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Aliases for FAM186A Gene

Aliases for FAM186A Gene

  • Family With Sequence Similarity 186, Member A 2 3

External Ids for FAM186A Gene

Previous GeneCards Identifiers for FAM186A Gene

  • GC12M049009
  • GC12M050721
  • GC12M047754

Summaries for FAM186A Gene

GeneCards Summary for FAM186A Gene

FAM186A (Family With Sequence Similarity 186, Member A) is a Protein Coding gene. An important paralog of this gene is FAM186B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM186A Gene

Genomics for FAM186A Gene

Regulatory Elements for FAM186A Gene

Genomic Location for FAM186A Gene

50,326,230 bp from pter
50,396,635 bp from pter
70,406 bases
Minus strand

Genomic View for FAM186A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FAM186A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186A Gene

Proteins for FAM186A Gene

  • Protein details for FAM186A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM186A
    Protein Accession:

    Protein attributes for FAM186A Gene

    2351 amino acids
    Molecular mass:
    262758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM186A Gene

Proteomics data for FAM186A Gene at MOPED

Post-translational modifications for FAM186A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM186A Gene

No data available for DME Specific Peptides for FAM186A Gene

Domains & Families for FAM186A Gene

Protein Domains for FAM186A Gene


Suggested Antigen Peptide Sequences for FAM186A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM186 family.
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186A: view

No data available for Gene Families for FAM186A Gene

Function for FAM186A Gene

Phenotypes for FAM186A Gene

GenomeRNAi human phenotypes for FAM186A:
genes like me logo Genes that share phenotypes with FAM186A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM186A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM186A Gene

Localization for FAM186A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM186A Gene

Pathways & Interactions for FAM186A Gene

SuperPathways for FAM186A Gene

No Data Available

Interacting Proteins for FAM186A Gene

Gene Ontology (GO) - Biological Process for FAM186A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM186A Gene

Drugs & Compounds for FAM186A Gene

No Compound Related Data Available

Transcripts for FAM186A Gene

mRNA/cDNA for FAM186A Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM186A Gene

Family with sequence similarity 186, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FAM186A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186A Gene

No ASD Table

Relevant External Links for FAM186A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM186A Gene

mRNA expression in normal human tissues for FAM186A Gene

mRNA differential expression in normal tissues according to GTEx for FAM186A Gene

This gene is overexpressed in Testis (x39.5).

Protein differential expression in normal tissues from HIPED for FAM186A Gene

This gene is overexpressed in Bone marrow stromal cell (40.2) and Serum (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM186A Gene

SOURCE GeneReport for Unigene cluster for FAM186A Gene Hs.133187

genes like me logo Genes that share expression patterns with FAM186A: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FAM186A Gene

Orthologs for FAM186A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM186A 35
  • 76.22 (n)
  • 61.89 (a)
FAM186A 36
  • 56 (a)
(Canis familiaris)
Mammalia FAM186A 35
  • 77.21 (n)
  • 62.77 (a)
FAM186A 36
  • 49 (a)
(Pan troglodytes)
Mammalia FAM186A 35
  • 95.74 (n)
  • 93.82 (a)
FAM186A 36
  • 79 (a)
(Monodelphis domestica)
Mammalia FAM186A 36
  • 63 (a)
(Mus musculus)
Mammalia Fam186a 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia FAM186A 36
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
Species with no ortholog for FAM186A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186A Gene

Gene Tree for FAM186A (if available)
Gene Tree for FAM186A (if available)

Paralogs for FAM186A Gene

Paralogs for FAM186A Gene

(1) SIMAP similar genes for FAM186A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM186A: view

Variants for FAM186A Gene

Sequence variations from dbSNP and Humsavar for FAM186A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4321029 -- 50,382,908(+) TTTTA(A/G)GACTG intron-variant
rs4477515 -- 50,376,508(+) ggata(G/T)cttct intron-variant
rs4479066 -- 50,359,582(+) ccccc(A/C)aaaaa intron-variant
rs4565983 -- 50,372,998(+) aggaa(A/G/T)gaaag intron-variant
rs4590959 -- 50,376,364(+) CAGAA(C/G)AGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM186A Gene

Variant ID Type Subtype PubMed ID
nsv899075 CNV Gain 21882294
esv1583460 CNV Deletion 17803354
esv260072 OTHER Complex 20981092
nsv899076 CNV Loss 21882294

Variation tolerance for FAM186A Gene

Gene Damage Index Score: 10.41; 90.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM186A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186A Gene

Disorders for FAM186A Gene

Relevant External Links for FAM186A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FAM186A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM186A Gene

Publications for FAM186A Gene

  1. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 67
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for FAM186A Gene

Sources for FAM186A Gene

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