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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FAM180A Gene

protein-coding GIFtS: 35
GCID: GC07M135413

family with sequence similarity 180, member A

Search for FAM180A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Family With Sequence Similarity 180, Member A¹ ²
HWKM1940¹ ²
UNQ1940¹ ²
Protein FAM180A²

External Ids:	HGNC: 33773¹	Entrez Gene: 389558²	Ensembl: ENSG00000189320⁷	UniProtKB: Q6UWF9³

Export aliases for FAM180A gene to outside databases

Previous GC identifers: GC07M135065 GC07M129717

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FAM180A gene promoter:
HFH-3 NF-1 GATA-3 AML1a p53 POU6F1 (c2) GATA-2 FOXI1 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FAM180A promoter sequence

Search SABiosciences Chromatin IP Primers for FAM180A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FAM180A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

FAM180A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FAM180A gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M135413: view genomic region (about GC identifiers)

Start:	135,413,096 bp from pter	End:	135,433,594 bp from pter
Size:	20,499 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 134,758,777-134,778,028

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: F180A_HUMAN, Q6UWF9 (See protein sequence)

Recommended Name: Protein FAM180A precursor

Size: 173 amino acids; 19733 Da

Subcellular location: Secreted (Potential)

Secondary accessions: B2RP85

Explore the universe of human proteins at neXtProt for FAM180A: NX_Q6UWF9

FAM180A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_995327.1

ENSEMBL proteins:

ENSP00000405281 ENSP00000406553 ENSP00000395467 ENSP00000342336

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	Uscn Proteins for FAM180A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

FAM180A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UWF9

UniProtKB/Swiss-Prot: F180A_HUMAN, Q6UWF9

Similarity: Belongs to the FAM180 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 MGI phenotypic allele

for Fam180a (no phenotypes)

FAM180A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Fam180a^tm1Lex for FAM180A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FAM180A

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM180A:
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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FAM180A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FAM180A
Search CenterWatch for drugs/clinical trials and news about FAM180A / F180A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FAM180A gene:

NM_205855.3

Unigene Cluster for FAM180A:

Family with sequence similarity 180, member A

Hs.55200 [show with all ESTs]

Unigene Representative Sequence: NM_205855

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000435869 ENST00000444083 ENST00000415751 ENST00000338588(uc003vtd.3 uc010lmt.3 uc010lmu.2)

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FAM180A:
		hsa-miR-1244 hsa-miR-199b-3p hsa-miR-376a* hsa-miR-199a-3p hsa-miR-202 hsa-miR-3129-5p hsa-miR-3605-5p
		SwitchGear 3'UTR luciferase reporter plasmid: FAM180A 3' UTR sequence

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Additional cDNA sequence:

AK290250.1 AK297754.1 AK310180.1 AY358803.1 BC137311.1 BC137312.1

2 DOTS entries:

DT.95223121 DT.97835518

19 AceView cDNA sequences:

BE670070 CA412529 AL597791 CA415090 BM995068 AW449822 CA446834 AY358803

CB052873 BQ014212 BU617005 BX103558 BQ009686 BQ027124 NM_205855 C21523

N98513 W31078 CD357161

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FAM180A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGGAAAAA

About this image

FAM180A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Bone

Liver

Primitive Streak

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)

Bone, Cartilage

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

See FAM180A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.55200

SABiosciences Custom PCR Arrays for FAM180A

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FAM180A

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FAM180A gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fam180a^{1 , 5}	family with sequence similarity 180, member A^{1, 5}	79.73(n)¹ 79.53(a)¹		6 (15.27 cM)⁵ 208164¹ NM_173375.1¹ NP_775551.1¹ 35312746⁵
chicken (Gallus gallus)	Aves	FAM180A¹	family with sequence similarity 180, member A	72.97(n) 70.12(a)		772003 XM_001235203.2 XP_001235204.2
lizard (Anolis carolinensis)	Reptilia	FAM180A⁶	--	69(a)	1 ↔ 1	GL343602.1(299524-314452)
zebrafish (Danio rerio)	Actinopterygii	LOC100538098¹	protein FAM180A-like	48.1(n) 36.71(a)		100538098 XM_003198212.1 XP_003198260.1

