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Aliases for FAM181B Gene

Aliases for FAM181B Gene

  • Family With Sequence Similarity 181 Member B 2 3 5
  • Family With Sequence Similarity 181, Member B 2

External Ids for FAM181B Gene

Previous GeneCards Identifiers for FAM181B Gene

  • GC11M082122
  • GC11M082443
  • GC11M078740

Summaries for FAM181B Gene

GeneCards Summary for FAM181B Gene

FAM181B (Family With Sequence Similarity 181 Member B) is a Protein Coding gene.

Additional gene information for FAM181B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM181B Gene

Genomics for FAM181B Gene

Regulatory Elements for FAM181B Gene

Enhancers for FAM181B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H082863 1.3 Ensembl ENCODE dbSUPER 11.6 -130.6 -130590 1 CTCF ESRRA MAX CEBPG ZBTB40 RAD21 RFX5 GATA3 GATA2 SMC3 DDIAS FAM181B PRCP ENSG00000254441
GH11H082867 1.2 Ensembl ENCODE dbSUPER 11.2 -133.7 -133696 0 CTCF ZNF654 ZNF362 RB1 HLF TRIM22 ZNF384 REST RAD21 CC2D1A DDIAS PRCP FAM181B ENSG00000255234 CCDC90B RAB30 ENSG00000254441
GH11H082857 1.1 Ensembl ENCODE dbSUPER 11.2 -124.9 -124878 2 BCOR JUN CEBPB ZMYM3 EP300 JUND PRDM6 MAFF KDM1A PRDM1 DDIAS FAM181B PRCP ENSG00000254441
GH11H082840 0.6 dbSUPER 11.1 -108.6 -108606 3 BCOR GATA3 FOXA2 SCRT2 ZMYM3 KDM1A FOXA1 PRCP DDIAS FAM181B ENSG00000254441
GH11H082771 0.4 ENCODE 12 -38.1 -38141 0 GATA3 JUND RAB30 FAM181B RAB30-AS1 LOC105369413
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM181B on UCSC Golden Path with GeneCards custom track

Promoters for FAM181B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042731 564 201 CTCF NCOA6 SUZ12 KLF9 ZBTB26 EZH2

Genomic Location for FAM181B Gene

Chromosome:
11
Start:
82,729,941 bp from pter
End:
82,733,864 bp from pter
Size:
3,924 bases
Orientation:
Minus strand

Genomic View for FAM181B Gene

Genes around FAM181B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM181B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM181B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM181B Gene

Proteins for FAM181B Gene

  • Protein details for FAM181B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEQ2-F181B_HUMAN
    Recommended name:
    Protein FAM181B
    Protein Accession:
    A6NEQ2
    Secondary Accessions:
    • B2RWP1

    Protein attributes for FAM181B Gene

    Size:
    426 amino acids
    Molecular mass:
    42657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM181B Gene

Post-translational modifications for FAM181B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM181B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM181B Gene

Domains & Families for FAM181B Gene

Gene Families for FAM181B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM181B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM181B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NEQ2

UniProtKB/Swiss-Prot:

F181B_HUMAN :
  • Belongs to the FAM181 family.
Family:
  • Belongs to the FAM181 family.
genes like me logo Genes that share domains with FAM181B: view

Function for FAM181B Gene

genes like me logo Genes that share phenotypes with FAM181B: view

Animal Models for FAM181B Gene

MGI Knock Outs for FAM181B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM181B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM181B Gene

Localization for FAM181B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM181B gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM181B Gene

Pathways & Interactions for FAM181B Gene

SuperPathways for FAM181B Gene

No Data Available

Interacting Proteins for FAM181B Gene

Gene Ontology (GO) - Biological Process for FAM181B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM181B Gene

Drugs & Compounds for FAM181B Gene

No Compound Related Data Available

Transcripts for FAM181B Gene

mRNA/cDNA for FAM181B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM181B Gene

Family with sequence similarity 181, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM181B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM181B Gene

No ASD Table

Relevant External Links for FAM181B Gene

GeneLoc Exon Structure for
FAM181B
ECgene alternative splicing isoforms for
FAM181B

Expression for FAM181B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM181B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM181B Gene

This gene is overexpressed in Brain - Amygdala (x4.7), Brain - Substantia nigra (x4.3), Brain - Spinal cord (cervical c-1) (x4.1), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for FAM181B Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM181B Gene



Protein tissue co-expression partners for FAM181B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM181B Gene:

FAM181B

SOURCE GeneReport for Unigene cluster for FAM181B Gene:

Hs.448218

Evidence on tissue expression from TISSUES for FAM181B Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with FAM181B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM181B Gene

Orthologs for FAM181B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM181B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748983 33
  • 99.3 (n)
FAM181B 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM181B 33 34
  • 87.43 (n)
dog
(Canis familiaris)
Mammalia FAM181B 33 34
  • 83.76 (n)
mouse
(Mus musculus)
Mammalia Fam181b 33 16
  • 80 (n)
rat
(Rattus norvegicus)
Mammalia Fam181b 33
  • 78.87 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM181B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM181B 33 34
  • 70.56 (n)
lizard
(Anolis carolinensis)
Reptilia FAM181B 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam181b 33
  • 54.01 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883805 33
  • 52.8 (n)
CR538726.1 34
  • 46 (a)
OneToOne
Species where no ortholog for FAM181B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM181B Gene

ENSEMBL:
Gene Tree for FAM181B (if available)
TreeFam:
Gene Tree for FAM181B (if available)

Paralogs for FAM181B Gene

No data available for Paralogs for FAM181B Gene

Variants for FAM181B Gene

Sequence variations from dbSNP and Humsavar for FAM181B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000847896 -- 82,731,961(+) GAAAA(-/C)CGTCC downstream-variant-500B
rs1000901102 -- 82,733,067(+) CGCAG(C/T)GGGAC reference, synonymous-codon
rs1001304501 -- 82,731,868(+) CCCTA(C/T)CCAAG downstream-variant-500B
rs1001354794 -- 82,731,599(+) ATTGA(C/T)ACAAA downstream-variant-500B
rs1002411199 -- 82,732,787(+) TCCCA(C/T)CACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FAM181B Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV loss 17666407
nsv413 CNV insertion 18451855

Variation tolerance for FAM181B Gene

Gene Damage Index Score: 11.99; 93.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM181B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM181B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM181B Gene

Disorders for FAM181B Gene

Relevant External Links for FAM181B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM181B

No disorders were found for FAM181B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM181B Gene

Publications for FAM181B Gene

  1. Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. (PMID: 26407640) Marks M … Wittler L (Gene 2016) 2 3 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for FAM181B Gene

Sources for FAM181B Gene

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