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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM181B Gene

protein-coding   GIFtS: 37
GCID: GC11M082443

family with sequence similarity 181, member B
  Search for FAM181B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FAM181B    

Aliases
for FAM181B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Family With Sequence Similarity 181, Member B1 2
LOC2203821
MGC338461
Protein FAM181B2

External Ids:    HGNC: 285121   Entrez Gene: 2203822   Ensembl: ENSG000001821037   UniProtKB: A6NEQ23   

Export aliases for FAM181B gene to outside databases

Previous GC identifers: GC11M082122 GC11M078740


Summaries
for FAM181B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for FAM181B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM181B gene promoter:
         AhR   TBP   LHX3b/Lhx3b   Arnt   C/EBPalpha   AREB6   S8   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM181B promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM181B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM181B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

FAM181B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM181B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M082443:  view genomic region     (about GC identifiers)

Start:
 82,443,046 bp from pter      End:
 82,444,906 bp from pter
Size:
 1,861 bases      Orientation:
 minus strand

Proteins
for FAM181B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F181B_HUMAN, A6NEQ2 (See protein sequence)
Recommended Name: Protein FAM181B  
Size: 426 amino acids; 42657 Da
Secondary accessions: B2RWP1

Explore the universe of human proteins at neXtProt for FAM181B: NX_A6NEQ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NEQ2

    • FAM181B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_787081.2  
    ENSEMBL proteins: 
     ENSP00000365295  

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    Protein Domains /
    Families
    for FAM181B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6NEQ2

    UniProtKB/Swiss-Prot: F181B_HUMAN, A6NEQ2
    Similarity: Belongs to the FAM181 family


    Function
    for FAM181B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FAM181B:
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    Inhib. RNA
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    1 GenomeRNAi human phenotype for FAM181B:
     Decreased number of cells in m 


    Pathways & Interactions
    for FAM181B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM181B

    Drugs & Compounds
    for FAM181B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FAM181B
    Search CenterWatch for drugs/clinical trials and news about FAM181B / F181B 

    Transcripts
    for FAM181B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FAM181B gene: 
    NM_175885.3  

    Unigene Cluster for FAM181B:

    Family with sequence similarity 181, member B
    Hs.448218  [show with all ESTs]
    Unigene Representative Sequence: NM_175885
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329203(uc001ozp.3)

    miRNA
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    hsa-miR-548b-3p
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FAM181B (see all 4)
    OriGene shRNA RFP: FAM181B
    OriGene siRNA: FAM181B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC039262.1 BC150621.1 

    2 DOTS entries:

    DT.40230576  DT.95199718 

    24/32 AceView cDNA sequences (see all 32):

    AI568502 AW297374 AA384164 AI973289 AW296016 AI355914 AI422508 AI419002 
    AI919447 AI424715 AI560365 AI951629 AW008680 BC039262 AW139080 AI144113 
    BX119005 BE856370 AK095054 H46934 AW205640 AI494314 NM_175885 AI422751 

    GeneLoc Exon Structure


    Expression
    for FAM181B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FAM181B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCGCCGCGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FAM181B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeForegutForegut Endoderm CellsEndoderm
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See FAM181B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FAM181B

    SOURCE GeneReport for Unigene cluster: Hs.448218
        SABiosciences Custom PCR Arrays for FAM181B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM181B

    Orthologs
    for FAM181B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FAM181B gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fam181b1 , 5 family with sequence similarity 181, member B1, 5 80.56(n)1
    79.28(a)1    		   7 (51.66 cM)5
    582381  NM_021427.21  NP_067402.21 
     930798795 
    chicken
    (Gallus gallus)    		 Aves FAM181B6
    		 Uncharacterized protein
    		 55(a)
    		 1 ↔ 1
    		 1(193324829-193326645)
    lizard
    (Anolis carolinensis)    		 Reptilia FAM181B6
    		 --
    		 49(a)
    		 1 ↔ 1
    		 3(202336721-202337560)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR538726.16
    		 --
    		 45(a)
    		 1 ↔ 1
    		 15(10299451-10300416)


    ENSEMBL Gene Tree for FAM181B (if available)
    TreeFam Gene Tree for FAM181B (if available) 

    Paralogs
    for FAM181B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FAM181B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/63 NCBI SNPs in FAM181B are shown (see all 63)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1426906351,2
    		--82442600(+) GTAGAA/GGAACA 1 -- ds50010--------
    rs1833413281,2
    		--82442657(+) TACAGC/TTTGCC 1 -- ds50010--------
    rs1505738481,2
    		--82442772(+) AAGCCG/TGCCGA 1 -- ds50010--------
    rs1144922001,2
    		--82442891(+) AAACCG/ATGACA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1395567391,2
    		--82442949(+) ACCGGC/GCTCCT 1 -- ds50010--------
    rs1875720731,2
    		--82442996(+) CCAGAC/TGGAAA 1 -- ds50010--------
    rs1454692231,2
    		--82443011(+) TCCTGC/TAAGAA 1 -- ds50010--------
    rs1913038251,2
    		--82443046(+) CTCCAC/TTCTTT 1 -- ut310--------
    rs753044641,2
    		--82443140(+) AATACA/CCTGAC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs37801,2
    		C,F,A,H,--82443417(+) TTCTTT/CAGATT 1 -- ut3123Minor allele frequency- C:0.34MN NS EA NA WA CSA 2542

    HapMap Linkage Disequilibrium report for FAM181B (82443046 - 82444906 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FAM181B
         1 CNV: 6945

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    Disorders / Diseases
    for FAM181B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for FAM181B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FAM181B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FAM181B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for FAM181B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FAM181B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220382 HGNC: 28512 AceView: MGC33846 Ensembl:ENSG00000182103 euGenes: HUgn220382
    ECgene: FAM181B H-InvDB: FAM181B

    Other Databases showing FAM181B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FAM181B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FAM181B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FAM181B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FAM181B gene:
    Search GeneIP for patents involving FAM181B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FAM181B gene

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    About This Section

     
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    von Willebrand factor
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