Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM180B Gene

Aliases for FAM180B Gene

  • Family With Sequence Similarity 180 Member B 2 3 5
  • Family With Sequence Similarity 180, Member B 2
  • Hypothetical Gene Supported By BC065704 2

External Ids for FAM180B Gene

Previous GeneCards Identifiers for FAM180B Gene

  • GC11P047566
  • GC11P047309

Summaries for FAM180B Gene

GeneCards Summary for FAM180B Gene

FAM180B (Family With Sequence Similarity 180 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM180B Gene

Genomics for FAM180B Gene

Regulatory Elements for FAM180B Gene

Enhancers for FAM180B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F047606 1 Ensembl ENCODE 12.3 +21.0 21004 1.9 PBX2 BHLHE40 HMBOX1 FOS EBF1 MAFK ZIC2 FNBP4 FAM180B KBTBD4 NDUFS3 PTPMT1 CELF1 ENSG00000231880 RNU5E-10P MTCH2 AGBL2
GH11F047611 1 Ensembl ENCODE 12.2 +25.1 25081 0.9 IKZF1 SPI1 FAM180B CELF1 NDUFS3 PTPMT1 KBTBD4 MTCH2 ENSG00000231880 RNU5E-10P RAPSN AGBL2
GH11F047617 0.6 ENCODE 12.2 +31.0 31043 1.2 CTCF ZNF654 CEBPB JUNB TRIM22 REST RAD21 TGIF2 ZNF143 SMC3 C1QTNF4 FAM180B NDUFS3 PTPMT1 CELF1 MTCH2 KBTBD4 ENSG00000231880 RNU5E-10P RAPSN
GH11F047506 1.1 FANTOM5 Ensembl ENCODE 11.7 -73.2 -73178 14.6 HDGF PKNOX1 WRNIP1 ZFP64 ZNF493 SIN3A FEZF1 ZNF2 ZNF121 GATA2 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 DDB2 ZNF408 CELF1 SLC39A13 NDUFS3
GH11F047498 1.3 Ensembl ENCODE 11.7 -87.5 -87478 2.4 ZNF493 WRNIP1 ZFP64 RAD21 ZNF155 YY1 ZEB1 ZNF354C ZNF138 KLF7 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 DDB2 ZNF408 SLC39A13 KBTBD4 CELF1 NDUFS3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FAM180B on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM180B Gene

Chromosome:
11
Start:
47,586,678 bp from pter
End:
47,589,194 bp from pter
Size:
2,517 bases
Orientation:
Plus strand

Genomic View for FAM180B Gene

Genes around FAM180B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM180B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM180B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM180B Gene

Proteins for FAM180B Gene

  • Protein details for FAM180B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P0A1-F180B_HUMAN
    Recommended name:
    Protein FAM180B
    Protein Accession:
    Q6P0A1

    Protein attributes for FAM180B Gene

    Size:
    224 amino acids
    Molecular mass:
    25167 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM180B Gene

Post-translational modifications for FAM180B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM180B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM180B Gene

Domains & Families for FAM180B Gene

Protein Domains for FAM180B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM180B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P0A1

UniProtKB/Swiss-Prot:

F180B_HUMAN :
  • Belongs to the FAM180 family.
Family:
  • Belongs to the FAM180 family.
genes like me logo Genes that share domains with FAM180B: view

No data available for Gene Families for FAM180B Gene

Function for FAM180B Gene

Phenotypes for FAM180B Gene

genes like me logo Genes that share phenotypes with FAM180B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM180B Gene

Localization for FAM180B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM180B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM180B Gene COMPARTMENTS Subcellular localization image for FAM180B gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FAM180B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM180B: view

Pathways & Interactions for FAM180B Gene

SuperPathways for FAM180B Gene

No Data Available

Interacting Proteins for FAM180B Gene

Gene Ontology (GO) - Biological Process for FAM180B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM180B Gene

Transcripts for FAM180B Gene

mRNA/cDNA for FAM180B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM180B Gene

Family with sequence similarity 180, member B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM180B Gene

No ASD Table

Relevant External Links for FAM180B Gene

GeneLoc Exon Structure for
FAM180B
ECgene alternative splicing isoforms for
FAM180B

Expression for FAM180B Gene

mRNA expression in normal human tissues for FAM180B Gene

mRNA differential expression in normal tissues according to GTEx for FAM180B Gene

This gene is overexpressed in Nerve - Tibial (x8.0), Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Adipose - Subcutaneous (x5.1).

Protein differential expression in normal tissues from HIPED for FAM180B Gene

This gene is overexpressed in Skin (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM180B Gene



Protein tissue co-expression partners for FAM180B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM180B Gene:

FAM180B

SOURCE GeneReport for Unigene cluster for FAM180B Gene:

Hs.502529
genes like me logo Genes that share expression patterns with FAM180B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FAM180B Gene

Orthologs for FAM180B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM180B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM180B 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia FAM180B 34 35
  • 89.98 (n)
cow
(Bos Taurus)
Mammalia FAM180B 34
  • 89.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM180B 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM180B 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM180B 35
  • 28 (a)
OneToOne
Species where no ortholog for FAM180B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM180B Gene

ENSEMBL:
Gene Tree for FAM180B (if available)
TreeFam:
Gene Tree for FAM180B (if available)

Paralogs for FAM180B Gene

No data available for Paralogs for FAM180B Gene

Variants for FAM180B Gene

Sequence variations from dbSNP and Humsavar for FAM180B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1040199 -- 47,588,528(-) AGATG(C/T)CAGAC utr-variant-3-prime
rs10742816 -- 47,585,432(+) GGCTA(C/T)AGGAA upstream-variant-2KB
rs10838731 -- 47,585,583(+) CCTCC(C/T)GGGTT upstream-variant-2KB
rs10838732 -- 47,586,388(+) GAGGG(C/G)GCAGA upstream-variant-2KB
rs11039307 -- 47,589,600(+) CGGGC(C/T)CGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FAM180B Gene

Variant ID Type Subtype PubMed ID
esv3579504 CNV loss 25503493
nsv509405 CNV insertion 20534489
nsv825872 CNV gain 20364138
nsv825873 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for FAM180B Gene

Gene Damage Index Score: 1.12; 22.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM180B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM180B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM180B Gene

Disorders for FAM180B Gene

Relevant External Links for FAM180B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM180B

No disorders were found for FAM180B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM180B Gene

Publications for FAM180B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for FAM180B Gene

Sources for FAM180B Gene

Content
Loading form....