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Aliases for FAM181A Gene

Aliases for FAM181A Gene

  • Family With Sequence Similarity 181 Member A 2 3 5
  • C14orf152 3 4
  • Family With Sequence Similarity 181, Member A 2
  • Chromosome 14 Open Reading Frame 152 2
  • Protein FAM181A 3

External Ids for FAM181A Gene

Previous HGNC Symbols for FAM181A Gene

  • C14orf152

Previous GeneCards Identifiers for FAM181A Gene

  • GC14P093456
  • GC14P094385
  • GC14P074566

Summaries for FAM181A Gene

GeneCards Summary for FAM181A Gene

FAM181A (Family With Sequence Similarity 181 Member A) is a Protein Coding gene.

Additional gene information for FAM181A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM181A Gene

Genomics for FAM181A Gene

Regulatory Elements for FAM181A Gene

Enhancers for FAM181A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H093916 0.5 ENCODE 18.9 -2.0 -1992 1 FOXA2 KLF4 MAFK FOXA1 FAM181A FAM181A-AS1 ENSG00000279593
GH14H093655 0.4 FANTOM5 2.5 -263.2 -263215 0 CTCF FAM181A PRIMA1 ENSG00000277826 GC14M093707
GH14H093902 0.9 ENCODE 0.4 -16.1 -16056 0 ELF3 FOXA2 MLX DNMT3B RARA CREM HMG20B PPARG TGIF2 NFIL3 ASB2 CCDC197 ENSG00000279593 FAM181A
GH14H093906 0.7 ENCODE 0.4 -12.0 -11985 0 CTCF ETV1 ZBTB40 RAD21 ETS1 E2F1 ELK1 SMC3 ZNF143 SMARCA5 ASB2 CCDC197 ENSG00000279593 FAM181A
GH14H093903 0.6 ENCODE 0.4 -15.2 -15195 0 CTCF ZNF654 FOXA2 SP5 FOXA3 CEBPG RAD21 RCOR2 SMAD4 ASB2 CCDC197 ENSG00000279593 FAM181A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM181A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM181A Gene

Chromosome:
14
Start:
93,918,894 bp from pter
End:
93,929,608 bp from pter
Size:
10,715 bases
Orientation:
Plus strand

Genomic View for FAM181A Gene

Genes around FAM181A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM181A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM181A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM181A Gene

Proteins for FAM181A Gene

  • Protein details for FAM181A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Y4-F181A_HUMAN
    Recommended name:
    Protein FAM181A
    Protein Accession:
    Q8N9Y4
    Secondary Accessions:
    • B2RD39
    • Q96GY1

    Protein attributes for FAM181A Gene

    Size:
    354 amino acids
    Molecular mass:
    38724 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM181A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM181A Gene

Post-translational modifications for FAM181A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM181A Gene

Domains & Families for FAM181A Gene

Gene Families for FAM181A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM181A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM181A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9Y4

UniProtKB/Swiss-Prot:

F181A_HUMAN :
  • Belongs to the FAM181 family.
Family:
  • Belongs to the FAM181 family.
genes like me logo Genes that share domains with FAM181A: view

Function for FAM181A Gene

genes like me logo Genes that share phenotypes with FAM181A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM181A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM181A Gene

Localization for FAM181A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM181A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM181A Gene

Pathways & Interactions for FAM181A Gene

SuperPathways for FAM181A Gene

No Data Available

Interacting Proteins for FAM181A Gene

Gene Ontology (GO) - Biological Process for FAM181A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM181A Gene

Drugs & Compounds for FAM181A Gene

No Compound Related Data Available

Transcripts for FAM181A Gene

Unigene Clusters for FAM181A Gene

Family with sequence similarity 181, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM181A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM181A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - - - -

Relevant External Links for FAM181A Gene

GeneLoc Exon Structure for
FAM181A
ECgene alternative splicing isoforms for
FAM181A

Expression for FAM181A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM181A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM181A Gene

This gene is overexpressed in Testis (x15.0) and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for FAM181A Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM181A Gene



Protein tissue co-expression partners for FAM181A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM181A Gene:

FAM181A

SOURCE GeneReport for Unigene cluster for FAM181A Gene:

Hs.525550
genes like me logo Genes that share expression patterns with FAM181A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM181A Gene

Orthologs for FAM181A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM181A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM181A 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia FAM181A 33 34
  • 87.27 (n)
cow
(Bos Taurus)
Mammalia FAM181A 33 34
  • 86.76 (n)
mouse
(Mus musculus)
Mammalia Fam181a 33 16 34
  • 80.25 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309028 33
  • 80.02 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM181A 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM181A 33 34
  • 66.08 (n)
lizard
(Anolis carolinensis)
Reptilia FAM181A 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam181a 33
  • 56.46 (n)
Str.13648 33
zebrafish
(Danio rerio)
Actinopterygii LOC101883716 33
  • 59.46 (n)
Species where no ortholog for FAM181A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM181A Gene

ENSEMBL:
Gene Tree for FAM181A (if available)
TreeFam:
Gene Tree for FAM181A (if available)

Paralogs for FAM181A Gene

No data available for Paralogs for FAM181A Gene

Variants for FAM181A Gene

Sequence variations from dbSNP and Humsavar for FAM181A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000047764 -- 93,924,687(+) AATCT(A/C/G)GTCTT intron-variant
rs1000114239 -- 93,926,193(+) GAGGC(A/G)TGAAA intron-variant, upstream-variant-2KB
rs1000129257 -- 93,929,773(+) GGAGC(A/G)GAGGA downstream-variant-500B
rs1000151128 -- 93,918,386(+) TCTTG(C/G)CTCTG intron-variant, upstream-variant-2KB
rs1000155478 -- 93,929,931(+) CCCCA(C/T)CTGCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM181A Gene

Variant ID Type Subtype PubMed ID
nsv521206 CNV loss 19592680
nsv832861 CNV loss 17160897

Variation tolerance for FAM181A Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM181A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM181A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM181A Gene

Disorders for FAM181A Gene

Relevant External Links for FAM181A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM181A

No disorders were found for FAM181A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM181A Gene

Publications for FAM181A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 60

Products for FAM181A Gene

Sources for FAM181A Gene

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