Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM185A Gene

Aliases for FAM185A Gene

  • Family With Sequence Similarity 185 Member A 2 3 5
  • Family With Sequence Similarity 185, Member A 2

External Ids for FAM185A Gene

Previous GeneCards Identifiers for FAM185A Gene

  • GC07P102177
  • GC07P102389
  • GC07P096751

Summaries for FAM185A Gene

GeneCards Summary for FAM185A Gene

FAM185A (Family With Sequence Similarity 185 Member A) is a Protein Coding gene.

Additional gene information for FAM185A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM185A Gene

Genomics for FAM185A Gene

Regulatory Elements for FAM185A Gene

Enhancers for FAM185A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H102572 1.1 ENCODE 32.1 -176.3 -176264 1 ARNT SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF207 SP3 REST ZNF592 CRYZP1 ENSG00000213385 DNAJC2 PMPCB PRKRIP1 FAM185A ENSG00000239486 NAPEPLD LRWD1 S100A11P1
GH07H101879 2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -866.1 -866100 6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 FOS FAM185A ENSG00000213385 CUX1 SH2B2 GC07P101859 ENSG00000272219
GH07H102870 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +125.1 125050 6 PKNOX1 FOXA2 SIN3A ATF7 FOS RUNX3 JUNB PPARG ZNF592 NFIL3 LRRC17 CRYZP1 FAM185A ENSG00000213385 POLR2J3 UPK3BL1 ARMC10 ORAI2 LRWD1 RN7SKP198
GH07H103660 1.3 Ensembl ENCODE 11.8 +912.8 912764 3 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 FOS CRYZP1 ENSG00000213385 PMPCB FAM185A ORC5 DNAJC2 RELN RPL19P12 PIR34993 GC07P103650
GH07H103073 1.1 ENCODE 11.8 +326.2 326152 2 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3 ENSG00000213385 CRYZP1 PRKRIP1 PMPCB FAM185A DNAJC2 NAPEPLD ARMC10 FBXL13 GC07M103088
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM185A on UCSC Golden Path with GeneCards custom track

Promoters for FAM185A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216144 256 1601 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 FOS SP3

Genomic Location for FAM185A Gene

Chromosome:
7
Start:
102,748,944 bp from pter
End:
102,912,918 bp from pter
Size:
163,975 bases
Orientation:
Plus strand

Genomic View for FAM185A Gene

Genes around FAM185A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM185A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM185A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM185A Gene

Proteins for FAM185A Gene

  • Protein details for FAM185A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U4-F185A_HUMAN
    Recommended name:
    Protein FAM185A
    Protein Accession:
    Q8N0U4
    Secondary Accessions:
    • A8MUR7
    • B4DQD3
    • C9IZ91

    Protein attributes for FAM185A Gene

    Size:
    392 amino acids
    Molecular mass:
    42301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM185A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM185A Gene

Post-translational modifications for FAM185A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM185A Gene

Domains & Families for FAM185A Gene

Gene Families for FAM185A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM185A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM185A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FAM185A: view

No data available for UniProtKB/Swiss-Prot for FAM185A Gene

Function for FAM185A Gene

Phenotypes From GWAS Catalog for FAM185A Gene

Phenotypes for FAM185A Gene

GenomeRNAi human phenotypes for FAM185A:
genes like me logo Genes that share phenotypes with FAM185A: view

Animal Model Products

CRISPR Products

miRNA for FAM185A Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM185A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM185A Gene

Localization for FAM185A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM185A gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM185A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with FAM185A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM185A Gene

Pathways & Interactions for FAM185A Gene

SuperPathways for FAM185A Gene

No Data Available

Interacting Proteins for FAM185A Gene

Gene Ontology (GO) - Biological Process for FAM185A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM185A Gene

Drugs & Compounds for FAM185A Gene

No Compound Related Data Available

Transcripts for FAM185A Gene

Unigene Clusters for FAM185A Gene

Family with sequence similarity 185, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM185A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM185A Gene

No ASD Table

Relevant External Links for FAM185A Gene

GeneLoc Exon Structure for
FAM185A
ECgene alternative splicing isoforms for
FAM185A

Expression for FAM185A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM185A Gene

Protein differential expression in normal tissues from HIPED for FAM185A Gene

This gene is overexpressed in Heart (29.5), Peripheral blood mononuclear cells (24.2), and Liver (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM185A Gene



Protein tissue co-expression partners for FAM185A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM185A Gene:

FAM185A

SOURCE GeneReport for Unigene cluster for FAM185A Gene:

Hs.202543

Evidence on tissue expression from TISSUES for FAM185A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FAM185A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM185A Gene

Orthologs for FAM185A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM185A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM185A 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia FAM185A 33 34
  • 87.21 (n)
dog
(Canis familiaris)
Mammalia FAM185A 33 34
  • 86.15 (n)
mouse
(Mus musculus)
Mammalia Fam185a 33 16 34
  • 79.78 (n)
rat
(Rattus norvegicus)
Mammalia Fam185a 33
  • 75.5 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM185A 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM185A 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM185A 33 34
  • 68.45 (n)
lizard
(Anolis carolinensis)
Reptilia FAM185A 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam185a 33
  • 62.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4927 33
zebrafish
(Danio rerio)
Actinopterygii LOC100332968 33
  • 50.66 (n)
FAM185A 34
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8187 34
  • 19 (a)
OneToOne
Species where no ortholog for FAM185A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM185A Gene

ENSEMBL:
Gene Tree for FAM185A (if available)
TreeFam:
Gene Tree for FAM185A (if available)

Paralogs for FAM185A Gene

Pseudogenes.org Pseudogenes for FAM185A Gene

genes like me logo Genes that share paralogs with FAM185A: view

No data available for Paralogs for FAM185A Gene

Variants for FAM185A Gene

Sequence variations from dbSNP and Humsavar for FAM185A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000005866 -- 102,879,144(+) AGCAT(C/T)TCAGC intron-variant
rs1000046218 -- 102,903,600(+) CCCTA(A/G)TTTTT intron-variant
rs1000067206 -- 102,816,734(+) ATGCC(C/T)AGTAG intron-variant
rs1000096810 -- 102,903,381(+) TCTTC(C/T)TTTTC intron-variant
rs1000098600 -- 102,878,840(+) CTGCC(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM185A Gene

Variant ID Type Subtype PubMed ID
dgv23n31 CNV gain 19718026
dgv6538n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
dgv6541n100 CNV gain 25217958
dgv6543n100 CNV loss 25217958
esv2752138 CNV loss 17911159
esv2761100 CNV gain+loss 21179565
esv3614357 CNV gain 21293372
esv3614358 CNV gain 21293372
nsv1034233 CNV loss 25217958
nsv1153843 CNV duplication 26484159
nsv469620 CNV loss 16826518
nsv470382 CNV loss 18288195
nsv608057 CNV loss 21841781
nsv966870 CNV duplication 23825009
nsv966871 CNV duplication 23825009
nsv970564 CNV duplication 23825009

Variation tolerance for FAM185A Gene

Gene Damage Index Score: 7.48; 82.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM185A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM185A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM185A Gene

Disorders for FAM185A Gene

Relevant External Links for FAM185A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM185A

No disorders were found for FAM185A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM185A Gene

Publications for FAM185A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for FAM185A Gene

Sources for FAM185A Gene

Content
Loading form....