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Aliases for FAM186B Gene

Aliases for FAM186B Gene

  • Family With Sequence Similarity 186 Member B 2 3 5
  • Family With Sequence Similarity 186, Member B 2 3
  • C12orf25 3 4
  • Chromosome 12 Open Reading Frame 25 2

External Ids for FAM186B Gene

Previous HGNC Symbols for FAM186B Gene

  • C12orf25

Previous GeneCards Identifiers for FAM186B Gene

  • GC12M048270
  • GC12M049981
  • GC12M047007

Summaries for FAM186B Gene

Entrez Gene Summary for FAM186B Gene

  • This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for FAM186B Gene

FAM186B (Family With Sequence Similarity 186 Member B) is a Protein Coding gene. An important paralog of this gene is FAM186A.

Gene Wiki entry for FAM186B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM186B Gene

Genomics for FAM186B Gene

Regulatory Elements for FAM186B Gene

Enhancers for FAM186B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM186B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM186B Gene

49,582,875 bp from pter
49,605,650 bp from pter
22,776 bases
Minus strand

Genomic View for FAM186B Gene

Genes around FAM186B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM186B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM186B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186B Gene

Proteins for FAM186B Gene

  • Protein details for FAM186B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM186B
    Protein Accession:
    Secondary Accessions:
    • B4DZ15
    • Q8TCP7
    • Q9H0L3

    Protein attributes for FAM186B Gene

    893 amino acids
    Molecular mass:
    103722 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM186B Gene


neXtProt entry for FAM186B Gene

Proteomics data for FAM186B Gene at MOPED

Post-translational modifications for FAM186B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM186B Gene

No data available for DME Specific Peptides for FAM186B Gene

Domains & Families for FAM186B Gene

Protein Domains for FAM186B Gene


Suggested Antigen Peptide Sequences for FAM186B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM186 family.
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186B: view

No data available for Gene Families for FAM186B Gene

Function for FAM186B Gene

genes like me logo Genes that share phenotypes with FAM186B: view

Animal Models for FAM186B Gene

MGI Knock Outs for FAM186B:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FAM186B Gene

Localization for FAM186B Gene

Subcellular locations from

Jensen Localization Image for FAM186B Gene COMPARTMENTS Subcellular localization image for FAM186B gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM186B Gene

Pathways & Interactions for FAM186B Gene

SuperPathways for FAM186B Gene

No Data Available

Interacting Proteins for FAM186B Gene

Gene Ontology (GO) - Biological Process for FAM186B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM186B Gene

Drugs & Compounds for FAM186B Gene

No Compound Related Data Available

Transcripts for FAM186B Gene

Unigene Clusters for FAM186B Gene

Family with sequence similarity 186, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186B Gene

No ASD Table

Relevant External Links for FAM186B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM186B Gene

mRNA expression in normal human tissues for FAM186B Gene

mRNA differential expression in normal tissues according to GTEx for FAM186B Gene

This gene is overexpressed in Testis (x41.1).

Protein differential expression in normal tissues from HIPED for FAM186B Gene

This gene is overexpressed in Liver (36.2), Lung (11.5), and Gallbladder (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM186B Gene

SOURCE GeneReport for Unigene cluster for FAM186B Gene Hs.524406

genes like me logo Genes that share expression patterns with FAM186B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM186B Gene

Orthologs for FAM186B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM186B 35
  • 80.56 (n)
  • 69.38 (a)
FAM186B 36
  • 69 (a)
(Canis familiaris)
Mammalia FAM186B 35
  • 81.21 (n)
  • 69.75 (a)
-- 36
  • 68 (a)
-- 36
  • 64 (a)
(Mus musculus)
Mammalia Fam186b 35
  • 72.97 (n)
  • 61.17 (a)
Fam186b 16
Fam186b 36
  • 55 (a)
(Pan troglodytes)
Mammalia FAM186B 35
  • 98.6 (n)
  • 97.49 (a)
FAM186B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fam186b 35
  • 74.59 (n)
  • 61.82 (a)
(Ornithorhynchus anatinus)
Mammalia FAM186B 36
  • 27 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
Species with no ortholog for FAM186B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186B Gene

Gene Tree for FAM186B (if available)
Gene Tree for FAM186B (if available)

Paralogs for FAM186B Gene

Paralogs for FAM186B Gene

(1) SIMAP similar genes for FAM186B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM186B: view

Variants for FAM186B Gene

Sequence variations from dbSNP and Humsavar for FAM186B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17853450 - 49,600,451(+) GCGCA(C/T)AGTCA nc-transcript-variant, reference, missense
rs12299908 - 49,599,983(+) ATCCT(C/G)CCCTA nc-transcript-variant, reference, missense
rs2005195 -- 49,589,696(-) CTTGA(C/T)TCTTT intron-variant
rs17123808 -- 49,585,630(+) CAGGC(C/T)GTCAG intron-variant
rs17123827 -- 49,598,500(+) TCTTT(C/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM186B Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897

Variation tolerance for FAM186B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM186B Gene

Disorders for FAM186B Gene

Relevant External Links for FAM186B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM186B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM186B Gene

Publications for FAM186B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM186B Gene

Sources for FAM186B Gene