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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FAM180A Gene

protein-coding   GIFtS: 34
GCID: GC07M135413

Family With Sequence Similarity 180, Member A

  Search for FAM180A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Family With Sequence Similarity 180, Member A1 2
HWKM19402
UNQ19402
Protein FAM180A2

External Ids:    HGNC: 337731   Entrez Gene: 3895582   Ensembl: ENSG000001893207   UniProtKB: Q6UWF93   

Export aliases for FAM180A gene to outside databases

Previous GC identifers: GC07M135065 GC07M129717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FAM180A Gene: 
FAM180A (family with sequence similarity 180, member A) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FAM180A gene promoter:
         HFH-3   NF-1   GATA-3   AML1a   p53   POU6F1 (c2)   GATA-2   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFAM180A promoter sequence
   Search SABiosciences Chromatin IP Primers for FAM180A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM180A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

FAM180A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM180A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M135413:  view genomic region     (about GC identifiers)

Start:
135,413,096 bp from pter      End:
135,433,594 bp from pter
Size:
20,499 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 134,758,777-134,778,028     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F180A_HUMAN, Q6UWF9 (See protein sequence)
Recommended Name: Protein FAM180A precursor  
Size: 173 amino acids; 19733 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B2RP85

Explore the universe of human proteins at neXtProt for FAM180A: NX_Q6UWF9

Explore proteomics data for FAM180A at MOPED 

FAM180A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FAM180A Protein Expression

REFSEQ proteins: NP_995327.1  
ENSEMBL proteins: 
 ENSP00000405281   ENSP00000406553   ENSP00000395467   ENSP00000342336  

Human Recombinant Protein Products for FAM180A: 
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Cloud-Clone Corp. Proteins for FAM180A 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

FAM180A for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for FAM180A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UWF9

UniProtKB/Swiss-Prot: F180A_HUMAN, Q6UWF9
Similarity: Belongs to the FAM180 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 MGI phenotypic allele for Fam180a (no phenotypes)

FAM180A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Fam180atm1Lex for FAM180A

   inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM180A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM180A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FAM180A 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FAM180A 

miRNA
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hsa-miR-1244 hsa-miR-199b-3p hsa-miR-376a* hsa-miR-199a-3p hsa-miR-202 hsa-miR-3129-5p hsa-miR-3605-5p
SwitchGear 3'UTR luciferase reporter plasmidFAM180A 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM180A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FAM180A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM180A (F180A)

Search CenterWatch for drugs/clinical trials and news about FAM180A / F180A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM180A gene: 
NM_205855.3  

Unigene Cluster for FAM180A:

Family with sequence similarity 180, member A
Hs.55200  [show with all ESTs]
Unigene Representative Sequence: NM_205855
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000435869 ENST00000444083 ENST00000415751 ENST00000338588(uc003vtd.3 uc010lmt.3 uc010lmu.2)

miRNA
Products:
     
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7 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM180A:
hsa-miR-1244 hsa-miR-199b-3p hsa-miR-376a* hsa-miR-199a-3p hsa-miR-202 hsa-miR-3129-5p hsa-miR-3605-5p
SwitchGear 3'UTR luciferase reporter plasmidFAM180A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FAM180A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FAM180A
Clone
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OriGene ORF clones in mouse, rat for FAM180A
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM180A
Sirion Biotech Customized lentivirus for stable overexpression of FAM180A 
                     Customized lentivirus expression plasmids for stable overexpression of FAM180A 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for FAM180A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM180A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM180A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM180A

Additional mRNA sequence: 

AK290250.1 AK297754.1 AK310180.1 AY358803.1 BC137311.1 BC137312.1 

2 DOTS entries:

DT.95223121  DT.97835518 

19 AceView cDNA sequences:

AL597791 CA412529 BE670070 CA415090 BU617005 NM_205855 BQ027124 CB052873 
CA446834 AY358803 BX103558 AW449822 BM995068 BQ009686 BQ014212 C21523 
N98513 CD357161 W31078 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM180A expression in normal human tissues (normalized intensities)      FAM180A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTGGAAAAA
FAM180A Expression
About this image


