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FAM184B Gene

protein-coding   GIFtS: 37
GCID: GC04M017634

Family With Sequence Similarity 184, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 184, Member B1 2
Protein FAM184B2
KIAA12763

External Ids:    HGNC: 292351   Entrez Gene: 271462   Ensembl: ENSG000000476627   UniProtKB: Q9ULE43   

Export aliases for FAM184B gene to outside databases

Previous GC identifers: GC04M017242 GC04M016988


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM184B Gene:
FAM184B (family with sequence similarity 184, member B) is a protein-coding gene. An important paralog of this gene is FAM184A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FAM184B gene promoter:
         Max1   Pax-5   MEF-2   Nkx2-2   FOXL1   Max   MEF-2A   aMEF-2   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM184B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM184B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p16

FAM184B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM184B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M017634:  view genomic region     (about GC identifiers)

Start:
17,630,929 bp from pter      End:
17,783,135 bp from pter
Size:
152,207 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F184B_HUMAN, Q9ULE4 (See protein sequence)
Recommended Name: Protein FAM184B  
Size: 1060 amino acids; 121044 Da
Sequence caution: Sequence=BAA86590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for FAM184B: NX_Q9ULE4

Explore proteomics data for FAM184B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM184B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056503.1  
    ENSEMBL proteins: 
     ENSP00000265018  

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    antibodies-online kits for FAM184B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9ULE4

    UniProtKB/Swiss-Prot: F184B_HUMAN, Q9ULE4
    Similarity: Belongs to the FAM184 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM184B:
     Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fam184b):
     normal 

    Find genes that share phenotypes with FAM184B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fam184btm1Mnkm for FAM184B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FAM184B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM184B

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    hsa-miR-1298 hsa-miR-92a-1* hsa-miR-186* hsa-miR-4282
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM184B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM184B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM184B
    Interactions:

        Search GeneGlobe Interaction Network for FAM184B

    1 Interacting protein for FAM184B (Q9ULE43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM184B (F184B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM184B gene: 
    NM_015688.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000265018(uc003gpm.4)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate FAM184B:
    hsa-miR-1298 hsa-miR-92a-1* hsa-miR-186* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FAM184B
    Predesigned siRNA for gene silencing in human, mouse, rat FAM184B
    Clone
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    OriGene clones in human, mouse for FAM184B (see all 6)
    OriGene ORF clones in mouse, rat for FAM184B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FAM184B (NM_015688)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM184B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FAM184B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM184B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM184B
      QuantiFast Probe-based Assays in human, mouse, rat FAM184B

    Selected AceView cDNA sequences (see all 25):

    BM806019 BF224085 BX495372 AI333934 W56708 BE165414 AI003689 AW967896 
    AK027311 W56753 AA708232 AB033102 AL712346 CA405441 AW964970 AW798963 
    BU676337 AW971628 BG912689 BF935532 AW964978 AW878937 BM806368 BF376920 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM184B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FAM184B Expression
    About this image


    FAM184B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Medulla Oblongata
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Bone (Muscoskeletal System)
             Rib
    FAM184B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM184B Protein Expression
        Custom PCR Arrays for FAM184B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FAM184B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM184B
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    QuantiFast Probe-based Assays in human, mouse, rat FAM184B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM184B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FAM184B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam184b5 family with sequence similarity 184, member B   --   5 (25.04 cM) 45529706 
    chicken
    (Gallus gallus)
    Aves FAM184B1 family with sequence similarity 184, member B 57.85(n)
    48.08(a)
      100859145  XM_003641223.2  XP_003641271.2 
    lizard
    (Anolis carolinensis)
    Reptilia FAM184B6
    family with sequence similarity 184, member B
    39(a)
    1 ↔ 1
    5(76977853-77087191)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004888001 protein FAM184B-like 53.51(n)
    40.03(a)
      100488800  XM_004911237.1  XP_004911294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam184b6
    family with sequence similarity 184, member B
    23(a)
    1 ↔ 1
    1(22280619-22331971) ENSDARG00000055099
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2786
    Protein TAG-278 (tag-278) mRNA, complete cds
    12(a)
    1 → many
    X(3684224-3689207) WBGene00015356


    ENSEMBL Gene Tree for FAM184B (if available)
    TreeFam Gene Tree for FAM184B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM184B gene
    FAM184A2  

    Find genes that share paralogs with FAM184B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM184B (see all 3431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681130681,2
    C--17047879(+) ATCTC-/A/AAA 
            
    AAAAA
    1 -- int11NA 2
    rs347586971,2
    C--17051877(+) GGAGA-/A/GA  
            
    ATGGT
    1 -- int10--------
    rs1385372211,2
    C--17633219(+) TACTT-/AATTC 
    C
    /ACTTCC
    AATTC
    2 -- cds10--------
    rs168953501,2
    C,F,H--17633227(+) TTCCAA/GTTCAT 1 -- ds500112Minor allele frequency- G:0.24NA NS WA CSA 1053
    rs1403946581,2
    C--17633313(+) CTTGTC/TTTAGA 1 -- ds50010--------
    rs2012914241,2
    C--17633486(+) GAGTT-/GGACTA 1 -- ds50010--------
    rs1503620441,2
    --17633569(+) GGAGTA/GTGATG 1 -- ds50010--------
    rs1380087021,2
    --17633614(+) AGTAAC/TGCTAA 1 -- ds50010--------
    rs1494859101,2
    --17633632(+) TTCCTA/GTAGAT 1 -- ds50010--------
    rs1439240101,2
    C--17633810(+) CTCCCA/GCCTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FAM184B (17630929 - 17783135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FAM184B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997752CNV Deletion20482838
    esv272317CNV Insertion20981092
    esv271490CNV Insertion20981092
    nsv878721CNV Loss21882294
    nsv527339CNV Loss19592680
    nsv289646CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM184B
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM184B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with FAM184B           About GenesLikeMe

    Genetic Association Database (GAD): FAM184B

    Export disorders for FAM184B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM184B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM184B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27146 HGNC: 29235 AceView: KIAA1276 Ensembl:ENSG00000047662 euGenes: HUgn27146
    ECgene: FAM184B H-InvDB: FAM184B

    (According to HUGE)
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    HUGE: KIAA1276

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM184B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM184B gene:
    Search GeneIP for patents involving FAM184B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM184B Predesigned siRNA for gene silencing in human, mouse, rat FAM184B
     QuantiFast Probe-based Assays in human, mouse, rat FAM184B QuantiTect SYBR Green Assays in human, mouse, rat FAM184B
     Custom PCR Arrays for FAM184B Search Chromatin IP Primers for FAM184B
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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