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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM183A Gene

protein-coding GIFtS: 31
GCID: GC01P043610

family with sequence similarity 183, member A

Search for FAM183A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 183, Member A¹ ²
HCG23177¹
LOC440585¹
Protein FAM183A²

External Ids:	HGNC: 34347¹	Entrez Gene: 440585²	Ensembl: ENSG00000186973⁷	UniProtKB: A6NL82³

Export aliases for FAM183A gene to outside databases

Previous GC identifers: GC01P043383 GC01P041733

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM183A gene promoter:
POU3F2 (N-Oct-5a) XBP-1 Nkx2-5 AP-4 RelA POU3F2 NF-kappaB S8 FOXO4 NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FAM183A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM183A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2

FAM183A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM183A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P043610: view genomic region (about GC identifiers)

Start:	43,610,029 bp from pter	End:	43,622,067 bp from pter
Size:	12,039 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F183A_HUMAN, A6NL82 (See protein sequence)

Recommended Name: Protein FAM183A

Size: 134 amino acids; 15996 Da

Secondary accessions: B7ZBL8

Explore the universe of human proteins at neXtProt for FAM183A: NX_A6NL82

FAM183A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001094846.2

ENSEMBL proteins:

ENSP00000387244 ENSP00000387249 ENSP00000386318 ENSP00000387018 ENSP00000387254

ENSP00000334415

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A6NL82

UniProtKB/Swiss-Prot: F183A_HUMAN, A6NL82

Similarity: Belongs to the FAM183 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM183A
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM183A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM183A (ENSP00000334415⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	ENSP00000372991⁴	STRING: ENSP00000372991

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM183A
Search CenterWatch for drugs/clinical trials and news about FAM183A / F183A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM183A gene:

NM_001101376.2

Unigene Cluster for FAM183A:

Family with sequence similarity 183, member A

Hs.657614 [show with all ESTs]

Unigene Representative Sequence: BM926539

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409706(uc009vwn.1) ENST00000410048 ENST00000409337 ENST00000410025(uc009vwo.3)

ENST00000409396 ENST00000481753 ENST00000335282

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FAM183A
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7 DOTS entries:

DT.205763 DT.450422 DT.75101928 DT.100745604 DT.92417245 DT.95154830 DT.99976962

24/44 AceView cDNA sequences (see all 44):

AW029496 AI469340 AW138367 BM976667 BF477758 R64685 AI681257 BQ025739

AA833578 AI611120 AA431291 BF061370 CD238494 N81028 BV189645 AI201524

BM926539 BU689027 AI635061 AI375550 AA431652 AI336882 BM978505 AI685578

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM183A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGCAGGCT

About this image

FAM183A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FAM183A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.657614

SABiosciences Custom PCR Arrays for FAM183A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM183A gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FAM183A¹	family with sequence similarity 183, member A	62.87(n) 56.1(a)		424557 XM_422395.3 XP_422395.1
zebrafish (Danio rerio)	Actinopterygii	LOC792834¹	protein FAM183A-like	52.3(n) 48.78(a)		792834 XM_001332144.4 XP_001332180.4

Species with no ortholog for FAM183A

ENSEMBL Gene Tree for FAM183A (if available)
TreeFam Gene Tree for FAM183A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FAM183A gene

FAM183B²

2 SIMAP similar genes for FAM183A using alignment to 5 protein entries: F183A_HUMAN (see all proteins):

FAM183B THEG6

FAM183A for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for FAM183A
PGOHUM00000244434 PGOHUM00000240231 PGOHUM00000249606

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189080044^1,2		--	43611657(+)	`GGACTA/GTCTCT`	1	--	us2k¹		0	--	--	--	--
rs181496626^1,2		--	43611682(+)	`GTGGGC/TCAACT`	1	--	us2k¹		0	--	--	--	--
rs12134851^1,2	H	--	43611693(+)	`ggataC/Gtcctt`	1	--	us2k¹		4		NS EA	420
rs61776910^1,2		--	43611863(+)	`GAAGTG/ATAAAA`	1	--	us2k¹		2		NA	122
rs116857794^1,2	F,	--	43611938(+)	`TCAAAC/TGTTGA`	1	--	us2k¹		1		EA	120
rs186038761^1,2		--	43611955(+)	`GACAAA/GTTGGA`	1	--	us2k¹		0	--	--	--	--
rs60128092^1,2	C,F,	--	43612017(+)	`TCTCTT/GAATGC`	1	--	us2k¹		5		WA CSA NA EA	362
rs653907^1,2	C,F,O,A,H,	--	43612105(+)	`TAAAAG/ATAACC`	1	--	us2k¹		18		MN NS EA NA WA CSA	1024
rs694557^1,2	C,F,A,H,	--	43612144(+)	`TTAAAA/C/TGAAAA`	1	--	us2k¹ tfbs³		20		NS EA NA CSA WA	1346
rs79939922^1,2	C	--	43612326(+)	`AACAAA/TCCAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FAM183A (43610029 - 43622067 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM183A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM183A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM183A)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The sequence of the human genome. (PubMed id 11181995)^{1, 3} Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 440585	HGNC: 34347	AceView: LOC440585	Ensembl:ENSG00000186973	euGenes: HUgn440585
ECgene: FAM183A	H-InvDB: FAM183A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM183A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM183A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM183A gene:
Search GeneIP for patents involving FAM183A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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FAM183A Gene

family with sequence similarity 183, member A

Aliases
for FAM183A gene

Summaries
for FAM183A gene

Genomic Views
for FAM183A gene

Proteins
for FAM183A gene

Protein Domains /
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for FAM183A gene

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for FAM183A gene

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FAM183A Gene

family with sequence similarity 183, member A

Aliasesfor FAM183A gene

Summariesfor FAM183A gene

Genomic Viewsfor FAM183A gene

Proteinsfor FAM183A gene

Protein Domains /Familiesfor FAM183A gene

Functionfor FAM183A gene

Pathways & Interactionsfor FAM183A gene

Drugs & Compoundsfor FAM183A gene

Transcriptsfor FAM183A gene

Expression for FAM183A gene

Orthologsfor FAM183A gene

Paralogsfor FAM183A gene

Genomic Variantsfor FAM183A gene

Disorders / Diseasesfor FAM183A gene

Publicationsfor FAM183A gene

External Searches for FAM183A gene

Genome Databases showing FAM183A gene

Other Databases showing FAM183A gene

Specialized Databases showing FAM183A gene

Intellectual Propertyfor FAM183A gene

Productsfor FAM183A gene

View Random Gene

Aliases
for FAM183A gene

Summaries
for FAM183A gene

Genomic Views
for FAM183A gene

Proteins
for FAM183A gene

Protein Domains /
Families
for FAM183A gene

Function
for FAM183A gene

Pathways & Interactions
for FAM183A gene

Drugs & Compounds
for FAM183A gene

Transcripts
for FAM183A gene

Expression
for FAM183A gene

Orthologs
for FAM183A gene

Paralogs
for FAM183A gene

Genomic Variants
for FAM183A gene

Disorders / Diseases
for FAM183A gene

Publications
for FAM183A gene

Intellectual Property
for FAM183A gene

Products
for FAM183A gene