junctional region of oropharynx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FAM186B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM186B
genes like me logo Genes that share disorders with FAM186B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM186B Gene

Publications for FAM186B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for FAM186B Gene

Sources for FAM186B Gene

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