FAM186A Gene
protein-coding GIFtS: 35
GCID: GC12M050721
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|
family with sequence similarity 186, member A
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Aliases
for FAM186A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
|---|
| Family With Sequence Similarity 186, Member A1 2 | | LOC1210061 | | Protein FAM186A2 |
| External Ids: | HGNC: 269801 | Entrez Gene: 1210062 | Ensembl: ENSG000001859587 | UniProtKB: A6NE013 |
Export aliases for FAM186A gene to outside databasesPrevious GC identifers: GC12M049009 GC12M047754
|---|
Summaries
for FAM186A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
fRNAdb sequence ontology for FAM186A:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
|
Genomic Views
for FAM186A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FAM186A gene promoter:
C/EBPbeta AP-4 E47 Arnt c-Ets-1 AREB6 HEN1 COMP1 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for FAM186A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM186A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.13FAM186A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M050721: view genomic region
(about GC identifiers)
Start:
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50,720,013 bp from pter |
End:
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50,790,405 bp from pter |
Size:
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70,393 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for FAM186A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: F186A_HUMAN, A6NE01 (See
protein sequence)Recommended Name: Protein FAM186A Size: 2351 amino acids; 262758 DaExplore the universe of human proteins at neXtProt for FAM186A: NX_A6NE01
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NE01
FAM186A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001138947.1
ENSEMBL proteins: ENSP00000441337 ENSP00000437706 ENSP00000329995 ENSP00000443703
Human Recombinant Protein Products for FAM186A:
FAM186A Antibody Products:
Assay Products for FAM186A: |
Protein
Domains /
Families
for FAM186A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A6NE01 UniProtKB/Swiss-Prot: F186A_HUMAN, A6NE01Similarity: Belongs to the FAM186 family |
Function
for FAM186A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FAM186A (NM_001145475) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM186A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM186A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM186A |
|
Pathways & Interactions
for FAM186A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM186A
|
Drugs & Compounds
for FAM186A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FAM186A
Search CenterWatch for drugs/clinical trials and news about FAM186A / F186A
|
Transcripts
for FAM186A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FAM186A gene: NM_001145475.1 Unigene Cluster for FAM186A: Family with sequence similarity 186, member A Hs.133187 [show with all ESTs]Unigene Representative Sequence: NM_0011454754 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543111(uc010smt.1 uc001rwl.2) ENST00000539751 ENST00000327337
ENST00000543096
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FAM186A (NM_001145475) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FAM186A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM186A |
Additional cDNA sequence: AL833333.1 BC054024.1 BC140703.1 4 DOTS entries: DT.92068088 DT.99984483 DT.65286586 DT.40202120 11 AceView cDNA sequences: AI051933 BX099768 AI808315 BU160118 AI808314 BG213977 BG184371 BG206781 BG207148 BG201903 BG220699
GeneLoc Exon Structure
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Expression
for FAM186A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FAM186A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAAGTAC
About this image
See FAM186A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM186A
SOURCE GeneReport for Unigene cluster: Hs.133187
SABiosciences Custom PCR Arrays for FAM186A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM186A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FAM186A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM186A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM186A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM186A |
Orthologs
for FAM186A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FAM186A gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
22(a) |
1 → many |
2(91421285-91430657) |
Species with no ortholog for FAM186A
ENSEMBL Gene Tree for FAM186A (if available)
TreeFam Gene Tree for FAM186A (if available) |
Paralogs
for FAM186A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FAM186A gene
- FAM186B2
1 SIMAP similar gene for FAM186A using alignment to 5 protein entries: F186A_HUMAN (see all proteins):FAM186B
FAM186A for paralogs About GeneDecksing
|
Genomic Variants
for FAM186A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FAM186A (50720013 - 50790405 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM186A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM186A |
|
Disorders
/ Diseases
for FAM186A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FAM186A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FAM186A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM186A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- (PubMed id 15103394)10
- (PubMed id 17451645)10
- (PubMed id 18089548)10
|
External Searches for FAM186A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FAM186A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FAM186A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FAM186A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FAM186A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FAM186A gene:
Search GeneIP for patents involving FAM186A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FAM186A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FAM186A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM186A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FAM186A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FAM186A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FAM186A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FAM186A | | OriGene Custom Protein Services for FAM186A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FAM186A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FAM186A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM186A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM186A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM186A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM186A |
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 |  |  |  | |
| | | | Search Tocris compounds for FAM186A |
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 | | | FAM186A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM186A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FAM186A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM186A |
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