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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM182B Gene

pseudogene   GIFtS: 26
GCID: GC20M025744

Family With Sequence Similarity 182, Member B

  Search for FAM182B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Family With Sequence Similarity 182, Member B1 2

External Ids:    HGNC: 345031   Entrez Gene: 7288822   Ensembl: ENSG000001751707   UniProtKB: Q5T3193   
ORGUL members:         
NONCODE14:n387192 n383882 n383881      

Export aliases for FAM182B gene to outside databases

Previous GC identifer: GC20M025692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM182B Gene: 
FAM182B (family with sequence similarity 182, member B) is a pseudogene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for FAM182B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FAM182B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM182B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11.1

FAM182B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM182B gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M025744:  view genomic region     (about GC identifiers)

Start:
25,744,102 bp from pter      End:
25,848,861 bp from pter
Size:
104,760 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FAM182B

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F182B_HUMAN, Q5T319 (See protein sequence)
Recommended Name: Protein FAM182B  
Size: 152 amino acids; 15775 Da
Secondary accessions: Q4G0Q1
Alternative splicing: 2 isoforms:  Q5T319-1   Q5T319-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for FAM182B: NX_Q5T319

Explore proteomics data for FAM182B at MOPED 

FAM182B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM182B Protein Expression

ENSEMBL proteins: 
 ENSP00000365585   ENSP00000464534   ENSP00000365586  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q5T319


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM182B

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for FAM182B (F182B)

Search CenterWatch for drugs/clinical trials and news about FAM182B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for FAM182B:

Family with sequence similarity 182, member B
Hs.682103  [show with all ESTs]
Unigene Representative Sequence: NR_026714
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000478164(uc010zth.1 uc010zti.2) ENST00000453481 ENST00000376403(uc002wve.3)
ENST00000485279 ENST00000584071 ENST00000582267 ENST00000584356 ENST00000424021
ENST00000376404(uc002wvd.1)
miRNA
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Additional mRNA sequence: 

AK054844.1 AL096727.1 NR_026714.2 NR_027061.2 

10 DOTS entries:

DT.208399  DT.120803187  DT.100682559  DT.120803206  DT.70102742  DT.208398  DT.75127200  DT.100689640 
DT.92019358  DT.120803226 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM182B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FAM182B Expression
About this image


See FAM182B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FAM182B

SOURCE GeneReport for Unigene cluster: Hs.682103
    SABiosciences Custom PCR Arrays for FAM182B
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM182B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM182B gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC1006084006
--
--
84(a)
84(a)
many → 1
many → 1
GL392679.1(15671-21218)
17(34315483-34321028)


ENSEMBL Gene Tree for FAM182B (if available)
TreeFam Gene Tree for FAM182B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FAM182B gene
1 SIMAP similar gene for FAM182B using alignment to 3 protein entries:     F182B_HUMAN (see all proteins):
FAM182A

FAM182B for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for FAM182B
PGOHUM00000236984 PGOHUM00000232767 PGOHUM00000233309 PGOHUM00000260603


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/946 SNPs in FAM182B are shown (see all 946)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22583021,2
C,F--25743673(+) CTGGGG/AGTCAC 1 -- ds50012Minor allele frequency- A:0.50NA 6
rs781042091,2
F--25743711(+) AATACG/AGAAGT 1 -- ds50012Minor allele frequency- A:0.50NA 6
rs1882506821,2
--25743796(+) TTCCAA/GTAGAC 1 -- ds50010--------
rs61152811,2
C,F--25743798(+) CCAATA/GGACTC 1 -- ds50012Minor allele frequency- G:0.00NA 4
rs1917991241,2
C--25743832(+) GTTGAA/CCCAGT 1 -- ds50010--------
rs1838572471,2
C--25743841(+) GTGAAA/CCATAG 1 -- ds50010--------
rs44476661,2
C,F,H--25743845(+) ACCATA/GGCCAG 1 -- ds50013Minor allele frequency- G:0.00NS EA 298
rs1820783621,2
--25743880(+) AAGAAA/CAATGA 1 -- ds50010--------
rs2019976991,2
C--25743911(+) CTGAAC/TTTTCA 1 -- ds50010--------
rs1883528651,2
C--25743928(+) TGCACC/TCCCAA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for FAM182B (25744102 - 25848861 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/11 variations for FAM182B (see all 11):    About this table     
Variant IDTypeSubtypePubMed ID
nsv820681CNV Duplication20802225
nsv510784CNV Loss20534489
nsv9794CNV Loss18304495
nsv470545CNV Gain18288195
nsv912834CNV Gain21882294
nsv522873CNV Gain19592680
esv990797CNV Gain20482838
esv23664CNV Gain+Loss19812545
esv363CNV CNV17122850
dgv1319e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM182B gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM182B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 728882 HGNC: 34503 Ensembl:ENSG00000175170 euGenes: HUgn728882 ECgene: FAM182B
H-InvDB: FAM182B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM182B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM182B gene:
Search GeneIP for patents involving FAM182B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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