FAM180A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/6 selected tissues (see all 6) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 4 entries
         Thoracic Rib
         HyStem+BMP4-induced 4D20.8 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
         Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc
         HyStem+BMP4-induced 4D20.8 cells
 
 Smooth Muscle (Muscoskeletal System)
         Human Tracheal Smooth Muscle Cells (HTSMC)   
 
 Lung (Muscoskeletal System)
         Human Tracheal Smooth Muscle Cells (HTSMC)   
 
 Primitive Streak (Early Embryonic Tissues)
         Notochord

See FAM180A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.55200
    SABiosciences Custom PCR Arrays for FAM180A
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for FAM180A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FAM180A
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FAM180A
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM180A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FAM180A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM180A gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam180a1 , 5 family with sequence similarity 180, member A1, 5 79.73(n)1
79.53(a)1
  6 (15.27 cM)5
2081641  NM_173375.11  NP_775551.11 
 353127465 
chicken
(Gallus gallus)
Aves FAM180A1 family with sequence similarity 180, member A 72.97(n)
70.12(a)
  772003  XM_001235203.2  XP_001235204.2 
lizard
(Anolis carolinensis)
Reptilia FAM180A6
Uncharacterized protein
67(a)
1 ↔ 1
GL343602.1(299129-318587)
zebrafish
(Danio rerio)
Actinopterygii LOC1005380981 protein FAM180A-like 48.1(n)
36.71(a)
  100538098  XM_003198212.1  XP_003198260.1 


ENSEMBL Gene Tree for FAM180A (if available)
TreeFam Gene Tree for FAM180A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/494 SNPs in FAM180A are shown (see all 494)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1879972541,2
--135414939(+) GTCTCC/TTGAGT 1 -- ut310--------
rs31123711,2
C,A,H--135415028(+) CTCACG/ACCTGT 1 -- ut313Minor allele frequency- A:0.17NA 6
rs1905659201,2
--135415093(+) GAGACC/TAGCCT 1 -- int10--------
rs1829413811,2
--135415341(+) CAGAAA/GTGGTT 1 -- int10--------
rs1875300041,2
--135415349(+) GTTACA/GTAAGT 1 -- int10--------
rs119754131,2
C,F,H--135415472(+) CAAAAT/CAGGAG 1 -- int12Minor allele frequency- C:0.12CSA WA 120
rs791945781,2
C,F--135415616(+) AAACAA/GTGATC 1 -- int11Minor allele frequency- G:0.09WA 118
rs1512394961,2
--135415655(+) CTCTAG/TTTACT 1 -- int10--------
rs624895301,2
C,F--135415660(+) GTTACT/AGAAAA 1 -- int13Minor allele frequency- A:0.04NA WA 240
rs737239031,2
C,F--135415695(+) GGTCAT/AGTCCT 1 -- int11Minor allele frequency- A:0.50WA 2

HapMap Linkage Disequilibrium report for FAM180A (135413096 - 135433594 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FAM180A: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FAM180A
DNA2.0 Custom Variant and Variant Library Synthesis for FAM180A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FAM180A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM180A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
  2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2, 3 Scherer S.W.... Tsui L.-C. (2003)
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 389558 HGNC: 33773 AceView: UNQ1940 Ensembl:ENSG00000189320 euGenes: HUgn389558
ECgene: FAM180A H-InvDB: FAM180A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FAM180A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FAM180A gene:
Search GeneIP for patents involving FAM180A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 SwitchGear 3'UTR luciferase reporter plasmids for FAM180A
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 ThermoFisher Antibodies for FAM180A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FAM180A
 inGenious Targeting Laboratory - Custom generated mouse model solutions for FAM180A
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FAM180A
Customized:
 lentivirus for stable overexpression of FAM180A
 lentivirus expression plasmids for stable overexpression of FAM180A
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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