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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM184B Gene

protein-coding   GIFtS: 37
GCID: GC04M017634

family with sequence similarity 184, member B
  Search for FAM184B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM184B    

Aliases
for FAM184B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 184, Member B1 2
KIAA12761 3
Protein FAM184B2

External Ids:    HGNC: 292351   Entrez Gene: 271462   Ensembl: ENSG000000476627   UniProtKB: Q9ULE43   

Export aliases for FAM184B gene to outside databases

Previous GC identifers: GC04M017242 GC04M016988


Summaries
for FAM184B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM184B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM184B gene promoter:
         Max1   Pax-5   MEF-2   Nkx2-2   FOXL1   Max   MEF-2A   aMEF-2   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM184B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM184B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p16

FAM184B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM184B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M017634:  view genomic region     (about GC identifiers)

Start:
 17,630,929 bp from pter      End:
 17,783,135 bp from pter
Size:
 152,207 bases      Orientation:
 minus strand

Proteins
for FAM184B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F184B_HUMAN, Q9ULE4 (See protein sequence)
Recommended Name: Protein FAM184B  
Size: 1060 amino acids; 121044 Da
Sequence caution: Sequence=BAA86590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for FAM184B: NX_Q9ULE4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULE4

    • FAM184B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056503.1  
    ENSEMBL proteins: 
     ENSP00000265018  

    Human Recombinant Protein Products: 
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    Uscn Proteins for FAM184B


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    Uscn ELISAs and CLIAs for FAM184B

    Protein Domains /
    Families
    for FAM184B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9ULE4

    UniProtKB/Swiss-Prot: F184B_HUMAN, Q9ULE4
    Similarity: Belongs to the FAM184 family


    Function
    for FAM184B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    hsa-miR-1298 hsa-miR-92a-1* hsa-miR-186* hsa-miR-4282
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM184B
    OriGene shRNA RFP: FAM184B
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM184B

    1 GenomeRNAi human phenotype for FAM184B:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Fam184btm1Mnkm for FAM184B
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fam184b):
     normal 

    FAM184B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FAM184B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM184B

    1 Interacting protein for FAM184B (Q9ULE43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=1 
    About this table

    Drugs & Compounds
    for FAM184B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM184B
    Search CenterWatch for drugs/clinical trials and news about FAM184B / F184B 

    Transcripts
    for FAM184B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM184B gene: 
    NM_015688.1  

    Unigene Cluster for FAM184B:

    Family with sequence similarity 184, member B
    Hs.18861  [show with all ESTs]
    Unigene Representative Sequence: NM_015688
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000265018(uc003gpm.4)

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM184B:
    hsa-miR-1298 hsa-miR-92a-1* hsa-miR-186* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM184B
    OriGene shRNA RFP: FAM184B
    OriGene siRNA: FAM184B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM184B
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB033102.1 AK027311.1 AK308144.1 

    6 DOTS entries:

    DT.110888  DT.313289  DT.75147642  DT.121232031  DT.95145760  DT.97764509 

    24/25 AceView cDNA sequences (see all 25):

    BM806019 BF224085 AL712346 AB033102 W56753 BE165414 BX495372 AA708232 
    AI003689 AW967896 AK027311 W56708 CA405441 AI333934 AW798963 AW971628 
    BU676337 AW964970 BG912689 BF935532 AW878937 AW964978 BF376920 BM806368 

    GeneLoc Exon Structure


    Expression
    for FAM184B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM184B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM184B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneThoracic RibBone
    BrainMedulla OblongataBrain
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FAM184B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM184B

    SOURCE GeneReport for Unigene cluster: Hs.18861
        SABiosciences Custom PCR Arrays for FAM184B
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM184B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM184B

    Orthologs
    for FAM184B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM184B gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fam184b1 , 5 family with sequence similarity 184, member B1, 5 78.61(n)1
    74.65(a)1    		   5 (25.04 cM)5
    582271  NM_021416.31  NP_067391.31 
     455297065 
    chicken
    (Gallus gallus)    		 Aves LOC1008591451 uncharacterized LOC100859145 52.83(n)
    42.08(a)    		   100859145  XM_003641223.1  XP_003641271.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FAM184B6
    		 --
    		 44(a)
    		 1 ↔ 1
    		 5(77002305-77083144)
    zebrafish
    (Danio rerio)    		 Actinopterygii fam184b1 family with sequence similarity 184, member B 46.92(n)
    32.39(a)    		   557812  NM_001201530.1  NP_001188459.1 


    ENSEMBL Gene Tree for FAM184B (if available)
    TreeFam Gene Tree for FAM184B (if available) 

    Paralogs
    for FAM184B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FAM184B gene
    FAM184A2  

    FAM184B for paralogs           About GeneDecksing



    Genomic Variants
    for FAM184B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FAM184B
         1 CNV: 6245
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FAM184B

    Disorders / Diseases
    for FAM184B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for FAM184B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM184B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM184B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)

    External Searches for FAM184B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM184B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27146 HGNC: 29235 AceView: KIAA1276 Ensembl:ENSG00000047662 euGenes: HUgn27146
    ECgene: FAM184B H-InvDB: FAM184B

    Other Databases showing FAM184B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1276

    Specialized Databases showing FAM184B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM184B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM184B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM184B gene:
    Search GeneIP for patents involving FAM184B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM184B gene

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    About This Section

     
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    VWF
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    von Willebrand factor
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