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FAM181B Gene

protein-coding   GIFtS: 37
GCID: GC11M082443

Family With Sequence Similarity 181, Member B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Family With Sequence Similarity 181, Member B1 2
Protein FAM181B2

External Ids:    HGNC: 285121   Entrez Gene: 2203822   Ensembl: ENSG000001821037   UniProtKB: A6NEQ23   

Export aliases for FAM181B gene to outside databases

Previous GC identifers: GC11M082122 GC11M078740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FAM181B Gene:
FAM181B (family with sequence similarity 181, member B) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FAM181B gene promoter:
         AhR   TBP   LHX3b/Lhx3b   Arnt   C/EBPalpha   AREB6   S8   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM181B promoter sequence
   Search Chromatin IP Primers for FAM181B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FAM181B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

FAM181B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM181B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M082443:  view genomic region     (about GC identifiers)

Start:
82,443,046 bp from pter      End:
82,444,906 bp from pter
Size:
1,861 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: F181B_HUMAN, A6NEQ2 (See protein sequence)
Recommended Name: Protein FAM181B  
Size: 426 amino acids; 42657 Da
Secondary accessions: B2RWP1

Explore the universe of human proteins at neXtProt for FAM181B: NX_A6NEQ2

Explore proteomics data for FAM181B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FAM181B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787081.2  
    ENSEMBL proteins: 
     ENSP00000365295  

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    antibodies-online proteins for FAM181B (3 products) 

     
    antibodies-online peptides for FAM181B

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    antibodies-online antibodies for FAM181B (2 products) 

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    antibodies-online kits for FAM181B (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A6NEQ2

    UniProtKB/Swiss-Prot: F181B_HUMAN, A6NEQ2
    Similarity: Belongs to the FAM181 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for FAM181B:
     Decreased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FAM181B

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    1 qRT-PCR Assays for microRNA that regulate FAM181B:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FAM181B
    Interactions:

        Search GeneGlobe Interaction Network for FAM181B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FAM181B (F181B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FAM181B gene: 
    NM_175885.3  

    Unigene Cluster for FAM181B:

    Family with sequence similarity 181, member B
    Hs.448218  [show with all ESTs]
    Unigene Representative Sequence: NM_175885
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329203(uc001ozp.3)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate FAM181B:
    hsa-miR-548b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFAM181B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FAM181B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FAM181B
      QuantiTect SYBR Green Assays in human, mouse, rat FAM181B
      QuantiFast Probe-based Assays in human, mouse, rat FAM181B

    Additional mRNA sequence: 

    BC039262.1 BC150621.1 

    2 DOTS entries:

    DT.40230576  DT.95199718 

    Selected AceView cDNA sequences (see all 32):

    AI568502 AI424715 AI560365 AI919447 AW297374 AW296016 AI422508 AA384164 
    AI951629 AI419002 AI973289 AI355914 AW205640 H46934 AI494314 BC039262 
    AW008680 BX119005 BE856370 AK095054 AI144113 NM_175885 AI422751 AW139080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FAM181B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGCCGCGC
    FAM181B Expression
    About this image


    FAM181B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Spinal Cord (Nervous System)
    FAM181B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FAM181B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448218
        Custom PCR Arrays for FAM181B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM181B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FAM181B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fam181b1 , 5 family with sequence similarity 181, member B1, 5 80(n)1
    78.55(a)1
      7 (51.66 cM)5
    582381  NM_021427.21  NP_067402.21 
     930798795 
    chicken
    (Gallus gallus)
    Aves FAM181B1 family with sequence similarity 181, member B 70.56(n)
    67.5(a)
      101751376  XM_004938953.1  XP_004939010.1 
    lizard
    (Anolis carolinensis)
    Reptilia FAM181B6
    family with sequence similarity 181, member B
    51(a)
    1 ↔ 1
    3(202336721-202337560)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fam181b1 family with sequence similarity 181, member B 54.01(n)
    47.15(a)
      100498232  XM_004912189.1  XP_004912246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018838051 protein FAM181B-like 52.8(n)
    47.94(a)
      101883805  XM_005157487.1  XP_005157544.1 


    ENSEMBL Gene Tree for FAM181B (if available)
    TreeFam Gene Tree for FAM181B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FAM181B (see all 83)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426906351,2
    --82442600(+) GTAGAA/GGAACA 1 -- ds50010--------
    rs1833413281,2
    --82442657(+) TACAGC/TTTGCC 1 -- ds50010--------
    rs1505738481,2
    --82442772(+) AAGCCG/TGCCGA 1 -- ds50010--------
    rs1144922001,2
    C,F--82442891(+) AAACCG/ATGACA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1395567391,2
    --82442949(+) ACCGGC/GCTCCT 1 -- ds50010--------
    rs1875720731,2
    --82442996(+) CCAGAC/TGGAAA 1 -- ds50010--------
    rs1454692231,2
    --82443011(+) TCCTGC/TAAGAA 1 -- ds50010--------
    rs1913038251,2
    --82443046(+) CTCCAC/TTCTTT 1 -- ut310--------
    rs753044641,2
    F--82443140(+) AATACA/CCTGAC 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs37801,2
    C,F,A,H--82443417(+) TTCTTT/CAGATT 1 -- ut3123Minor allele frequency- C:0.34MN NS EA NA WA CSA 2542

    HapMap Linkage Disequilibrium report for FAM181B (82443046 - 82444906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FAM181B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv413CNV Insertion18451855
    esv33531CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FAM181B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FAM181B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220382 HGNC: 28512 AceView: MGC33846 Ensembl:ENSG00000182103 euGenes: HUgn220382
    ECgene: FAM181B H-InvDB: FAM181B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FAM181B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FAM181B gene:
    Search GeneIP for patents involving FAM181B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM181B
     SwitchGear 3'UTR luciferase reporter plasmids for FAM181B
     SwitchGear Promoter luciferase reporter plasmids for FAM181B
     Search ThermoFisher Antibodies for FAM181B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM181B
     Browse compounds at ApexBio
     Search Addgene for plasmids for FAM181B
      Search eBioscience for proteins for FAM181B
      Search eBioscience for elisas for FAM181B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FAM181B
     antibodies-online antibodies for FAM181B (2 products)
     antibodies-online kits for FAM181B (6 products)
     antibodies-online peptides for FAM181B
     antibodies-online proteins for FAM181B (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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