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FAM182A Gene

RNA gene   GIFtS: 30
GCID: GC20P026035

Family With Sequence Similarity 182, Member A

(Previous name: chromosome 20 open reading frame 91)
(Previous symbol: C20orf91)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Family With Sequence Similarity 182, Member A1 2
C20orf911 2 3
Chromosome 20 Open Reading Frame 911
bB329D4.12

External Ids:    HGNC: 162221   Entrez Gene: 2848002   Ensembl: ENSG000001258047   UniProtKB: Q5T1J63   
ORGUL members:         

Export aliases for FAM182A gene to outside databases

Previous GC identifers: GC20P025988 GC20P025926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM182A Gene:
FAM182A (family with sequence similarity 182, member A) is an RNA gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FAM182A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FAM182A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM182A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.1   Ensembl cytogenetic band:  20p11.1   HGNC cytogenetic band: 20p11

FAM182A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM182A gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P026035:  view genomic region     (about GC identifiers)

Start:
26,035,250 bp from pter      End:
26,073,683 bp from pter
Size:
38,434 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F182A_HUMAN, Q5T1J6 (See protein sequence)
Recommended Name: Protein FAM182A  
Size: 154 amino acids; 17173 Da
Secondary accessions: A2RRD0 Q8N947

Explore the universe of human proteins at neXtProt for FAM182A: NX_Q5T1J6

Explore proteomics data for FAM182A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM182A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5T1J6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM182A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM182A
    Interactions:

        Search GeneGlobe Interaction Network for FAM182A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM182A (F182A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM182A gene: 
    NM_182583.1  

    Unigene Cluster for FAM182A:

    Family with sequence similarity 182, member A
    Hs.516956  [show with all ESTs]
    Unigene Representative Sequence: NR_026713
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376398(processed_transcript) ENST00000389261(processed_transcript) ENST00000439881(processed_transcript) ENST00000471057(processed_transcript) ENST00000482133(processed_transcript)
    ENST00000415411(processed_transcript)
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    Additional mRNA sequence: 

    AK095693.1 BC030737.1 BC038849.1 BC131537.1 NR_004846.2 NR_026713.1 XR_159358.1 

    11 DOTS entries:

    DT.100745006  DT.92418840  DT.97836627  DT.120803187  DT.75135109  DT.99930907  DT.120803228  DT.75127200 
    DT.306678  DT.75199133  DT.95215560 

    22 AceView cDNA sequences:

    BX093846 AI161331 AA902670 BM702808 CR607715 AA953753 BM984943 AI476717 
    AK095693 AW135038 AI990210 AI149914 AI243019 BU662160 NM_182583 BU662154 
    H14536 AL732297 AL731911 H14535 BX280969 BQ447386 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FAM182A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                    -                                       
    SP2:                                                            
    SP3:        -     -     -     -     -     -     -               


    ECgene alternative splicing isoforms for FAM182A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    Expression evidence for FAM182A:none

    FAM182A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCTGGGC
    FAM182A Expression
    About this image

    FAM182A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM182A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516956
        Custom PCR Arrays for FAM182A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM182A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for FAM182A (if available)
    TreeFam Gene Tree for FAM182A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FAM182A gene
    1 SIMAP similar gene for FAM182A using alignment to 3 protein entries:     F182A_HUMAN (see all proteins):
    FAM182B

    Find genes that share paralogs with FAM182A           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FAM182A
    PGOHUM00000259632 PGOHUM00000232768 PGOHUM00000233308 PGOHUM00000260604


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM182A (see all 828)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438271361,2
    C--26034470(+) TCAGAA/GTCATG 1 -- us2k10--------
    rs769830511,2
    C--26034485(-) CCTTTC/TACCTC 1 -- us2k10--------
    rs1399406411,2
    --26034499(+) TCTTAC/TATGGC 1 -- us2k10--------
    rs1498578431,2
    --26034507(+) GGCAGA/CAGCAA 1 -- us2k10--------
    rs2011917091,2
    --26039580(+) CATTT-/GTTTCG 1 -- int10--------
    rs2018180441,2
    --26040734(+) TCTCT-/TCTC  
            
    TCTCT
    1 -- int10--------
    rs1999263841,2
    C--26042966(+) AGAAAG/TCTACC 1 -- int10--------
    rs2010153491,2
    C--26043022(+) GGCAAA/GCATGT 1 -- int10--------
    rs1492962991,2
    --26043365(+) TGTCCC/TAAGTG 1 -- int10--------
    rs2012098381,2
    C--26046954(+) AAAAA-/GTACAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FAM182A (26035250 - 26073683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FAM182A (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665127CNV Deletion23128226
    nsv821510CNV Duplication20802225
    nsv9797CNV Loss18304495
    nsv470545CNV Gain18288195
    nsv522873CNV Gain19592680
    nsv9798CNV Gain18304495
    esv25843CNV Gain+Loss19812545
    esv363CNV CNV17122850
    essv21671CNV CNV17122850
    dgv1322e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FAM182A
    DNA2.0 Custom Variant and Variant Library Synthesis for FAM182A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM182A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM182A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284800 HGNC: 16222 AceView: FLJ38374 Ensembl:ENSG00000125804 euGenes: HUgn284800
    ECgene: FAM182A H-InvDB: FAM182A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM182A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM182A gene:
    Search GeneIP for patents involving FAM182A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     antibodies-online kits for FAM182A (2 products)
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      Search antibodies-online for proteins for FAM182A
           
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