ENSEMBL Gene Tree for FAM180A (if available)
TreeFam Gene Tree for FAM180A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187997254^1,2		--	135414939(+)	`GTCTCC/TTGAGT`	1	--	ut3¹		0	--	--	--	--
rs3112371^1,2	C,A,H	--	135415028(+)	`CTCACG/ACCTGT`	1	--	ut3¹		3		NA	6
rs190565920^1,2		--	135415093(+)	`GAGACC/TAGCCT`	1	--	int¹		0	--	--	--	--
rs182941381^1,2		--	135415341(+)	`CAGAAA/GTGGTT`	1	--	int¹		0	--	--	--	--
rs187530004^1,2		--	135415349(+)	`GTTACA/GTAAGT`	1	--	int¹		0	--	--	--	--
rs11975413^1,2	C,H	--	135415472(+)	`CAAAAT/CAGGAG`	1	--	int¹		2		CSA WA	120
rs79194578^1,2	F	--	135415616(+)	`AAACAA/GTGATC`	1	--	int¹		1		WA	118
rs151239496^1,2		--	135415655(+)	`CTCTAG/TTTACT`	1	--	int¹		0	--	--	--	--
rs62489530^1,2		--	135415660(+)	`GTTACT/AGAAAA`	1	--	int¹		3		NA WA	240
rs73723903^1,2	C	--	135415695(+)	`GGTCAT/AGTCCT`	1	--	int¹		1		WA	2

HapMap Linkage Disequilibrium report for FAM180A (135413096 - 135433594 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FAM180A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FAM180A gene integrated from 9 sources:
(articles sorted by number of sources associating them with FAM180A)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2, 3} Scherer S.W.... Tsui L.-C. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389558	HGNC: 33773	AceView: UNQ1940	Ensembl:ENSG00000189320	euGenes: HUgn389558
ECgene: FAM180A	H-InvDB: FAM180A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FAM180A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FAM180A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FAM180A gene:
Search GeneIP for patents involving FAM180A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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FAM180A Gene

family with sequence similarity 180, member A

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for FAM180A gene

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for FAM180A gene

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for FAM180A gene

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Export list of displayed genes

FAM180A Gene

family with sequence similarity 180, member A

Aliasesfor FAM180A gene

Summariesfor FAM180A gene

Genomic Viewsfor FAM180A gene

Proteinsfor FAM180A gene

Protein Domains /Familiesfor FAM180A gene

Functionfor FAM180A gene

Pathways & Interactionsfor FAM180A gene

Drugs & Compoundsfor FAM180A gene

Transcriptsfor FAM180A gene

Expression for FAM180A gene

Orthologsfor FAM180A gene

Paralogsfor FAM180A gene

Genomic Variantsfor FAM180A gene

Disorders / Diseasesfor FAM180A gene

Publicationsfor FAM180A gene

External Searches for FAM180A gene

Genome Databases showing FAM180A gene

Other Databases showing FAM180A gene

Specialized Databases showing FAM180A gene

Intellectual Propertyfor FAM180A gene

Productsfor FAM180A gene

View Random Gene

Aliases
for FAM180A gene

Summaries
for FAM180A gene

Genomic Views
for FAM180A gene

Proteins
for FAM180A gene

Protein Domains /
Families
for FAM180A gene

Function
for FAM180A gene

Pathways & Interactions
for FAM180A gene

Drugs & Compounds
for FAM180A gene

Transcripts
for FAM180A gene

Expression
for FAM180A gene

Orthologs
for FAM180A gene

Paralogs
for FAM180A gene

Genomic Variants
for FAM180A gene

Disorders / Diseases
for FAM180A gene

Publications
for FAM180A gene

Intellectual Property
for FAM180A gene

Products
for FAM180A gene