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Aliases for FAM181B Gene

Aliases for FAM181B Gene

  • Family With Sequence Similarity 181 Member B 2 3 5
  • Family With Sequence Similarity 181, Member B 2

External Ids for FAM181B Gene

Previous GeneCards Identifiers for FAM181B Gene

  • GC11M082122
  • GC11M082443
  • GC11M078740

Summaries for FAM181B Gene

GeneCards Summary for FAM181B Gene

FAM181B (Family With Sequence Similarity 181 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM181B Gene

Genomics for FAM181B Gene

Regulatory Elements for FAM181B Gene

Genomic Location for FAM181B Gene

82,729,941 bp from pter
82,733,864 bp from pter
3,924 bases
Minus strand

Genomic View for FAM181B Gene

Genes around FAM181B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM181B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM181B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM181B Gene

Proteins for FAM181B Gene

  • Protein details for FAM181B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM181B
    Protein Accession:
    Secondary Accessions:
    • B2RWP1

    Protein attributes for FAM181B Gene

    426 amino acids
    Molecular mass:
    42657 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM181B Gene

Proteomics data for FAM181B Gene at MOPED

Post-translational modifications for FAM181B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM181B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM181B Gene

Domains & Families for FAM181B Gene

Protein Domains for FAM181B Gene


Suggested Antigen Peptide Sequences for FAM181B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM181 family.
  • Belongs to the FAM181 family.
genes like me logo Genes that share domains with FAM181B: view

No data available for Gene Families for FAM181B Gene

Function for FAM181B Gene

genes like me logo Genes that share phenotypes with FAM181B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM181B Gene

Localization for FAM181B Gene

Subcellular locations from

Jensen Localization Image for FAM181B Gene COMPARTMENTS Subcellular localization image for FAM181B gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM181B Gene

Pathways & Interactions for FAM181B Gene

SuperPathways for FAM181B Gene

No Data Available

Interacting Proteins for FAM181B Gene

Gene Ontology (GO) - Biological Process for FAM181B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM181B Gene

Drugs & Compounds for FAM181B Gene

No Compound Related Data Available

Transcripts for FAM181B Gene

mRNA/cDNA for FAM181B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM181B Gene

Family with sequence similarity 181, member B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM181B Gene

No ASD Table

Relevant External Links for FAM181B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM181B Gene

mRNA expression in normal human tissues for FAM181B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM181B Gene

This gene is overexpressed in Brain - Amygdala (x4.7), Brain - Substantia nigra (x4.3), Brain - Spinal cord (cervical c-1) (x4.1), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for FAM181B Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM181B Gene

SOURCE GeneReport for Unigene cluster for FAM181B Gene Hs.448218

genes like me logo Genes that share expression patterns with FAM181B: view

Protein tissue co-expression partners for FAM181B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FAM181B Gene

Orthologs for FAM181B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM181B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM181B 35
  • 87.43 (n)
  • 84.96 (a)
FAM181B 36
  • 85 (a)
(Canis familiaris)
Mammalia FAM181B 35
  • 83.76 (n)
  • 81.41 (a)
FAM181B 36
  • 81 (a)
(Mus musculus)
Mammalia Fam181b 35
  • 80 (n)
  • 78.55 (a)
Fam181b 16
(Pan troglodytes)
Mammalia LOC748983 35
  • 99.3 (n)
  • 99.06 (a)
FAM181B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam181b 35
  • 78.87 (n)
  • 76.56 (a)
(Monodelphis domestica)
Mammalia FAM181B 36
  • 62 (a)
(Gallus gallus)
Aves FAM181B 35
  • 70.56 (n)
  • 67.5 (a)
FAM181B 36
  • 61 (a)
(Anolis carolinensis)
Reptilia FAM181B 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam181b 35
  • 54.01 (n)
  • 47.15 (a)
(Danio rerio)
Actinopterygii LOC101883805 35
  • 52.8 (n)
  • 47.94 (a)
CR538726.1 36
  • 46 (a)
Species with no ortholog for FAM181B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM181B Gene

Gene Tree for FAM181B (if available)
Gene Tree for FAM181B (if available)

Paralogs for FAM181B Gene

No data available for Paralogs for FAM181B Gene

Variants for FAM181B Gene

Sequence variations from dbSNP and Humsavar for FAM181B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs986097 - 82,733,174(-) GTGAG(C/G)TGGCT reference, missense
rs6592081 - 82,732,630(+) GGCCC(C/G)GCCCG reference, missense
rs3780 -- 82,732,375(+) TTCTT(C/T)AGATT utr-variant-3-prime
rs986096 -- 82,733,184(-) CCGGC(G/T)GGGGG reference, synonymous-codon
rs2291793 -- 82,732,775(-) ACCTA(C/T)TGTAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FAM181B Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
nsv413 CNV Insertion 18451855

Variation tolerance for FAM181B Gene

Gene Damage Index Score: 11.99; 93.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM181B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM181B Gene

Disorders for FAM181B Gene

Relevant External Links for FAM181B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM181B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM181B Gene

Publications for FAM181B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for FAM181B Gene

Sources for FAM181B Gene

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