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Aliases for FAM183A Gene

Aliases for FAM183A Gene

  • Family With Sequence Similarity 183 Member A 2 3 5
  • Family With Sequence Similarity 183, Member A 2
  • Protein FAM183A 3
  • HCG23177 3

External Ids for FAM183A Gene

Previous GeneCards Identifiers for FAM183A Gene

  • GC01P043383
  • GC01P043610
  • GC01P041733

Summaries for FAM183A Gene

GeneCards Summary for FAM183A Gene

FAM183A (Family With Sequence Similarity 183 Member A) is a Protein Coding gene.

Additional gene information for FAM183A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM183A Gene

Genomics for FAM183A Gene

GeneHancer (GH) Regulatory Elements for FAM183A Gene

Promoters and enhancers for FAM183A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I043147 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 558.9 +4.9 4922 1 HDAC1 PKNOX1 ARID4B NEUROD1 KLF17 SIN3A BMI1 RFX5 ETS1 ZNF335 FAM183A CFAP57 EBNA1BP2 GC01P043162
GH01I043143 Enhancer 0.8 ENCODE 550.8 +0.9 946 0.8 HDAC1 CLOCK ATF1 RB1 ARNT ZBTB40 RAD21 ZNF143 FOS ATF7 FAM183A CFAP57 EBNA1BP2 GC01P043162
GH01I043144 Enhancer 0.7 ENCODE 550.8 +0.4 406 0.2 HDAC1 CTCF LEF1 CLOCK ATF1 NFATC3 ARNT ZBTB40 RAD21 CC2D1A FAM183A CFAP57 GC01P043162
GH01I043120 Enhancer 1.1 Ensembl ENCODE 24.8 -21.7 -21700 1.9 ATF1 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS ATF7 SP3 YY2 FAM183A CFAP57 EBNA1BP2 ENSG00000277513
GH01I043171 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 +29.1 29121 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 CFAP57 MIR6733 EBNA1BP2 FAM183A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM183A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM183A gene promoter:

Genomic Locations for FAM183A Gene

Genomic Locations for FAM183A Gene
chr1:43,142,979-43,156,396
(GRCh38/hg38)
Size:
13,418 bases
Orientation:
Plus strand
chr1:43,610,824-43,622,067
(GRCh37/hg19)

Genomic View for FAM183A Gene

Genes around FAM183A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM183A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM183A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM183A Gene

Proteins for FAM183A Gene

  • Protein details for FAM183A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NL82-F183A_HUMAN
    Recommended name:
    Protein FAM183A
    Protein Accession:
    A6NL82
    Secondary Accessions:
    • B7ZBL8

    Protein attributes for FAM183A Gene

    Size:
    134 amino acids
    Molecular mass:
    15996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM183A Gene

Post-translational modifications for FAM183A Gene

No Post-translational modifications

Other Protein References for FAM183A Gene

No data available for DME Specific Peptides for FAM183A Gene

Domains & Families for FAM183A Gene

Gene Families for FAM183A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM183A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM183A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NL82

UniProtKB/Swiss-Prot:

F183A_HUMAN :
  • Belongs to the FAM183 family.
Family:
  • Belongs to the FAM183 family.
genes like me logo Genes that share domains with FAM183A: view

Function for FAM183A Gene

Phenotypes From GWAS Catalog for FAM183A Gene

genes like me logo Genes that share phenotypes with FAM183A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM183A Gene

Localization for FAM183A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM183A gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM183A Gene

Pathways & Interactions for FAM183A Gene

SuperPathways for FAM183A Gene

No Data Available

Interacting Proteins for FAM183A Gene

Gene Ontology (GO) - Biological Process for FAM183A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM183A Gene

Drugs & Compounds for FAM183A Gene

No Compound Related Data Available

Transcripts for FAM183A Gene

Unigene Clusters for FAM183A Gene

Family with sequence similarity 183, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM183A Gene

No ASD Table

Relevant External Links for FAM183A Gene

GeneLoc Exon Structure for
FAM183A
ECgene alternative splicing isoforms for
FAM183A

Expression for FAM183A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM183A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM183A Gene

This gene is overexpressed in Fallopian Tube (x7.5), Pituitary (x7.2), Brain - Hypothalamus (x4.3), and Cervix - Endocervix (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of FAM183A Gene:

FAM183A

SOURCE GeneReport for Unigene cluster for FAM183A Gene:

Hs.657614

Evidence on tissue expression from TISSUES for FAM183A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FAM183A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM183A Gene

Orthologs for FAM183A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM183A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM183A 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia FAM183A 34
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam183b 34
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM183A 34
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAM183B 34
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for FAM183A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM183A Gene

ENSEMBL:
Gene Tree for FAM183A (if available)
TreeFam:
Gene Tree for FAM183A (if available)

Paralogs for FAM183A Gene

(2) SIMAP similar genes for FAM183A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FAM183A Gene

genes like me logo Genes that share paralogs with FAM183A: view

No data available for Paralogs for FAM183A Gene

Variants for FAM183A Gene

Sequence variations from dbSNP and Humsavar for FAM183A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000486698 -- 43,151,714(+) T/G intron_variant
rs1000669947 -- 43,146,750(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000763138 -- 43,146,658(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000928324 -- 43,147,097(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001192168 -- 43,152,224(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM183A Gene

Variant ID Type Subtype PubMed ID
nsv829693 CNV loss 17160897

Variation tolerance for FAM183A Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM183A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM183A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM183A Gene

Disorders for FAM183A Gene

Additional Disease Information for FAM183A

No disorders were found for FAM183A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM183A Gene

Publications for FAM183A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 2 3 58
  3. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) König R … Chanda SK (Cell 2008) 3 58

Products for FAM183A Gene

Sources for FAM183A Gene

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