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Aliases for FAM181A Gene

Aliases for FAM181A Gene

  • Family With Sequence Similarity 181 Member A 2 3 5
  • Family With Sequence Similarity 181, Member A 2 3
  • C14orf152 3 4
  • Chromosome 14 Open Reading Frame 152 2

External Ids for FAM181A Gene

Previous HGNC Symbols for FAM181A Gene

  • C14orf152

Previous GeneCards Identifiers for FAM181A Gene

  • GC14P093456
  • GC14P094385
  • GC14P074566

Summaries for FAM181A Gene

GeneCards Summary for FAM181A Gene

FAM181A (Family With Sequence Similarity 181 Member A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM181A Gene

Genomics for FAM181A Gene

Regulatory Elements for FAM181A Gene

Enhancers for FAM181A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM181A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM181A Gene

93,918,894 bp from pter
93,929,608 bp from pter
10,715 bases
Plus strand

Genomic View for FAM181A Gene

Genes around FAM181A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM181A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM181A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM181A Gene

Proteins for FAM181A Gene

  • Protein details for FAM181A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM181A
    Protein Accession:
    Secondary Accessions:
    • B2RD39
    • Q96GY1

    Protein attributes for FAM181A Gene

    354 amino acids
    Molecular mass:
    38724 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM181A Gene


neXtProt entry for FAM181A Gene

Proteomics data for FAM181A Gene at MOPED

Post-translational modifications for FAM181A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM181A Gene

Domains & Families for FAM181A Gene

Protein Domains for FAM181A Gene


Suggested Antigen Peptide Sequences for FAM181A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM181 family.
  • Belongs to the FAM181 family.
genes like me logo Genes that share domains with FAM181A: view

No data available for Gene Families for FAM181A Gene

Function for FAM181A Gene

genes like me logo Genes that share phenotypes with FAM181A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM181A Gene

Localization for FAM181A Gene

Subcellular locations from

Jensen Localization Image for FAM181A Gene COMPARTMENTS Subcellular localization image for FAM181A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM181A Gene

Pathways & Interactions for FAM181A Gene

SuperPathways for FAM181A Gene

No Data Available

Interacting Proteins for FAM181A Gene

Gene Ontology (GO) - Biological Process for FAM181A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM181A Gene

Drugs & Compounds for FAM181A Gene

No Compound Related Data Available

Transcripts for FAM181A Gene

Unigene Clusters for FAM181A Gene

Family with sequence similarity 181, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM181A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: -
SP3: - -
SP5: - - - - -

Relevant External Links for FAM181A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM181A Gene

mRNA expression in normal human tissues for FAM181A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM181A Gene

This gene is overexpressed in Testis (x15.0) and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for FAM181A Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM181A Gene

SOURCE GeneReport for Unigene cluster for FAM181A Gene Hs.525550

genes like me logo Genes that share expression patterns with FAM181A: view

Protein tissue co-expression partners for FAM181A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FAM181A Gene

Orthologs for FAM181A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM181A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FAM181A 35
  • 86.76 (n)
  • 85.62 (a)
FAM181A 36
  • 82 (a)
(Canis familiaris)
Mammalia FAM181A 35
  • 87.27 (n)
  • 86.96 (a)
FAM181A 36
  • 80 (a)
(Mus musculus)
Mammalia Fam181a 35
  • 80.25 (n)
  • 76.71 (a)
Fam181a 16
Fam181a 36
  • 77 (a)
(Pan troglodytes)
Mammalia FAM181A 35
  • 99.32 (n)
  • 98.97 (a)
FAM181A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1309028 35
  • 80.02 (n)
  • 76.71 (a)
(Monodelphis domestica)
Mammalia FAM181A 36
  • 64 (a)
(Gallus gallus)
Aves FAM181A 35
  • 66.08 (n)
  • 60.64 (a)
FAM181A 36
  • 74 (a)
(Anolis carolinensis)
Reptilia FAM181A 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam181a 35
  • 56.46 (n)
  • 57.2 (a)
Str.13648 35
(Danio rerio)
Actinopterygii LOC101883716 35
  • 59.46 (n)
  • 50 (a)
Species with no ortholog for FAM181A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM181A Gene

Gene Tree for FAM181A (if available)
Gene Tree for FAM181A (if available)

Paralogs for FAM181A Gene

No data available for Paralogs for FAM181A Gene

Variants for FAM181A Gene

Sequence variations from dbSNP and Humsavar for FAM181A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_022834 -
rs34220325 - 93,928,583(+) AGGTG(A/C/T)TGAGG reference, synonymous-codon, missense
rs7148282 -- 93,929,823(+) GGTCC(A/T)ACGTG downstream-variant-500B
rs8011050 -- 93,929,895(+) CTGTG(C/G)GGCCA downstream-variant-500B
rs35757230 -- 93,929,612(+) ATCTT(-/G)GGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM181A Gene

Variant ID Type Subtype PubMed ID
nsv832861 CNV Loss 17160897
nsv902206 CNV Loss 21882294
nsv521206 CNV Loss 19592680

Variation tolerance for FAM181A Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM181A Gene

Disorders for FAM181A Gene

Relevant External Links for FAM181A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM181A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM181A Gene

Publications for FAM181A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FAM181A Gene

Sources for FAM181A Gene