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Aliases for FAM180A Gene

Aliases for FAM180A Gene

  • Family With Sequence Similarity 180 Member A 2 3 5
  • Family With Sequence Similarity 180, Member A 2
  • Protein FAM180A 3
  • HWKM1940 3
  • UNQ1940 3

External Ids for FAM180A Gene

Previous GeneCards Identifiers for FAM180A Gene

  • GC07M135065
  • GC07M135413
  • GC07M129717

Summaries for FAM180A Gene

GeneCards Summary for FAM180A Gene

FAM180A (Family With Sequence Similarity 180 Member A) is a Protein Coding gene.

Additional gene information for FAM180A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM180A Gene

Genomics for FAM180A Gene

Regulatory Elements for FAM180A Gene

Enhancers for FAM180A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H135771 1.8 VISTA FANTOM5 Ensembl ENCODE dbSUPER 31.2 -24.4 -24370 3 FOXA2 ZNF175 CEBPG ZIC2 ZNF2 RAD21 FOSL1 GATA3 CTBP1 FOS FAM180A STMP1 SLC13A4 LOC105375522 GC07M135854
GH07H135743 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +3.6 3562 3 PKNOX1 ATF1 JUN ZSCAN4 BACH1 ZNF175 ZMYM3 CEBPG ZBTB40 FOSL1 STMP1 RPL15P11 FAM180A ENSG00000224746 SLC13A4
GH07H135712 1.2 Ensembl ENCODE 11.6 +34.8 34767 4 HDGF PKNOX1 ARNT YBX1 FEZF1 GLI4 ZNF2 FOS ZNF488 REST STMP1 NUP205 RPL15P11 C7orf49 FAM180A WDR91 SLC13A4 ENSG00000224746 ENSG00000273219
GH07H135672 1.2 Ensembl ENCODE dbSUPER 9.7 +75.7 75661 1 CTCF TFAP4 ZNF654 STAT1 ARNT MNT REST RAD21 ZNF664 JUND STMP1 RPL15P11 FAM180A C7orf49 GC07P135677 GC07M135666 RNU6-1154P
GH07H135716 1 ENCODE 11.6 +31.9 31914 0 PKNOX1 ARNT FEZF1 ZNF2 ZNF121 FOS YY2 TSHZ1 ZNF488 ZNF623 NUP205 ENSG00000273219 FAM180A STMP1 SLC13A4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM180A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM180A Gene

Chromosome:
7
Start:
135,728,348 bp from pter
End:
135,748,867 bp from pter
Size:
20,520 bases
Orientation:
Minus strand

Genomic View for FAM180A Gene

Genes around FAM180A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM180A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM180A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM180A Gene

Proteins for FAM180A Gene

  • Protein details for FAM180A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWF9-F180A_HUMAN
    Recommended name:
    Protein FAM180A
    Protein Accession:
    Q6UWF9
    Secondary Accessions:
    • B2RP85

    Protein attributes for FAM180A Gene

    Size:
    173 amino acids
    Molecular mass:
    19733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM180A Gene

Post-translational modifications for FAM180A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM180A Gene

No data available for DME Specific Peptides for FAM180A Gene

Domains & Families for FAM180A Gene

Gene Families for FAM180A Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FAM180A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM180A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWF9

UniProtKB/Swiss-Prot:

F180A_HUMAN :
  • Belongs to the FAM180 family.
Family:
  • Belongs to the FAM180 family.
genes like me logo Genes that share domains with FAM180A: view

Function for FAM180A Gene

Phenotypes From GWAS Catalog for FAM180A Gene

Phenotypes for FAM180A Gene

genes like me logo Genes that share phenotypes with FAM180A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM180A

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM180A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM180A Gene

Localization for FAM180A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM180A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM180A gene
Compartment Confidence
extracellular 4
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM180A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM180A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM180A Gene

Pathways & Interactions for FAM180A Gene

SuperPathways for FAM180A Gene

No Data Available

Interacting Proteins for FAM180A Gene

Gene Ontology (GO) - Biological Process for FAM180A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM180A Gene

Drugs & Compounds for FAM180A Gene

No Compound Related Data Available

Transcripts for FAM180A Gene

mRNA/cDNA for FAM180A Gene

Unigene Clusters for FAM180A Gene

Family with sequence similarity 180, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FAM180A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FAM180A Gene

No ASD Table

Relevant External Links for FAM180A Gene

GeneLoc Exon Structure for
FAM180A
ECgene alternative splicing isoforms for
FAM180A

Expression for FAM180A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM180A Gene

mRNA differential expression in normal tissues according to GTEx for FAM180A Gene

This gene is overexpressed in Artery - Aorta (x12.9).

Protein differential expression in normal tissues from HIPED for FAM180A Gene

This gene is overexpressed in Serum (22.7), Bone (15.2), Esophagus (13.0), Bone marrow mesenchymal stem cell (9.9), and Lung (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM180A Gene



Protein tissue co-expression partners for FAM180A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM180A Gene:

FAM180A

SOURCE GeneReport for Unigene cluster for FAM180A Gene:

Hs.55200
genes like me logo Genes that share expression patterns with FAM180A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM180A Gene

Orthologs for FAM180A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM180A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM180A 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia FAM180A 33 34
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia FAM180A 33 34
  • 86.32 (n)
rat
(Rattus norvegicus)
Mammalia Fam180a 33
  • 81.09 (n)
mouse
(Mus musculus)
Mammalia Fam180a 33 16 34
  • 79.73 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM180A 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM180A 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM180A 33 34
  • 72.97 (n)
lizard
(Anolis carolinensis)
Reptilia FAM180A 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam180a 33
  • 63.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538098 33
  • 51.3 (n)
CABZ01068473.1 34
  • 35 (a)
OneToOne
Species where no ortholog for FAM180A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM180A Gene

ENSEMBL:
Gene Tree for FAM180A (if available)
TreeFam:
Gene Tree for FAM180A (if available)

Paralogs for FAM180A Gene

No data available for Paralogs for FAM180A Gene

Variants for FAM180A Gene

Sequence variations from dbSNP and Humsavar for FAM180A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000052751 -- 135,748,642(+) GCAGG(C/T)ATGCC utr-variant-5-prime
rs1000068627 -- 135,744,056(+) AATTG(A/G)TCTCA intron-variant
rs1000182555 -- 135,745,301(+) ACTTA(A/G)AAAAT intron-variant
rs1000188586 -- 135,748,273(+) GGGTA(A/C)TCTCT intron-variant
rs1000439721 -- 135,743,121(+) CAAAA(A/C)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM180A Gene

Variant ID Type Subtype PubMed ID
nsv608460 CNV gain 21841781

Variation tolerance for FAM180A Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM180A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM180A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM180A Gene

Disorders for FAM180A Gene

Relevant External Links for FAM180A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM180A

No disorders were found for FAM180A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM180A Gene

Publications for FAM180A Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 2 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 60
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for FAM180A Gene

Sources for FAM180A Gene

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