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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM183A Gene

protein-coding   GIFtS: 31
GCID: GC01P043610

Family With Sequence Similarity 183, Member A

  Search for FAM183A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 183, Member A1 2
hCG231772
Protein FAM183A2

External Ids:    HGNC: 343471   Entrez Gene: 4405852   Ensembl: ENSG000001869737   UniProtKB: A6NL823   

Export aliases for FAM183A gene to outside databases

Previous GC identifers: GC01P043383 GC01P041733


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM183A Gene: 
FAM183A (family with sequence similarity 183, member A) is a protein-coding gene. An important paralog of this gene is FAM183B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM183A gene promoter:
         POU3F2 (N-Oct-5a)   XBP-1   Nkx2-5   AP-4   RelA   POU3F2   NF-kappaB   S8   FOXO4   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM183A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM183A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

FAM183A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM183A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043610:  view genomic region     (about GC identifiers)

Start:
43,610,824 bp from pter      End:
43,622,067 bp from pter
Size:
11,244 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F183A_HUMAN, A6NL82 (See protein sequence)
Recommended Name: Protein FAM183A  
Size: 134 amino acids; 15996 Da
Secondary accessions: B7ZBL8

Explore the universe of human proteins at neXtProt for FAM183A: NX_A6NL82

Explore proteomics data for FAM183A at MOPED 

FAM183A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM183A Protein Expression

REFSEQ proteins: NP_001094846.2  
ENSEMBL proteins: 
 ENSP00000387249   ENSP00000387018   ENSP00000387254   ENSP00000334415  

Human Recombinant Protein Products for FAM183A: 
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Cloud-Clone Corp. ELISAs for FAM183A 
Cloud-Clone Corp. CLIAs for FAM183A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A6NL82

UniProtKB/Swiss-Prot: F183A_HUMAN, A6NL82
Similarity: Belongs to the FAM183 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM183A 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM183A 
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM183A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM183A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for FAM183A (ENSP000003344154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000173503ENSP000003729914STRING: ENSP00000372991
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM183A (F183A)

Search CenterWatch for drugs/clinical trials and news about FAM183A / F183A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM183A gene: 
NM_001101376.2  

Unigene Cluster for FAM183A:

Family with sequence similarity 183, member A
Hs.657614  [show with all ESTs]
Unigene Representative Sequence: BM926539
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000410048 ENST00000409337 ENST00000410025(uc009vwo.3) ENST00000409396
ENST00000335282 ENST00000481753
miRNA
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Inhib. RNA
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM183A
Clone
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OriGene clones in human, mouse for FAM183A (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FAM183A (NM_001101376)
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FAM183A
Sirion Biotech Customized lentivirus for stable overexpression of FAM183A 
                     Customized lentivirus expression plasmids for stable overexpression of FAM183A 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for FAM183A
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FAM183A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM183A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM183A

7 DOTS entries:

DT.205763  DT.450422  DT.75101928  DT.100745604  DT.92417245  DT.95154830  DT.99976962 

24/44 AceView cDNA sequences (see all 44):

BM976667 BF477758 AW138367 AI469340 AW029496 R64685 AI681257 AA431291 
BU689027 BU676445 CD239034 AI685578 AA431652 BF061370 AI633732 BQ025739 
AI375550 AA833578 CD238494 AI336882 AI201524 BV189645 BM926539 N81028 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM183A expression in normal human tissues (normalized intensities)      FAM183A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCGCAGGCT
FAM183A Expression
About this image


FAM183A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 
 Neural Crest (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 
 Pancreas (Endocrine System)
         Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
 
 Mesoderm (Gastrulation Derivatives)
         PureStem Z11, Meso Progenitor
 
 Uncategorized (Uncategorized)
         PureStem Progenitor ES-199

See FAM183A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.657614
    SABiosciences Custom PCR Arrays for FAM183A
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM183A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM183A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM183A gene from 3/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves FAM183A1 family with sequence similarity 183, member A 62.87(n)
56.1(a)
  424557  XM_422395.3  XP_422395.1 
lizard
(Anolis carolinensis)
Reptilia --
--
49(a)
1 → many
4(107023339-107026366)
zebrafish
(Danio rerio)
Actinopterygii LOC7928341 protein FAM183A-like 52.3(n)
48.78(a)
  792834  XM_001332144.4  XP_001332180.4 
        Species with no ortholog for FAM183A

ENSEMBL Gene Tree for FAM183A (if available)
TreeFam Gene Tree for FAM183A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM183A gene
FAM183B2  
2 SIMAP similar genes for FAM183A using alignment to 5 protein entries:     F183A_HUMAN (see all proteins):
FAM183B    THEG6

FAM183A for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for FAM183A
PGOHUM00000244434 PGOHUM00000240231 PGOHUM00000249606


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/289 SNPs in FAM183A are shown (see all 289)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1890800441,2
--43611657(+) GGACTA/GTCTCT 1 -- us2k10--------
rs1814966261,2
--43611682(+) GTGGGC/TCAACT 1 -- us2k10--------
rs121348511,2
H--43611693(+) ggataC/Gtcctt 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
rs617769101,2
C,F--43611863(+) GAAGTG/ATAAAA 1 -- us2k12Minor allele frequency- A:0.04NA 122
rs1168577941,2
C,F--43611938(+) TCAAAC/TGTTGA 1 -- us2k11Minor allele frequency- T:0.02EA 120
rs1860387611,2
--43611955(+) GACAAA/GTTGGA 1 -- us2k10--------
rs601280921,2
C,F--43612017(+) TCTCTT/GAATGC 1 -- us2k15Minor allele frequency- G:0.17WA CSA NA EA 362
rs6539071,2
C,F,O,A,H--43612105(+) TAAAAG/ATAACC 1 -- us2k118Minor allele frequency- A:0.37MN NS EA NA WA CSA 1024
rs6945571,2
C,F,A,H--43612144(+) TTAAAA/C/TGAAAA 1 -- us2k1 tfbs320NS EA NA CSA WA 1346
rs799399221,2
C--43612326(+) AACAAA/TCCAAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FAM183A (43610824 - 43622067 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for FAM183A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv829693CNV Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM183A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM183A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  2. The sequence of the human genome. (PubMed id 11181995)1, 3 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 440585 HGNC: 34347 AceView: LOC440585 Ensembl:ENSG00000186973 euGenes: HUgn440585
ECgene: FAM183A H-InvDB: FAM183A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM183A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM183A gene:
Search GeneIP for patents involving FAM183A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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